Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4
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- 作者：Yangyang Changa ; d ; Yaohui Baia ; Qinghua Jia ; d ; Yang Huoa ; d ; Huijuan Liub ; John C. Crittendenc ; john.crittenden@ce.gatech.edu" class="auth_mail" title="E-mail the corresponding author ; Jiuhui Qua ; jhqu@rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author ; jhqu@mail.rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Genotoxicity ; Combined effects ; N-DBPs ; Chlorination ; SOS/umu test
- 刊名：Journal of Hazardous Materials
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：322
- 期：part_PB
- 页码：387-393
- 全文大小：1425 K
文摘
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Genotoxicity of chlorinated mixture (GCM) is not predicted by that of single (GCI).
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pH is an important factor affecting difference between GCM and GCI (GΔ = GCM-GCI).
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GΔ > 0 occurred at pH 5.0–6.1 and GΔ < 0 occurred at pH 6.3–8.0.
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GΔ is determined by N-DBPs decrease in mixture and combined effects between DBPs.
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TON ratio can be used to estimate the GΔ value.