Facile and scalable preparation of 2-imidazolylpyridines
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- 作者：Andreas Raba ; Markus R. Anneser ; Dominik Jantke ; Mirza Cokoja ; Wolfgang A. Herrmann ; wolfgangherrmann@ch.tum.de ; Fritz E. Kü ; hn ; fritz.kuehn@ch.tum.de
- 关键词：Nucleophilic aromatic substitution ; 2-Imidazolylpyridine ; Solvent free synthesis ; Metal free coupling
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：26 June, 2013
- 年：2013
- 卷：54
- 期：26
- 页码：3384-3387
- 全文大小：270 K
文摘
A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable.