id="p0020">Mindfulness has shown an inverse relationship with avoidant coping styles, PTSD symptoms, and substance use disorders.
id="p0025">Trait mindfulness and mindfulness training are associated with treatment efficacy in comorbid substance abuse and PTSD.
id="p0030">The current study suggests mindfulness mediates the relationship between PTSD symptoms and substance dependence.
id="p0035">A reverse mediation model suggests mindfulness mediates the relationship between substance dependence and PTSD symptoms.
id="p6035">Results may point to the role of mindfulness in the bidirectional and cyclical nature of this comorbidity.
id="p0040">Findings contribute to understanding underlying processes of comorbid PTSD and substance use, and may inform treatment.