四川省地震灾区甲型肝炎疫苗群体性预防接种效果评估
|
摘要
目的评价四川省5.12地震灾区甲肝疫苗(HepA疫苗)群体性接种的效果。方法采用随机抽样的方法,检测四川省5个开展了灾后甲肝疫苗(HepA疫苗)群体性接种的灾区县和5个对照县1～12岁健康儿童的甲肝(HAV)IgG抗体,并比较灾区县和对照县在接种前后甲肝报告发病水平。结果灾区县1～12岁健康儿童血清HAV-IgG抗体阳性率为72.40%,对照县为39.87%(两者差异有统计学意义);灾区县在开展灾区HepA疫苗群体性接种前的3年平均发病率高于对照县,在开展接种后的2年平均发病率低于对照县,差异均有统计学意义。结论四川省5.12地震灾区HepA疫苗群体性接种产生了良好的免疫效果,有效的控制了地震后灾区甲肝的发病水平。
OBJECTIVE To evaluate the effect of mass immunization activity of hepatitis A vaccine at 5.12 earthquake area in Sichuan province.METHODS Carried out random sampling to investigate the HAV IgG of healthy children aged 1-12 years from 5 earthquake counties with mass immunization of HepA vaccine and 5 contrast counties;compared HepA incidence of the disaster counties and contrast counties before and after the vaccination in statistics.RESULTS The positive rate of HAV-IgG in the children from disaster counties was 72.40%,which in the contrast county was 39.87%,and differences were significant.During the 3 years before the massive vaccination,the average incidence of HepA in disaster counties was higher than that of contrast counties;during the 2 years after the massive vaccination,and the average incidence of HepA in disaster counties was lower than that of contrast counties,and the differences were significant.CONCLUSION Mass immunization activity of hepatitis A vaccine at the 5.12 earthquake area achieves the great impact to control the incidence of HepA effectively.
OBJECTIVE To evaluate the effect of mass immunization activity of hepatitis A vaccine at 5.12 earthquake area in Sichuan province.METHODS Carried out random sampling to investigate the HAV IgG of healthy children aged 1-12 years from 5 earthquake counties with mass immunization of HepA vaccine and 5 contrast counties;compared HepA incidence of the disaster counties and contrast counties before and after the vaccination in statistics.RESULTS The positive rate of HAV-IgG in the children from disaster counties was 72.40%,which in the contrast county was 39.87%,and differences were significant.During the 3 years before the massive vaccination,the average incidence of HepA in disaster counties was higher than that of contrast counties;during the 2 years after the massive vaccination,and the average incidence of HepA in disaster counties was lower than that of contrast counties,and the differences were significant.CONCLUSION Mass immunization activity of hepatitis A vaccine at the 5.12 earthquake area achieves the great impact to control the incidence of HepA effectively.
引文
[1]戴志澄,祁国明.中国病毒性肝炎血清流行病学调查(上卷) [M].北京:科学技术文献出版社,1997: 19-35.
[2]赵玉良,孟宗达,郭俊杰.甲型肝炎减毒活疫苗在甲型肝炎暴发中的保护效果[J].中华预防医学杂志,2000,34 (3): 144-146.
[3]蔺心海,孙家明,李明珠,等.应用甲肝疫苗前后肝炎流行特征的变化[J].上海预防医学杂志,2000,12 (9): 412-413.
[4]李德明,李晓燕,周安雄,等.甲肝疫苗预防保护效果的流行病学调查[J].宁夏医学杂志,2002,24 (6): 347-348.
[5]Domínguez A,Oviedo M,Carmona G,et al.Impact and effective-ness of a mass hepatitis A vaccination programme of preadolescents seven years after introduction [J].Vaccine,2008,26 ( 14) : 1737-1741.
[6]丁先广,包名家,罗依兰,等.佳木斯市522人接种甲型肝炎减毒活疫苗后的抗体水平分析[J].职业与健康,2004,20 (6): 45.
[7]龚晓红,王富珍,韩莉莉,等.北京市1990-2004年甲型肝炎疫情报告病例的流行病学分析及甲肝疫苗接种效果评价[J].疾病控制杂志,2007,11 (1): 96-98.
[2]赵玉良,孟宗达,郭俊杰.甲型肝炎减毒活疫苗在甲型肝炎暴发中的保护效果[J].中华预防医学杂志,2000,34 (3): 144-146.
[3]蔺心海,孙家明,李明珠,等.应用甲肝疫苗前后肝炎流行特征的变化[J].上海预防医学杂志,2000,12 (9): 412-413.
[4]李德明,李晓燕,周安雄,等.甲肝疫苗预防保护效果的流行病学调查[J].宁夏医学杂志,2002,24 (6): 347-348.
[5]Domínguez A,Oviedo M,Carmona G,et al.Impact and effective-ness of a mass hepatitis A vaccination programme of preadolescents seven years after introduction [J].Vaccine,2008,26 ( 14) : 1737-1741.
[6]丁先广,包名家,罗依兰,等.佳木斯市522人接种甲型肝炎减毒活疫苗后的抗体水平分析[J].职业与健康,2004,20 (6): 45.
[7]龚晓红,王富珍,韩莉莉,等.北京市1990-2004年甲型肝炎疫情报告病例的流行病学分析及甲肝疫苗接种效果评价[J].疾病控制杂志,2007,11 (1): 96-98.
版权所有：© 2023 中国地质图书馆 中国地质调查局地学文献中心