杀真菌化合物SCU-2028对环境生物的毒性与安全性评价
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摘要
通过参照《化学农药环境安全评价试验准则》中化合物对环境有益生物,如鱼类、蚯蚓、家蚕、水藻类的急性毒性的测定方法,进行化合物SCU-2028的环境安全性评价.结果表明化合物SCU-2028对斜生栅列藻72 h的EC_(50)值为7.872 mg/L,对斑马鱼96 h的LC_(50)> 12 mg/L,对蚯蚓14 d的LC_(50)> 40 mg/kg和对3龄家蚕96 h的LC_(50)> 4800 mg/kg桑叶.这显示出化合物SCU-2028对鱼类、蚯蚓、家蚕、藻类均为低毒.
By referring to the assay for determining the acute toxicity of compounds to environmental organisms, such as fishes,earthworms,silkworms and algaes in "environmental safety evaluation tests of chemical pesticides standards", the environmental safety of compound SCU-2028 was evaluated. The results showed that the EC_(50) value against algaes in 72 h was 7.872 mg/L,the LC_(50) value against fishes in 96 h was more than 12 mg/L, the LC_(50) value against earthworms in 14 d was more than 40 mg/kg and the LC_(50) value against silkworms in 96 h was more than 4800 mg/kg. This showed that compound SCU-2028 had low toxicity to environmental organisms.
By referring to the assay for determining the acute toxicity of compounds to environmental organisms, such as fishes,earthworms,silkworms and algaes in "environmental safety evaluation tests of chemical pesticides standards", the environmental safety of compound SCU-2028 was evaluated. The results showed that the EC_(50) value against algaes in 72 h was 7.872 mg/L,the LC_(50) value against fishes in 96 h was more than 12 mg/L, the LC_(50) value against earthworms in 14 d was more than 40 mg/kg and the LC_(50) value against silkworms in 96 h was more than 4800 mg/kg. This showed that compound SCU-2028 had low toxicity to environmental organisms.
引文
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[20] 李祥英,梁惠君,何裕坚,等.5种杀菌剂对3种水生生物的急性毒性与安全性评价 [J].广东农业科学,2014,16:125.
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[25] 王彦华,陈丽萍,赵学平,等.新烟碱类和阿维菌素类药剂对蚯蚓的急性毒性效应 [J].农业环境科学学报,2010,29:2299.
[26] 蒋猷龙,陈清其,冯家新,等.浙江省蚕桑志 [M].杭州:浙江大学出版社,2004:160.
[27] 陈伟国,戴建忠,董瑞华,等.5种双酰胺类杀虫剂对家蚕的毒性比较和安全性评价 [J].蚕业科学,2016,42:288.引用本文格式:中文:杨艺华,张爱贵,岳莹,等.杀真菌化合物SCU-2028对环境生物的毒性与安全性评价 [J].四川大学学报:自然科学版,2019,56:553.英文:Yang Y H,Zhang A G,Yue Y,et al.Toxicity andsafety evaluation of fungicidal compound SCU-2028 to the environmental organisms [J].J Sichuan Univ:Nat Sci Ed,2019,56:553.
[2] 王宏宇,张肖肖,高续恒,等.二芳胺基呋喃甲酰胺类化合物的合成设计及抗菌活性研究 [J].四川大学学报:自然科学版,2017,54:845.
[3] 陈晓明,王陈龙,薄瑞.中国农药使用现状及对策建议 [J].农药科学与管理,2016,37:4.
[4] 曹瑾,张一宾.吡唑类农药的研究进展 [J].精细化工中间体,2007,37:1.
[5] 梁英,贺红武.具有杀菌活性的吡唑类衍生物的研究进展 [J].农药,2005,44:14.
[6] 贾新彦,徐端红.吡唑酰胺类化合物的合成及杀菌活性研究进展 [J].河南农业,2016,06:43.
