创新驱动引领下的广东省遗传学研究
摘要
<正>遗传学(genetics)是探究生物遗传和变异规律的科学。从1866年孟德尔发表"植物杂交实验"论文,标志着经典遗传学的创立;到1953年沃森和兊里兊提出DNA双螺旋结构模型,开启了分子遗传学研究的大门;随着分子生物学的发展和多学科交叉融合,以PCR技术、DNA重组技术、高通量基因组测序
引文
[1]张永清,薛勇彪.遗传学:生命科学领域的引领学科.遗传, 2018, 40(10):791–793.
[2] Zhao YP, Ni GJ. Professor Ding Ying's exploration and contribution to cultivation and origin of Oryza sativa.Agric Archaeol, 2013, 4:266–271.赵色萍,倪根金.丁颖教授在稻作(种)起源问题上的探索及贡献.农业耂古, 2013, 4:266–271.
[3]赖寄丹,钟国辉.创造水稻世界奇迹的:―中国半矮杄水稻之父‖黄耀祥.中国农垦, 1998, 4:17–18.
[4]卢永根,张桂权.特异亲和基因及其在杂交水稻育种上利用的设想.福建稻麦科技, 1992, 10(1):1–4.
[5] Xie YY, Tang JT, Yang BW, Hu J, Liu YG, Chen LT.Current advance on molecular genetics regulation of rice fertility. Hereditas(Beijing), 2019, 41(8):703–715.谢勇尧,汤金涛,杨博文,胡骏,刘耀光,陈乐天.水稻育性调控的分子遗传研究迚展.遗传, 2019, 41(8):703–715.
[6] Zhang GQ. The platform of breeding by design based on the SSSL library in rice. Hereditas(Beijing), 2019, 41(8):754–760.张桂权.基于SSSL文库的水稻设计育种平台.遗传,2019, 41(8):754–760.
[7] Zhang QQ, Shang X, Lin WY, Xu XM. Effect of genetic modifiers on the clinical severity ofβ-thalassemia.Hereditas(Beijing), 2019, 41(8):669–676.张倩倩,商璇,林宛颖,徐湘民.影响β-地中海贫血表型的遗传修饰作用.遗传, 2019, 41(8):669–676.
[8] Zhang QQ, Zhang L, Tang YH, Li XR, Xu XP, Qi M, Xu XM. A comprehensive repository of mutation data and a clinical assistant decision system for hemoglobinopathy in the Chinese population. Hereditas(Beijing), 2019, 41(8):746–753.张倩倩,张立,唐耀华,李厦戎,徐晓鹏,祁鸣,徐湘民.中国人血红蛋白病突变数据集和临床辅助决策管理系统.遗传, 2019, 41(8):746–753.
[9] Liang WQ, Hou Y, Zhao CY. Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function. Hereditas(Beijing), 2019, 41(8):677–685.梁文权,侯豫,赵存友.精神分裂症相关单核苷酸多态性调控microRNA功能研究迚展.遗传, 2019, 41(8):677–685.
[10] Zhang XQ, Wang J, Xiong F, Lv WB, Zhou YQ, Yang SM,Zhang YT, Tian XY, Lian W, Xu XM. Ectrodactyly caused by chromosome 10q24.31 duplication and its genetic linkage. Hereditas(Beijing), 2019, 41(8):716–724.张秀泉,王建,熊符,吕伟标,周进青,杨少民,张玉婷,田小燕,连蔚,徐湘民.染艱体10q24.31片段重复导致先天性缺指/缺趾畸形的一个家系致病机理分析.遗传,2019, 41(8):716–724.
[11] Lu HZ, Wang Dk, Wang Z. Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load. Hereditas(Beijing), 2019, 41(8):725–735.卢涣滋,王迪侃,王智. HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析.遗传, 2019, 41(8):725–735.
[12] Zhao X, Yang HQ. Progress on spermatogonial stem cells of large animals. Hereditas(Beijing), 2019, 41(8):686–702.赵鑫,杨化强.大动物精原干细胞研究迚展.遗传,2019, 41(8):686–702.
[13] Mo JX, Wang HQ, Huang GY, Cai GY, Wu ZF, Zhang XW.Heterogenous expression and enzymatic property analysis of microbial-derived pectinases in pig PK15 cells.Hereditas(Beijing), 2019, 41(8):736–745.莫健新,王豪强,黄广燕,蔡更元,吴珍芳,张献伟.微生物源果胶酶在猪PK15细胞中异源表达及其酶学性质分析.遗传, 2019, 41(8):736–745.
[14] Wang B, Liu F, Zhang EC, Wo CL, Chen ZJ, Qian PY, Lu HR, Zeng WJ, Chen T, Wei JP, Wan Q, Wang R, Xu X.The China National GeneBank—owned by all, completed by all and shared by all. Hereditas(Beijing), 2019, 41(8):761–772.王博,刘芳,张二春,沃晨亮,陈振家,钱璞毅,卢浩荣,曾文君,陈泰,危金普,七仟,王韧,徐讯.国家基因库:共有、共为、共享.遗传, 2019, 41(8):761–772.
[15] Zhang W, Zhao G, Luo Z, Lin Y, Wang L, Guo Y, Wang A,Jiang S, Jiang Q, Gong J, Wang Y, Hou S, Huang J, Li T,Qin Y, Dong J, Qin Q, Zhang J, Zou X, He X, Zhao L,Xiao Y, Xu M, Cheng E, Huang N, Zhou T, Shen Y,Walker R, Luo Y, Kuang Z, Mitchell LA, Yang K,Richardson SM, Wu Y, Li BZ, Yuan YJ, Yang H, Lin J,Chen GQ, Wu Q, Bader JS, Cai Y, Boeke JD, Dai J.Engineering the ribosomal DNA in a megabase synthetic chromosome. Science, 2017, 355(6329):pii:eaaf3981.
[16] Liu W, Luo Z, Wang Y, Pham NT, Tuck L, Pérez-Pi I, Liu L, Shen Y, French C, Auer M, Marles-Wright J, Dai J, Cai Y. Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. Nat Commun, 2018, 9(1):1936.
[17] Luo Z, Wang L, Wang Y, Zhang W, Guo Y, Shen Y, Jiang L,Wu Q, Zhang C, Cai Y, Dai J. Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES. Nat Commun, 2018, 9(1):1930.
[18] Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G,Zhao H, Wei H, Pei Z, Li S, Lai L, Li XJ. A Huntingtin knockin pig model recapitulates features of selective neurodegeneration in Huntington's disease. Cell, 2018,173(4):989–1002. e13.
[19] Jin H, Fu M, Duan Z, Duan S, Li M, Dong X, Liu B, Feng D, Wang J, Peng L, Wang HB. LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis. Proc Natl Acad Sci USA,2018, 115(26):E6075–E6084.
[20] Guo YX, Li BY, Wang XX. Bacterial toxin-antitoxin systems:yin and yang of death and persistence. Acta Microb Sin, 2017, 57(11):1708–1715.郭云学,李百元,王晓雪.细菌的毒素–抗毒素系统:定时炸弹还是克死金牉.微生物学报, 2017, 57(11):1708–1715.
[2] Zhao YP, Ni GJ. Professor Ding Ying's exploration and contribution to cultivation and origin of Oryza sativa.Agric Archaeol, 2013, 4:266–271.赵色萍,倪根金.丁颖教授在稻作(种)起源问题上的探索及贡献.农业耂古, 2013, 4:266–271.
[3]赖寄丹,钟国辉.创造水稻世界奇迹的:―中国半矮杄水稻之父‖黄耀祥.中国农垦, 1998, 4:17–18.
[4]卢永根,张桂权.特异亲和基因及其在杂交水稻育种上利用的设想.福建稻麦科技, 1992, 10(1):1–4.
[5] Xie YY, Tang JT, Yang BW, Hu J, Liu YG, Chen LT.Current advance on molecular genetics regulation of rice fertility. Hereditas(Beijing), 2019, 41(8):703–715.谢勇尧,汤金涛,杨博文,胡骏,刘耀光,陈乐天.水稻育性调控的分子遗传研究迚展.遗传, 2019, 41(8):703–715.
[6] Zhang GQ. The platform of breeding by design based on the SSSL library in rice. Hereditas(Beijing), 2019, 41(8):754–760.张桂权.基于SSSL文库的水稻设计育种平台.遗传,2019, 41(8):754–760.
[7] Zhang QQ, Shang X, Lin WY, Xu XM. Effect of genetic modifiers on the clinical severity ofβ-thalassemia.Hereditas(Beijing), 2019, 41(8):669–676.张倩倩,商璇,林宛颖,徐湘民.影响β-地中海贫血表型的遗传修饰作用.遗传, 2019, 41(8):669–676.
[8] Zhang QQ, Zhang L, Tang YH, Li XR, Xu XP, Qi M, Xu XM. A comprehensive repository of mutation data and a clinical assistant decision system for hemoglobinopathy in the Chinese population. Hereditas(Beijing), 2019, 41(8):746–753.张倩倩,张立,唐耀华,李厦戎,徐晓鹏,祁鸣,徐湘民.中国人血红蛋白病突变数据集和临床辅助决策管理系统.遗传, 2019, 41(8):746–753.
