丹参川芎嗪注射液联合乌司他丁治疗湿热壅滞证急性胰腺炎临床研究
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摘要
目的:探讨丹参川芎嗪注射液联合乌司他丁治疗湿热壅滞证急性胰腺炎(AP)的临床效果。方法:将湿热壅滞证AP患者96例采用随机数字表法分为2组各48例。所有患者均给予常规对症处理,对照组采用乌司他丁静脉滴注治疗,观察组给予丹参川芎嗪注射液联合乌司他丁治疗,均持续治疗2周。比较2组患者症状体征缓解效果、住院时间,检测2组治疗前后血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、淀粉酶(AMS)和白细胞介素-6 (IL-6)水平,评估2组疗效和不良反应情况。结果:观察组腹痛缓解时间、血AMS恢复正常时间、白细胞恢复正常时间、住院时间均短于对照组,差异有统计学意义(P <0.05)。2组治疗前血清CRP、TNF-α、AMS和IL-6水平比较,差异无统计学意义(P> 0.05),治疗后较治疗前下降(P <0.05)。观察组治疗后血清CRP、TNF-α、AMS和IL-6水平均低于对照组,差异有统计学意义(P <0.05)。观察组、对照组临床总有效率分别为95.83%、79.17%,组间比较,差异有统计学意义(P <0.05)。2组治疗观察期间均未见明显不良反应。结论:丹参川芎嗪注射液联合乌司他丁治疗湿热壅滞证AP效果显著,安全性好。
Objective: To discuss the clinical effect of Danshen Chuanxiongqin injection combined with ulinastatin on acute pancreatitis(AP) with syndrome of stagnant and jamming dampness-heat. Methods: A total of 96 cases of AP patients with syndrome of stagnant and jamming dampness-heat were divided into the control group and the observation group according to the random number table method, 48 cases in each group. Both groups were given routine symptomatic treatment. The control group was treated with intravenous drips of ulinastatin, and the observation group was additionally treated with Danshen Chuanxiongqin injection based on the treatment of the control group. Both groups were treated for two weeks. The alleviating effect of symptoms and signs and the hospitalization time of patients in the two groups were compared. Before and after treatment, the levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α), amylase(AMS) and interleukin-6(IL-6) in serum in the two groups were detected. The curative effect and adverse reactions in the two groups were evaluated. Results: The remission time of abdominal pain, the recovery time of AMS as well as leukocytes in serum and the hospitalization time in the observation group were shorter than those in the control group, the difference being significant(P < 0.05). Before treatment, compared the levels of CRP, TNF-α, AMS and IL-6 in serum in the two groups, there was no significance in the difference(P > 0.05); after treatment, the above levels were decreased when compared with those before treatment(P < 0.05). After treatment, the above levels in the observation group were lower than those in the control group, the difference being significant(P < 0.05). The total clinical effective rate was 95.83% in the observation group and 79.17% in the control group, the difference being significant(P <0.05). There was no obvious adverse reaction in the two groups during treatment and observation. Conclusion: The therapy of Danshen Chuanxiongqin injection combined with ulinastatin in treating AP with syndrome of stagnant and jamming dampness-heat has significant effect and with high safety.
Objective: To discuss the clinical effect of Danshen Chuanxiongqin injection combined with ulinastatin on acute pancreatitis(AP) with syndrome of stagnant and jamming dampness-heat. Methods: A total of 96 cases of AP patients with syndrome of stagnant and jamming dampness-heat were divided into the control group and the observation group according to the random number table method, 48 cases in each group. Both groups were given routine symptomatic treatment. The control group was treated with intravenous drips of ulinastatin, and the observation group was additionally treated with Danshen Chuanxiongqin injection based on the treatment of the control group. Both groups were treated for two weeks. The alleviating effect of symptoms and signs and the hospitalization time of patients in the two groups were compared. Before and after treatment, the levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α), amylase(AMS) and interleukin-6(IL-6) in serum in the two groups were detected. The curative effect and adverse reactions in the two groups were evaluated. Results: The remission time of abdominal pain, the recovery time of AMS as well as leukocytes in serum and the hospitalization time in the observation group were shorter than those in the control group, the difference being significant(P < 0.05). Before treatment, compared the levels of CRP, TNF-α, AMS and IL-6 in serum in the two groups, there was no significance in the difference(P > 0.05); after treatment, the above levels were decreased when compared with those before treatment(P < 0.05). After treatment, the above levels in the observation group were lower than those in the control group, the difference being significant(P < 0.05). The total clinical effective rate was 95.83% in the observation group and 79.17% in the control group, the difference being significant(P <0.05). There was no obvious adverse reaction in the two groups during treatment and observation. Conclusion: The therapy of Danshen Chuanxiongqin injection combined with ulinastatin in treating AP with syndrome of stagnant and jamming dampness-heat has significant effect and with high safety.
