Right ventricular pressure-volume loops using simultaneous radionuclide angiography with a multiwire gamma camera and right heart catheterization

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• 作者：Thein Htay ; Deval Mehta ; Liang Sun ; Jeffrey Lacy ; Raed Aqel ; Jaekyeong Heo ; Ami E. Isk ; rian
• 关键词：Right ventricular function ; pressure-volume loop ; heart failure ; radionuclide angiography ; cardiac catheterization
• 刊名：Journal of Nuclear Cardiology
• 出版年：2005
• 出版时间：July-August 2005
• 年：2005
• 卷：12
• 期：4
• 页码：435-440
• 全文大小：290 K

文摘

Background

The purpose of this study was to generate right ventricular (RV) pressure-volume loops (PVLs) from time-activity curves obtained by first-pass radionuclide angiography (RNA) and RV pressures obtained by right heart catheterization.

Methods and Results

Short-lived tantalum 178 was used to obtain first-pass RNA at baseline (n = 31), after nitroglycerin (n = 5), or after the conclusion of cardiac catheterization (n = 13). From the radionuclide-derived RV ejection fraction and thermodilution stroke volume, the RV end-diastolic volume and end-systolic volume were measured. Special proprietary software was developed and used to integrate the pressure and the RNA data. The mean heart rate was 80 ± 17 beats/min; RV ejection fraction, 39 % ± 12 % ; RV end-diastolic volume, 217 ± 79 mL; RV end-systolic volume, 142 ± 74 mL; and RV end-diastolic pressure, 10 ± 7 mm Hg. The RV PVLs were of high quality and reproducible.

Conclusions

This study provides proof of concept of the feasibility of generating RV PVL; the short half-life (10 minutes) and low energy (59 keV) of Ta-178 allow the generation of multiple loops at low radiation exposure. Such studies could be performed at the bedside and provide a wealth of information that may have clinical and research merits.