围绝经期综合征的影响因素及中医证候临床研究
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摘要
目的
本课题采用横断面流行病学研究方法,对160例围绝经期综合征妇女出现的常见症状、舌象、脉象及人口学资料进行观察,并对其中医证候规律进行了较为深入的研究,这样从实际出发概括出来的分型,避免了理论推测的盲目臆断性,可以探索围绝经期综合征的证候分型特征及影响因素,为临床提供具有重要理论与实践价值的资料,进而为制定相应的中医或中西医结合治疗方案提供依据。方法
主要通过横断面流行病学的研究方法,对台湾社区人群的人口学资料情况、常见临床症状、舌象、脉象进行观察,根据被调查者填写内容,结合查体结果,参考《中药新药临床研究指导原则》制定的围绝经期综合征判断标准。将合格问卷录入Epidata3.02,采用SPSS15.0对录入数据进行描述性分析、x2检验、wilcoxon秩和检验等,统计分析台湾地区围绝经期综合征妇女的年龄、职业、经济收入、月经情况等一般资料、中医证候分型分布等。结果
1.围绝经期综合征患者人口学特征
共收到合格调查表143例,年龄在35-55岁之间,35-39岁占18.9%,40-44岁占25.9%,45-49岁占30.8%,50-55岁占24.5%,平均年龄49.49岁。职业家庭事务者占63.6%,有工作者共占36.4%。学历大专以上占23.1%,高中占26.6%,中专占33.6%,初中及以下占16.8%。所调查人群均为已婚女性。经济状况中等水平占79.0%,上等占8.4%,下等占12.6%。夫妻不和睦占58.0%,一般占28.0%,和睦占14.0%。亲友支持占总人数50.3%,一般占33.6%,不支持占16.1%。月经初潮年龄14-17岁,约占62.2%,小于13岁约占19.6%,大于18岁约占18.2%。绝经占21%,平均绝经年龄为49.56岁,月经规律者约占25.9%,月经不规律约占53.1%。轻度痛经约占48.3%,无痛经约占41.9%,重度痛经约占9.8%。月经周期≤22天者,约占7.7%,23-28天者约占66.4%,≥29天者,约占25.9%,性格特征：内向95人,占总人数66.4%；外向48人,占33.6%；内向性格居多。
2.围绝经期综合征影响因素调查
被调查围绝经期综合征妇女有轻度症状的有38人,约占26.6%；中度症状的有87人,约占60.8%；重度症状的有18人,约占12.6%。
调查结果显示：学历水平、有无工作、经济情况、夫妻和睦、亲友支持、性格特征等因素与围绝经期综合征病情程度相关(P＜0.05或P＜0.01)。学历越高,无工作、经济较好、夫妻亲友不支持、性格内向者,围绝经期综合征症状较重。
其它因素如婚姻状况、月经情况、绝经情况、痛经情况等与围绝经期综合征病情程度比较,差异无统计学意义(P＞0.05)。因本调查样本量较小,此结论还需要大样本流行病学调查进一步佐证。
3.围绝经期综合征临床主要症状特征
围绝经期综合征患者临床主要症状出现最多的症状有烦躁易怒(72.72%)、骨关节痛(70.62%)、疲倦乏力(68.53%)、失眠(67.13%)、潮热出汗(65.73%)、头晕(64.34%)、头痛(62.24%)、抑郁(61.54%)。由此可以看出围绝经期综合征病机以肝郁、肾阴虚、阳亢为主。
4.围绝经期综合征证型分布情况
143例围绝经期综合征妇女当中,证型以心肝火旺居多,占72.7%,其次为肾阴虚型,占70.6%。肝肾阴虚型占36.4%,肝郁气滞型占26.6%,肾阳虚型占17.5%,肾阴阳俱虚型、脾肾阳虚型所占比例最少,合占11.2%。围绝经期综合征患者主要以肝、肾两脏的病变为主。
5.围绝经期综合征舌诊分布情况
143例围绝经期综合征妇女当中,舌诊临床上主要观察如下：肝郁气滞型组,检查舌质色淡红,舌缘印有齿痕,舌苔白黄色偏腻。心肝火旺组偏盛以红舌为最多见,伴如黄苔易见于全舌,偶舌尖独赤起刺。肝肾阴虚或肾阴虚组舌质以红舌为最多见,舌苔以偏白黄苔为主,偶见舌下脉络瘀黑。肾阳虚和肾阴阳俱虚组舌质以淡红舌胖嫩有齿痕为最多见,苔薄一般,偶舌苔偏白滑润。脾肾阳虚湿滞组明显时,白苔粘滑厚腻,为最常见的舌诊表现。
6.围绝经期综合征脉诊分布情况
143例围绝经期综合征妇女当中,临床上主要观察如下：心肝火旺组脉诊弦数脉为多,肝肾阴虚或肾阴虚组脉诊细数脉多见,肝郁气滞型脉诊多见弦或脉细数,肾阳虚脉诊沉细弱脉多见,肾阴阳俱虚组脉诊沉弱脉多见,脾肾阳虚组脉诊沉细脉可见。
结论
围绝经期综合征可能病机以肝郁化火、肾阴虚、阴虚于下阳亢于上为主,且与患者的情志因素、社会家庭支持、生活习惯有关。故调理情志、体育锻炼、饮食起居调养、药物预防等进行早期干预,将有效降低围绝经期综合征的发病率,调理肝肾在围绝经期综合征的治疗与预防中将起重要作用。
Objective
This study takes T-sect epidemiological methods, observes the common symptoms, tongue demonstration, pulse demonstration and demographical information of 160 women of perimenopausal syndrome and makes in-depth research of Chinese Medicine syndrome rules. The differentiated types avoid blindness of theoretical inference. It discusses the syndrome classification and affecting factors of perimenopausal syndrome, provides theoretical and practical reference for clinical treatment as well as basis for making Chinese Medicine or Integrated Chinese and Western Medicine treatment plans.
Methods
This study takes T-sect epidemiological methods, observes the common clinical symptoms, tongue demonstration, pulse demonstration and demographical information of Taiwan community populations. The author refers to the diagnostic standard of perimenopausal syndrome of Guidelines for Clinical Research of Chinese Medicine New Drug based on the answers of the interviewees the physical examination results. Input the qualified questionnaires into computer with software EPIDATA 3.1 and make descriptive analysis, x2 test and Wilcoxon rank sum test with software SPSS 15.0. Make statistical analysis of the general information including age, occupation, income and menstruation and the Chinese Medicine syndrome distribution, etc.
