Anti-Hepatitis C Virus Replicon Activity of Alkoxyalkyl Esters of (S)-HPMPA and Other Acyclic Nucleoside Phosphonates

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• 作者：Yaya Liu ; Pamela Donner ; Wen Jiang ; Teresa Ng ; Vijaya Gracias ; Steve Baumeister ; Paul Wiedeman ; Linda Traphagen ; Usha Warrior ; Clarence Maring ; Warren Kati ; Stevan Djuric ; Akhteruzzaman Molla
• 关键词：Chemometric ; Partial least square ; Partial least square discriminant analysis ; Lavandin var. Grosso ; Essential oil ; Infrared ; Gas chromatography
• 刊名：Antiviral Research
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：78
• 期：2
• 页码：A21
• 全文大小：70 K

文摘

Lavandin, a sterile hybrid of Lavandula angustifolia P. Mill. × Lavandula latifolia (L.f.) Medikus (Lamiaceae) is a plant widely cultivated for essential oil production in the South of France. Chemometric treatment by mid-infrared (MID-IR) spectroscopy data was assessed for the differentiation of Grosso Lavandin Essential Oils of Controlled Area (GLEOCA) and results were compared to those obtained by gas chromatography for MID-IR short time technique validation. The quantification of the main 13 hydrocarbons and oxygenated compounds generally controlled by industrial perfumers in GLEOCA samples (n = 83) of three geographic origins: “Simiane”, “Puimoisson” (with two producers) and “Richerenches” and their classification were successfully obtained by partial least square discriminant analysis (PLS-DA) by comparison with gas chromatography. The best prediction results were obtained using first derivate spectral data in the 1800–700 cm⁻¹ range. The spectroscopic interpretation of regression vectors showed that each geographic origin was correlated to components of GLEOCA. Chemometric MID-IR spectra treatments allowed us to obtain similar results than those obtained by time consuming analytical techniques such as GC and therefore constitute a robust and help fast method for authentication of GLEOCA and should be extended to other essential oils for authentication of geographic origin.