Preparation of the micro/nano structures of the biomimetic coating stent for loading MiRNA126 by four-beam laser interference

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• 作者：Junnan Wang^a ; Yongliang Li^b ; ^{liubin1964@163.com" class="auth_mail" title="E-mail the corresponding author} ; Longyue Gao^b ; Siqi Wang^b ; Aofei Mao^b ; Bin Liu^a ; ^{liubin1964@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Material surface modification ; Laser interference ; Micro/Nano structure ; Stent ; Bionic coating ; miRNA126
• 刊名：Optik - International Journal for Light and Electron Optics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：247-252
• 全文大小：1368 K

文摘

We demonstrated the preparation of drug loading micro structures on the surface of metal coronary stent by using laser interference and provide a good substrate for the next step by using the method of miRNA-126 for the first time to our knowledge. Compared with the drug used in the existing drug eluting stent, miRNA-126 has a better effect on promoting the differentiation of vascular endothelial cells, inhibiting the inflammatory reaction and the proliferation of smooth muscle cells. The laser wavelength is 1064 nm, the single pulse energy is 2 J, the pulse width is 8 ns and the exposure time is 80 s. When the incident angle is 2.8°, between beam angle is 90°, we got the bionic micro nano structure witch cycle is 10.21 μm. Different cycles can be obtained by changing the angle of incidence and the angle between the laser beam, After a preliminary comparison test, the cycle 10.21 μm bracket micro nano structure is better than cycle 5.077 μ m and 20.9 μ m in the assembly adhesion force and loading capacity.