高原病的发病及防治
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摘要
<正>我国是世界上高原面积最大的国家,海拔在3000 m以上的地区约占全国总面积的1/6,前不久在我国青海省玉树发生的地震所处地区的平均海拔4493 m,氧含量仅有平原地区的55%,因此在青海玉树抗震救灾的各类救援人员中都不同程度的
引文
[1]格日力.中国高原医学研究回顾[J].青海医学院学报,2005,26(1):37.
[2]魏元涛.正确认识高原病[J].解放军健康,2002,6(1):49.
[3]张静.高原病研究的新进展[J].临床医学,2009,12(6):17-19.
[4]高原医学杂志编委会.我国高原病命名、分型及诊断标准[J].高原医学杂志,1996,6(1):224.
[5]党仁全,雷明强.高原肺水肿32例救治体会[J].人民军医,2003,46(1):18.
[6]张宏伟,加永泽培.急性高原病的诊疗进展[J].医学综述,2005,11(3):246-248.
[7]耿东升,兰建国,刘发.高原肺水肿和脑水肿的发病机制及其药物治疗[M].北京:人民卫生出版社,2007:72.
[8]Hackett PH,Roach RC.High altitude medicine[A]Auerbach PS,ed.Wilderness medicine[M].St.Louis:Mosby,2001:2-43.
[9]Dehnert C,GrunigE,MerelesD,et al.Identification of in-dividuls susceptibleto high altitude pulmoary oedema at 10W altitude[J].Eur RespirJ,2005,25(3):545-551.
[10]Maggiorini M,Melot C,Pierre S,et al.High altitudepulmonary edema is initially caused by an increase incapillary pressure[J].Circulation,2001,103(16):2078-2083.
[11]Scherrer U,Sartori C,Lepori M,et al.High altitude pul-monary edema:from exaggerated pulmonary hyperten-sion to a defect in transepithelial sodium transport[A].Roach RC,Wagner PD,Hackett PH.Hypoxia:into thenext millennium.Vol.474 of Advances in experimen-talmedicine and biology[M].New York:Kluwer Academ-ic/Plenum,1999:93-107.
[12]Duplain H,Vollenweider L,Delabays A,et al.Aug-mented sympathetic activation during short term hypoxiaand high altitude exposure in subjects susceptible tohigh altitude pulmonary edema[J].Circulation,1999,99(13):1713-1718.
[13]Gibbs JS.Pulmonary hemodynamics:implications forhigh altitude pulmonary edema(HAPE).A review[J].Adv Exp Med Biol,1999,474:81-91.
[14]Hartmann G,Tschop M,Fischer R,et al.High altitudeincreases circulatinginterleukin26,interleukin21 recep-torantagonistandCreactiveprotein[J].Cytokine,2000,12(3):246-252.
[15]Schoene RB,Hackett PH,Henderson WR,et al.High-altitude pul-mo-nary edema.Characeristics of Lunglavage fluid[J].JAMA,2003,256(1):63-66.
[16]Kaner Rj,Crystal RG.Pathogenesis of high altitudepulmonary edema:does alveolar epithelial lining fluidvascular endothelial growth factorexacerbate capillaryleak[J].HighAltMedBiol,2005,5(4):399-403.
[17]Hanaoka M,Droma Y,Naramoto A,et al.Vascular en-dothelial growth factor in patients with high altitude pul-monary edema[J].J Appl Physilo,2003,94(5):1836-1842.
[18]Hackett PH,Roach RC.High-altitude illness[J].NEngl JMed,2001,345(2):107-114.
[19]Kanai M,Nishihara F,Shiga T,et al.Alterations inau-tonomic nervous control of heart rate among tourists at2700 and 3700 m above sea level[J].Wilderness Envi-ronMed,2001,12:8-12.
[20]Yun XL,Su JD,Lin Xiao,et al.Desferoxamine precon-ditioningprotects against cerebral ischemia in rats by inducingexpressionsof hypoxia inducible factor 1αanderythropoietin[J].Neurosci Bull,2008,24(2):89-95.
[21]Beleslin-Cokic BB,Cokic VP,Yu X,et al.Erythropoi-etin andhypoxia stimulate erythropoietin receptor andnitric oxideproduction by endothelial cells[J].Blood,2004;104(7):2073-2080.
[22]张善春,齐惠英,杜闻莹,等.内源性促红细胞生成素水平和肾功能对慢性心力衰竭患者贫血的影响[J].中国医药导刊,2008,10(2):188-191.
[23]张熔,李丰益,高举,等.慢性肾功衰肾性贫血患者pro-hepcidin的检测及临床意义探讨[J].华西医学,2008,23(2):286-288.
[24]Scortegagna M,Ding K,Zhang QY,et al.HIF-2 alpharegulatesmurine hematopoietic development in anery-thropoietindependent manner[J].Blood.2005,105(8):3133-3140.
[25]Koistinen PO,Rusko H,Irjala K,et al.EPO,red cells,and serumtransferrin receptor in continuous and inter-mittent hypoxia[J].Medicine Science in Sports Exer-cise,2000,32:800-804.
[26]李素芝,牟信兵,薛增军,等.高原红细胞增多症患者血清EPO含量变化及其意义[J].高原医学杂志,1998,8(3):30-31.
[27]熊思齐,夏晓波.正常氧及低氧环境下小干扰RNA抑制促红细胞生成素表达的研究[J].国际眼科杂志,2008,8(11):16-19.
[28]Tsantes A,Tassiopoulos S,Papadhimitriou SI,et al.Sub-optimalErythropoietic Response to Hypoxemia in Idio-pathic PulmonaryFibrosis[J].Chest,2003,124:548-553.
