Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization-Dimerization Cascade Reaction of Homopropargylic Amines for the Construction of Complex Fused Nitrogen-Containing Tetracycles
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- 作者：Lingyan Liu ; Chan Wang ; Qiangqiang Liu ; Yuanfang Kong ; Weixing Chang and Jing Li
- 刊名：European Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：2016
- 期：22
- 页码：3684-3690
- 全文大小：1129K
- ISSN：1099-0690
文摘
A Cu(OTf)2-catalyzed cascade cyclization reaction of simple homopropargylic amines was developed. The sequence involved an intramolecular radical hydroamination cyclization followed by dimerization by a Povarov-type reaction. Through this cascade reaction, a complex nitrogen-containing tetracycle framework was constructed in one pot with the formation of four new bonds and five stereocenters. Noteworthy, the aglycon of the natural product incargranine B was facilely and efficiently synthesized by using this method.