Result
1. Demographic Features of Perimenopausal Syndrome Patients
143 qualified questionnaires are collected. Subjects are between 35 and 55 with 18.9% of 35-39,25.9% of 40-44,30.8% of 45-49,24.5% of 50-55 years old and the average age is 49.49 years old.63.6% are occupational homemakers and 36.4% have jobs. Education degree:23.1% received junior college education or above,26.6% received senior high school education,33.6% received occupational school education, and 16.8% received junior high school education or below.95.8% have married and have spouses and 4.2% haven't.79.0% have medium,8.4% superior and 12.6 low economical status.58.0% have good,28.0% have mediocre and 14.0% have bad husband and wife relationships.50.3% have relatives' support,33.6% have mediocre support and 16.1% don't have the support.62.2% have the menarche at 14-17,19.6% below 13 and 18.2% above 18 years old.73.4% have menopause and the average menopause age is 49.56 years old.8.4% have regular menstruation and 18.2% have irregular menstruation. 18.3% have mild difficult menstruation,41.9% don't have difficult menstruation and 9.8% have serious difficult menstruation.7.7% of the subjects have a menstruation cycle of≤22 days,66.4% between 23-28 days and 25.9%≥29 days. Personalities:95 subjects (66.4%) are introvert and 48 (33.6%) are extrovert with the majority of introvert personality.
2. Affecting Factors of Perimenopausal Syndrome
Among the investigated perimenopausal syndrome women,38 (26.6%) have mild symptoms,87 (60.8%) have medium symptoms and 18 (12.6%) have serious symptoms.
The investigation results show that factors like education level, working status, economical situation, spouse relationship, relatives'support and personalities are related to the severity degree of this disease (P<0.05 or P<0.01). Patients who have higher education degree haven't jobs, have good economical conditions and introvert personalities without relative's and spouse's support usually have more serious perimenopausal syndrome symptoms.
Compare other factors including marriage status, menstruation, menopause and difficult menstruation and the severity of the perimenopausal syndrome and the author finds the difference has no statistical significance (P> 0.05). Since the sample size is small, this conclusion needs further confirmation with large-sample epidemiological investigation.
3. Major Clinical Symptoms of Perimenopausal Syndrome
The most frequently occurred symptoms of perimenopausal syndrome are fidgety (72.72%), osteoarthritis (70.62%), languor and debility (68.53%), insomnia(67.13%), hectic fever and perspiration (65.73%), vertigo(64.34%), headache (62.24%) and depression (61.54%). It can be found that its pathogenesis is mainly liver depression, kidney yin deficiency and yang excess.
4. Type Distribution of Perimenopausal Syndrome
Among the 143 perimenopausal syndrome women patients, the major syndrome type is heart and liver fire (72.7%). The next is kidney yin deficiency (70.6%), liver and kidney yin deficiency (36.4%), liver depression and qi stagnation (26.6%), kidney yang deficiency (17.5%), both of kidney yin and yan deficiency together with spleen and kidney yang deficiency (11.2%). Perimenopausal syndrome patients mainly have liver and kidney pathological changes.
5. Tongue Demonstration of Perimenopausal Syndrome
The tongue demonstration of the 143 subjects shows that subjects in the liver depression and qi stagnation group have pale red texture, fat tongue body, indentation at tongue border, thin lingual fur, white color and greasy feature; the heart and liver fire group subjects have mainly red tongue, yellow fur on the whole tongue, and sometimes red tongue tip only with pricks; the liver and kidney yin deficiency group or the kidney yin deficiency group subjects mainly have red tongue and white yellow fur; the kidney yang deficiency group and the kidney yin and yang deficiency group subjects have pale red tongue, thin fur and sometimes white and slippery fur; spleen and kidney yang deficiency group subjects have white, slippery, thick and greasy fur with fat tongue body and indentation marks as the most frequent demonstrations.
6. Pulse demonstration of Perimenopausal Syndrome
The clinical observation of the 143 perimenopausal syndrome women is listed as follows:the heart and liver fire group subjects mainly have the string-like pulse; the liver and kidney yin deficiency and the kidney yin deficiency group mainly have the fine and quick pulses; the liver depression and qi stagnation group mainly have string-like pulses; the kidney yang deficiency group mainly have heavy and feeble pulses; the liver yin and yang deficiency group mainly have fine pulses; the spleen and kidney yang deficiency group mainly have heavy and fine pulses.
Conclusion
The possible pathogenesis of perimenopausal syndrome is mainly fire derived from liver depression, kidney yin deficiency, yin deficiency and yang excess. It's related to the sentiment, social and family support and living habits. Therefore conducting the early-stage interference like adjusting sentiment, taking physical exercises, adjusting living habits and applying medical prevention, etc will effectively decrease the incidence ratio. Regulating liver and kidney plays an important role in the prevention and treatment of perimenopausal syndrome.
本课题采用横断面流行病学研究方法,对160例围绝经期综合征妇女出现的常见症状、舌象、脉象及人口学资料进行观察,并对其中医证候规律进行了较为深入的研究,这样从实际出发概括出来的分型,避免了理论推测的盲目臆断性,可以探索围绝经期综合征的证候分型特征及影响因素,为临床提供具有重要理论与实践价值的资料,进而为制定相应的中医或中西医结合治疗方案提供依据。方法
主要通过横断面流行病学的研究方法,对台湾社区人群的人口学资料情况、常见临床症状、舌象、脉象进行观察,根据被调查者填写内容,结合查体结果,参考《中药新药临床研究指导原则》制定的围绝经期综合征判断标准。将合格问卷录入Epidata3.02,采用SPSS15.0对录入数据进行描述性分析、x2检验、wilcoxon秩和检验等,统计分析台湾地区围绝经期综合征妇女的年龄、职业、经济收入、月经情况等一般资料、中医证候分型分布等。结果
