Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC-MS/MS method to determine 6 major bile acids in rat liver and plasma

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• 作者：Ziying Liu^a ; Yu Zhang^a ; Ruowen Zhang^b ; Liqiang Gu^a ; Xiaohui Chen^a ; ^{cxh_syphu@hotmail.com}
• 关键词：SMYAD ; Si-miao-yong-an decoction ; TCM ; traditional Chinese medicine ; TC ; total cholesterol ; TG ; total triglyceride ; LDL-c ; low-density lipoprotein cholesterol ; HDL-c ; high-density lipoprotein cholesterol ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; TCA ; taurocholic acid ; GCA ; glycocholic acid ; TCDCA ; taurochenodeoxycholic acid ; GCDCA ; glyco chenodeoxycholic acid ; AST ; glutamic oxalacetic transaminase ; ALT ; glutamic pyruvic transaminase
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：167-175
• 全文大小：3195 K
• 卷排序：135

文摘

An LC–MS/MS method was established and well validated for the determination of endogenic bile acids. A new perspective to evaluate the cholesterol lowing effect of Si-miao-yong-an decoction. Quantitative method to clarify the possible mechanism. A convenient and efficient method to produce blank biological matrix by activated carbon.