Factors Related to the Selection of Surgical Versus Percutaneous Revascularization in Diabetic Patients With Multivessel Coronary Artery Disease in the BARI 2D (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes) Trial

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• 作者：Lauren J. Kim ; PhD^?/sup> ; Spencer B. King III ; MD^&dagger ; ; Kenneth Kent ; MD^&Dagger ; ; Maria Mori Brooks ; PhD^§ ; ; Kevin E. Kip ; PhD^?/sup> ; J. Dawn Abbott ; MD^¶ ; ; Alice K. Jacobs ; MD^# ; Charanjit Rihal ; MD^?? ; Whady A. Hueb ; MD^&dagger ; &dagger ; ; Edwin Alderman ; MD^&Dagger ; &Dagger ; ; Ivan R. Pena Sing ; MD^&Dagger ; &Dagger ; ; Michael J. Attubato ; MD^§ ; § ; ; Frederick Feit ; MD^§ ; § ; ; ^{frederick.feit@med.nyu.edu} ; BARI 2D (Bypass Angioplasty Revascularization Investigation Type 2 Diabetes) Study Group
• 关键词：revascularization selection ; diabetes ; percutaneous coronary intervention ; coronary artery bypass graft surgery
• 刊名：JACC: Cardiovascular Interventions
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：2
• 期：5
• 页码：384-392
• 全文大小：631 K

文摘

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Objectives

We evaluated demographic, clinical, and angiographic factors influencing the selection of coronary artery bypass graft (CABG) surgery versus percutaneous coronary intervention (PCI) in diabetic patients with multivessel coronary artery disease (CAD) in the BARI 2D (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes) trial.

Background

Factors guiding selection of mode of revascularization for patients with diabetes mellitus and multivessel CAD are not clearly defined.

Methods

In the BARI 2D trial, the selected revascularization strategy, CABG or PCI, was based on physician discretion, declared independent of randomization to either immediate or deferred revascularization if clinically warranted. We analyzed factors favoring selection of CABG versus PCI in 1,593 diabetic patients with multivessel CAD enrolled between 2001 and 2005.

Results

Selection of CABG over PCI was declared in 44 % of patients and was driven by angiographic factors including triple vessel disease (odds ratio [OR]: 4.43), left anterior descending stenosis ?0 % (OR: 2.86), proximal left anterior descending stenosis ?0 % (OR: 1.78), total occlusion (OR: 2.35), and multiple class C lesions (OR: 2.06) (all p < 0.005). Nonangiographic predictors of CABG included age ?5 years (OR: 1.43, p = 0.011) and non-U.S. region (OR: 2.89, p = 0.017). Absence of prior PCI (OR: 0.45, p < 0.001) and the availability of drug-eluting stents conferred a lower probability of choosing CABG (OR: 0.60, p = 0.003).

Conclusions

The majority of diabetic patients with multivessel disease were selected for PCI rather than CABG. Preference for CABG over PCI was largely based on angiographic features related to the extent, location, and nature of CAD, as well as geographic, demographic, and clinical factors. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes [BARI 2D]; )