香味荧光笔挥发物的质谱分析及安全性研究
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摘要
香味荧光笔在中小学生中应用很普遍,但尚不确定香味荧光笔是否有毒.为此,首次开展国产香味荧光笔挥发物检测实验研究.采用固相微萃取-气相色谱-质谱(SPME-GC-MS)分析方法,对整支荧光笔及各拆解部件逐个进行挥发物检测,结果表明荧光笔气味来自笔内墨水;在带香味的四种品牌迷你型荧光笔中,共计检测出了15种挥发物,各品牌均含有高毒物质丙烯腈以及禁止人为添加物质乙苯.利用质子转移反应质谱在线监测方法,测量了荧光笔书写时纸张上方不同高度处的丙烯腈浓度,结果表明只要与纸张保持20 cm以上距离,可以有效降低有毒成分对使用者的侵害。
Scented highlighter is widely used by primary and secondary students, but it is not certained that whether scented highlighter has toxicity. Therefore the first mass spectrometry analysis for the volatiles from the domestic scented highlighter was carried out. The volatiles emitted from the whole highlighter and each disassembled components were detected using solid-phase microextraction gas chromatography mass spectrometry(SPME-GC-MS). The experimental results showed that the highlighter odor arises from the ink inside. In four brands of mini highlighters, 15 kinds of volatile compounds were detected. Among them, high toxic acrylonitrile and banned additive ethylbenzene occurred in all brands. Using proton transfer reaction mass spectrometry online monitoring method, during highlighter wrote on the paper, the concentrations of acrylonitrile diffused to different height positions above the paper were determined. It is suggested that, as long as the distance from the paper is more than 20 cm, the infringement caused by inhaling poisonous odor can be effectively reduced.
Scented highlighter is widely used by primary and secondary students, but it is not certained that whether scented highlighter has toxicity. Therefore the first mass spectrometry analysis for the volatiles from the domestic scented highlighter was carried out. The volatiles emitted from the whole highlighter and each disassembled components were detected using solid-phase microextraction gas chromatography mass spectrometry(SPME-GC-MS). The experimental results showed that the highlighter odor arises from the ink inside. In four brands of mini highlighters, 15 kinds of volatile compounds were detected. Among them, high toxic acrylonitrile and banned additive ethylbenzene occurred in all brands. Using proton transfer reaction mass spectrometry online monitoring method, during highlighter wrote on the paper, the concentrations of acrylonitrile diffused to different height positions above the paper were determined. It is suggested that, as long as the distance from the paper is more than 20 cm, the infringement caused by inhaling poisonous odor can be effectively reduced.
引文
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[2]Chen Jianjun, Diao Chunxia, Ye Ping, et al. Investigation and analysis on the status of hygiene and safety of student supplies in Taizhou City[J]. Chinese Rural Health Service Administration, 2016, 36(11):1407-1408(in Chinese).陈建军,刁春霞,叶平,等.泰州市学生用品卫生安全现状调查分析[J].中国农村卫事业管理,2016, 36(11):1407-1408
[3] Wei Qinzhi, He Chunla, Cao Qingqing, et al. Investigation and analysis of pupil's health in Guangzhou influenced by fragrant-stationery[J]. Modern Preventive Medicine, 2010, 37(8):1482-1484, 1487(in Chinese).卫秦芝,何春拉,曹青青,等·香味文具对广州市小学生健康危害的初步调查[J].现代预防医学,2010,37(8):1482-1484,1487.
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[7] Yao Tingting. Determination method of volatile organic compounds in scented stationary[J]. Guangdong Chemical Industry, 2016, 43(4):125-126(in Chinese).姚婷婷.香味文具中挥发性有机物的检测技术[J].广东化工,2016, 43(4):125-126.
[8]He Haixia,Ma Ping, Ye Wenhai. Simultaneous determination of 37 allergens in fragrant stationery by gas chromatography mass spectrometry[J]. Chemical Enterprise Management, 2017(22):40-43, 80(in Chinese).何海霞,马萍,叶文海·气相色谱-质谱法同时测定香味文具中37种致敏源物质[J].化工管理,2017(22):40-43,80.
[9] Ctorina R, Tysman M, Bradman A, et al. Volatile organic compound emissions from markers used in preschools,schools, and homes[J]. International Journal of Environmental Analytical Chemistry, 2016, 96(13):1247-1263.
[10] Bartsch J, Uhde E, Salthammer T. Analysis of odour compounds from scented consumer products using gas chromatography-mass spectrometry and gas chromatography-olfactometry[J]. Analytica Chimica Acta, 2016,904:98-106.
[11] Cao Jinghao, Kang Meng, Zou Xue, et al. Characteristics and source apportionment of volatile organic compounds in Hefei Dongpu reservoir[J]. Journal of Atmospheric and Environmental Optics, 2017, 12(5):362-370(in Chinese).曹京昊,康萌,邹雪,等.合肥董铺水库大气VOCs成分变化特征及源解析[J].大气与环境光学学报,2017,12(5):362-370.
[12] Lu Y, Niu W Q, Zou X, et al. Glass bottle sampling solid phase microextraction gas chromatography mass spectrometry for breath analysis of drug metabolites[J]. Journal of Chromatography A, 2017, 1496:20-24.
[13] Shen Chengyin, Li Jianquan, Wang Hongzhi, et al. Proton transfer reaction mass spectrometry for on-line detection of trace volatile organic compounds in breath[J]. Chinese Journal of Analytical Chemistry, 2012,40(5):773-777(in Chinese).沈成银,李建权,王宏志,等.呼气中痕量挥发性有机物的质子转移反应质谱在线检测研究[J].分析化学,2012,40(5):773-777.
