内毒素吸附治疗汶川大地震中的脓毒症患者
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摘要
目的总结汶川地震中应用内毒素吸附治疗脓毒症患者的效果。方法对2例地震脓毒症患者应用多粘菌素B结合纤维(PMX)进行内毒素吸附。结果2例患者经内毒素吸附疗法治疗后病情好转,生命体征稳定。结论PMX吸附内毒素对脓毒症患者是一项很有前景的治疗措施。
Objective To observe the efficacy of endotoxin absorption for treatment of the 2008 Wenchuan earthquake victims with severe sepsis.Methods Two patients with severe sepsis was given endotoxin absorption with PMX treatment.Results Both patients recovered from near-fatal conditions.Conclusion PMX is a new effective approach for the treatment of patients with severe sepsis.
Objective To observe the efficacy of endotoxin absorption for treatment of the 2008 Wenchuan earthquake victims with severe sepsis.Methods Two patients with severe sepsis was given endotoxin absorption with PMX treatment.Results Both patients recovered from near-fatal conditions.Conclusion PMX is a new effective approach for the treatment of patients with severe sepsis.
引文
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2Kastow sky M,Gutberlet T,Bradaczek H.Molecular model-ling of the three dimensional structure and conformational flexibility of bacterial lipopolysaccharide.Bacterial,1992,174:4798.
3Raetz CRH.Biochemistry of endotoxins.Annu Rev Bio-chem,1990,59:129.
4Deitch EA.Multiple organ failure:pathophysiology and po-tential future therapy.Ann Surg,1992,216:117.
5Deitch EA,Ma WJ,Ma L,et al.Endotoxin induced bacteria Translocation:a study of mechanism.Surgery,1989,106:292.
6Cruz DN,Bellomo R,Ronco C.Clinical effects of polymyxin B immobilized fiber column in septic patients.Contrib Nephrol,2007,156:444-451.
7Shoji H,Minaga M,Sakai Y,et al.Design and development of endotoxin detoxifying column PMX and its clinical appli-cation.Jpn Art Organs,1993,22:204.
8Hanasawa K,Tani T,Kodama M.Newapproach to endotoxic and septic shock by means of polymyxin B immobilized fiber.Surg Gynecol Obstet,1989,168:323.
9Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the cir-culation of septic patients.Critical Care Med,1993,21:522.
10Andrew M,Calvin B.Reversal of postburn immunosuppres-sion with low dose polymyxin B.Trauma,1986,26:995-998.
11Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mono-nuclear cells,even during activation.Surg Res,2001,100:127-134.
12Kodama M,Hanasawa K,Tani T.Blood purification for crit-ical care medicine:endotoxin adsorption.Ther Apher,1997,1:224-227.
13Sato T,Shoji H,Koga N.Endotoxin adsorption by polymyx-inB immobilized fiber column in patients with systemic in-flammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258.
2Kastow sky M,Gutberlet T,Bradaczek H.Molecular model-ling of the three dimensional structure and conformational flexibility of bacterial lipopolysaccharide.Bacterial,1992,174:4798.
3Raetz CRH.Biochemistry of endotoxins.Annu Rev Bio-chem,1990,59:129.
4Deitch EA.Multiple organ failure:pathophysiology and po-tential future therapy.Ann Surg,1992,216:117.
5Deitch EA,Ma WJ,Ma L,et al.Endotoxin induced bacteria Translocation:a study of mechanism.Surgery,1989,106:292.
6Cruz DN,Bellomo R,Ronco C.Clinical effects of polymyxin B immobilized fiber column in septic patients.Contrib Nephrol,2007,156:444-451.
7Shoji H,Minaga M,Sakai Y,et al.Design and development of endotoxin detoxifying column PMX and its clinical appli-cation.Jpn Art Organs,1993,22:204.
8Hanasawa K,Tani T,Kodama M.Newapproach to endotoxic and septic shock by means of polymyxin B immobilized fiber.Surg Gynecol Obstet,1989,168:323.
9Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the cir-culation of septic patients.Critical Care Med,1993,21:522.
10Andrew M,Calvin B.Reversal of postburn immunosuppres-sion with low dose polymyxin B.Trauma,1986,26:995-998.
11Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mono-nuclear cells,even during activation.Surg Res,2001,100:127-134.
12Kodama M,Hanasawa K,Tani T.Blood purification for crit-ical care medicine:endotoxin adsorption.Ther Apher,1997,1:224-227.
13Sato T,Shoji H,Koga N.Endotoxin adsorption by polymyx-inB immobilized fiber column in patients with systemic in-flammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258.
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