女性更年期综合征的中医证候分布及健康状况评估研究
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摘要
更年期(C1 imacterium)是每个妇女必经的特殊生理时期,据国内外有关资料统计报道,在45-55岁的年龄段,约有90%的妇女均有不同程度的临床表现。更年期综合征(C1 imacteric Syndrome),就是围绕在绝经前后时间出现的以植物神经系统功能紊乱为主的一组症候群。现代医学以激素替代疗法(hormone replacement therapy, HRT)为主治疗该病,具有潜在的危险性和不良反应,而传统医学在整体观的指导下对更年期综合征辨证论治,具有一定的特色和优势,减少了不良副作用影响。但是更年期综合征的临床症状纷繁复杂,目前存在多种辨证分型,各证型间彼此交错覆盖,不利于开展针对性治疗,因此有必要进一步完善更年期综合征的中医辨证体系。
目的
本课题主要通过横断面的流行病学研究方法,对女性更年期综合征的中医证候分布及健康状况进行了流行病学调查研究。期望进一步规范更年期综合征临床研究,获得较好的社会效益。为中医药防治更年期综合征的临床研究及其新药开发建立必备的评估系统和提供严谨的科研资料。
方法
采用问卷调查的方式,遵循临床流行病学调研方法,设计统一的临床调研表,包括女性更年期综合征体质调查表、临床证候及证型调查表,逐一询问患者并填写流调表,中医辨证由高年资深的专科中医教授结合临床经验进行,按照中、西医诊断标准诊断,得出中医证候。以妇科经带方面的情况、实验室血清E2和血清FSH、生存质量为观察指标。观察对象以组成更年期综合征的围绝经期和绝经后来分为两类,比较两类病人在各观察指标上的异同。
结果
本调查共收集病例208份,排除错漏、矛盾和缺损病例8份,有效病历200份,有效应答率96.15%。200例更年期患者中围绝经期患者和绝经后患者分别有100例。
绝经年龄：200例更年期综合征患者,年龄42-65岁,绝经年龄46～53岁,平均48.07岁。比以往文献报道的提前1岁。提示现代女性工作、精神压力较大。
更年期综合征评分：绝经后期患者Kupperman症状总得分高于围绝经期患者得分,差异有统计学意义(P＜0.05)。说明绝经后期患者更年期综合征症状较围绝经期严重,尤其表现在失眠、头晕、疲乏无力、心悸等症状上。
妇科症状：月经紊乱、夹有血块、性欲减退、带下异常、阴部异常感是更年期综合征出现频率较高的妇科症状。绝经后期患者在阴部异常感和性欲减退方面明显多于围绝经期患者(P0.05),说明月经不调、性生活不和谐会导致更年期综合征的提前发生。
中医临床症状：烘热汗出、口咽干燥、失眠、烦躁、健忘、腰酸、焦虑、乏力是更年期综合征出现频率较高的临床症状。以肝肾两经证候最为多见。提示女性更年期综合征患者的病理因素以阴虚、血虚、气滞、气虚等有关,涉及肝(郁)、肾(虚)、脾(虚)、心(虚)等脏。
中医证型：调查发现肝肾阴虚证出现频次最多(99例,约占49.5%)；肝气郁结次之(84例,约42.0%)。心肾不交约占7.5%。单纯肾阴虚、肾阳虚证出现较少。围绝经期和绝经后期的中医证候构成比较,差异无统计学意义(P＞50.05)。
情志：本次调查还发现更年期综合征患者常有不同程度的精神症状,200名患者精神抑郁101人,约50.7%；焦虑167人,约83.7%；烦躁170人,约85.2%。此外性欲减退(110人,55.0%)、阴部异常感(107人,53.5%)出现频次也较高。提示情绪异常与性生活不和谐可能是导致更年期综合征发生的关键因素。
生存质量：围绝经期和绝经后期在PF、RP、VT、RE、MH五个维度评分比较,差异有统计意义(P0.05),从两类患者八个维度的得分可以看出,围绝经期患者躯体功能、躯体角色、精力评分高于绝经后期,而情感角色、心理健康评分低于绝经后期患者。结果表明绝经后期更年期综合征患者的生存质量显著降低。而围绝经期的患者情感角色和心理健康两个维度却比绝经后期要低。这可能与刚步入更年期的妇女心理不适应的缘故。
结论
更年期综合征的病位主要累及肝、肾,证型以肝肾阴虚、肝气郁结较多。绝经后期患者更年期综合征症状较围绝经期严重。绝经后期更年期综合征患者的生存质量显著降低,围绝经期的患者情感角色和心理健康两个维度降低。
Climacterium is a special physiology stage that every women should come through. According to report from domestic or abroad, about 90% women have different kinds of clinical symptoms during the age of 45 to 55. Climacteric Syndrome is a series of symptoms mainly due to autonomic nerve system dysfunction which happen during this special stage. Modern medicine treats mainly with hormone replacement therapy (HRT), but this treatment has some potential risk and adverse effects. While traditional Chinese medicine which lowers the side-effects has its unique characteristic and predominance under the direction of entirety concept. However, the symptoms of Climacteric Syndrome are complicated, and have different kinds of dialectical patterns. Each pattern interlaces and mixes together, which is not good to carry out personal therapies, therefore it is necessary to consummate the dialectical system of Climacteric Syndrome. Objective
We make the epidemiological investigation about the syndrome pattern distribution regularity and health status of women with Climacteric Syndrome through the cross-sectional epidemiological study, in order to standardize the clinical trail of Climacteric Syndrome, gain a good social effect, establish the evaluation system of the clinical trail and new drugs development, and provide rigorous data of scientific research.
Methods
We use the questionnaire, follow the investigation methods of clinical epidemiology, design unified clinical scales include constitution、clinical symptoms and syndrome patterns of women with Climacteric Syndrome, inquest patients one by one and complete the scales. The differentiations are made by senior professors of traditional Chinese medicine based on his experiences. The observation index due to menstruation and leucorrhea、blood-serum level of E2 and FSH、living quality. We divide the objects into two groups (peri-menopausal group and post-menopause group), compare the differences in the index of the two groups.
Results
We collecte 208 cases, eliminate 8 mistaken and defect cases,200 cases left are valid, during which response rate was 96.15%. There are 100 patients in the peri-menopausal group and 100 in the post-menopause group.
Menopausal age:200 patients, age from 42 to 65, menopausal age from 46 to 53,48.07 in average, younger than those reported, which shows that the stress that women suffered today was harder.
Scores of Climacteric Syndrome:Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (P<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia、dizziness、fatigue and palpitation.
Symptoms of gynecology:menstrual disorder、hyposexuality、leucorrhea disorder and vagina abnormality are symptoms happened frequently in Climacteric Syndrome. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05), which shows that menstrual disorder and disharmony of the sexual life may happen ahead of schedule.
Clinical symptoms and signs of traditional Chinese medicine:hectic fever、pharyngoxerosis、insomnia、restlessness、forgetfulness、sore waist、anxiety and fatigue are symptoms happened frequently in Climacteric Syndrome, especially symptoms of the liver and kidney meridian, which shows that the pathogenesis of the Climacteric Syndrome mainly are yin asthenia、blood deficiency、qi-stagnation and qi-deficiency, related to liver(stagnant)、kidney(deficient)、spleen(deficient)、heart (deficient) and et cetera.
Syndrome patterns:hepatic and renal yin deficiency happens most frequently (99 cases, about 49.5%), depression of liver-qi comes next (84 cases, about 42.0%). Imbalance between heart-yang and kidney-yin occupies 7.5%. The patterns of merely deficiency of kidney-yin and kidney-yang are less seen. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients(P>0.05).
Sentiment:in the study we find different kinds of psychiatric symptoms of patients with Climacteric Syndrome, among 200 patients, there are 101 with deprementia, about 50.7%; 167 with anxiety; about 83.7%; 170 with restlessness, about 85.2%; 110 with hyposexuality, about 55.0%; 107 with vagina abnormality, about 53.5%. All of this shows that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.
Living quality:there is statistical significance in scores of PF、RP、VT、RE、MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function、body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role、mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role、mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period. Conclusion
1. There are 200 patients with Climacteric Syndrome in the study, whose menopausal ages are between 46-53, average in 48.5.
2. The syndrome of hepatic and renal yin deficiency happens most frequently (49.5%), depression of liver-qi comes next (42.0%), Imbalance between heart-yang and kidney-yin occupies 8.6%, and the patterns of merely deficiency of kidney-yin and kidney-yang are 8.5%. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients (P>0.05).
3. The constitutional symptoms which happen most frequenctly are as follows: hectic fever、pharyngoxerosis、insomnia、restlessness、forgetfulness、sore waist、anxiety、fatigue and etc. Symptoms of gynecology happen most frequently are as follows:menstrual disorder、hyposexuality、leucorrhea disorder and vagina abnormality. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05).
4. Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (p<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia、dizziness、fatigue and palpitation.
5. The study also finds different kinds of symptoms in Climacteric Syndrome, including deprementia(50.7%)、anxiety(83.7%)、restlessness (85.2%)、hyposexuality(55.0%)、vagina abnormality(53.5%), which indicates that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.
6. There is statistical significance in scores of PF, RP、VT、RE、MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function、body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role、mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role、mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period.
目的
本课题主要通过横断面的流行病学研究方法,对女性更年期综合征的中医证候分布及健康状况进行了流行病学调查研究。期望进一步规范更年期综合征临床研究,获得较好的社会效益。为中医药防治更年期综合征的临床研究及其新药开发建立必备的评估系统和提供严谨的科研资料。
方法
采用问卷调查的方式,遵循临床流行病学调研方法,设计统一的临床调研表,包括女性更年期综合征体质调查表、临床证候及证型调查表,逐一询问患者并填写流调表,中医辨证由高年资深的专科中医教授结合临床经验进行,按照中、西医诊断标准诊断,得出中医证候。以妇科经带方面的情况、实验室血清E2和血清FSH、生存质量为观察指标。观察对象以组成更年期综合征的围绝经期和绝经后来分为两类,比较两类病人在各观察指标上的异同。
结果
本调查共收集病例208份,排除错漏、矛盾和缺损病例8份,有效病历200份,有效应答率96.15%。200例更年期患者中围绝经期患者和绝经后患者分别有100例。
绝经年龄：200例更年期综合征患者,年龄42-65岁,绝经年龄46～53岁,平均48.07岁。比以往文献报道的提前1岁。提示现代女性工作、精神压力较大。
更年期综合征评分：绝经后期患者Kupperman症状总得分高于围绝经期患者得分,差异有统计学意义(P＜0.05)。说明绝经后期患者更年期综合征症状较围绝经期严重,尤其表现在失眠、头晕、疲乏无力、心悸等症状上。
妇科症状：月经紊乱、夹有血块、性欲减退、带下异常、阴部异常感是更年期综合征出现频率较高的妇科症状。绝经后期患者在阴部异常感和性欲减退方面明显多于围绝经期患者(P0.05),说明月经不调、性生活不和谐会导致更年期综合征的提前发生。
中医临床症状：烘热汗出、口咽干燥、失眠、烦躁、健忘、腰酸、焦虑、乏力是更年期综合征出现频率较高的临床症状。以肝肾两经证候最为多见。提示女性更年期综合征患者的病理因素以阴虚、血虚、气滞、气虚等有关,涉及肝(郁)、肾(虚)、脾(虚)、心(虚)等脏。
中医证型：调查发现肝肾阴虚证出现频次最多(99例,约占49.5%)；肝气郁结次之(84例,约42.0%)。心肾不交约占7.5%。单纯肾阴虚、肾阳虚证出现较少。围绝经期和绝经后期的中医证候构成比较,差异无统计学意义(P＞50.05)。
情志：本次调查还发现更年期综合征患者常有不同程度的精神症状,200名患者精神抑郁101人,约50.7%；焦虑167人,约83.7%；烦躁170人,约85.2%。此外性欲减退(110人,55.0%)、阴部异常感(107人,53.5%)出现频次也较高。提示情绪异常与性生活不和谐可能是导致更年期综合征发生的关键因素。
生存质量：围绝经期和绝经后期在PF、RP、VT、RE、MH五个维度评分比较,差异有统计意义(P0.05),从两类患者八个维度的得分可以看出,围绝经期患者躯体功能、躯体角色、精力评分高于绝经后期,而情感角色、心理健康评分低于绝经后期患者。结果表明绝经后期更年期综合征患者的生存质量显著降低。而围绝经期的患者情感角色和心理健康两个维度却比绝经后期要低。这可能与刚步入更年期的妇女心理不适应的缘故。
结论
更年期综合征的病位主要累及肝、肾,证型以肝肾阴虚、肝气郁结较多。绝经后期患者更年期综合征症状较围绝经期严重。绝经后期更年期综合征患者的生存质量显著降低,围绝经期的患者情感角色和心理健康两个维度降低。
Climacterium is a special physiology stage that every women should come through. According to report from domestic or abroad, about 90% women have different kinds of clinical symptoms during the age of 45 to 55. Climacteric Syndrome is a series of symptoms mainly due to autonomic nerve system dysfunction which happen during this special stage. Modern medicine treats mainly with hormone replacement therapy (HRT), but this treatment has some potential risk and adverse effects. While traditional Chinese medicine which lowers the side-effects has its unique characteristic and predominance under the direction of entirety concept. However, the symptoms of Climacteric Syndrome are complicated, and have different kinds of dialectical patterns. Each pattern interlaces and mixes together, which is not good to carry out personal therapies, therefore it is necessary to consummate the dialectical system of Climacteric Syndrome. Objective
We make the epidemiological investigation about the syndrome pattern distribution regularity and health status of women with Climacteric Syndrome through the cross-sectional epidemiological study, in order to standardize the clinical trail of Climacteric Syndrome, gain a good social effect, establish the evaluation system of the clinical trail and new drugs development, and provide rigorous data of scientific research.