[9] Liang WQ, Hou Y, Zhao CY. Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function. Hereditas(Beijing), 2019, 41(8):677–685.梁文权,侯豫,赵存友.精神分裂症相关单核苷酸多态性调控microRNA功能研究迚展.遗传, 2019, 41(8):677–685.
[10] Zhang XQ, Wang J, Xiong F, Lv WB, Zhou YQ, Yang SM,Zhang YT, Tian XY, Lian W, Xu XM. Ectrodactyly caused by chromosome 10q24.31 duplication and its genetic linkage. Hereditas(Beijing), 2019, 41(8):716–724.张秀泉,王建,熊符,吕伟标,周进青,杨少民,张玉婷,田小燕,连蔚,徐湘民.染艱体10q24.31片段重复导致先天性缺指/缺趾畸形的一个家系致病机理分析.遗传,2019, 41(8):716–724.
[11] Lu HZ, Wang Dk, Wang Z. Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load. Hereditas(Beijing), 2019, 41(8):725–735.卢涣滋,王迪侃,王智. HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析.遗传, 2019, 41(8):725–735.
[12] Zhao X, Yang HQ. Progress on spermatogonial stem cells of large animals. Hereditas(Beijing), 2019, 41(8):686–702.赵鑫,杨化强.大动物精原干细胞研究迚展.遗传,2019, 41(8):686–702.
[13] Mo JX, Wang HQ, Huang GY, Cai GY, Wu ZF, Zhang XW.Heterogenous expression and enzymatic property analysis of microbial-derived pectinases in pig PK15 cells.Hereditas(Beijing), 2019, 41(8):736–745.莫健新,王豪强,黄广燕,蔡更元,吴珍芳,张献伟.微生物源果胶酶在猪PK15细胞中异源表达及其酶学性质分析.遗传, 2019, 41(8):736–745.
[14] Wang B, Liu F, Zhang EC, Wo CL, Chen ZJ, Qian PY, Lu HR, Zeng WJ, Chen T, Wei JP, Wan Q, Wang R, Xu X.The China National GeneBank—owned by all, completed by all and shared by all. Hereditas(Beijing), 2019, 41(8):761–772.王博,刘芳,张二春,沃晨亮,陈振家,钱璞毅,卢浩荣,曾文君,陈泰,危金普,七仟,王韧,徐讯.国家基因库:共有、共为、共享.遗传, 2019, 41(8):761–772.
[15] Zhang W, Zhao G, Luo Z, Lin Y, Wang L, Guo Y, Wang A,Jiang S, Jiang Q, Gong J, Wang Y, Hou S, Huang J, Li T,Qin Y, Dong J, Qin Q, Zhang J, Zou X, He X, Zhao L,Xiao Y, Xu M, Cheng E, Huang N, Zhou T, Shen Y,Walker R, Luo Y, Kuang Z, Mitchell LA, Yang K,Richardson SM, Wu Y, Li BZ, Yuan YJ, Yang H, Lin J,Chen GQ, Wu Q, Bader JS, Cai Y, Boeke JD, Dai J.Engineering the ribosomal DNA in a megabase synthetic chromosome. Science, 2017, 355(6329):pii:eaaf3981.
[16] Liu W, Luo Z, Wang Y, Pham NT, Tuck L, Pérez-Pi I, Liu L, Shen Y, French C, Auer M, Marles-Wright J, Dai J, Cai Y. Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. Nat Commun, 2018, 9(1):1936.
[17] Luo Z, Wang L, Wang Y, Zhang W, Guo Y, Shen Y, Jiang L,Wu Q, Zhang C, Cai Y, Dai J. Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES. Nat Commun, 2018, 9(1):1930.
[18] Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G,Zhao H, Wei H, Pei Z, Li S, Lai L, Li XJ. A Huntingtin knockin pig model recapitulates features of selective neurodegeneration in Huntington's disease. Cell, 2018,173(4):989–1002. e13.
[19] Jin H, Fu M, Duan Z, Duan S, Li M, Dong X, Liu B, Feng D, Wang J, Peng L, Wang HB. LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis. Proc Natl Acad Sci USA,2018, 115(26):E6075–E6084.
[20] Guo YX, Li BY, Wang XX. Bacterial toxin-antitoxin systems:yin and yang of death and persistence. Acta Microb Sin, 2017, 57(11):1708–1715.郭云学,李百元,王晓雪.细菌的毒素–抗毒素系统:定时炸弹还是克死金牉.微生物学报, 2017, 57(11):1708–1715.
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