不同来源干细胞在口腔骨再生中的应用
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摘要
背景:近年来,随着干细胞与再生技术的不断进步,骨组织工程得到了迅速的发展。虽然应用于骨组织工程中的种子细胞已经有很多,但对于不同的疾病,研究人员和临床工作者仍然面临着最佳种子细胞选择的问题。口腔骨组织重建是近年来研究的一个热点,目前应用于口腔骨组织修复的方法很多,但还没有一种方法能够取得满意的临床效果。因此,充分利用干细胞在骨再生过程中的潜能将为口腔骨组织缺损修复提供一种新思路。目的:对不同来源干细胞促进口腔骨组织再生的潜能进行综述,进而为组织工程选择种子细胞提供依据。方法:以"干细胞,骨修复,牙槽骨再生,成骨,骨组织""stem cell, bone repair, alveolar bone regenerate,osteogenesis,bonetissue"为关键词,检索中国生物医学文献数据库(CBM)、CNKI、PubMed、Elsevier以及Web of Science等数据库,通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,最终纳入81篇文献进行结果分析。结果与结论:组织工程为口腔骨再生修复提供了新的方法,但是对于干细胞的选择还没有标准化。应用于骨组织再生的干细胞种类有很多,但因其来源不同在体内发挥的作用也不尽相同,对于特定组织损伤的修复,选择一种合适的干细胞就显得很重要。文章对胚胎干细胞、间充质干细胞以及诱导多能干细胞在口腔骨组织再生中的优缺点进行了比较,旨在为口腔骨组织再生修复种子细胞的选择提供一种参考。
BACKGROUND: In recent years, with the development of stem cell and regeneration technologies, bone tissue engineering has been rapidly developed. Despite there are a variety of seed cells for bone tissue engineering,researchers need to decide which types of stem cells are the best suitable for their specific purposes. To date,there is no ideal treatment for oral bone tissue repair, although a plenty of therapeutic methods have been proposed. Therefore, it will provide a new idea for repairing oral bone defects by fully utilizing the potential of stem cells during bone regeneration.OBJECTIVE: To review the osteogenic potential of stem cells from different sources on oral bone regeneration,thereby providing a basis for selecting seed cells for tissue engineering.METHODS: Databases of CBM, CNKI, PubMed, Elsevier, and Web of Science were retrieved with the keywords of "stem cell, bone repair,alveolar bone regenerate, osteogenesis, bone tissue" in English and Chinese, respectively. After initial screening of titles and abstracts,irrelevant articles were excluded and 81 eligible articles were included in final analysis.RESULTS AND CONCLUSION: Tissue engineering technology provides a new approach to oral bone regeneration, but the choice of stem cells has not been standardized. Many types of stem cells have been used for bone tissue regeneration, but their roles in the body vary due to different origins of stem cells. Therefore, choosing a suitable type of stem cells is important for the repair of specific tissue damage. In this review, we compared the advantages and disadvantages of embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the oral bone regeneration, and attempted to provide a reference for the selection of seed cells for the regeneration and repair of oral bone tissue.
BACKGROUND: In recent years, with the development of stem cell and regeneration technologies, bone tissue engineering has been rapidly developed. Despite there are a variety of seed cells for bone tissue engineering,researchers need to decide which types of stem cells are the best suitable for their specific purposes. To date,there is no ideal treatment for oral bone tissue repair, although a plenty of therapeutic methods have been proposed. Therefore, it will provide a new idea for repairing oral bone defects by fully utilizing the potential of stem cells during bone regeneration.OBJECTIVE: To review the osteogenic potential of stem cells from different sources on oral bone regeneration,thereby providing a basis for selecting seed cells for tissue engineering.METHODS: Databases of CBM, CNKI, PubMed, Elsevier, and Web of Science were retrieved with the keywords of "stem cell, bone repair,alveolar bone regenerate, osteogenesis, bone tissue" in English and Chinese, respectively. After initial screening of titles and abstracts,irrelevant articles were excluded and 81 eligible articles were included in final analysis.RESULTS AND CONCLUSION: Tissue engineering technology provides a new approach to oral bone regeneration, but the choice of stem cells has not been standardized. Many types of stem cells have been used for bone tissue regeneration, but their roles in the body vary due to different origins of stem cells. Therefore, choosing a suitable type of stem cells is important for the repair of specific tissue damage. In this review, we compared the advantages and disadvantages of embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the oral bone regeneration, and attempted to provide a reference for the selection of seed cells for the regeneration and repair of oral bone tissue.