引文
[1]江玮琪，方俊杰，邬琪焕，等．急性胰腺炎患者腹腔感染的危险因素和病原学分析[J]．中华医院感染学杂志，2017,27(10):2282-2285.
[2]朱宗文，李广洲，王水平，等．老年中重症和重症急性胰腺炎死亡风险早期预测模型的建立及应用[J]．国际外科学杂志，2018,45(9):632.
[3]王助衡，张静，周冠华．急性胰腺炎的治疗进展[J]．医学综述，2017,23(1):91-94.
[4]王春友，李非，赵玉沛，等．急性胰腺炎诊治指南(2014)[J]．中国实用外科杂志，2015,21(1):1-4.
[5]张声生，李慧臻．急性胰腺炎中医诊疗专家共识意见(2017)[J]．中华中医药杂志，2017,32(9):4085-4088.
[6]许春阳，叶宏伟，陈波，等．凉膈散联合西医综合疗法对急性胰腺炎的疗效观察[J]．内科急危重症杂志，2018,24(1):28-30.
[7]中国中西医结合学会普通外科专业委员会．重症急性胰腺炎中西医结合诊治指南(2014年，天津)[J]．中国中西医结合外科杂志，2014,31(4):327-331.
[8]林建姣，刘艳，胡红松，等．急性胰腺炎患者血浆PTX3水平与早期炎症反应及病情严重程度的关系[J]．山东医药，2016,56(22):85-86.
[9]石振国，苏锦，任永乐，等．茯苓多糖对急性胰腺炎大鼠肠道屏障功能损伤和炎性反应的作用[J]．海南医学，2017,28(3):356-359.
[10]王静，黄忠，魏尉，等．HMGB1在重症急性胰腺炎大鼠肺损伤中的表达及乌司他丁的干预效应[J]．西部医学，2018,30(2):174-177.
[11]奚锦要，朱永钦，朱永苹，等．重症急性胰腺炎中西医结合治疗进展[J]．辽宁中医药大学学报，2017,13(6):115-118.
[12]陈成．中西医结合治疗急性胰腺炎120例临床观察[J]．新中医，2018,50(3):78-80.
[13]李聃，刘召明，张华，等．丹参川芎嗪注射液治疗重症急性胰腺炎的临床研究[J]．检验医学与临床，2017,14(20):3035-3037.
[14]高爽，李丽，柳瀚元，等．生长抑素与丹参川芎嗪注射液对HL-SAP患者预后的影响[J]．中国医药导刊，2017,19(12):1333-1336.
[2]朱宗文，李广洲，王水平，等．老年中重症和重症急性胰腺炎死亡风险早期预测模型的建立及应用[J]．国际外科学杂志，2018,45(9):632.
[3]王助衡，张静，周冠华．急性胰腺炎的治疗进展[J]．医学综述，2017,23(1):91-94.
[4]王春友，李非，赵玉沛，等．急性胰腺炎诊治指南(2014)[J]．中国实用外科杂志，2015,21(1):1-4.
[5]张声生，李慧臻．急性胰腺炎中医诊疗专家共识意见(2017)[J]．中华中医药杂志，2017,32(9):4085-4088.
[6]许春阳，叶宏伟，陈波，等．凉膈散联合西医综合疗法对急性胰腺炎的疗效观察[J]．内科急危重症杂志，2018,24(1):28-30.
[7]中国中西医结合学会普通外科专业委员会．重症急性胰腺炎中西医结合诊治指南(2014年，天津)[J]．中国中西医结合外科杂志，2014,31(4):327-331.
[8]林建姣，刘艳，胡红松，等．急性胰腺炎患者血浆PTX3水平与早期炎症反应及病情严重程度的关系[J]．山东医药，2016,56(22):85-86.
[9]石振国，苏锦，任永乐，等．茯苓多糖对急性胰腺炎大鼠肠道屏障功能损伤和炎性反应的作用[J]．海南医学，2017,28(3):356-359.
[10]王静，黄忠，魏尉，等．HMGB1在重症急性胰腺炎大鼠肺损伤中的表达及乌司他丁的干预效应[J]．西部医学，2018,30(2):174-177.
[11]奚锦要，朱永钦，朱永苹，等．重症急性胰腺炎中西医结合治疗进展[J]．辽宁中医药大学学报，2017,13(6):115-118.
[12]陈成．中西医结合治疗急性胰腺炎120例临床观察[J]．新中医，2018,50(3):78-80.
[13]李聃，刘召明，张华，等．丹参川芎嗪注射液治疗重症急性胰腺炎的临床研究[J]．检验医学与临床，2017,14(20):3035-3037.
[14]高爽，李丽，柳瀚元，等．生长抑素与丹参川芎嗪注射液对HL-SAP患者预后的影响[J]．中国医药导刊，2017,19(12):1333-1336.
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