Application of quantitative computed tomography for assessment of trabecular bone mineral density, microarchitecture and mechanical property

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• 作者：Song Shou Mao ^{smao@labiomed.org" class="auth_mail" title="E-mail the corresponding author} ; Dong Li ^{dli@labiomed.org" class="auth_mail" title="E-mail the corresponding author} ; Yanting Luo ^{yluo@labiomed.org" class="auth_mail" title="E-mail the corresponding author} ; Younus Saleem Syed ^{ysyed@labiomed.org" class="auth_mail" title="E-mail the corresponding author} ; Matthew J. Budoff ; ^{mbudoff@labiomed.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MDCT ; Multi-row detector CT ; CACs ; Coronary artery calcium scan ; QCT ; Quantitative CT ; BMD ; Bone mineral density ; CTHU ; CT hounsfeild unit
• 刊名：Clinical Imaging
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：40
• 期：2
• 页码：330-338
• 全文大小：658 K

文摘

Osteoporosis is a common metabolic bone disease, causing increased skeletal fragility characterized by a low bone mass and trabecular microarchitectural deterioration. Assessment of the bone mineral density (BMD) is the primary determinant of skeletal fragility. Computed tomography (CT)-based trabecular microarchitectural and mechanical assessments are important methods to evaluate the skeletal strength. In this review, we focus the feasibility of QCT BMD measurement using a calibration phantom or phantomless. The application of QCT could extend the bone mineral density assessment to all patients who underwent a heart, lung, whole-body, and as well as all routine clinical implications of CT scan.