引文
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[12]Buduru SD,Gulei D,Zimta AA,et al.The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes.Cells.2019;8(1):E29.
[13]Andrews PW,Benvenisty N,McKay R,et al.The International Stem Cell Initiative:toward benchmarks for human embryonic stem cell research.Nat Biotechnol.2005;23(7):795-797.
[14]Nishikawa S,Jakt LM,Era T.Embryonic stem-cell culture as a tool for developmental cell biology.Nat Rev Mol Cell Biol.2007;8(6):502-507.
[15]Bielby RC,Boccaccini AR,Polak JM,et al.In vitro differentiation and in vivo mineralization of osteogenic cells derived from human embryonic stem cells.Tissue Eng.2004;10(9-10):1518-1525.
[16]Aldahmash A,Atteya M,Elsafadi M,et al.Teratoma formation in immunocompetent mice after syngeneic and allogeneic implantation of germline capable mouse embryonic stem cells.Asian Pac J Cancer Prev.2013;14(10):5705-5711.
[17]Hwang NS,Varghese S,Lee HJ,et al.Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells.Tissue Eng Part A.2013;19(15-16):1723-1732.
[18]Kuznetsov SA,Cherman N,Robey PG.In vivo bone formation by progeny of human embryonic stem cells.Stem Cells Dev.2011;20(2):269-287.
[19]Both SK,van Apeldoorn AA,Jukes JM,et al.Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells.J Tissue Eng Regen Med.2011;5(3):180-190.
[20]江中明,季佩红,刘军,等.小鼠胚胎干细胞向成牙本质样细胞的诱导分化[J].上海口腔医学.2006,15(6):653-656.
[21]Zhang Y,Li Y,Shi R,et al.Generation of tooth-periodontium complex structures using high-odontogenic potential dental epithelium derived from mouse embryonic stem cells.Stem Cell Res Ther.2017;8(1):141.
[22]Tomioka I,Honma Y,Sasada H,et al.In Vitro Induction of Potential Primordial Germ Cells from Mouse Embryonic Stem Cells by Culture with Undifferentiated Gonadal Cells.J Mamm Ova Res.2008,25(1):37-43.
[23]English K,Wood KJ.Immunogenicity of embryonic stem cell-derived progenitors after transplantation.Curr Opin Organ Transplant.2011;16(1):90-95.
[24]Estrela C,Alencar AH,Kitten GT,et al.Mesenchymal stem cells in the dental tissues:perspectives for tissue regeneration.Braz Dent J.2011;22(2):91-98.
[25]Yang H,Gao LN,An Y,et al.Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions.Biomaterials.2013;34(29):7033-7047.
[26]Miura M,Gronthos S,Zhao M,et al.SHED:stem cells from human exfoliated deciduous teeth.Proc Natl Acad Sci U S A.2003;100(10):5807-5812.
[27]Lindemann D,Werle SB,Steffens D,et al.Effects of cryopreservation on the characteristics of dental pulp stem cells of intact deciduous teeth.Arch Oral Biol.2014;59(9):970-976.
[28]Behnia A,Haghighat A,Talebi A,et al.Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect.World J Stem Cells.2014;6(4):505-510.
[29]Seo BM,Sonoyama W,Yamaza T,et al.SHED repair critical-size calvarial defects in mice.Oral Dis.2008;14(5):428-434.
[30]Vakhrushev IV,Antonov EN,Popova AV,et al.Design of tissue engineering implants for bone tissue regeneration of the basis of new generation polylactoglycolide scaffolds and multipotent mesenchymal stem cells from human exfoliated deciduous teeth(SHED cells).Bull Exp Biol Med.2012;153(1):143-147.
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