[7] Zhang X X,Jin H,Deng Y J,et al.Synthesis and biological evaluation of novel pvrazole carboxamide with diarylamine-modified scaffold as potent antifung alagents [J].Chin Chem Lett,2017,28:1731.
[8] 侯太平,张肖肖,金洪,等.含二芳胺基的吡唑甲酰胺类化合物及其在农药中的应用:ZL201610019343.1 [P].2016-10-01.
[9] 国家环保局.化学农药环境安全评价试验准则:GB/T31270.11-2014 [S].北京:中国标准出版社,2015:22.
[10] 雷斌,常晓春,张波,等.18.6%拌·福·乙酰甲悬浮种衣剂对环境生物的毒性与安全性评价 [J].农药,2011,50:903.
[11] 党建友.农药对有益生物安全性评价生测方法研究 [D].北京:中国农业大学,2003.
[12] 冯磊.三种新烟碱类杀虫剂对蚯蚓的影响 [D].北京:中国农业科学院,2014.
[13] 陈爱梅,王金花,夏晓明,等.不同剂型吡虫啉对蚯蚓和斑马鱼的急性毒性评价 [J].农业环境科学学报,2013,32:1758.
[14] 孙仕仙,张庆,薛涛.等.杀虫双对蚯蚓的单一及其复合毒性试验 [J].现代农业科学,2009,16:13.
[15] 张中霄,王开运,姜莉莉,等.新型杀虫剂甲硫丁醚脲对家蚕的毒性与安全性评价 [J].蚕业科学,2017,43:704.
[16] 池艳艳,乔康,姜辉,等.氯虫苯甲酰胺对家蚕的毒性与安全性评价 [J].蚕业科学,2014,40:694.
[17] 陈伟国,鲁兴萌.农药对家蚕的毒性与安全性评价研究 [J].蚕业科学,2012,38:329.
[18] 赵玉艳,蔡磊明.几种藻类毒性试验统计方法的差异 [J].农药,2004,43:298.
[19] 沈艳,陈亮,孙如意,等.噻呋酰胺对3种水生物的急性毒性与安全性评价 [J].农药,2016,55:817.
[20] 李祥英,梁惠君,何裕坚,等.5种杀菌剂对3种水生生物的急性毒性与安全性评价 [J].广东农业科学,2014,16:125.
[21] Zhang Z Y,Yu X Y,Wang D L,et al.Acute toxicity to zebrafish of two organophosphates and four pyrethroids and their binary mixtures [J].Pest Manag Sci,2010,66:84.
[22] Scholz S,Fischer S,EKüster,et al.The zebrafish embryo model in environmental risk assessment applications beyond acute toxicity testing [J].Environ Sci Pollut R,2008,15:394.
[23] Embry M R,Belanger S E,Braunbeck T A,et al.The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research [J].Aquat Toxicol,2010,97:79.
[24] 林琎.氟吡菌胺的环境安全性及其在黄瓜和土壤中的残留动态研究 [D].泰安:山东农业大学,2015.
[25] 王彦华,陈丽萍,赵学平,等.新烟碱类和阿维菌素类药剂对蚯蚓的急性毒性效应 [J].农业环境科学学报,2010,29:2299.
[26] 蒋猷龙,陈清其,冯家新,等.浙江省蚕桑志 [M].杭州:浙江大学出版社,2004:160.
[27] 陈伟国,戴建忠,董瑞华,等.5种双酰胺类杀虫剂对家蚕的毒性比较和安全性评价 [J].蚕业科学,2016,42:288.引用本文格式:中文:杨艺华,张爱贵,岳莹,等.杀真菌化合物SCU-2028对环境生物的毒性与安全性评价 [J].四川大学学报:自然科学版,2019,56:553.英文:Yang Y H,Zhang A G,Yue Y,et al.Toxicity andsafety evaluation of fungicidal compound SCU-2028 to the environmental organisms [J].J Sichuan Univ:Nat Sci Ed,2019,56:553.
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