五常市傍河水源水雄激素干扰效应及健康风险评价
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摘要
采用重组雄激素受体(AR)基因酵母法,结合健康风险评价技术,开展五常市傍河水源水雄激素干扰效应的检测及其风险评价。结果表明:所有水样均未检出雄激素诱导活性,均检出雄激素抑制活性,最大抑制率为29. 3%,初步表明五常市傍河水源水中存在雄激素抑制化合物。傍河取水(RBF)工艺对上述化合物有较好的去除,经RBF处理的地下水样雄激素抑制活性显著降低,且随着与河岸距离的增加,岸滤系统的去除率进一步增大。河流水样雄激素干扰效应表现出显著的季节变化特征,丰水期和融冰期雄激素抑制活性高于枯水期;傍河地下水受季节变化影响有限。健康风险评价结果表明,五常市傍河水源水雄激素干扰化合物对不同人群的潜在健康风险水平有限。
The recombinant androgen receptor( AR) gene yeast assay combined with a health risk assessment method were used to evaluate the androgen disrupting activity and assess the potential health risk of riverside groundwater samples collected in Wuchang City,in Heilongjiang Province. The results showed that the AR agonistic activities were not detected while the AR antagonistic activities were found in all water samples. The maximum antagonistic activity was 29. 3%,indicating that there were anti-androgenic compounds in the groundwater samples. The AR antagonistic activities of groundwater samples were significantly reduced after treatment by the river bank filtration( RBF),suggesting RBF was effective to remove these compounds,and the removal rate of RBF further increased with the increasing of the distance from the bank. For river water samples,the AR antagonistic activities showed a significant seasonal variation characteristic,and the AR antagonistic activities were higher in rainy seasons and ice melting period than in dry seasons; riverside groundwater was slightly influenced by seasonal variation. The results of health risk assessment showed that the androgen disrupting compound in the riverside groundwater of Wuchang City had limited potential health risk to different groups of people.
The recombinant androgen receptor( AR) gene yeast assay combined with a health risk assessment method were used to evaluate the androgen disrupting activity and assess the potential health risk of riverside groundwater samples collected in Wuchang City,in Heilongjiang Province. The results showed that the AR agonistic activities were not detected while the AR antagonistic activities were found in all water samples. The maximum antagonistic activity was 29. 3%,indicating that there were anti-androgenic compounds in the groundwater samples. The AR antagonistic activities of groundwater samples were significantly reduced after treatment by the river bank filtration( RBF),suggesting RBF was effective to remove these compounds,and the removal rate of RBF further increased with the increasing of the distance from the bank. For river water samples,the AR antagonistic activities showed a significant seasonal variation characteristic,and the AR antagonistic activities were higher in rainy seasons and ice melting period than in dry seasons; riverside groundwater was slightly influenced by seasonal variation. The results of health risk assessment showed that the androgen disrupting compound in the riverside groundwater of Wuchang City had limited potential health risk to different groups of people.
引文
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[20] Ascott M J,Lapworth D J,Gooddy D C,et al. Impacts of extreme flooding on riverbank filtration water quality[J]. Sci Total Environ,2016,s,554-555:89-101.
[21] Ray C,Soong T W,Lian Y Q,et al. Effect of flood-induced chemical load on filtrate quality at bank filtration sites[J]. J Hydrol,2002,266(3):235-258.
[22]王钰涵.吉林省饮用水水质监测结果分析[D].长春:吉林大学,2017.
[23] Sugita F,Nakane K. Combined effects of rainfall patterns and porous media properties on nitrate leaching[J]. Vadose Zone J.2007,6(3):548-553.
[24]曹伟娟.黄河头道拐断面冰封期PCBs和HCHs的分布特征研究[D].呼和浩特:内蒙古农业大学,2013.
[25] JECFA. Toxicological evaluation of certain veterinary drug residues in food[M]. Geneva,Switzerland:World Health Organization Food Additives Series:43, IPCS-International Programme on Chemical Safety,2011.
[26] Li J,Wang Z,Ma M,et al. Analysis of environmental endocrine disrupting activities using recombinant yeast assay in wastewater treatment plant effluents[J]. B Environ Contam Tox,2010,84(5):529-535.
[27]杨艳玲,徐晓虹.增塑剂DEHP的神经和行为发育毒性[J].心理科学进展,2013,21(6):1007-1013.
