Lipids and lipid management in diabetes

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• 作者：Mamta Jaiswal ; MBBS ; PhD ; Post-doctoral Fellow^a ; Ashley Schinske ; RN-BSN ; Medical Student^b ; Rodica Pop-Busui ; MD ; PhD^c ; ^{rpbusui@umich.edu" class="auth_mail} (Associate Professor of Internal Medicine)
• 关键词：type 2 diabetes ; type 1 diabetes ; dyslipidemia ; cardiovascular disease ; lifestyle intervention ; statins ; fibrates
• 刊名：Best Practice Research Clinical Endocrinology Metabolism
• 出版年：June 2014
• 年：2014
• 卷：28
• 期：3
• 页码：325-338
• 全文大小：398 K

文摘

Cardiovascular disease is more prevalent in type 1 and type 2 diabetes, and continues to be the leading cause of death among adults with diabetes. Although atherosclerotic vascular disease has a multi-factorial etiology, disorders of lipid metabolism play a central role. The coexistence of diabetes with other risk factors, in particular with dyslipidemia, further increases cardiovascular disease risk. A characteristic pattern, termed diabetic dyslipidemia, consists of increased levels of triglycerides, low levels of high density lipoprotein cholesterol, and postprandial lipemia, and is mostly seen in patients with type 2 diabetes or metabolic syndrome.

ra0015">This review summarizes the trends in the prevalence of lipid disorders in diabetes, advances in the mechanisms contributing to diabetic dyslipidemia, and current evidence regarding appropriate therapeutic recommendations.