高分子囊泡渗透性与微结构协同调控
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摘要
高分子囊泡通常由疏水的双层膜包覆亲水的空腔构成.这种独特的形貌使得高分子囊泡被广泛地用于构筑人工细胞(器)、纳米反应器和药物递送载体.为了实现这些功能应用,调控高分子囊泡双层膜的渗透性并保持囊泡结构的稳定性极为重要.然而传统调控囊泡渗透性的方法步骤相对繁琐、常导致组装体的解离.本文总结了我们近期在协同调控高分子囊泡稳定性和渗透性方面的研究进展.首先,提出了"无痕"交联的策略并实现了高分子囊泡渗透性和稳定性的协同增强.其次,利用多重协同非共价键相互作用,实现了高分子囊泡渗透性的可逆调节.这些新型的调控策略解决了高分子囊泡结构稳定性和渗透性的矛盾并展现了良好的应用前景.
Polymersomes, also referred to as polymer vesicles, are self-assembled from amphiphilic synthetic polymers, representing a type of hollow nanostructures containing aqueous lumens enclosed by bilayer membranes. This unique hollow and compartmentalized structure has been extensively used in the fabrication of artificial cells, drug carriers, and nanoreactors. Albeit more stable than liposomes, polymersomes exhibit relatively low permeability toward macromolecules, small molecules, ions, and even water molecules. This drawback remarkably hampers the biomedical applications of polymersomes. Thus, it is of crucial importance to regulate the permeability of polymersomes while maintaining structural integrity. Although a number of methods have been proposed to enhance the permeability of polymersomes such as the fabrication of stimuli-responsive polymersomes and the introduction of channel proteins, these procedures suffer from either tedious protocols or disruption of the vesicular structures. In this feature article, we summarize our recent achievements in the(ir)reversible regulation of the permeability of polymersomes. First, we conceived a new concept, termed as"traceless" cross-linking, to synergistically stabilize and permeate polymersomes. This concept originates from photoresponsive polymersomes, in which we found that the photo-caged primary amines underwent inter/intrachain amidation reactions other than protonation reactions within the initially hydrophobic bilayer membranes. Moreover, this robust strategy can be readily extended to other bio-related triggering events such as enzyme and redox. Notably, "traceless " cross-linking generally led to irreversible chemical cross-linking of polymersomes. Thus, in the following section, we showcased the representative examples in reversible modulation the permeability of polymersomes by taking advantage of cooperative noncovalent interactions. These new methodologies successfully resolve the dilemma of the structural stability and bilayer permeability of polymersomes and can be used for the fabrication of smart nanocarriers and nanoreactors. Finally, we give a brief summary and outlook of this emerging field.
Polymersomes, also referred to as polymer vesicles, are self-assembled from amphiphilic synthetic polymers, representing a type of hollow nanostructures containing aqueous lumens enclosed by bilayer membranes. This unique hollow and compartmentalized structure has been extensively used in the fabrication of artificial cells, drug carriers, and nanoreactors. Albeit more stable than liposomes, polymersomes exhibit relatively low permeability toward macromolecules, small molecules, ions, and even water molecules. This drawback remarkably hampers the biomedical applications of polymersomes. Thus, it is of crucial importance to regulate the permeability of polymersomes while maintaining structural integrity. Although a number of methods have been proposed to enhance the permeability of polymersomes such as the fabrication of stimuli-responsive polymersomes and the introduction of channel proteins, these procedures suffer from either tedious protocols or disruption of the vesicular structures. In this feature article, we summarize our recent achievements in the(ir)reversible regulation of the permeability of polymersomes. First, we conceived a new concept, termed as"traceless" cross-linking, to synergistically stabilize and permeate polymersomes. This concept originates from photoresponsive polymersomes, in which we found that the photo-caged primary amines underwent inter/intrachain amidation reactions other than protonation reactions within the initially hydrophobic bilayer membranes. Moreover, this robust strategy can be readily extended to other bio-related triggering events such as enzyme and redox. Notably, "traceless " cross-linking generally led to irreversible chemical cross-linking of polymersomes. Thus, in the following section, we showcased the representative examples in reversible modulation the permeability of polymersomes by taking advantage of cooperative noncovalent interactions. These new methodologies successfully resolve the dilemma of the structural stability and bilayer permeability of polymersomes and can be used for the fabrication of smart nanocarriers and nanoreactors. Finally, we give a brief summary and outlook of this emerging field.