1.围绝经期综合征患者人口学特征
共收到合格调查表143例,年龄在35-55岁之间,35-39岁占18.9%,40-44岁占25.9%,45-49岁占30.8%,50-55岁占24.5%,平均年龄49.49岁。职业家庭事务者占63.6%,有工作者共占36.4%。学历大专以上占23.1%,高中占26.6%,中专占33.6%,初中及以下占16.8%。所调查人群均为已婚女性。经济状况中等水平占79.0%,上等占8.4%,下等占12.6%。夫妻不和睦占58.0%,一般占28.0%,和睦占14.0%。亲友支持占总人数50.3%,一般占33.6%,不支持占16.1%。月经初潮年龄14-17岁,约占62.2%,小于13岁约占19.6%,大于18岁约占18.2%。绝经占21%,平均绝经年龄为49.56岁,月经规律者约占25.9%,月经不规律约占53.1%。轻度痛经约占48.3%,无痛经约占41.9%,重度痛经约占9.8%。月经周期≤22天者,约占7.7%,23-28天者约占66.4%,≥29天者,约占25.9%,性格特征：内向95人,占总人数66.4%；外向48人,占33.6%；内向性格居多。
2.围绝经期综合征影响因素调查
被调查围绝经期综合征妇女有轻度症状的有38人,约占26.6%；中度症状的有87人,约占60.8%；重度症状的有18人,约占12.6%。
调查结果显示：学历水平、有无工作、经济情况、夫妻和睦、亲友支持、性格特征等因素与围绝经期综合征病情程度相关(P＜0.05或P＜0.01)。学历越高,无工作、经济较好、夫妻亲友不支持、性格内向者,围绝经期综合征症状较重。
其它因素如婚姻状况、月经情况、绝经情况、痛经情况等与围绝经期综合征病情程度比较,差异无统计学意义(P＞0.05)。因本调查样本量较小,此结论还需要大样本流行病学调查进一步佐证。
3.围绝经期综合征临床主要症状特征
围绝经期综合征患者临床主要症状出现最多的症状有烦躁易怒(72.72%)、骨关节痛(70.62%)、疲倦乏力(68.53%)、失眠(67.13%)、潮热出汗(65.73%)、头晕(64.34%)、头痛(62.24%)、抑郁(61.54%)。由此可以看出围绝经期综合征病机以肝郁、肾阴虚、阳亢为主。
4.围绝经期综合征证型分布情况
143例围绝经期综合征妇女当中,证型以心肝火旺居多,占72.7%,其次为肾阴虚型,占70.6%。肝肾阴虚型占36.4%,肝郁气滞型占26.6%,肾阳虚型占17.5%,肾阴阳俱虚型、脾肾阳虚型所占比例最少,合占11.2%。围绝经期综合征患者主要以肝、肾两脏的病变为主。
5.围绝经期综合征舌诊分布情况
143例围绝经期综合征妇女当中,舌诊临床上主要观察如下：肝郁气滞型组,检查舌质色淡红,舌缘印有齿痕,舌苔白黄色偏腻。心肝火旺组偏盛以红舌为最多见,伴如黄苔易见于全舌,偶舌尖独赤起刺。肝肾阴虚或肾阴虚组舌质以红舌为最多见,舌苔以偏白黄苔为主,偶见舌下脉络瘀黑。肾阳虚和肾阴阳俱虚组舌质以淡红舌胖嫩有齿痕为最多见,苔薄一般,偶舌苔偏白滑润。脾肾阳虚湿滞组明显时,白苔粘滑厚腻,为最常见的舌诊表现。
6.围绝经期综合征脉诊分布情况
143例围绝经期综合征妇女当中,临床上主要观察如下：心肝火旺组脉诊弦数脉为多,肝肾阴虚或肾阴虚组脉诊细数脉多见,肝郁气滞型脉诊多见弦或脉细数,肾阳虚脉诊沉细弱脉多见,肾阴阳俱虚组脉诊沉弱脉多见,脾肾阳虚组脉诊沉细脉可见。
结论
围绝经期综合征可能病机以肝郁化火、肾阴虚、阴虚于下阳亢于上为主,且与患者的情志因素、社会家庭支持、生活习惯有关。故调理情志、体育锻炼、饮食起居调养、药物预防等进行早期干预,将有效降低围绝经期综合征的发病率,调理肝肾在围绝经期综合征的治疗与预防中将起重要作用。
Objective
This study takes T-sect epidemiological methods, observes the common symptoms, tongue demonstration, pulse demonstration and demographical information of 160 women of perimenopausal syndrome and makes in-depth research of Chinese Medicine syndrome rules. The differentiated types avoid blindness of theoretical inference. It discusses the syndrome classification and affecting factors of perimenopausal syndrome, provides theoretical and practical reference for clinical treatment as well as basis for making Chinese Medicine or Integrated Chinese and Western Medicine treatment plans.
Methods
This study takes T-sect epidemiological methods, observes the common clinical symptoms, tongue demonstration, pulse demonstration and demographical information of Taiwan community populations. The author refers to the diagnostic standard of perimenopausal syndrome of Guidelines for Clinical Research of Chinese Medicine New Drug based on the answers of the interviewees the physical examination results. Input the qualified questionnaires into computer with software EPIDATA 3.1 and make descriptive analysis, x2 test and Wilcoxon rank sum test with software SPSS 15.0. Make statistical analysis of the general information including age, occupation, income and menstruation and the Chinese Medicine syndrome distribution, etc.
Result
1. Demographic Features of Perimenopausal Syndrome Patients
143 qualified questionnaires are collected. Subjects are between 35 and 55 with 18.9% of 35-39,25.9% of 40-44,30.8% of 45-49,24.5% of 50-55 years old and the average age is 49.49 years old.63.6% are occupational homemakers and 36.4% have jobs. Education degree:23.1% received junior college education or above,26.6% received senior high school education,33.6% received occupational school education, and 16.8% received junior high school education or below.95.8% have married and have spouses and 4.2% haven't.79.0% have medium,8.4% superior and 12.6 low economical status.58.0% have good,28.0% have mediocre and 14.0% have bad husband and wife relationships.50.3% have relatives' support,33.6% have mediocre support and 16.1% don't have the support.62.2% have the menarche at 14-17,19.6% below 13 and 18.2% above 18 years old.73.4% have menopause and the average menopause age is 49.56 years old.8.4% have regular menstruation and 18.2% have irregular menstruation. 18.3% have mild difficult menstruation,41.9% don't have difficult menstruation and 9.8% have serious difficult menstruation.7.7% of the subjects have a menstruation cycle of≤22 days,66.4% between 23-28 days and 25.9%≥29 days. Personalities:95 subjects (66.4%) are introvert and 48 (33.6%) are extrovert with the majority of introvert personality.
2. Affecting Factors of Perimenopausal Syndrome
Among the investigated perimenopausal syndrome women,38 (26.6%) have mild symptoms,87 (60.8%) have medium symptoms and 18 (12.6%) have serious symptoms.
The investigation results show that factors like education level, working status, economical situation, spouse relationship, relatives'support and personalities are related to the severity degree of this disease (P<0.05 or P<0.01). Patients who have higher education degree haven't jobs, have good economical conditions and introvert personalities without relative's and spouse's support usually have more serious perimenopausal syndrome symptoms.
Compare other factors including marriage status, menstruation, menopause and difficult menstruation and the severity of the perimenopausal syndrome and the author finds the difference has no statistical significance (P> 0.05). Since the sample size is small, this conclusion needs further confirmation with large-sample epidemiological investigation.
3. Major Clinical Symptoms of Perimenopausal Syndrome
The most frequently occurred symptoms of perimenopausal syndrome are fidgety (72.72%), osteoarthritis (70.62%), languor and debility (68.53%), insomnia(67.13%), hectic fever and perspiration (65.73%), vertigo(64.34%), headache (62.24%) and depression (61.54%). It can be found that its pathogenesis is mainly liver depression, kidney yin deficiency and yang excess.
4. Type Distribution of Perimenopausal Syndrome
Among the 143 perimenopausal syndrome women patients, the major syndrome type is heart and liver fire (72.7%). The next is kidney yin deficiency (70.6%), liver and kidney yin deficiency (36.4%), liver depression and qi stagnation (26.6%), kidney yang deficiency (17.5%), both of kidney yin and yan deficiency together with spleen and kidney yang deficiency (11.2%). Perimenopausal syndrome patients mainly have liver and kidney pathological changes.
5. Tongue Demonstration of Perimenopausal Syndrome
The tongue demonstration of the 143 subjects shows that subjects in the liver depression and qi stagnation group have pale red texture, fat tongue body, indentation at tongue border, thin lingual fur, white color and greasy feature; the heart and liver fire group subjects have mainly red tongue, yellow fur on the whole tongue, and sometimes red tongue tip only with pricks; the liver and kidney yin deficiency group or the kidney yin deficiency group subjects mainly have red tongue and white yellow fur; the kidney yang deficiency group and the kidney yin and yang deficiency group subjects have pale red tongue, thin fur and sometimes white and slippery fur; spleen and kidney yang deficiency group subjects have white, slippery, thick and greasy fur with fat tongue body and indentation marks as the most frequent demonstrations.
6. Pulse demonstration of Perimenopausal Syndrome
The clinical observation of the 143 perimenopausal syndrome women is listed as follows:the heart and liver fire group subjects mainly have the string-like pulse; the liver and kidney yin deficiency and the kidney yin deficiency group mainly have the fine and quick pulses; the liver depression and qi stagnation group mainly have string-like pulses; the kidney yang deficiency group mainly have heavy and feeble pulses; the liver yin and yang deficiency group mainly have fine pulses; the spleen and kidney yang deficiency group mainly have heavy and fine pulses.
Conclusion
The possible pathogenesis of perimenopausal syndrome is mainly fire derived from liver depression, kidney yin deficiency, yin deficiency and yang excess. It's related to the sentiment, social and family support and living habits. Therefore conducting the early-stage interference like adjusting sentiment, taking physical exercises, adjusting living habits and applying medical prevention, etc will effectively decrease the incidence ratio. Regulating liver and kidney plays an important role in the prevention and treatment of perimenopausal syndrome.
引文
[1]全国围绝经期妇女健康调查协作组[J].中华医学杂志,1991,71(10)：585-587.
[2]闰润虎,刘志诚.女性更年期综合征的中西药认识[J].现代中西医结合杂志,2003,12(13)：1442.1443.
[3]许丽绵,欧阳惠卿,卢如铃.更年期综合征病因病机及其证治述要[J].中医药学刊,2003,21(9)：1550-1553.
[4]陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139-140.
[5]张颖,褚贵保.倪宗咖治疗更年期综合征经验[J].实用中医药杂志,2001,17(1)：34.
[6]伏晓华.从肾论治更年期综合症[J].中国中医基础医学杂志,2003,9(6)：57-58.
[7]王淑萍.妇女更年期综合征中医治疗八法[J].现代中医药,2002,(5)：59-60.
[8]汤月萍.夏桂成辨治妇女更年期综合征的经验[J].湖北中医杂志,1999,19(2)：6-7.
[9]罗元恺,郑国平.以补肾为主治疗更年期综合征经验[J].中国医学学报,1990,5(2)：23.
[10]张蓓贞,中医药生活质评估之效指针建立研究[J].中医药年报,2005,23(3)：433.
[11]叶晓玲.论围绝经期综合征之治法应以滋肾养肝为主[J].亚太传统医药,2009,5(6)：142-143.
[12]王晓萍.从奇经论治妇女更年期综合征[J].中国医药学报,1995,10(4)：43-45.
[13]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18,(4)：205.
[14]李艳菊.女性更年期综合征从瘀辨治的体会[J].中国中医药信息杂志,2000,7(9)：74.
[15]李义方,熊超.从肾虚挟癖论治更年期综合征[J].吉林中医药,1998, (3)：29.
[16]刘晓伟,邓虹珠.更年期综合征中医辨治研究进展[J].现代中西医结合杂志,2001,10(8)：792.
[17]张人伟,庞玉琴.庞清治教授治疗更年期综合征的经验[J].河南中医药学刊,2000,15(3)：6-7.
[18]杨小清.百地益肾汤治疗更年期综合征80例临床观察[J].内蒙古中医药,2004,(3)：6-7.
[19]黄英.抑肝补肾法治疗围绝经期综合征48例[J].右江医学,2008,36(1)：104-105.
[20]陈黎明.益肾平肝汤治疗妇女肝肾阴虚型更年期综合征38例疗效观察[J].云南中医药杂志,2004,25(2)：15.
[21]刘燕萍,李绍轩.滋肾涵肝法治疗围绝经期综合征疗效观察[J].临床和实验医学杂
志,2009,8(10)：117-118.
[22]许莉,杨丽,郭娜,等.滋肾养肝清心法治疗围绝经期综合征109例[J].河北中医,2009,31(3)：343-344.
[23]张玉珍。中医妇科学[M].第七版：168-171.
[24]黄美珍.自拟更年汤治疗更年期综合征38例疗效观察[J].云南中医药杂志,2004,25(1)：19-20.
[25]皮精英.二仙汤加减治疗围绝经期综合征78例[J].河南中医,2006,26(10)：73-74.
[26]马珊。辨证分型治疗更年期综合征65例临床观察[J].北京中医,1998,18(5)：32.
[27]黄波。左归丸合二至丸治疗肾阴虚型围绝经期诸症64例[J].现代医药卫生,2008,24(3)：404-405.
[28]张金钊。右归丸加味治疗妇女更年期综合征100例[J].国医论坛,2005,20(5)：32.
[29]张爱梅.二仙汤加减治疗妇女更年期综合征106例[J].云南中医药杂志,2008,29(11)：36.
[30]刘枫,唐露.辨证论治围绝经期综合征50例[J].光明中医,2009,24(2)：274-276.
[31]黄瑞霞,郭惠敏.从肾阴虚冲气上逆论治围绝经期综合征100例[J].河北中医,2009,31(5)：687-688.
[32]黄淑琼,林丽明,陈效畅.滋肾宁心汤治疗绝经前后诸症疗效观察[J].吉林中医药,2003,23(8)：25-26.
[33]刘金淑.辨证治疗女性更年期综合征[J].光明中医,2007,22(8)：11.
[34]金凤丽.心肾并重治疗绝经前后诸证67例[J].云南中医学院学报,2008,31(6)：51-52.
[35]王雅琴.辨证治疗围绝经期综合征258例[J].中医研究,2009,22(6)：46-47.
[36]田万静.补肾活血法治疗围绝经期综合征24例[J].中医中药·中西医结合,2009,1(12)：134.
[37]胡蔚洁.平更汤治疗更年期综合征54例[J].四川中医,2003,21(4)：501.
[38]李艺.柴胡甘麦汤治疗更年期综合征23例[J].云南中医学院学报,1999,22(3)：51.
[39]闫冬梅.滋清安神饮治疗妇女更年期综合征275例[J].江苏中医,1997,18(12)：17.
[40]王纪云.五子衍宗丸为主治疗女性更年期综合征42例[J].云南中医中药杂志,1998,19(5)：26.
[41]孟照芹.二仙汤化裁治疗围绝经期综合征60例临床分析[J].中国现代药物应用,2009,3(24)：159-160.
[42]胡克晋.丹栀逍遥散加减治疗围绝经期综合征84例[J].中国中医药现代远程教育,2009,7(11)：27-28.
[43]李彩荣,邓秀莲.秦艽鳖甲散加减治疗围绝经期综合征52例临床观察[J].河北中医,2009,31(8)：1180.
[44]钱宏图,陈霞.益坤口服液治疗肝肾阴虚型围绝经期综合征合并脂质代谢紊乱的临床观察[J].湖北中医杂志,2009,31(12)：52-53.
[45]王淑琴.中西医结合治疗围绝经期综合征32例[[J].甘肃中医学院学报,2009,26(3)：28-29.
[46]王淑丽.中西医结合治疗围绝经期综合征50例观察[J].实用中医药杂志,2009,25(6)：388-389.
[47]陈铁龙.二仙汤合小柴胡汤加减治疗围绝经期综合征111例[J].江苏中医药,2010,42(2)：39.
[48]徐新亚,陈少春.更年欢汤治疗围绝经期综合征30例临床观察[J].浙江中医杂志,2010,45(2)：127-128.
[49]钟五荣,王俊松,范扬卿.中医综合疗法治疗围绝经期综合征40例[J].中国医药导报,2010,7(2)：78-79.
[50]陈颖异,鲁光钱,叶剑,等.助阳滋阴汤治疗围绝经期综合征肾阴阳两虚证30例[J].中国中医药科技,2010,17(1)：83-84.
[51]张映兰,王抗战.自拟益天癸方治疗围绝经期综合症疗效观察[J].甘肃医药,2009,28(6)：463-464.
[52]王健,彭艳芳.参松养心胶囊治疗围绝经期综合征的疗效观察[J].医学新知杂志,2009,19(1)：50-51.
[53]洪育萍,谌剑飞.甜梦胶囊治疗围绝经期综合征临床观察[J].现代中西医结合杂志,2009,18(11)：1248-1249.
[54]岳树香,陈玉.血府逐瘀汤加味治疗围绝经期综合征50例疗效观察[J].河北中医,2009,31(3)：391.
[55]钟宏量,蒙珊,杜艳.中药内服加耳穴贴压治疗肾阴虚型围绝经期综合征疗效观察[J].广西中医药,2009,32(1)：13-14.
[56]金真,张秀萍.松龄血脉康胶囊治疗更年期综合征66例临床观察[J].浙江中医学院学报,1999,23(3)：34.
[57]梁文珍,刘道芳.紫参颗粒治疗同绝经期综合征临床研究[J].安徽中医学院学报,2004,23(2)：21-22.
[58]郝玉芳.妇复春胶囊治疗更年期综合征疗效观察[J].中国水电医学,2006,3：151.
[59]王磊,程卫东,王彩霞,等.玫参颗粒治疗围绝经期综合征30例疗效观察[J].新中医,2008,40(10)：59-60.
[60]舒晓春,余菊花.凤宝胶囊治疗更年期综合征50例[J].陕西中医,2003,23(8)：715-717.
[61]周云.河车大造胶囊治疗更年期综合征32例[J].吉林中医药,2008,28(12)：895.
[62]岳喜格.佳蓉片治疗围绝经期综合征60例观察[J].中国社区医师,2009,11(213)：146.
[63]詹光宗.体针治疗妇女更年期综合征疗效观察[J].两南军医,2007,9(6)：65.
[64]张永刚,李瓦里,李庆云,等.针刺治疗女性更年期综合征肝肾阴虚证65例临床观察[J].针灸临床杂志,2002,18(1)：1.
[65]张淼,徐琛,孙远征.背俞穴电针对人鼠罔绝经期综合征性激素影响的研究[J].针灸临床杂志,2007,23(12)：40.
[66]张道武,郑秀芝,王秋景.针灸治疗更年期综合征临床研究[J].上海针灸杂志,1999,18(4)：20-21.
[67]金亚蓓,孙占玲,金慧芳.耳针治疗围绝经期综合征34例临床观察[J].中医杂志,2008,49(4)：331-333,352.
[68]孙远征,王伟华,卫彦.俞募通经电针法对围绝经期综合征信号转导相关基因表达影响的研究[J].针灸临床杂志,2009,25(8)：43-45.
[69]李艺,夏勇,刘世敏,等.电针对围绝经期综合征患者Kupperman评分的效应[J].上海针灸杂志,2009,28(10)：559-561.
[70]肖菊层.按摩治疗更年期综合征38例临床体会[J].光明中医,2007,22(1)：79-80.
[71]邵雪英,俞琦,胡丽珍.足穴推拿疗法对围绝经期妇女性激素影响的临床研究[J].中国中医药科技,2008,15(1)：14-15.
[72]胡丽珍,邵雪英,俞琦.足穴推拿疗法对围绝经期妇女性激素及生活质量的影响[J].浙江中医杂志,2007,42(7)：398-399.
[73]王玲,黄建华.穴敷疗法对妇女更年期综合征植物神经及某些内分泌功能的影响[J].江西中医药,1998,29(6)：37-38
[74]李芳芳,吴新华.浅谈对围绝经期综合征的中医认识和治疗[J]。光明中医,2009,24(9)·1783-1784·
[75]Hudong互动百科http://www. hudong. com/wiki.
[76]丰有吉,沈铿.妇产科学[M].第七版：258-263.
[77]张雅萍,王秀霞.坤宁安丸对更年期综合征患者生殖内分泌免疫功能的影响[J].中医药信息,2001,18(3)：52-55.
[78]陈亚琼,叶雪清.血浆吲哚类神经递质与绝经综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41-42.
[79]去卵巢鼠尾部基础皮温升高及对降钙素基因相关反应增强[J].国外医学妇产科学分册,1996,23(6)：360.
[80]鲁遂荣,方学温,侯安继,等.更年平调液对更年期大鼠自由基影响的实验研究[J].中国中医基础医学杂志,1998,4(8)：35-36.
[81]刘静,蒋艳,耿兴玲,等.围绝经期综合征的影响因素及干预措施的研究[J].中国妇幼保健,2003,(18)：633-634.
[82]Solerte SB, Fioravanti M, Spinillo A, et al. Association be-tween hormonal and haemorheological changes during the men-strual cycle in healthy women[J]. Br J Obstet Gynaecol,1998,95:1305.
[83]Larsson H, Persson S, Hedner 1', et al. Studies on blood viscosity during the menstrual cycle and in the postmenopausalpedod in healthy women[J]. Acta Obstet Gyneool Scand,1998,68:483.
[84]Woodward M, Rumley A, Tunstall—Pedoe H, et al. Asso—cimions ofblood rheology and interleukin-6 with cardiovascu-lax risk factors and prevalent cardiovascular disease[J]. Br JHaematol,1999,104:246.
[85]Lowe GD, Lee AJ, Rumley A, et al. Blood viscosity andrisk of cardiovascular events:the Edinburgh artery study[J]. Br J Haemat01. 1999,96:168.
[86]Leo AJ, Lowe GoSmith W, et al. Plasma fibrinogen in women:relationships with oral contraception, the menopause and hormone replacement therapy [J]. Br J Haemaoal.1999,83:616.
[87]Frohlich M, Schunkcrt H, Hense H, et al. Effects of hormone replacement therapies on fibrinogen and plasma viscosi-ty in postmenopausal women[J]. Br J HaemacOl.2000,100:577.
[88]赵俊娟,屈爱春.67例女性更年期综合征血液流变学指标的检测及其分析[J].中国微循环,2002,6(3).
[89]张玉珍.中医妇科学[M].北京：中国中医药出版社,2002：168-172.
[90]华嘉增。妇女保健学[M].上海：复旦大学出版社,第2版,2003：218-243.
[91]绍芬,陆湘云,丁爱华.绝经内分泌与临床[M].北京：人民卫生出版社,2005,1：178.
[92]陈亚琼,叶雪清.血浆吲哚类神经递质与更年期综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41.
[93]步世忠,孙梅,张沅,等.更年健上调老年雌性大鼠下丘脑雌激素受体mRNA表达对P物质和β-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28.
[94]李大金.更年期综合征生殖内分泌免疫功能[J].上海医学,1996,19(1)：42-44.
[95]张家庆.更年期综合征患者白细胞雌激素受体的变化及六味地黄丸的疗效[J].中西医结合杂志,1991,11(9)：521-523.
[96]闰琳丽.围绝经期卵巢功能和老化机制的研究[J].国外医学妇产科学分册,1996,23(5)：264.
[97]许小凤.更年期综合征病理生理研究进展[J].医学研究通讯,2000,29(8)：34-35.
[98]曾辉,陈明哲.降低雌激素水平对大鼠降钙素基因相关肽合成与释放的影响[J].华心血管病杂志,2000,28(1)：61-64.
[99]陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139.
[100]姚石安.补肾化瘀法治疗更年期综合征的理论与实践依据是什么[J].中医杂志,1994,35(4)：245.
[101]张昱,李勇生.肾虚血瘀是妇女更年期综合征的病理基础[J].陕西中医,1999,20(5)：239.
[102]刘晓伟,邓虹珠.更年期综合征中医辨治研究进展[J].现代中西医结合杂志,2001,10(8)：792.
[103]叶燕萍.106例妇女更年期综合症中医病机及辨证分型的研究[J].福建中医药,2000,31(5)：18.
[104]李庆生.治疗妇女更年期综合征应重视柔肝疏肝、气阴双调[J].云南中医中药杂志,1997,18(3)：4.
[105]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18(4)：205.
[106]余庆.脾胃阴火与更年期综合征[J].福建中医学院学报,1999,9(3)：34.
[107]冯素兰.绝经前后诸证发病机理刍议[J].内蒙古中医药,1991,4：35.
[108]华嘉增.妇女保健学[M].第2版.上海：复旦大学出版社,2003：218-243.
[109]周美清.李亚里现代老年妇科学[M].北京：人民军医出版社,1999：4.
[110]LindsayR. Prevention of osteoporosis. Preventive medicine[J].1994, 23(5):722-726.
[111]林守清.雌激素缺乏和绝经[M].北京：北京医科大学,中国协和医科大学联合出版社,1998.
[112]王大增,朱燕清,李燕萍,等.更年舒治疗妇女更年期综合征的临床及实验研究[J].中国中西医结合杂志,1994,14(7)：396-399.
[2]闰润虎,刘志诚.女性更年期综合征的中西药认识[J].现代中西医结合杂志,2003,12(13)：1442.1443.
[3]许丽绵,欧阳惠卿,卢如铃.更年期综合征病因病机及其证治述要[J].中医药学刊,2003,21(9)：1550-1553.
[4]陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139-140.
[5]张颖,褚贵保.倪宗咖治疗更年期综合征经验[J].实用中医药杂志,2001,17(1)：34.
[6]伏晓华.从肾论治更年期综合症[J].中国中医基础医学杂志,2003,9(6)：57-58.
[7]王淑萍.妇女更年期综合征中医治疗八法[J].现代中医药,2002,(5)：59-60.
[8]汤月萍.夏桂成辨治妇女更年期综合征的经验[J].湖北中医杂志,1999,19(2)：6-7.
[9]罗元恺,郑国平.以补肾为主治疗更年期综合征经验[J].中国医学学报,1990,5(2)：23.
[10]张蓓贞,中医药生活质评估之效指针建立研究[J].中医药年报,2005,23(3)：433.
[11]叶晓玲.论围绝经期综合征之治法应以滋肾养肝为主[J].亚太传统医药,2009,5(6)：142-143.
[12]王晓萍.从奇经论治妇女更年期综合征[J].中国医药学报,1995,10(4)：43-45.
[13]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18,(4)：205.
[14]李艳菊.女性更年期综合征从瘀辨治的体会[J].中国中医药信息杂志,2000,7(9)：74.
[15]李义方,熊超.从肾虚挟癖论治更年期综合征[J].吉林中医药,1998, (3)：29.
[16]刘晓伟,邓虹珠.更年期综合征中医辨治研究进展[J].现代中西医结合杂志,2001,10(8)：792.
[17]张人伟,庞玉琴.庞清治教授治疗更年期综合征的经验[J].河南中医药学刊,2000,15(3)：6-7.
[18]杨小清.百地益肾汤治疗更年期综合征80例临床观察[J].内蒙古中医药,2004,(3)：6-7.
[19]黄英.抑肝补肾法治疗围绝经期综合征48例[J].右江医学,2008,36(1)：104-105.
[20]陈黎明.益肾平肝汤治疗妇女肝肾阴虚型更年期综合征38例疗效观察[J].云南中医药杂志,2004,25(2)：15.
[21]刘燕萍,李绍轩.滋肾涵肝法治疗围绝经期综合征疗效观察[J].临床和实验医学杂
志,2009,8(10)：117-118.
[22]许莉,杨丽,郭娜,等.滋肾养肝清心法治疗围绝经期综合征109例[J].河北中医,2009,31(3)：343-344.
[23]张玉珍。中医妇科学[M].第七版：168-171.
[24]黄美珍.自拟更年汤治疗更年期综合征38例疗效观察[J].云南中医药杂志,2004,25(1)：19-20.
[25]皮精英.二仙汤加减治疗围绝经期综合征78例[J].河南中医,2006,26(10)：73-74.
[26]马珊。辨证分型治疗更年期综合征65例临床观察[J].北京中医,1998,18(5)：32.
[27]黄波。左归丸合二至丸治疗肾阴虚型围绝经期诸症64例[J].现代医药卫生,2008,24(3)：404-405.
[28]张金钊。右归丸加味治疗妇女更年期综合征100例[J].国医论坛,2005,20(5)：32.
[29]张爱梅.二仙汤加减治疗妇女更年期综合征106例[J].云南中医药杂志,2008,29(11)：36.
[30]刘枫,唐露.辨证论治围绝经期综合征50例[J].光明中医,2009,24(2)：274-276.
[31]黄瑞霞,郭惠敏.从肾阴虚冲气上逆论治围绝经期综合征100例[J].河北中医,2009,31(5)：687-688.
[32]黄淑琼,林丽明,陈效畅.滋肾宁心汤治疗绝经前后诸症疗效观察[J].吉林中医药,2003,23(8)：25-26.
[33]刘金淑.辨证治疗女性更年期综合征[J].光明中医,2007,22(8)：11.
[34]金凤丽.心肾并重治疗绝经前后诸证67例[J].云南中医学院学报,2008,31(6)：51-52.
[35]王雅琴.辨证治疗围绝经期综合征258例[J].中医研究,2009,22(6)：46-47.
[36]田万静.补肾活血法治疗围绝经期综合征24例[J].中医中药·中西医结合,2009,1(12)：134.
[37]胡蔚洁.平更汤治疗更年期综合征54例[J].四川中医,2003,21(4)：501.
[38]李艺.柴胡甘麦汤治疗更年期综合征23例[J].云南中医学院学报,1999,22(3)：51.
[39]闫冬梅.滋清安神饮治疗妇女更年期综合征275例[J].江苏中医,1997,18(12)：17.
[40]王纪云.五子衍宗丸为主治疗女性更年期综合征42例[J].云南中医中药杂志,1998,19(5)：26.
[41]孟照芹.二仙汤化裁治疗围绝经期综合征60例临床分析[J].中国现代药物应用,2009,3(24)：159-160.
[42]胡克晋.丹栀逍遥散加减治疗围绝经期综合征84例[J].中国中医药现代远程教育,2009,7(11)：27-28.
[43]李彩荣,邓秀莲.秦艽鳖甲散加减治疗围绝经期综合征52例临床观察[J].河北中医,2009,31(8)：1180.
[44]钱宏图,陈霞.益坤口服液治疗肝肾阴虚型围绝经期综合征合并脂质代谢紊乱的临床观察[J].湖北中医杂志,2009,31(12)：52-53.
[45]王淑琴.中西医结合治疗围绝经期综合征32例[[J].甘肃中医学院学报,2009,26(3)：28-29.
[46]王淑丽.中西医结合治疗围绝经期综合征50例观察[J].实用中医药杂志,2009,25(6)：388-389.
[47]陈铁龙.二仙汤合小柴胡汤加减治疗围绝经期综合征111例[J].江苏中医药,2010,42(2)：39.
[48]徐新亚,陈少春.更年欢汤治疗围绝经期综合征30例临床观察[J].浙江中医杂志,2010,45(2)：127-128.
[49]钟五荣,王俊松,范扬卿.中医综合疗法治疗围绝经期综合征40例[J].中国医药导报,2010,7(2)：78-79.
[50]陈颖异,鲁光钱,叶剑,等.助阳滋阴汤治疗围绝经期综合征肾阴阳两虚证30例[J].中国中医药科技,2010,17(1)：83-84.
[51]张映兰,王抗战.自拟益天癸方治疗围绝经期综合症疗效观察[J].甘肃医药,2009,28(6)：463-464.
[52]王健,彭艳芳.参松养心胶囊治疗围绝经期综合征的疗效观察[J].医学新知杂志,2009,19(1)：50-51.
[53]洪育萍,谌剑飞.甜梦胶囊治疗围绝经期综合征临床观察[J].现代中西医结合杂志,2009,18(11)：1248-1249.
[54]岳树香,陈玉.血府逐瘀汤加味治疗围绝经期综合征50例疗效观察[J].河北中医,2009,31(3)：391.
[55]钟宏量,蒙珊,杜艳.中药内服加耳穴贴压治疗肾阴虚型围绝经期综合征疗效观察[J].广西中医药,2009,32(1)：13-14.
[56]金真,张秀萍.松龄血脉康胶囊治疗更年期综合征66例临床观察[J].浙江中医学院学报,1999,23(3)：34.
[57]梁文珍,刘道芳.紫参颗粒治疗同绝经期综合征临床研究[J].安徽中医学院学报,2004,23(2)：21-22.
[58]郝玉芳.妇复春胶囊治疗更年期综合征疗效观察[J].中国水电医学,2006,3：151.
[59]王磊,程卫东,王彩霞,等.玫参颗粒治疗围绝经期综合征30例疗效观察[J].新中医,2008,40(10)：59-60.
[60]舒晓春,余菊花.凤宝胶囊治疗更年期综合征50例[J].陕西中医,2003,23(8)：715-717.
[61]周云.河车大造胶囊治疗更年期综合征32例[J].吉林中医药,2008,28(12)：895.
[62]岳喜格.佳蓉片治疗围绝经期综合征60例观察[J].中国社区医师,2009,11(213)：146.
[63]詹光宗.体针治疗妇女更年期综合征疗效观察[J].两南军医,2007,9(6)：65.
[64]张永刚,李瓦里,李庆云,等.针刺治疗女性更年期综合征肝肾阴虚证65例临床观察[J].针灸临床杂志,2002,18(1)：1.
[65]张淼,徐琛,孙远征.背俞穴电针对人鼠罔绝经期综合征性激素影响的研究[J].针灸临床杂志,2007,23(12)：40.
[66]张道武,郑秀芝,王秋景.针灸治疗更年期综合征临床研究[J].上海针灸杂志,1999,18(4)：20-21.
[67]金亚蓓,孙占玲,金慧芳.耳针治疗围绝经期综合征34例临床观察[J].中医杂志,2008,49(4)：331-333,352.
[68]孙远征,王伟华,卫彦.俞募通经电针法对围绝经期综合征信号转导相关基因表达影响的研究[J].针灸临床杂志,2009,25(8)：43-45.
[69]李艺,夏勇,刘世敏,等.电针对围绝经期综合征患者Kupperman评分的效应[J].上海针灸杂志,2009,28(10)：559-561.
[70]肖菊层.按摩治疗更年期综合征38例临床体会[J].光明中医,2007,22(1)：79-80.
[71]邵雪英,俞琦,胡丽珍.足穴推拿疗法对围绝经期妇女性激素影响的临床研究[J].中国中医药科技,2008,15(1)：14-15.
[72]胡丽珍,邵雪英,俞琦.足穴推拿疗法对围绝经期妇女性激素及生活质量的影响[J].浙江中医杂志,2007,42(7)：398-399.
[73]王玲,黄建华.穴敷疗法对妇女更年期综合征植物神经及某些内分泌功能的影响[J].江西中医药,1998,29(6)：37-38
[74]李芳芳,吴新华.浅谈对围绝经期综合征的中医认识和治疗[J]。光明中医,2009,24(9)·1783-1784·
[75]Hudong互动百科http://www. hudong. com/wiki.
[76]丰有吉,沈铿.妇产科学[M].第七版：258-263.
[77]张雅萍,王秀霞.坤宁安丸对更年期综合征患者生殖内分泌免疫功能的影响[J].中医药信息,2001,18(3)：52-55.
[78]陈亚琼,叶雪清.血浆吲哚类神经递质与绝经综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41-42.
[79]去卵巢鼠尾部基础皮温升高及对降钙素基因相关反应增强[J].国外医学妇产科学分册,1996,23(6)：360.
[80]鲁遂荣,方学温,侯安继,等.更年平调液对更年期大鼠自由基影响的实验研究[J].中国中医基础医学杂志,1998,4(8)：35-36.
[81]刘静,蒋艳,耿兴玲,等.围绝经期综合征的影响因素及干预措施的研究[J].中国妇幼保健,2003,(18)：633-634.
[82]Solerte SB, Fioravanti M, Spinillo A, et al. Association be-tween hormonal and haemorheological changes during the men-strual cycle in healthy women[J]. Br J Obstet Gynaecol,1998,95:1305.
[83]Larsson H, Persson S, Hedner 1', et al. Studies on blood viscosity during the menstrual cycle and in the postmenopausalpedod in healthy women[J]. Acta Obstet Gyneool Scand,1998,68:483.
[84]Woodward M, Rumley A, Tunstall—Pedoe H, et al. Asso—cimions ofblood rheology and interleukin-6 with cardiovascu-lax risk factors and prevalent cardiovascular disease[J]. Br JHaematol,1999,104:246.
[85]Lowe GD, Lee AJ, Rumley A, et al. Blood viscosity andrisk of cardiovascular events:the Edinburgh artery study[J]. Br J Haemat01. 1999,96:168.
[86]Leo AJ, Lowe GoSmith W, et al. Plasma fibrinogen in women:relationships with oral contraception, the menopause and hormone replacement therapy [J]. Br J Haemaoal.1999,83:616.
[87]Frohlich M, Schunkcrt H, Hense H, et al. Effects of hormone replacement therapies on fibrinogen and plasma viscosi-ty in postmenopausal women[J]. Br J HaemacOl.2000,100:577.
[88]赵俊娟,屈爱春.67例女性更年期综合征血液流变学指标的检测及其分析[J].中国微循环,2002,6(3).
[89]张玉珍.中医妇科学[M].北京：中国中医药出版社,2002：168-172.
[90]华嘉增。妇女保健学[M].上海：复旦大学出版社,第2版,2003：218-243.
[91]绍芬,陆湘云,丁爱华.绝经内分泌与临床[M].北京：人民卫生出版社,2005,1：178.
[92]陈亚琼,叶雪清.血浆吲哚类神经递质与更年期综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41.
[93]步世忠,孙梅,张沅,等.更年健上调老年雌性大鼠下丘脑雌激素受体mRNA表达对P物质和β-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28.
[94]李大金.更年期综合征生殖内分泌免疫功能[J].上海医学,1996,19(1)：42-44.
[95]张家庆.更年期综合征患者白细胞雌激素受体的变化及六味地黄丸的疗效[J].中西医结合杂志,1991,11(9)：521-523.
[96]闰琳丽.围绝经期卵巢功能和老化机制的研究[J].国外医学妇产科学分册,1996,23(5)：264.
[97]许小凤.更年期综合征病理生理研究进展[J].医学研究通讯,2000,29(8)：34-35.
[98]曾辉,陈明哲.降低雌激素水平对大鼠降钙素基因相关肽合成与释放的影响[J].华心血管病杂志,2000,28(1)：61-64.
[99]陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139.
[100]姚石安.补肾化瘀法治疗更年期综合征的理论与实践依据是什么[J].中医杂志,1994,35(4)：245.
[101]张昱,李勇生.肾虚血瘀是妇女更年期综合征的病理基础[J].陕西中医,1999,20(5)：239.
[102]刘晓伟,邓虹珠.更年期综合征中医辨治研究进展[J].现代中西医结合杂志,2001,10(8)：792.
[103]叶燕萍.106例妇女更年期综合症中医病机及辨证分型的研究[J].福建中医药,2000,31(5)：18.
[104]李庆生.治疗妇女更年期综合征应重视柔肝疏肝、气阴双调[J].云南中医中药杂志,1997,18(3)：4.
[105]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18(4)：205.
[106]余庆.脾胃阴火与更年期综合征[J].福建中医学院学报,1999,9(3)：34.
[107]冯素兰.绝经前后诸证发病机理刍议[J].内蒙古中医药,1991,4：35.
[108]华嘉增.妇女保健学[M].第2版.上海：复旦大学出版社,2003：218-243.
[109]周美清.李亚里现代老年妇科学[M].北京：人民军医出版社,1999：4.
[110]LindsayR. Prevention of osteoporosis. Preventive medicine[J].1994, 23(5):722-726.
[111]林守清.雌激素缺乏和绝经[M].北京：北京医科大学,中国协和医科大学联合出版社,1998.
[112]王大增,朱燕清,李燕萍,等.更年舒治疗妇女更年期综合征的临床及实验研究[J].中国中西医结合杂志,1994,14(7)：396-399.
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