Cannabinoid receptor agonists modulate calcium channels in rat retinal müller cells
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- 作者：W. Yanga ; c ; d ; f ; &dagger ; ; Q. Lia ; c ; d ; f ; &dagger ; ; S.-Y. Wanga ; c ; d ; f ; F. Gaoa ; b ; d ; e ; f ; W.-J. Qiana ; c ; d ; f ; F. Lia ; c ; d ; f ; M. Jia ; b ; d ; e ; f ; &Dagger ; ; X.-H. Suna ; b ; d ; e ; f ; Y. Miaoa ; c ; d ; f ; yymiao@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Z. Wanga ; b ; c ; d ; e ; f ; zfwang@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-AG ; 2-arachidonoyl glycerol ; AEA ; anandamide ; [Ca2+]i ; intracellular calcium concentration ; CB1R ; cannabinoid CB1 receptor ; CB2R ; cannabinoid CB2 receptor ; DMSO ; dimethyl sulfoxide ; eCB ; endocannabinoid ; GS ; glutamine synthetase ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde ; PTX ; pertussis toxin ; TTX ; tetrodotoxin
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：213-224
- 全文大小：2737 K
文摘
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CaV3.1, CaV3.2, CaV3.3 and CaV1.2 are expressed in rat Müller cells.
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CB1R agonist WIN55212-2 dose-dependently suppresses Ca2+ currents in Müller cells.
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WIN55212-2-induced suppression of Ca2+ currents is independent of CB1R/CB2R.
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Endocannabinoids 2-AG/AEA suppress Ca2+ currents in a CB1R-independent manner.
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The 2-AG effect is not, but the AEA effect is partially mediated by CB2Rs.