地震对人们情绪及细胞因子TNF-α、IL-6和Hs-CRP的影响
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摘要
目的观察地震对人们情绪及体内细胞因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和超敏C反应蛋白(Hs-CRP)的影响。方法对汶川地震伤患者于入院时及出院时行汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)进行测定,并同时在治疗前后测定TNF-α、IL-6和Hs-CRP的变化。结果与健康对照组比较,地震伤患者存在焦虑抑郁情绪,其血清中TNF-α、IL-6和Hs-CRP水平在入院时均很高,出院时Hs-CRP降至正常水平,TNF-α、IL-6还处于比健康人群高的水平。结论地震这种突发灾难导致了人们广泛的焦虑抑郁情绪,而且这种长期的负面情绪可能影响TNF-α、IL-6水平,使其居高不下。
Objective To investigate the impact of earthquake on people's mood and serum levels of TNF-α,IL-6 and hs-CRP.Methods The patients with earthquake wound were evaluated with Hamilton Depression Rating Scale(HAMD) and Hamilton Anxiety Rating Scale(HAMA) before and after treatment in hospital.Serum levels of TNF-α,IL-6 and hs-CRP were measured and analyzed.Results HAMD and HAMA scores were higher in earthquake wound people than those in control.The serum levels of TNF-α,IL-6 and hs-CRP were higher on admission.Hs-CRP decreased after treatment,but TNF-α and IL-6 did not change obviously.Conclusion Earthquake is a disaster to people which made people anxious and depressed.And anxiety and depressive emotion may have impact on the level of TNF-α、IL-6。
Objective To investigate the impact of earthquake on people's mood and serum levels of TNF-α,IL-6 and hs-CRP.Methods The patients with earthquake wound were evaluated with Hamilton Depression Rating Scale(HAMD) and Hamilton Anxiety Rating Scale(HAMA) before and after treatment in hospital.Serum levels of TNF-α,IL-6 and hs-CRP were measured and analyzed.Results HAMD and HAMA scores were higher in earthquake wound people than those in control.The serum levels of TNF-α,IL-6 and hs-CRP were higher on admission.Hs-CRP decreased after treatment,but TNF-α and IL-6 did not change obviously.Conclusion Earthquake is a disaster to people which made people anxious and depressed.And anxiety and depressive emotion may have impact on the level of TNF-α、IL-6。
引文
[1]卞建民,王书奎,江滨,等.多种细胞因子检测对严重感染患者的意义[J].中国危重病急救医学,2002,14(6):353-355.
[2]Van Loey NE,Van Son MJ.Psychopathology and psychological prob-lems in patients with burn scar[J].J Am Clin Dermatol,2003,4(4):245-272.
[3]Goenjian AK,Walling D,Steinberg AM,et al.Depression and PTSD symptoms among bereaved adolescents6(1/2)years after the1988spi-tak earthquake[J].J Affect Disord,2008,7:9.
[4]张剑,颜碧清,徐俊龙,等.创伤性休克患者血清TNF-α、IL-6变化的意义[J].浙江中西医结合杂志,2008,18(2):103-104.
[5]吴孝苹,王东,宋中金,等.焦虑抑郁情绪对烧伤后创面愈合及TNF-α、IL-6水平的影响[J].四川大学学报(医学版),2008,39(1):105-107.
[2]Van Loey NE,Van Son MJ.Psychopathology and psychological prob-lems in patients with burn scar[J].J Am Clin Dermatol,2003,4(4):245-272.
[3]Goenjian AK,Walling D,Steinberg AM,et al.Depression and PTSD symptoms among bereaved adolescents6(1/2)years after the1988spi-tak earthquake[J].J Affect Disord,2008,7:9.
[4]张剑,颜碧清,徐俊龙,等.创伤性休克患者血清TNF-α、IL-6变化的意义[J].浙江中西医结合杂志,2008,18(2):103-104.
[5]吴孝苹,王东,宋中金,等.焦虑抑郁情绪对烧伤后创面愈合及TNF-α、IL-6水平的影响[J].四川大学学报(医学版),2008,39(1):105-107.
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