木薯淀粉微球的止血性能初步研究

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英文篇名：Preliminary Study on Hemostatic Properties of Cassava Starch Microspheres 作者：曹勇 ; 黎演明 ; 冼学权 ; 苏志恒 ; 李晓捷 ; 李秉正 英文作者：CAO Yong;LI Yanming;XIAN Xuequan;SU Zhiheng;LI Xiaojie;LI Bingzheng;College of Stomatology,Guangxi Medical University;State Key Laboratory of Non-food Biomass and Enzyme Technology,National Engineering Research Center for Non-food Biorefinery,Guangxi Biomass Industrialization Engineering Institute,Guangxi Key Laboratory of Biorefinery,Guangxi Academy of Science;Pharmaceutical College,Guangxi Medical University; 关键词：木薯淀粉微球 ; 止血材料 ; 全血凝固时间 ; 血浆复钙时间 ; 局部止血 英文关键词：cassava starch microsphere;;hemostatic material;;whole blood coagulation time;;plasma recalcification time;;topical haemostasis 中文刊名：广西科学 英文刊名：Guangxi Sciences 机构：广西医科大学口腔医学院;广西科学院非粮生物质酶解国家重点实验室国家非粮生物质能源工程技术研究中心广西生物质产业化工程院广西生物质炼制重点实验室;广西医科大学药学院; 出版日期：2019-03-21 16:35 出版单位：广西科学 年：2019 期：02 基金：广西自然科学基金项目(2015GXNSFAA139281);; 广西高校中青年教师基础能力提升项目(KY2016LX051)资助 语种：中文; 页：80-84 页数：5 CN：45-1206/G3 ISSN：1005-9164 分类号：R318.08

摘要

为了初步探索木薯淀粉微球用作局部止血材料的止血性能,本研究以酸改性木薯淀粉为原料,三偏磷酸钠为交联剂,采用水包水乳液-交联法制备木薯淀粉微球。通过体外和体内止血试验评价木薯淀粉微球的止血性能。研究结果表明,木薯淀粉微球组的全血凝固时间、血浆复钙时间及家兔脾脏划破止血时间均显著低于空白对照组(P<0.05),与云南白药组相比无显著差异(P>0.05)。初步证明木薯淀粉微球的体外及体内止血性能良好,具有用作局部止血材料的良好潜力。
        To preliminarily investigate the hemostatic properties of cassava starch microspheres as topical hemostatic material,using acid modified tapioca starch as raw material and sodium trimetaphosphate as cross-linking agent,cassava starch microspheres were prepared by water-in-water emulsion-crosslinking method. The hemostatic properties of cassava starch microspheres were evaluated by in vitro and in vivo hemostatic tests. The whole blood coagulation time,recalcification time and the hemostatic time of experimental splenic bleeding model in rabbit in the cassava starch microsphere group were significantly lower than that in the blank control group( P < 0.05),and there were no significant differences when compared with the Yunnan Baiyao group( P > 0.05). The results preliminarily showed that cassava starch microspheres had good hemostatic performance in vitro and in vivo,and had good potential as a topical hemostatic material.

引文

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