Effect of folic acid on human trophoblast health and function in vitro
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- 作者：Tasfia Ahmeda ; tasfia@live.com" class="auth_mail" title="E-mail the corresponding author ; Ilan Fellusa ; ifell101@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Jeremiah Gaudeta ; jeremiah.gaudet@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Amanda J. MacFarlaneb ; amanda.macfarlane@hc-sc.gc.ca" class="auth_mail" title="E-mail the corresponding author ; Bé ; né ; dicte Fontaine-Bissonc ; bfontain@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Shannon A. Bainbridgea ; d ; e ; Shannon.bainbridge@uottawa.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Folic acid ; Placenta ; Trophoblast ; Proliferation ; Invasion ; Apoptosis
- 刊名：Placenta
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：7-15
- 全文大小：1630 K
文摘
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Trophoblast health was assessed following exposure to increasing folic acid (FA).
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Intracellular total folate increases with elevated concentrations of FA.
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Supra-physiological FA exposure has minimal effect on trophoblast health.
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FA deficiency decreases viability and invasiveness of extravillous trophoblasts.