大肠埃希菌耐药机制研究进展
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摘要
大肠埃希菌在自然界中广泛存在,在一定的条件下可以引起畜禽患病,在长期治疗过程中,由于药物的选择压力可以引起其对药物的抗性,而且耐药广泛、耐药机制复杂,给疾病临床治疗带来了一定的困难。大肠埃希菌耐药机制主要包括细胞膜通透性改变、细菌产生灭活酶或者钝化酶、靶点结构改变、主动外排泵、质粒介导的大肠埃希菌耐药等。论文介绍了我国部分地区畜牧业中大肠埃希菌耐药现状、大肠埃希菌耐药机制以及应对大肠埃希菌耐药的策略,以便了解耐药大肠埃希菌的传播特点,为防治大肠埃希菌耐药性产生和临床治疗大肠埃希菌感染提供一定的理论指导。
Escherichia coli exists widely in nature and can cause diseases in livestock and poultry under certain conditions.Escherichia coli can be resistant to drugs due to the pressure of drug selection in the longterm treatment process.Escherichia coli has a wide spectrum of drug resistance and the mechanisms of drug-resistance are complex and diverse,which have brought some difficulties to clinical treatment.The resistance mechanisms of Escherichia coli mainly include changes in cell membrane permeability,producing inactivation enzymes,changes in target structure,active efflux pumps,and plasmid-mediated Escherichia coli resistance.The status of drug-resistance in animal husbandry in some areas of China,the main mechanisms of drug-resistance and coping strategies for drug-resistance of Escherichia coli were summarized in this paper,which can provide better understanding of transmission characteristics of drug-resistant Escherichia coli and theoretical guidance for preventing the production of the resistance stains and treating Escherichia coli infection.
Escherichia coli exists widely in nature and can cause diseases in livestock and poultry under certain conditions.Escherichia coli can be resistant to drugs due to the pressure of drug selection in the longterm treatment process.Escherichia coli has a wide spectrum of drug resistance and the mechanisms of drug-resistance are complex and diverse,which have brought some difficulties to clinical treatment.The resistance mechanisms of Escherichia coli mainly include changes in cell membrane permeability,producing inactivation enzymes,changes in target structure,active efflux pumps,and plasmid-mediated Escherichia coli resistance.The status of drug-resistance in animal husbandry in some areas of China,the main mechanisms of drug-resistance and coping strategies for drug-resistance of Escherichia coli were summarized in this paper,which can provide better understanding of transmission characteristics of drug-resistant Escherichia coli and theoretical guidance for preventing the production of the resistance stains and treating Escherichia coli infection.
引文
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[20] Aitha M,Moller A J,Sahu I D,et al.Investigating the position of the hairpin loop in New Delhi metallo-β-lactamase,NDM-1,during catalysis and inhibitor binding[J].J Inorg Biochem,2016,156:35-39.
[21] 马玉茹,赵红霞,高清志.新德里金属β-内酰胺酶NDM-1的研究进展[J].药学学报,2018,53(1):28-36.
[22] 吴立婷.扬州地区宠物源大肠杆菌耐药性分析及耐药基因检测[D].江苏扬州:扬州大学,2017.
[23] 罗永乾.动物源大肠杆菌、沙门氏菌和金黄色葡萄球菌耐药表型与氯霉素类抗菌药物耐药基因型的研究[D].重庆:西南大学,2017.
[24] Wang Y H,Wang G Q.Detection of floR gene and active efflux mechanism of Escherichia coli in Ningxia,China[J].Microb Pathog,2018,117:310-314.
[25] 苏思婷,毛丹丹,许师文,等.青霉素结合蛋白及其介导细菌耐药的研究进展[J].微生物学通报,2017,44(4):902-910.
[26] Aissa N,Mayer N,Bert F,et al.A new mechanism to render clinical isolates of Escherichia coli non-susceptible to imipenem:substitutions in the PBP2 penicillin-binding domain[J].J Antimicrob Chemother,2017,71(1):76-79.
[27] 卢琴,罗青平,张腾飞,等.耐氟喹诺酮类药物禽源大肠埃希菌gyrA基因的检测分析[J].动物医学进展,2017,38(4):52-57.
[28] Dasgupta N,Paul D,Chanda D D,et al.Observation of a new pattern of mutations in gyrA and parC within Escherichia coli exhibiting fluroquinolone resistance.[J].Indian J Med Microbiol,2018,36(1):131-135.
[29] Ou B,Chen L,Song Y,et al.Impact of acquisition of 16S rRNA methylase RmtB on the fitness of Escherichia coli[J].J Glob Antimicrob Resist,2016,6:32-38.
[30] Puzari M,Chetia P.RND efflux pump mediated antibiotic resistance in Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa:a major issue worldwide[J].World J Microbiol Biotechnol,2017,33(2):24-31.
[31] Crow A,Greene N P,Kaplan E,et al.Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily[J].Proc Natl Acad Sci USA,2017,114(47):12572-12577.
[32] Liu Y Y,Wang Y,Walsh T R,et al.Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China:a microbiological and molecular biological study[J].Lancet Infect Dis,2016,16(2):161-168.
[33] Wang Q,Sun J,Li J,et al.Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs[J].Microbiome,2017,5(1):70-78.
[34] 刘金平,吕世明,谭艾娟,等.中药提取物恢复耐药大肠杆菌对氨基糖苷类药物敏感性的研究[J].畜牧与兽医,2018,50(3):107-111.
[35] 王帅兵,王婧,陈海峰,等.8种中药对猪源大肠杆菌的体外抑菌效果[J].贵州农业科学,2018,46(4):94-97.
[2] Ranjan A,Scholz J,Semmler T,et al.ESBL-plasmid carriage in E.coli enhances in vitro bacterial competition fitness and serum resistance in some strains of pandemic sequence types without overall fitness cost[J].Gut Pathog,2018,10(1):24-32.
[3] 朱永江,吕文新,吴铁花,等.40株动物源性大肠杆菌耐药性分析及氨基糖苷修饰酶耐药基因的检测[J].黑龙江畜牧兽医,2017(22):115-117.
[4] Tfifha M,Ferjani A,Mallouli M,et al.Carriage of multidrug-resistant bacteria among pediatric patients before and during their hospitalization in a tertiary pediatric unit in Tunisia[J].Libyan J Med,2018,13(1):1419047-1419052.
[5] Poirel L,Madec J Y,Lupo A,et al.Antimicrobial resistance in Escherichia coli[J].Microbiol Spectr,2018,6(4):ARBA-0026-2017.
[6] Mishra M,Arukha A P,Patel A K,et al.Multi-drug resistant coliform:Water sanitary standards and health hazards[J].Front Pharmacol,2018,9:311-318.
[7] 索朗斯珠,王刚,罗润波,等.西藏牦牛源大肠埃希菌主要耐药表型及耐药基因检测[J].中国兽医学报,2017,37(8):1501-1506.
[8] 刘艳红,吕淑霞,李颖,等.大肠杆菌耐药性及氟苯尼考耐药基因floR的研究[J].中国畜牧杂志,2017,53(1):115-118.
[9] 张炳亮,王文文,杨国栋,等.洛阳地区规模化猪场大肠杆菌耐药基因检测及耐药性分析[J].黑龙江畜牧兽医,2018(5):125-128.
[10] 李穗霞,席美丽,王盼盼,等.8省市鸡肉源性大肠杆菌分离鉴定及其耐药性检测[J].中国人兽共患病学报,2018,34(2):158-164.
[11] 赵勇,李欢,张昭寰,等.食源性致病菌耐药机制研究进展[J].生物加工过程,2018,16(2):1-10.
[12] Hejair H M A,Zhu Y,Ma J,et al.Functional role of ompF,and ompC,porins in pathogenesis of avian pathogenic Escherichia coli[J].Microb Pathog,2017,107:29-37.
[13] Blair J M,Webber M A,Baylay A J,et al.Molecular mechanisms of antibiotic resistance[J].Nat Rev Microbiol,2015,13(1):42-51.
[14] 贺艳艳.鸡源性大肠埃希菌耐β内酰胺类药物机制的研究[D].山东济南:山东大学,2017.
[15] Palzkill T.Structural and mechanistic basis for extended-spectrum drug-resistance mutations in altering the specificity of TEM,CTX-M,and KPC β-lactamases[J].Front Mol Biosci,2018,5:16-34.
[16] He D,Partridge S R,Shen J,et al.CTX-M-123,a novel hybrid of the CTX-M-1 and CTX-M-9 group β-lactamases recovered from Escherichia coli isolates in China[J].Antimicrob Agents Chemother,2013,57(8):4068-4071.
[17] Wang J,Li Y,Yan H,et al.Semi-rational screening of the inhibitors and β-lactam antibiotics against the New Delhi metallo-β-lactamase 1 (NDM-1) producing E.coli[J].RSC Adv,2018,8(11):5936-5944.
[18] Mojica M F,Bonomo R A,Fast W.B1-Metallo-beta-Lactamases:Where do we stand?[J].Curr Drug Targets,2016,17(9):1029-1050.
[19] Khan A U,Maryam L,Zarrilli R.Structure,genetics and worldwide spread of New Delhi metallo-β-lactamase (NDM):a threat to public health[J].BMC Microbiology,2017,17(1):101-112.
[20] Aitha M,Moller A J,Sahu I D,et al.Investigating the position of the hairpin loop in New Delhi metallo-β-lactamase,NDM-1,during catalysis and inhibitor binding[J].J Inorg Biochem,2016,156:35-39.
[21] 马玉茹,赵红霞,高清志.新德里金属β-内酰胺酶NDM-1的研究进展[J].药学学报,2018,53(1):28-36.
[22] 吴立婷.扬州地区宠物源大肠杆菌耐药性分析及耐药基因检测[D].江苏扬州:扬州大学,2017.
[23] 罗永乾.动物源大肠杆菌、沙门氏菌和金黄色葡萄球菌耐药表型与氯霉素类抗菌药物耐药基因型的研究[D].重庆:西南大学,2017.
[24] Wang Y H,Wang G Q.Detection of floR gene and active efflux mechanism of Escherichia coli in Ningxia,China[J].Microb Pathog,2018,117:310-314.
[25] 苏思婷,毛丹丹,许师文,等.青霉素结合蛋白及其介导细菌耐药的研究进展[J].微生物学通报,2017,44(4):902-910.
[26] Aissa N,Mayer N,Bert F,et al.A new mechanism to render clinical isolates of Escherichia coli non-susceptible to imipenem:substitutions in the PBP2 penicillin-binding domain[J].J Antimicrob Chemother,2017,71(1):76-79.
[27] 卢琴,罗青平,张腾飞,等.耐氟喹诺酮类药物禽源大肠埃希菌gyrA基因的检测分析[J].动物医学进展,2017,38(4):52-57.
[28] Dasgupta N,Paul D,Chanda D D,et al.Observation of a new pattern of mutations in gyrA and parC within Escherichia coli exhibiting fluroquinolone resistance.[J].Indian J Med Microbiol,2018,36(1):131-135.
[29] Ou B,Chen L,Song Y,et al.Impact of acquisition of 16S rRNA methylase RmtB on the fitness of Escherichia coli[J].J Glob Antimicrob Resist,2016,6:32-38.
[30] Puzari M,Chetia P.RND efflux pump mediated antibiotic resistance in Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa:a major issue worldwide[J].World J Microbiol Biotechnol,2017,33(2):24-31.
[31] Crow A,Greene N P,Kaplan E,et al.Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily[J].Proc Natl Acad Sci USA,2017,114(47):12572-12577.
[32] Liu Y Y,Wang Y,Walsh T R,et al.Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China:a microbiological and molecular biological study[J].Lancet Infect Dis,2016,16(2):161-168.
[33] Wang Q,Sun J,Li J,et al.Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs[J].Microbiome,2017,5(1):70-78.
[34] 刘金平,吕世明,谭艾娟,等.中药提取物恢复耐药大肠杆菌对氨基糖苷类药物敏感性的研究[J].畜牧与兽医,2018,50(3):107-111.
[35] 王帅兵,王婧,陈海峰,等.8种中药对猪源大肠杆菌的体外抑菌效果[J].贵州农业科学,2018,46(4):94-97.
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