Biophysics in cancer: The relevance of drug-membrane interaction studies
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- 作者：Ana Catarina Alves ; Daniela Ribeiro ; Clá ; udia Nunes ; Salette Reis ; shreis@ff.up.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：DEPC ; 1 ; 2-dierucoyl-sn-glycero-3-phosphocholine ; DMPG ; 1 ; 2-ditetradecanoyl-sn-glycero-3-phospho-(1&prime ; -rac-glycerol) ; DSPC ; 1 ; 2-dioctadecanoyl-sn-glycero-3-phosphocholine ; DOTAP ; 1 ; 2-dioleoyl-3-trimethylammonium-propane ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; DPPE ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphoethanolamine ; DPPG ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphoglycerol ; DMPC ; 1 ; 2-ditetradecanoyl-sn-glycero-3-phosphocholine ; CEUs ; 1-aryl-3-(2-chloroethyl) ureas ; POPC ; 1-palmitoyl-2-oleo
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：2231-2244
- 全文大小：1619 K
文摘
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Cancer cells present changes in phospholipid constitution, surface charge and membrane fluidity.
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The structural, biophysical and functional differences between cancer and normal cell membranes can modulate drug activity.
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Mimetic models have been developed to overcome membrane's complexity and used to study anticancer drug-membrane interactions.
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20">Research of new cancer therapies using membrane biophysics may be a path to overcome the problems found in clinical practice.