北川羌族人群高尿酸血症及痛风流行病学调查
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摘要
目的调查5.12地震后,绵阳市北川羌族人群高尿酸血症及痛风的患病率情况。方法采用随机、分层、整群抽样的方法,调查安置在板房居住的北川羌族人群2275人的高尿酸血症与痛风的患病率情况。结果①血尿酸水平及高尿酸血症情况:总体血尿酸水平为(341.4±89.4)μmol/L,其中男性为(375.4±85.5)μmmol/L,女性为(318.7±7l.9)μmmol/L;两者之间差异有统计学意义(P<0.01);高尿酸血症患病率为14.2%,男性患病率为9.67%,女性为4.57%,两者比较差异有统计学意义,②痛风患病率:患痛风例数为21人,痛风患病率为0.92%,其中男18人(1.37%),女3人(0.40%),两者之间差异有统计学意义(x2=30,38,P<0.01)。男性高尿酸人群中痛风患病率为7.8%(18/230),女性高尿酸人群中痛风患病率为2.9%(3/104);③血尿酸存在性别差异:男性血尿酸水平随年龄增长变化不明显,而女性血尿酸随年龄增长逐渐升高,尤以48岁后增速加快,68岁后与男性的血尿酸水平接近。④与血尿酸正常组比较,高尿酸血症组及痛风组年龄较大,同时合并高血压、糖尿病的患者多,BMI、TG、TC、LDL-C值更高,HDL-C值更低,饮酒者较多。结论绵阳北川羌族人群高尿酸血症及痛风患病率较其它地区低,男性高尿酸血症及痛风的患病率高于女性,且趋于年轻化。高尿酸血症及痛风患者合并高血压、脂代谢紊乱、糖尿病、肥胖者较血尿酸正常组明显增高。
Objective To investigate The epidemiology of gout and hyperuricemia in Qiang population of Mianyang city after 5.12 earthquake.Methods 2275 Qiang people were sampled from Beichuan population who settled down in the board room by stratified randomized cluster sampling survey.Results ①overall plasma uric is (341.4±89.4)μmol/L,the male plasma uric is (375.4±85.5) μmmol/L,female is (318.7±7l.9) μmmol/L,overall hyperuricemia morbidity is 14.2%,the male is 9.67%,female is 4.57%,male is significantly higher than female in this two datum(P<0.01).② the overall gout morbidity is 0.92%(21/2275),the male is 1.37%,female is 0.40%,the difference is significantly(x2=30,38,P<0.01).The male gout morbidity in hyperuricemia is 7.8%(18/230),female is 2.9%(3/104).③ gender difference is existing in plasma uric:the male plasma uric is stable with age increase,but the female's plasma uric rises with age increase,especially after 48 years old,which is close to male after 68 years old.④ Control with the normal plasma uric,people with hyperuricemia and gout are older,more people combined with high blood pressure and Diabetic Mellitus,BMI(Body Mass Index)、TG(Triglyceride)、TC(total cholesterol)、LDL-C(low density lipoprotein) are higher,HDL-C(high-density lipoprotein) is lower,more people are drinkers.Conclusion The hyperuricemia and gout morbidity are lower in Beichuan Qiang population than other areas,male is higher than female,people with hyperuricemia and gout are older,more people combined with high blood pressure,Diabetic Mellitus,adiposity and lipid metabolism disturbance.
Objective To investigate The epidemiology of gout and hyperuricemia in Qiang population of Mianyang city after 5.12 earthquake.Methods 2275 Qiang people were sampled from Beichuan population who settled down in the board room by stratified randomized cluster sampling survey.Results ①overall plasma uric is (341.4±89.4)μmol/L,the male plasma uric is (375.4±85.5) μmmol/L,female is (318.7±7l.9) μmmol/L,overall hyperuricemia morbidity is 14.2%,the male is 9.67%,female is 4.57%,male is significantly higher than female in this two datum(P<0.01).② the overall gout morbidity is 0.92%(21/2275),the male is 1.37%,female is 0.40%,the difference is significantly(x2=30,38,P<0.01).The male gout morbidity in hyperuricemia is 7.8%(18/230),female is 2.9%(3/104).③ gender difference is existing in plasma uric:the male plasma uric is stable with age increase,but the female's plasma uric rises with age increase,especially after 48 years old,which is close to male after 68 years old.④ Control with the normal plasma uric,people with hyperuricemia and gout are older,more people combined with high blood pressure and Diabetic Mellitus,BMI(Body Mass Index)、TG(Triglyceride)、TC(total cholesterol)、LDL-C(low density lipoprotein) are higher,HDL-C(high-density lipoprotein) is lower,more people are drinkers.Conclusion The hyperuricemia and gout morbidity are lower in Beichuan Qiang population than other areas,male is higher than female,people with hyperuricemia and gout are older,more people combined with high blood pressure,Diabetic Mellitus,adiposity and lipid metabolism disturbance.
引文
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[4]陈晓云,扬慧东,扬健英.云南大理城镇居民高尿酸血症及痛风患病率调查[J].中国实用医学,2009,4(10):257-259.
[5]Sundstrom J,Sullivan LD,Agostino RB,et al.Relation of serum uric acid to longitudinal blood pressure tracking and hypertension incidence[J].Hypertension,2005,45(1):18-20.
[6]Jiunn-hoenf Chen,Shao-yan Chuang,Hsin-Jin Chen,et al.Serum uric acid level as an independent risk factor for all-cause cardiovascular,and ischemic strok mortality:a Chinese cohort study[J].Arthritis and Rheumatism,2009,61(2):225-232.
[7]刘倩.社区痛风病人的管理及健康教育干预的效果评价[J].当代医学,2010,16(3):155-156.
[2]刘鑫,徐小鹏.雌激素治疗绝经后妇女高尿酸血症疗效观察(附32例报告)[J].中华医学实践杂志,2004,3(9):821-822.
[3]苗志敏,赵世华,王毅刚,等.山东沿海居民高尿酸血症及痛风的流行病学词查[J].中华内分泌代谢杂志,2006,22(5):421-425.
[4]陈晓云,扬慧东,扬健英.云南大理城镇居民高尿酸血症及痛风患病率调查[J].中国实用医学,2009,4(10):257-259.
[5]Sundstrom J,Sullivan LD,Agostino RB,et al.Relation of serum uric acid to longitudinal blood pressure tracking and hypertension incidence[J].Hypertension,2005,45(1):18-20.
[6]Jiunn-hoenf Chen,Shao-yan Chuang,Hsin-Jin Chen,et al.Serum uric acid level as an independent risk factor for all-cause cardiovascular,and ischemic strok mortality:a Chinese cohort study[J].Arthritis and Rheumatism,2009,61(2):225-232.
[7]刘倩.社区痛风病人的管理及健康教育干预的效果评价[J].当代医学,2010,16(3):155-156.
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