Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer
详细信息 查看全文
- 作者：Sunil Singhal1 ; 5 ; Pratik S. Bhojnagarwala1 ; Shaun O'Brien2 ; Edmund K. Moon2 ; Alfred L. Garfall3 ; Abhishek S. Rao1 ; Jon G. Quatromoni1 ; Tom Li Stephen6 ; Leslie Litzky4 ; Charuhas Deshpande4 ; Michael D. Feldman4 ; Wayne W. Hancock4 ; 7 ; Jose R. Conejo-Garcia6 ; Steven M. Albelda2 ; Evgeniy B. Eruslanov1 ; evgeniy.eruslanov@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：30
- 期：1
- 页码：120-135
- 全文大小：4958 K
文摘
- •
Lung tumors accumulate a subset of TANs with a granulocyte and APC hybrid phenotype
- •
APC-like hybrid neutrophils are able to stimulate the anti-tumor T cell responses
- •
IFN-γ and GM-CSF are requisite factors for the development of hybrid neutrophils
- •
Ikaros negatively regulates the development of hybrid neutrophils from progenitors