Therapeutic Effects of a NEDD8-Activating Enzyme Inhibitor, Pevonedistat, on Sclerodermatous Graft-versus-Host Disease in Mice

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• 作者：Chien-Chun Steven Pai¹ ; ^&dagger ; ; Lam T. Khuat¹ ; ^&dagger ; ; Mingyi Chen² ; William J. Murphy¹ ; ³ ; ^&Dagger ; ; ^{wmjmurphy@ucdavis.edu} ; Mehrdad Abedi³ ; ^&Dagger ;
• 关键词：Pevonedistat ; Sclerodermatous graft-versus-host disease ; Graft-versus-tumor effect
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：30-37
• 全文大小：2830 K
• 卷排序：23

文摘

Pevonedistat treatment at the onset stage strongly inhibits sclerodermatous graft-versus-host disease. Pevonedistat inhibits antigen-presenting cells while having minimal effects on T cells. Pevonedistat maintains graft-versus-tumor effects.