Sequence and Membrane Determinants of the Random Coil-Helix Transition of 伪-Synuclein
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- 作者：Sowmya B. Lokappa ; Jae-Eun Suk ; Adithya Balasubramanian ; Soma Samanta ; Alan J. Situ ; Tobias S. Ulmer ; tulmer@usc.edu" class="auth_mail
- 关键词：伪S ; 伪-synuclein ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; DOPE ; 1 ; 2-dioleoyl-sn-glycero-3-phosphoethanolamine ; DOPS ; 1 ; 2-dioleoyl-sn-glycero-3-phospho-l-serine ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; ITC ; isothermal titration calorimetry ; POPC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; POPS ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine ; SUV ; small unilamellar vesicle ; POPG ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1&prime ; -rac-glycerol) ; DLS ; dynamic light scat
- 刊名：Journal of Molecular Biology
- 出版年：15 May 2014
- 年：2014
- 卷：426
- 期：10
- 页码：2130-2144
- 全文大小：1039 K
文摘
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275">伪S folding on membrane surfaces produces an unusually long 伪-helix.
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280">Helix propagation requires non-uniform distributions of lipid affinities and helix dynamics.
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285">The attained helix propagation correlates to membrane stabilization.
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290">Membrane leakage increases at non-saturating lipid conditions or upon rigidifying the helix.
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295">伪S folding parameters appear narrowly matched to its target membrane.