[29]Alan JD,David GB Michael WQ,et al.Erythropoietinresponse incritically ill mechanically ventilated patients:a prospectiveobservational study[J].Critical Care,2005,9:172-176.
[2]魏元涛.正确认识高原病[J].解放军健康,2002,6(1):49.
[3]张静.高原病研究的新进展[J].临床医学,2009,12(6):17-19.
[4]高原医学杂志编委会.我国高原病命名、分型及诊断标准[J].高原医学杂志,1996,6(1):224.
[5]党仁全,雷明强.高原肺水肿32例救治体会[J].人民军医,2003,46(1):18.
[6]张宏伟,加永泽培.急性高原病的诊疗进展[J].医学综述,2005,11(3):246-248.
[7]耿东升,兰建国,刘发.高原肺水肿和脑水肿的发病机制及其药物治疗[M].北京:人民卫生出版社,2007:72.
[8]Hackett PH,Roach RC.High altitude medicine[A]Auerbach PS,ed.Wilderness medicine[M].St.Louis:Mosby,2001:2-43.
[9]Dehnert C,GrunigE,MerelesD,et al.Identification of in-dividuls susceptibleto high altitude pulmoary oedema at 10W altitude[J].Eur RespirJ,2005,25(3):545-551.
[10]Maggiorini M,Melot C,Pierre S,et al.High altitudepulmonary edema is initially caused by an increase incapillary pressure[J].Circulation,2001,103(16):2078-2083.
[11]Scherrer U,Sartori C,Lepori M,et al.High altitude pul-monary edema:from exaggerated pulmonary hyperten-sion to a defect in transepithelial sodium transport[A].Roach RC,Wagner PD,Hackett PH.Hypoxia:into thenext millennium.Vol.474 of Advances in experimen-talmedicine and biology[M].New York:Kluwer Academ-ic/Plenum,1999:93-107.
[12]Duplain H,Vollenweider L,Delabays A,et al.Aug-mented sympathetic activation during short term hypoxiaand high altitude exposure in subjects susceptible tohigh altitude pulmonary edema[J].Circulation,1999,99(13):1713-1718.
[13]Gibbs JS.Pulmonary hemodynamics:implications forhigh altitude pulmonary edema(HAPE).A review[J].Adv Exp Med Biol,1999,474:81-91.
[14]Hartmann G,Tschop M,Fischer R,et al.High altitudeincreases circulatinginterleukin26,interleukin21 recep-torantagonistandCreactiveprotein[J].Cytokine,2000,12(3):246-252.
[15]Schoene RB,Hackett PH,Henderson WR,et al.High-altitude pul-mo-nary edema.Characeristics of Lunglavage fluid[J].JAMA,2003,256(1):63-66.
[16]Kaner Rj,Crystal RG.Pathogenesis of high altitudepulmonary edema:does alveolar epithelial lining fluidvascular endothelial growth factorexacerbate capillaryleak[J].HighAltMedBiol,2005,5(4):399-403.
[17]Hanaoka M,Droma Y,Naramoto A,et al.Vascular en-dothelial growth factor in patients with high altitude pul-monary edema[J].J Appl Physilo,2003,94(5):1836-1842.
[18]Hackett PH,Roach RC.High-altitude illness[J].NEngl JMed,2001,345(2):107-114.
[19]Kanai M,Nishihara F,Shiga T,et al.Alterations inau-tonomic nervous control of heart rate among tourists at2700 and 3700 m above sea level[J].Wilderness Envi-ronMed,2001,12:8-12.
[20]Yun XL,Su JD,Lin Xiao,et al.Desferoxamine precon-ditioningprotects against cerebral ischemia in rats by inducingexpressionsof hypoxia inducible factor 1αanderythropoietin[J].Neurosci Bull,2008,24(2):89-95.
[21]Beleslin-Cokic BB,Cokic VP,Yu X,et al.Erythropoi-etin andhypoxia stimulate erythropoietin receptor andnitric oxideproduction by endothelial cells[J].Blood,2004;104(7):2073-2080.
[22]张善春,齐惠英,杜闻莹,等.内源性促红细胞生成素水平和肾功能对慢性心力衰竭患者贫血的影响[J].中国医药导刊,2008,10(2):188-191.
[23]张熔,李丰益,高举,等.慢性肾功衰肾性贫血患者pro-hepcidin的检测及临床意义探讨[J].华西医学,2008,23(2):286-288.
[24]Scortegagna M,Ding K,Zhang QY,et al.HIF-2 alpharegulatesmurine hematopoietic development in anery-thropoietindependent manner[J].Blood.2005,105(8):3133-3140.
[25]Koistinen PO,Rusko H,Irjala K,et al.EPO,red cells,and serumtransferrin receptor in continuous and inter-mittent hypoxia[J].Medicine Science in Sports Exer-cise,2000,32:800-804.
[26]李素芝,牟信兵,薛增军,等.高原红细胞增多症患者血清EPO含量变化及其意义[J].高原医学杂志,1998,8(3):30-31.
[27]熊思齐,夏晓波.正常氧及低氧环境下小干扰RNA抑制促红细胞生成素表达的研究[J].国际眼科杂志,2008,8(11):16-19.
[28]Tsantes A,Tassiopoulos S,Papadhimitriou SI,et al.Sub-optimalErythropoietic Response to Hypoxemia in Idio-pathic PulmonaryFibrosis[J].Chest,2003,124:548-553.
[29]Alan JD,David GB Michael WQ,et al.Erythropoietinresponse incritically ill mechanically ventilated patients:a prospectiveobservational study[J].Critical Care,2005,9:172-176.
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