汶川地震对灾区人群血浆同型半胱氨酸水平的影响
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摘要
目的探讨地震对灾区人群血浆同型半胱氨酸(homocysteine,HCY)水平的影响。方法随机抽取150名汶川地震灾民(研究组)、150名健康体检者(对照组)进行心理问卷调查,测定血浆HCY水平。结果研究组症状自评量表得分显著高于对照组,血浆HCY水平显著高于对照组[(24.4±10.9)μmol/L vs(17.2±3.8)μmol/L,P<0.01];血浆HCY水平与焦虑自评量表(Self-Rating Anxiety Scale,SAS)和抑郁自评量表(Self-Rating Depression Scale,SDS)得分呈正相关(HCY与SAS:r=0.968;HCY与SDS:r=0.979,均P<0.01)。结论地震可引起灾民生理应激状态,导致机体血浆HCY水平升高。
Objective The aim of the study was to investigate the influence of earthquake on serum homocysteine(HCY) level in victims.Methods A total of 150 victims were assigned to study group and 150 healthy individuals were assigned to control group.The mental status of the two groups was investigated with Self-Rating Anxiety Scale(SAS) and Self-Rating Depression Scale(SDS).The level of serum HCY was detected.Results The questionnaire score of study group was higher than that of control group.The level of serum HCY of study group was significantly higher than that of control group[(24.4±10.9) μmol/L vs.(17.2±3.8) μmol/L,P < 0.01].There was a positive correlation between Hcy and SAS(r = 0.968,P < 0.01) as well as Hcy and SDS(r = 0.979,P < 0.01).Conclusions Earthquake can cause physical stress for victims,which leads to the increase of serum HCY level.
Objective The aim of the study was to investigate the influence of earthquake on serum homocysteine(HCY) level in victims.Methods A total of 150 victims were assigned to study group and 150 healthy individuals were assigned to control group.The mental status of the two groups was investigated with Self-Rating Anxiety Scale(SAS) and Self-Rating Depression Scale(SDS).The level of serum HCY was detected.Results The questionnaire score of study group was higher than that of control group.The level of serum HCY of study group was significantly higher than that of control group[(24.4±10.9) μmol/L vs.(17.2±3.8) μmol/L,P < 0.01].There was a positive correlation between Hcy and SAS(r = 0.968,P < 0.01) as well as Hcy and SDS(r = 0.979,P < 0.01).Conclusions Earthquake can cause physical stress for victims,which leads to the increase of serum HCY level.
引文
[1]宋明宝,钱德慧,黄岚.地震灾害对心血管疾病的影响[J].心血管康复医学杂志,2009,18(3):298-301.
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[5]Tsuchida M,Kawashiri MA,Teramoto R,et al.Impact of severeearthquake on the occurrence of acute coronary syndrome and strokein a rural area of Japan[J].Circ J,2009,73(7):1195-1199.
[6]Armenian HK,Melkonian AK,Hovanesian AP.Long term mortalityand morbidity related to degree of damage following the 1998 earthquake in Armenia[J].Am J Epidemiol,1998,148(11):1077-1084.
[7]Hata S.Cardiovascular disease caused by earthquake-induced stress:psychological stress and cardiovascular disease[J].Circ J,2009,73(7):1243-1247.
[8]Oudi ME,Aouni Z,Mazigh C,et al.Homocysteine and markers ofinflammation in acute coronary syndrome[J].Exp Clin Cardiol,2010,15(2):e 25-28.
[9]Graham IM,Daly LE,Refsum HM,et al.Plasma homocysteine as arisk factor for vascular disease:The European Concerted Action Pro-ject[J].JAMA,1997,277:1775-1781.
[10]谢玉兰,冯毅,沈成兴.老年冠心病患者同型半胱氨酸、高敏C反应蛋白和胰岛素抵抗的相关性[J].中华高血压杂志,2007,10(15):861-862.
[11]周波,周东,肖军.5.12汶川大地震灾民创伤后应激障碍的特点分析[J].实用医院临床杂志,2009,6(1)32-34.
[2]汪向东.心理卫生评定量表手册[S].中国心理卫生杂志社,1999.
[3]Brown D.Disparate effects of the1989Loma Prieta and1994Northridge earthquakes on hospital admissions for acute myocardialinfarction:Importance of superimposition of triggers[J].Am HeartJ,1999,137(5):830-836.
[4]Nakagawa I,Nakamura K,et al.Long term effects of the Niigata-Chuetsu earthquake in Japan on acute myocardial infarction mortali-ty:an analysis of death certificate data[J].Heart,2009,95(24):2009-2013.
[5]Tsuchida M,Kawashiri MA,Teramoto R,et al.Impact of severeearthquake on the occurrence of acute coronary syndrome and strokein a rural area of Japan[J].Circ J,2009,73(7):1195-1199.
[6]Armenian HK,Melkonian AK,Hovanesian AP.Long term mortalityand morbidity related to degree of damage following the 1998 earthquake in Armenia[J].Am J Epidemiol,1998,148(11):1077-1084.
[7]Hata S.Cardiovascular disease caused by earthquake-induced stress:psychological stress and cardiovascular disease[J].Circ J,2009,73(7):1243-1247.
[8]Oudi ME,Aouni Z,Mazigh C,et al.Homocysteine and markers ofinflammation in acute coronary syndrome[J].Exp Clin Cardiol,2010,15(2):e 25-28.
[9]Graham IM,Daly LE,Refsum HM,et al.Plasma homocysteine as arisk factor for vascular disease:The European Concerted Action Pro-ject[J].JAMA,1997,277:1775-1781.
[10]谢玉兰,冯毅,沈成兴.老年冠心病患者同型半胱氨酸、高敏C反应蛋白和胰岛素抵抗的相关性[J].中华高血压杂志,2007,10(15):861-862.
[11]周波,周东,肖军.5.12汶川大地震灾民创伤后应激障碍的特点分析[J].实用医院临床杂志,2009,6(1)32-34.
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