作者：M. Ramanan¹ ; ^{meera.ramanan79@gmail.com} ; V.S. Pilli¹ ; G.K. Aradhyam ^{agk@iitm.ac.in} ; M. Doble ; ^{mukeshd@iitm.ac.in}

关键词：Cancer ; Inflammation ; Prostaglandins ; Transcription factor ; c-myc ; mPGES1

刊名：Biochemical and Biophysical Research Communications

出版年：2017

作者：Gianluigi Lauro^a ; Michele Manfra^b ; Silvana Pedatella^e ; Katrin Fischer^d ; Vincenza Cantone^a ; ^d ; Stefania Terracciano^a ; Alessia Bertamino^a ; Carmine Ostacolo^c ; Isabel Gomez-Monterrey^c ; Mauro De Nisco^b ; Raffaele Riccio^a ; Ettore Novellino^c ; Oliver Werz^d ; Pietro Campiglia^a ; ^{pcampiglia@unisa.it} ; Giuseppe Bifulco^a ; ^{bifulco@unisa.it}

关键词：Molecular docking ; Cancer ; Inflammation ; mPGES-1 inhibitors ; Virtual screening

刊名：European Journal of Medicinal Chemistry

出版年：2017

作者：Marina Aparicio-Soto^a ; Marina Sá ; nchez-Hidalgo^a ; Ana Cá ; rdeno^a ; Alejandro Gonzá ; lez-Benjumea^b ; José ; G. Ferná ; ndez-Bolañ ; os^b ; Catalina Alarcó ; n-de-la-Lastra^a ; ^{calarcon@us.es}

关键词：ERK ; extracellular signal-regulated kinase ; EVOO ; extra virgin olive oil ; FCS ; foetal calf serum ; HO-1 ; haem oxygenase-1 ; HTy-Ac ; hydroxytyrosyl acetate ; HTy ; hydroxytyrosol ; iNOS ; inducible nitric oxide synthase ; IKB-α ; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha ; JNK ; c-Jun N-terminal kinase ; LPS ; lipopolysaccharide ; MAPK ; mitogen-activated protein kinase ; mPGES-1 ; microsomal prostaglandin E synthase-1 ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetraz

刊名：Journal of Functional Foods

出版年：2017

作者：Kazuhiro Tamura^a ; ^{hiro@toyaku.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroaki Naraba^b ; Takahiko Hara^c ; Kota Nakamura^a ; Mikihiro Yoshie^a ; Hiroshi Kogo^a ; Eiichi Tachikawa^a

关键词：COX ; cyclooxygenase ; cPGES ; cytosolic prostaglandin E synthase ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; Egr-1 ; early growth response factor ; EGF ; epidermal growth factor ; EIA ; enzyme immunoassay ; FBS ; fetal bovine serum ; FSH ; follicle-stimulating hormone ; GC ; granulosa cell ; LH ; luteinizing hormone ; LPS ; lipopolysaccharide ; mPGES ; microsomal prostaglandin E synthase ; P4 ; progesterone ; PBS ; phosphate-buffered saline ; PGE ; prostaglandin E ; PMA ; phorbol 12-myristate-13-acetate ; PR ; pr

刊名：Prostaglandins and Other Lipid Mediators

出版年：2016

作者：Steven L. Kuklish^a ; ^{Kuklish_Steven@lilly.com" class="auth_mail" title="E-mail the corresponding author} ; Stephen Antonysamy^b ; Shobha N. Bhattachar^a ; Srinivasan Chandrasekhar^a ; ^&dagger ; ; Matthew J. Fisher^a ; Adrian J. Fretland^a ; ^&Dagger ; ; Karen Gooding^a ; ^&dagger ; ; Anita Harvey^a ; ^&dagger ; ; Norman E. Hughes^a ; John G. Luz^b ; Peter R. Manninen^a ; James E. McGee^a ; Antonio Navarro^a ; Bryan H. Norman^a ; Katherine M. Partridge^a ; Steven J. Quimby^a ; Matthew A. Schiffler^a ; Ashley V. Sloan^a ; Alan M. Warshawsky^a ; Jeremy S. York^a ; Xiao-Peng Yu^a

关键词：mPGES-1 ; Prostaglandin pathway ; Dog bioavailability ; Biomarker

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

作者：Simone Di Micco^a ; Carmela Spatafora^b ; Nunzio Cardullo^b ; Raffaele Riccio^a ; Katrin Fischer^c ; Carlo Pergola^c ; Andreas Koeberle^c ; Oliver Werz^c ; Malik Chalal^d ; Dominique Vervandier-Fasseur^d ; Corrado Tringali^b ; Giuseppe Bifulco^a ; ^{bifulco@unisa.it" class="auth_mail" title="E-mail the corresponding author}