[2]刘国义,周志祥,秦延军,等.傍河取水水源地地下水资源评价及实例研究[J].安全与环境工程,2008,15(2):37-39.
[3]王丽雪.第二松花江流域(丰满以下)傍河取水对区域水资源的影响分析[D].长春:吉林大学,2017.
[4]段丽菊,张军峰,李博,等.黄河滩地傍河取水工程对黄河水微囊藻毒素的去除效果[J].卫生研究,2010,39(6):723-725.
[5]张丽萍.青浦区太浦河水源地傍河取水研究[D].上海:东华大学,2009.
[6]陆继龙,郝立波,王春珍,等.第二松花江中下游水体邻苯二甲酸酯分布特征[J].环境科学与技术,2007(12):35-37,119.
[7]张国军.环境抗雄激素影响及机制[J].国外医学:卫生学分册,2003,30(2):79-83.
[8]韩伟,李艳霞,杨明,等.环境雄激素的危害、来源与环境行为[J].生态学报,2010,30(6):1594-1603.
[9] Lee L S, Carmosini N, Sassman S A, et al. Agricultural contributions of antimicrobials and hormones on soil and water quality[J]. Adv Agron,2007,93(6):1-68.
[10] Brien S E, Heaton J P, Racz W J, et al. Effects of an environmental anti-androgen on erectile function in an animal penile erection model[J]. J Urology,2000,163(4):1315-1321.
[11] Bhatia H,Kumar A,Chapman J C,et al. Effects of short-term exposure to the model antiandrogen, flutamide on reproductive function based endpoints in female Murray rainbowfish(Melanotaenia fluviatile-es)[J]. Ecotox Environ Safe,2014,109:143-151.
[12]孔东东,李剑,任姝娟.应用重组基因酵母法检测松花江吉林段土壤有机组分甲状腺激素干扰效应[J].中国科技论文,2013,8(12):1271-1276.
[13]李剑,李沫蕊,孔东东,等.松花江吉林段土壤有机组分的雄激素干扰效应[J].环境科学研究,2014,27(8):898-903.
[14]王之瑞,王亚平,田延忠.五常市地表水资源评价及其合理开发利用[J].黑龙江水专学报,1997,39(3):59-61.
[15]孙登锋,武伟,李金凤.对五常市拉林河谷地下水动态监测报告的分析[J].黑龙江水利科技,2011,39(5):141-142.
[16] Plotan M,Elliott C T,Frizzell C,et al. Estrogenic endocrine disruptors present in sports supplements:a risk assessment for human health[J]. Food Chem,2014,159:157-165.
[17] Shen Y,Kong D D,Teng Y G,et al. An assessment of the presence and health risks of endocrine-disrupting chemicals in the drinking water treatment plant of Wu Chang,China[J]. Hum Ecol Risk Assess,2018(2):1-11.
[18]朱威,朱心强.农药的抗雄激素作用及其机制[J].国外医学:卫生学分册,2005,32(1):14-19.
[19]刘宝林.松花江流域(吉林省部分)水环境持久性污染物的环境特征[D].长春:吉林大学,2013.
[20] Ascott M J,Lapworth D J,Gooddy D C,et al. Impacts of extreme flooding on riverbank filtration water quality[J]. Sci Total Environ,2016,s,554-555:89-101.
[21] Ray C,Soong T W,Lian Y Q,et al. Effect of flood-induced chemical load on filtrate quality at bank filtration sites[J]. J Hydrol,2002,266(3):235-258.
[22]王钰涵.吉林省饮用水水质监测结果分析[D].长春:吉林大学,2017.
[23] Sugita F,Nakane K. Combined effects of rainfall patterns and porous media properties on nitrate leaching[J]. Vadose Zone J.2007,6(3):548-553.
[24]曹伟娟.黄河头道拐断面冰封期PCBs和HCHs的分布特征研究[D].呼和浩特:内蒙古农业大学,2013.
[25] JECFA. Toxicological evaluation of certain veterinary drug residues in food[M]. Geneva,Switzerland:World Health Organization Food Additives Series:43, IPCS-International Programme on Chemical Safety,2011.
[26] Li J,Wang Z,Ma M,et al. Analysis of environmental endocrine disrupting activities using recombinant yeast assay in wastewater treatment plant effluents[J]. B Environ Contam Tox,2010,84(5):529-535.
[27]杨艳玲,徐晓虹.增塑剂DEHP的神经和行为发育毒性[J].心理科学进展,2013,21(6):1007-1013.
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