Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages

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• 作者：Kan&rsquo ; ichiro Ishiuchi^a ; ^b ; ^&dagger ; ; Wen-Ping Jiang^c ; ^&dagger ; ; Yukio Fujiwara^d ; Jin-Bin Wu^c ; ^{jbwu@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Susumu Kitanaka^a ; ^{kitanaka.susumu@nihon-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lycopodium alkaloids ; Lycopodium serratum var. longipetiolatum ; Serralongamines B ; C and D ; Atherosclerosis ; Human monocyte-derived macrophages ; Foam cells
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 June 2016
• 年：2016
• 卷：26
• 期：11
• 页码：2636-2640
• 全文大小：832 K

文摘

Three new Lycopodium alkaloids, serralongamines B–D (1–3), have been isolated from the club moss Lycopodium serratum var. longipetiolatum, and the structures were elucidated on the basis of spectroscopic data and chemical transformation. 1 and 3 significantly exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.