Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives
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- 作者：A. Chris Krueger ; Darold L. Madigan ; Brian E. Green ; Douglas K. Hutchinson ; Wen W. Jiang ; Warren M. Kati ; Yaya Liu ; Clarence J. Maring ; Sherie V. Masse ; Keith F. McDaniel ; et al.
- 关键词：HCV ; NS5B ; Polymerase ; 1-Hydroxy-4 ; 4-dialkyl-3-oxo-3 ; 4-dihydronaphthalene benzothiadiazine
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：15 April 2007
- 年：2007
- 卷：17
- 期：8
- 页码：2289-2292
- 全文大小：145 K
文摘
Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure–activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs.