MVECs抗炎症感染作用及应用前景
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摘要
炎症是动物机体对外界刺激产生的重要防御反应。微血管内皮细胞具有重要的生理学功能,参与机体多种平衡调节、细胞功能及炎症反应,维持局部内环境的稳态,在抑制炎症发生等病理性过程中具有重要的作用,中药通过对MVECs的保护作用,为兽医临床使用和研究中药防治细菌性疾病提供了一定的理论依据。
Microvascular endothelial cells has important physiology functions, participate in a variety of body balance adjustment, cell function and inflammation, maintain the steady state of local internal environment, the inhibition of inflammation such as pathological plays an important role in the process, through the protection of MVECs, traditional Chinese medicine provides some experimental data for veterinary clinical use and research on the prevention and treatment of bacterial diseases.
Microvascular endothelial cells has important physiology functions, participate in a variety of body balance adjustment, cell function and inflammation, maintain the steady state of local internal environment, the inhibition of inflammation such as pathological plays an important role in the process, through the protection of MVECs, traditional Chinese medicine provides some experimental data for veterinary clinical use and research on the prevention and treatment of bacterial diseases.
引文
[1]娄晋宁.微血管内皮细胞的培养及其在医学研究中的应用[J].微循环学杂志,2004,14(3):5-8.
[2]索占伟,穆祥.从微血管内皮细胞角度浅谈防治细菌内毒素病的新思路[C]//第6届家畜内科学学术研讨会论文集.武汉:2006:519-522.
[3]Ahluwalia A,De Felipe C O,Brien J,et al.Impaired IL-1 beta-induced neutrophil accumulation in tachykinin NK1receptor knockout mice[J].Br J pharmacol,1998,124(6):1013-1015.
[4]Beck-Schimmer B,Schwendener R,Pasch T,et al.Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung in jury[J].Respir Res,2005,6:61.
[5]Chen G Y,Nunez G.Sterile inflammation:sensing and reacting to damage[J].Nat Rev Immunol,2010,10(12):826-837.
[6]Papayannopoulos V,Metzler K D,Hakkim A,et al.Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps[J].The Journal of Cell Biology,2010,191(3):677-691.
[7]Borregaard N.Neutrophils,from marrow to microbes[J].Immunity,2010,33(5):657-670.
[8]Bae G H,Lee H Y,Jung Y S,et al.Identification of novel peptides that stimulate human neutrophils[J].Exp Mol Med,2012,44(2):130-137.
[9]Pillay J,Hietbrink F,Koenderman L,et al.The systemic inflammatory response induced by multiple phenotypes of blood mentrophils[J].Injury,2007,38(12):1365-1372.
[10]Segel G B,Halterman M W,Lichtman M A.The paradox of the neutrophils role in tissue injury[J].J Lenkoc Biol,2011,89(3):359-372.
[11]Hsu L C,Enzler T,Seita J,et al.IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase Ikkp[J].Nat Immunol,2011,12(2):144-150.
[12]李海鹏,姚建华,孙天胜.中性粒细胞在炎症反应中的作用及机制[J].医学综述,2015(9):1576-1578.
[13]Hwang T L,Wang W H,Wang T Y,et al.Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase3[J].Bioorg Med Chem,2015,23:1123-1134.
[14]罗梅宏,周永明.中药抗组织损伤与白细胞黏附[J].中西医结合学报,2005(4):322-325.
[15]Medina E,Rohde M,Chhatwal G S.Intracelluar Survival of Streptococcus Pyoenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence[J].Infect Immun,2003,71(9):5376-5380.
[16]高琳琳,王浩.中药保护血管内皮细胞结构和功能的研究进展[J].中国动脉硬化杂志,2006,14(10):907-910.
[17]马妍,郭利平.芪参益气滴丸预适应内皮细胞对心肌细胞缺氧损伤的延迟保护作用[J].西部中医药,2015,28(10):11-14.
[18]明松林,何冬梅,王凤英,等.清源生化汤对创伤后脓毒症患者血管内皮细胞的保护作用[J].中医药临床杂志,2015,27(4):536-538.
[2]索占伟,穆祥.从微血管内皮细胞角度浅谈防治细菌内毒素病的新思路[C]//第6届家畜内科学学术研讨会论文集.武汉:2006:519-522.
[3]Ahluwalia A,De Felipe C O,Brien J,et al.Impaired IL-1 beta-induced neutrophil accumulation in tachykinin NK1receptor knockout mice[J].Br J pharmacol,1998,124(6):1013-1015.
[4]Beck-Schimmer B,Schwendener R,Pasch T,et al.Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung in jury[J].Respir Res,2005,6:61.
[5]Chen G Y,Nunez G.Sterile inflammation:sensing and reacting to damage[J].Nat Rev Immunol,2010,10(12):826-837.
[6]Papayannopoulos V,Metzler K D,Hakkim A,et al.Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps[J].The Journal of Cell Biology,2010,191(3):677-691.
[7]Borregaard N.Neutrophils,from marrow to microbes[J].Immunity,2010,33(5):657-670.
[8]Bae G H,Lee H Y,Jung Y S,et al.Identification of novel peptides that stimulate human neutrophils[J].Exp Mol Med,2012,44(2):130-137.
[9]Pillay J,Hietbrink F,Koenderman L,et al.The systemic inflammatory response induced by multiple phenotypes of blood mentrophils[J].Injury,2007,38(12):1365-1372.
[10]Segel G B,Halterman M W,Lichtman M A.The paradox of the neutrophils role in tissue injury[J].J Lenkoc Biol,2011,89(3):359-372.
[11]Hsu L C,Enzler T,Seita J,et al.IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase Ikkp[J].Nat Immunol,2011,12(2):144-150.
[12]李海鹏,姚建华,孙天胜.中性粒细胞在炎症反应中的作用及机制[J].医学综述,2015(9):1576-1578.
[13]Hwang T L,Wang W H,Wang T Y,et al.Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase3[J].Bioorg Med Chem,2015,23:1123-1134.
[14]罗梅宏,周永明.中药抗组织损伤与白细胞黏附[J].中西医结合学报,2005(4):322-325.
[15]Medina E,Rohde M,Chhatwal G S.Intracelluar Survival of Streptococcus Pyoenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence[J].Infect Immun,2003,71(9):5376-5380.
[16]高琳琳,王浩.中药保护血管内皮细胞结构和功能的研究进展[J].中国动脉硬化杂志,2006,14(10):907-910.
[17]马妍,郭利平.芪参益气滴丸预适应内皮细胞对心肌细胞缺氧损伤的延迟保护作用[J].西部中医药,2015,28(10):11-14.
[18]明松林,何冬梅,王凤英,等.清源生化汤对创伤后脓毒症患者血管内皮细胞的保护作用[J].中医药临床杂志,2015,27(4):536-538.
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