BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies

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• 作者：Black ; Gillian F ; Weir ; Rosemary E ; Floyd ; Sian ; Bliss ; Lyn ; Warndorff ; David K ; Crampin ; Amelia C ; et. al.
• 刊名：The Lancet
• 出版年：2002
• 出版时间：April 20, 2002
• 年：2002
• 卷：359
• 期：315
• 页码：1393-1401
• 全文大小：117 K

文摘

Background The efficacy of BCG vaccines against pulmonary tuberculosis varies between populations, showing no protection in Malawi but 50–80 % protection in the UK. To investigate the mechanism underlying these differences, randomised controlled studies were set up to measure vaccine-induced immune responsiveness to mycobacterial antigens in both populations.