Adenine Glycosylase MutY of Corynebacterium pseudotuberculosis presents the antimutator phenotype and evidences of glycosylase/AP lyase activity in vitro
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- 作者：Rafael Canç ; ado de Fariaa ; fael.faria09@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Liliane Gonç ; alves Vila-Novaa ; lgvilanova@yhaoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Mainá ; Bitarc ; duonlumo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bruno Carvalho Resendea ; bruno_carvalho_resende@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Larissa Sousa Arantesa ; larissarantes1@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Arnaldo Basso Rebelatoa ; arnaldo.br@me.com" class="auth_mail" title="E-mail the corresponding author ; Vasco Ariston Carvalho Azevedob ; vascoariston@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Gló ; ria Regina Francoc ; gfranco@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Carlos Renato Machadoc ; crmachad@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Luciana Lara dos Santosa ; llaramg@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Dé ; bora de Oliveira Lopesa ; debora@ufsj.edu.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：APBS ; adaptive Poisson-Boltzmann Solver ; AP ; apurinic/apyrimidinic ; BCIP ; 5-bromo-4-chloro-3-indolyl phosphate ; BER ; base excision repair ; BLAST ; Basic Local Alignment Search Tool ; OD ; optical density ; IPTG ; isopropyl b-d-thiogalactopyranoside ; NBT ; nitro-blue tetrazolium ; PAGE ; polyacrylamide gel electrophoresis ; PDB ; Protein Data Bank ; PVDF ; polyvinylidene difluoride ; SDS ; sodium dodecyl sulfate ; ROS ; reactive oxygen species ; 7 ; 8-dihydro-8-oxo-dGuanine ; 8-oxoguanine
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：318-329
- 全文大小：1789 K
文摘
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CpMutY prevents spontaneous mutation in mutY-gene-deficient
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CpMutY confers advantage on growth under oxidative stress in mutY-gene-deficient
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CpMutY presents a bifunctional glycosylase/AP Lyase activity
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CpMutY presents 8-oxoguanine:A selective activity.
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Important features related to the activity of adenine glycosylase/AP Lyase are preserved in CpMutY.