双波长可见吸收光谱法测定盐酸米多君

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英文篇名：Determination of midodrine hydrochloride by double-wavelength visible absorption spectrometry 作者：卢俊伶 ; 江虹 ; 姜权利 英文作者：LU Jun-ling;JIANG Hong;JIANG Quan-li;Collaborative Innovation Center for Green Development in Wuling Mountain Areas,School of Chemistry and Chemical Engineering,Yangtze Normal University; 关键词：双波长 ; 吸收光谱 ; 盐酸米多君 ; 溴甲酚绿 ; 乙醇 英文关键词：dual-wavelength;;absorption spectrum;;midodrine hydrochloride;;bromocresol green;;ethanol 中文刊名：现代化工 英文刊名：Modern Chemical Industry 机构：长江师范学院化学化工学院长江师范学院武陵山片区绿色发展协同创新中心; 出版日期：2019-05-17 出版单位：现代化工 年：2019 期：05 基金：重庆市教委科技基金资助项目(KJ1401226);; 长江师范学院科技基金资助项目(2018CXX111) 语种：中文; 页：251-254 页数：4 CN：11-2172/TQ ISSN：0253-4320 分类号：O657.3;TQ460.72

摘要

在弱碱性乙醇溶液中,溴甲酚绿与盐酸米多君以静电引力结合生成具有1个较强正吸收峰和1个较强负吸收峰的二元离子缔合物,最大正吸收峰位于553 nm,最大负吸收峰位于444 nm,表观摩尔吸光系数(κ)分别为2. 06×104L/(mol·cm)(553 nm)和2. 07×104L/(mol·cm)(444 nm)。当用双波长法测定时,表观摩尔吸光系数(κ)可达4. 13×104L/(mol·cm),线性范围均为0. 2～8. 7 mg/L,检出限分别为0. 15 mg/L(单波长法,553 nm)、0. 14 mg/L(单波长法,444 nm)和0. 072 mg/L(双波长法)。据此建立了测定盐酸米多君的双波长可见吸收光谱法,该方法用于盐酸米多君片剂中盐酸米多君的测定,回收率和相对标准偏差RSD(n=5)分别为98. 4%～102%和1. 8%～2. 3%。
        In a weak-alkaline ethanol solution,bromocresol green combines with midodrine hydrochloride by electrostatic attraction to form a binary ionic association complex with a strong positive absorption peak and a strong negative absorption peak.The maximum positive absorption peak locates at 553 nm and the minimum negative absorption peak locates at 444 nm.The apparent molar absorptivity(κ) are 2. 06×104 L/(mol·cm) for 553 nm peak and 2. 07×104 L/(mol·cm) for 444 nm peak,respectively.When the dual-wavelength absorption spectrophotometry is used to determine the content of midodrine hydrochloride,its apparent molar absorptivity(κ) can achieve 4. 13× 104 L/(mol·cm),their linear ranges both are in the range of 0. 2 to 8. 7 mg·L-1,and their detection limits are 0. 072 mg·L-1.When the singlewavelength method is used,the detection limits are 0. 15 mg·L-1(for 553 nm) and 0. 14 mg·L-1(for 444 nm).Accordingly,a dual-wavelength visible absorption spectrometric method for the determination of midodrine hydrochloride is established.The recovery rate and relative standard deviation RSD(n = 5) are 98. 4%-102% and 1. 8%-2. 3%,respectively when the method is applied to determine the content of midodrine hydrochloride in commercially available midodrine hydrochloride tablets.

引文

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