Wounds that heal and wounds that don’t − The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

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• 作者：Neal L. Millar^a ; Charlotte O&rsquo ; Donnell^b ; Iain B. McInnes^a ; Elizabeth Brint^b ; ^c ; ^{e.brint@ucc.ie}
• 关键词：Interleukin 33 ; ST2 ; Tissue damage ; Fibrosis ; Tumorigenesis
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：41-50
• 全文大小：1508 K
• 卷排序：61

文摘

IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”. Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.