[14] Zou X, Kang M, Li A Y, et al. Spray inlet proton transfer reaction mass spectrometry(SI-PTR-MS)for rapid and sensitive online monitoring of benzene in water[J]. Analytical Chemistry, 2016, 88(6):3144-3148.
[15] Li Jianquan, Shen Chengyin, Wang Hongmei, et al. Development and validation of proton transfer reaction mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2008(1):132-136(in Chinese).李建权,沈成银,王鸿梅,等·质子转移反应质谱的建立与性能研究[J].分析化学,2008(1):132-136.
[16] Caito S,Park M,Aschner M. Resistance of mouse primary microglia and astrocytes to acrylonitrile-induced oxidative stress[J]. Neurotoxicology, 2017, 63:120-125.
[17]北京西林布克网络科技有限公司.Chemical Book[OL]. https://www.chemicalbook. com/Productlndex.aspx.
[2]Chen Jianjun, Diao Chunxia, Ye Ping, et al. Investigation and analysis on the status of hygiene and safety of student supplies in Taizhou City[J]. Chinese Rural Health Service Administration, 2016, 36(11):1407-1408(in Chinese).陈建军,刁春霞,叶平,等.泰州市学生用品卫生安全现状调查分析[J].中国农村卫事业管理,2016, 36(11):1407-1408
[3] Wei Qinzhi, He Chunla, Cao Qingqing, et al. Investigation and analysis of pupil's health in Guangzhou influenced by fragrant-stationery[J]. Modern Preventive Medicine, 2010, 37(8):1482-1484, 1487(in Chinese).卫秦芝,何春拉,曹青青,等·香味文具对广州市小学生健康危害的初步调查[J].现代预防医学,2010,37(8):1482-1484,1487.
[4] Fujian Industrial Products Production License Review Tchnology Center. Beware of safety hazards of learning goods[J]. Fujian Quality&Technology Supervision, 2017(6):51(in Chinese).福建省工业产品生产许可证审查技术中心.谨防学习用品安全隐患[J].福建质量技术监督,2017(6):51.
[5] Chen Haibo. Be vigilant about the poisonous stationery of"fragrant"[J]. Quality Exploration, 2013(4):32(in Chinese).陈海波.警惕飘“香”的毒文具[J].质量探索,2013(4):32.
[6] Li Peng. Does fragrance stationery are poisonous[N]. Elder Life Newspaper, 2011-03-15(9)(in Chinese).李鹏.香味文具有毒吗[N].老年生活报,2011-03-15(9).
[7] Yao Tingting. Determination method of volatile organic compounds in scented stationary[J]. Guangdong Chemical Industry, 2016, 43(4):125-126(in Chinese).姚婷婷.香味文具中挥发性有机物的检测技术[J].广东化工,2016, 43(4):125-126.
[8]He Haixia,Ma Ping, Ye Wenhai. Simultaneous determination of 37 allergens in fragrant stationery by gas chromatography mass spectrometry[J]. Chemical Enterprise Management, 2017(22):40-43, 80(in Chinese).何海霞,马萍,叶文海·气相色谱-质谱法同时测定香味文具中37种致敏源物质[J].化工管理,2017(22):40-43,80.
[9] Ctorina R, Tysman M, Bradman A, et al. Volatile organic compound emissions from markers used in preschools,schools, and homes[J]. International Journal of Environmental Analytical Chemistry, 2016, 96(13):1247-1263.
[10] Bartsch J, Uhde E, Salthammer T. Analysis of odour compounds from scented consumer products using gas chromatography-mass spectrometry and gas chromatography-olfactometry[J]. Analytica Chimica Acta, 2016,904:98-106.
[11] Cao Jinghao, Kang Meng, Zou Xue, et al. Characteristics and source apportionment of volatile organic compounds in Hefei Dongpu reservoir[J]. Journal of Atmospheric and Environmental Optics, 2017, 12(5):362-370(in Chinese).曹京昊,康萌,邹雪,等.合肥董铺水库大气VOCs成分变化特征及源解析[J].大气与环境光学学报,2017,12(5):362-370.
[12] Lu Y, Niu W Q, Zou X, et al. Glass bottle sampling solid phase microextraction gas chromatography mass spectrometry for breath analysis of drug metabolites[J]. Journal of Chromatography A, 2017, 1496:20-24.
[13] Shen Chengyin, Li Jianquan, Wang Hongzhi, et al. Proton transfer reaction mass spectrometry for on-line detection of trace volatile organic compounds in breath[J]. Chinese Journal of Analytical Chemistry, 2012,40(5):773-777(in Chinese).沈成银,李建权,王宏志,等.呼气中痕量挥发性有机物的质子转移反应质谱在线检测研究[J].分析化学,2012,40(5):773-777.
[14] Zou X, Kang M, Li A Y, et al. Spray inlet proton transfer reaction mass spectrometry(SI-PTR-MS)for rapid and sensitive online monitoring of benzene in water[J]. Analytical Chemistry, 2016, 88(6):3144-3148.
[15] Li Jianquan, Shen Chengyin, Wang Hongmei, et al. Development and validation of proton transfer reaction mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2008(1):132-136(in Chinese).李建权,沈成银,王鸿梅,等·质子转移反应质谱的建立与性能研究[J].分析化学,2008(1):132-136.
[16] Caito S,Park M,Aschner M. Resistance of mouse primary microglia and astrocytes to acrylonitrile-induced oxidative stress[J]. Neurotoxicology, 2017, 63:120-125.
[17]北京西林布克网络科技有限公司.Chemical Book[OL]. https://www.chemicalbook. com/Productlndex.aspx.
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