关键词：GSH ; glutathione ; MAPEG ; membrane-associated proteins in eicosanoid and glutathione metabolism ; MGST-1 ; microsomal glutathione transferase 1 ; mPGES-1 ; microsomal prostaglandin E2 synthase-1 ; COX ; cyclooxygenase ; PG ; prostaglandin

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

作者：Liliana Machado-Carvalho ; MS^a ; ^b ; ^{lsmachad@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author} ; Margarita Martín ; PhD^a ; ^c ; Rosa Torres ; PhD^a ; ^b ; ^d ; Marta Gabasa ; PhD^a ; ^b ; Isam Alobid ; MD ; PhD^a ; ^b ; ^e ; Joaquim Mullol ; MD ; PhD^a ; ^b ; ^e ; Laura Pujols ; PhD^a ; ^b ; Jordi Roca-Ferrer ; PhD^a ; ^b ; ^&lowast ; ; Cesar Picado ; MD ; FERS ; PhD^a ; ^b ; ^f ; ^&lowast ;

关键词：Aspirin-exacerbated respiratory disease ; COX-2 ; E-prostanoid 2 receptor ; fibroblasts ; IL-1β ; IL-1 receptor type I ; microsomal prostaglandin E synthase 1 ; nasal mucosa ; nasal polyps ; prostaglandin E2

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

作者：Nagarajan Muthukaman^a ; Sanjay Deshmukh^a ; Neelam Sarode^a ; Shital Tondlekar^a ; Macchindra Tambe^a ; Dnyandeo Pisal^a ; Mahamadhanif Shaikh^a ; Vidya G. Kattige^b ; Srinivasa Honnegowda^b ; Vikas Karande^b ; Abhay Kulkarni^b ; Satyawan B. Jadhav^c ; Mahamad Yunnus A. Mahat^c ; Girish S. Gudi^c ; Neelima Khairatkar-Joshi^b ; Laxmikant A. Gharat^a ; ^{Laxmikant.gharat@glenmarkpharma.com}

关键词：Rheumatoid arthritis ; Benzimidazole ; mPGES-1 inhibitor ; PGE2 ; CSF concentration ; Scaffold hopping

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

作者：C. Pierre¹ ; ² ; ^{clement.pierre@biomeostasis.com" class="auth_mail" title="E-mail the corresponding author} ; C. Tardivel² ; R. Barbouche² ; B. Bariohay¹ ; S. Rami² ; J.-D. Troadec²

刊名：Nutrition Clinique et Métabolisme

出版年：2016

作者：Ulrike Garscha^a ; ¹ ; ^{ulrike.garscha@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Susanna Voelker^a ; ¹ ; ^{susanna.voelker@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; Simona Pace^a ; ^{simona.pace@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Jana Gerstmeier^a ; ^{jana.gerstmeier@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Besa Emini^a ; ^{eminibesa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Stefanie Liening^a ; ^{stefanie.liening@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Antonietta Rossi^b ; ^{antrossi@unina.it" class="auth_mail" title="E-mail the corresponding author} ; Christina Weinigel^c ; ^{christina.weinigel@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Silke Rummler^c ; ^{silke.rummler@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Ulrich S. Schubert^d ; ^e ; ^{ulrich.schubert@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Gerhard K.E. Scriba^a ; ^{gerhard.scriba@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Erşan Ç ; elikoğlu^f ; ^{ersancelikoglu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Burcu Ç ; alışkan^f ; ^{brcaliskan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Erden Banoglu^f ; ^{banoglu@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Lidia Sautebin^b ; ^{sautebin@unina.it" class="auth_mail" title="E-mail the corresponding author} ; Oliver Werz^a ; ^d ; ^{oliver.werz@uni-jena.de" class="auth_mail" title="E-mail the corresponding author}

关键词：5-LO ; 5-lipoxygenase ; AA ; arachidonic acid ; COX ; cyclooxygenase ; cPLA2 ; cytosolic phospholipase A2 ; FLAP ; 5-lipoxygenase-activating protein ; fMLP ; N-formyl-methionyl-leucyl-phenylalanine ; H(P)ETE ; hydro(pero)oxyeicosatetraenoic acid ; HHT ; hydroxyheptadecatrienoic acid ; IL ; interleukin ; LPS ; lipopolysaccharide ; LT ; leukotriene ; mPGES-1 ; microsomal prostaglandin E2 synthase 1 ; MPO ; myeloperoxidase ; PG ; phosphate-buffered saline plus 1  ; mg/ml glucose ; PGC ; phosphate-buffered saline plus 1 

刊名：Biochemical Pharmacology

出版年：2016