引文
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73 Liu G H,Zhang G F,Hu J M,Wang X R,Zhu M Q,Liu S Y.J Am Chem Soc,2015,137(36):11645-11655
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2 Hartgerink J D,Beniash E,Stupp S I.Science,2001,294(5547):1684-1688
3 Marguet M,Bonduelle C,Lecommandoux S.Chem Soc Rev,2013,42(2):512-529
4 Checot F,Lecommandoux S,Gnanou Y,Klok H A.Angew Chem Int Ed,2002,41(8):1339-1343
5 Vanhest J C M,Delnoye D A P,Baars M W P L,Vangenderen M H P,Meijer E W.Science,1995,268(5217):1592-1595
6 Du J Z,O’Reilly R K.Chem Soc Rev,2011,40(5):2402-2416
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8 Li Yaming(李亚明),Liu Shiyong(刘世勇).Acta Polymerica Sinica(高分子学报),2017,(7):1178-1190
9 Bai Y,Xie F Y,Tian W.Chinese J Polym Sci,2018,36(3):406-416
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11 Feng X R,Ding J X,Gref R,Chen X S.Chinese J Polym Sci,2017,35(6):693-699
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14 Li X X,Huo X,Han H J,Lin S L.Chinese J Polym Sci,2017,35(11):1363-1372
15 Liu D,Wang Y Y,Sun Y C,Han Y Y,Cui J,Jiang W.Chinese J Polym Sci,2018,36(7):888-896
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17 Lu X J,Yang X Y,Meng Y,Li S Z.Chinese J Polym Sci,2017,35(4):534-546
18 Lyu X L,Pan H B,Shen Z H,Fan X H.Chinese J Polym Sci,2018,36(7):811-821
19 Meng F D,Ni Y X,Ji S F,Fu X H,Wei Y H,Sun J,Li Z B.Chinese J Polym Sci,2017,35(10):1243-1252
20 Xu M M,Liu R J,Yan Q.Chinese J Polym Sci,2018,36(3):347-365
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28 Xiao Y F,Sung H,Du J Z.J Am Chem Soc,2017,139(22):7640-7647
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32 Yao C,Wang X,Liu G,Hu J,Liu S.Macromolecules,2016,49(21):8282-8295
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34 Sun Z,Liu G,Hu J,Liu S.Biomacromolecules,2018,19(6):2071-2081
35 Tanner P,Baumann P,Enea R,Onaca O,Palivan C,Meier W.Acc Chem Res,2011,44(10):1039-1049
36 Bian B,Zhang Y Y,Dong Y C,Wu F,Wang C,Wang S,Xu Y,Liu D S.Sci China Chem,2018,61(12):1568-1571
37 Wu S X,Li J,Liang H,Wang L P,Chen X,Jin G X,Xu X P,Yang H H.Sci China Chem,2017,60(5):628-634
38 Xiao J G,Hu Y,Du J Z.Sci China Chem,2018,61(5):569-575
39 Yang S,Luan Z L,Gao C,Yu J J,Qu D H.Sci China Chem,2018,61(3):306-310
40 Zhang Y Y,Li M,Li Z H,Li Q,Aldalbahi A,Shi J Y,Wang L H,Fan C H,Zuo X L.Sci China Chem,2017,60(11):1474-1480
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44 Kim K T,Cornelissen J J L M,Nolte R J M,van Hest J C M.Adv Mater,2009,21(27):2787-2791
45 Amstad E,Kim S H,Weitz D A.Angew Chem Int Ed,2012,51(50):12499-12503
46 Hu J M,Zhang G Q,Liu S Y.Chem Soc Rev,2012,41(18):5933-5949
47 Yan Q,Wang J B,Yin Y W,Yuan J Y.Angew Chem Int Ed,2013,52(19):5070-5073
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49 Spulber M,Najer A,Winkelbach K,Glaied O,Waser M,Pieles U,Meier W,Bruns N.J Am Chem Soc,2013,135(24):9204-9212
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51 Read E S,Armes S P.Chem Commun,2007,43(29):3021-3035
52 Habault D,Zhang H J,Zhao Y.Chem Soc Rev,2013,42(17):7244-7256
53 Zhu K,Deng Z,Liu G,Hu J,Liu S.Macromolecules,2017,50(3):1113-1125
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57 Wang C,Zhang G Y,Liu G H,Hu J M,Liu S Y.J Control Release,2017:259149-159
58 Marguet M,Sandre O,Lecommandoux S.Langmuir,2012,28(4):2035-2043
59 Xu W,Ledin P A,Iatridi Z,Tsitsilianis C,Tsukruk V V.Angew Chem Int Ed,2016,55(16):4908-4913
60 Li Y M,Liu G H,Wang X R,Hu J M,Liu S Y.Angew Chem Int Ed,2016,55(5):1760-1764
61 Ding Y,Kang Y T,Zhang X.Chem Commun,2015,51(6):996-1003
62 Hotamisligil G S.Nature,2006,444(7121):860-867
63 Circu M L,Aw T Y.Free Radical Biol Med,2010,48(6):749-762
64 Deng Z,Qian Y,Yu Y,Liu G,Hu J,Zhang G,Liu S.J Am Chem Soc,2016,138(33):10452-10466
65 Cheng R,Feng F,Meng F H,Deng C,Feijen J,Zhong Z Y.J Control Release,2011,152(1):2-12
66 Deng Z Y,Yuan S,Xu R X,Liang H J,Liu S Y.Angew Chem Int Ed,2018,57(29):8896-8900
67 Che H L,van Hest J C M.J Mater Chem,2016,4(27):4632-4647
68 Che H L,Cao S P,van Hest J C M.J Am Chem Soc,2018,140(16):5356-5359
69 Yan Q,Zhou R,Fu C K,Zhang H J,Yin Y W,Yuan J Y.Angew Chem Int Ed,2011,50(21):4923-4927
70 Feng A C,Zhan C B,Yan Q,Liu B W,Yuan J Y.Chem Commun,2014,50(64):8958-8961
71 Hu X L,Zhai S D,Liu G H,Xing D,Liang H J,Liu S Y.Adv Mater,2018,30(21):1706307
72 Liu G H,Shi G H,Sheng H Y,Jiang Y Y,Liang H J,Liu S Y.Angew Chem Int Ed,2017,56(30):8686-8691
73 Liu G H,Zhang G F,Hu J M,Wang X R,Zhu M Q,Liu S Y.J Am Chem Soc,2015,137(36):11645-11655
74 Hu X L,Liu G H,Li Y,Wang X R,Liu S Y.J Am Chem Soc,2015,137(1):362-368
75 Liu G H,Wang X R,Hu J M,Zhang G Y,Liu S Y.J Am Chem Soc,2014,136(20):7492-7497
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