Methods
We use the questionnaire, follow the investigation methods of clinical epidemiology, design unified clinical scales include constitution、clinical symptoms and syndrome patterns of women with Climacteric Syndrome, inquest patients one by one and complete the scales. The differentiations are made by senior professors of traditional Chinese medicine based on his experiences. The observation index due to menstruation and leucorrhea、blood-serum level of E2 and FSH、living quality. We divide the objects into two groups (peri-menopausal group and post-menopause group), compare the differences in the index of the two groups.
Results
We collecte 208 cases, eliminate 8 mistaken and defect cases,200 cases left are valid, during which response rate was 96.15%. There are 100 patients in the peri-menopausal group and 100 in the post-menopause group.
Menopausal age:200 patients, age from 42 to 65, menopausal age from 46 to 53,48.07 in average, younger than those reported, which shows that the stress that women suffered today was harder.
Scores of Climacteric Syndrome:Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (P<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia、dizziness、fatigue and palpitation.
Symptoms of gynecology:menstrual disorder、hyposexuality、leucorrhea disorder and vagina abnormality are symptoms happened frequently in Climacteric Syndrome. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05), which shows that menstrual disorder and disharmony of the sexual life may happen ahead of schedule.
Clinical symptoms and signs of traditional Chinese medicine:hectic fever、pharyngoxerosis、insomnia、restlessness、forgetfulness、sore waist、anxiety and fatigue are symptoms happened frequently in Climacteric Syndrome, especially symptoms of the liver and kidney meridian, which shows that the pathogenesis of the Climacteric Syndrome mainly are yin asthenia、blood deficiency、qi-stagnation and qi-deficiency, related to liver(stagnant)、kidney(deficient)、spleen(deficient)、heart (deficient) and et cetera.
Syndrome patterns:hepatic and renal yin deficiency happens most frequently (99 cases, about 49.5%), depression of liver-qi comes next (84 cases, about 42.0%). Imbalance between heart-yang and kidney-yin occupies 7.5%. The patterns of merely deficiency of kidney-yin and kidney-yang are less seen. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients(P>0.05).
Sentiment:in the study we find different kinds of psychiatric symptoms of patients with Climacteric Syndrome, among 200 patients, there are 101 with deprementia, about 50.7%; 167 with anxiety; about 83.7%; 170 with restlessness, about 85.2%; 110 with hyposexuality, about 55.0%; 107 with vagina abnormality, about 53.5%. All of this shows that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.
Living quality:there is statistical significance in scores of PF、RP、VT、RE、MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function、body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role、mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role、mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period. Conclusion
1. There are 200 patients with Climacteric Syndrome in the study, whose menopausal ages are between 46-53, average in 48.5.
2. The syndrome of hepatic and renal yin deficiency happens most frequently (49.5%), depression of liver-qi comes next (42.0%), Imbalance between heart-yang and kidney-yin occupies 8.6%, and the patterns of merely deficiency of kidney-yin and kidney-yang are 8.5%. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients (P>0.05).
3. The constitutional symptoms which happen most frequenctly are as follows: hectic fever、pharyngoxerosis、insomnia、restlessness、forgetfulness、sore waist、anxiety、fatigue and etc. Symptoms of gynecology happen most frequently are as follows:menstrual disorder、hyposexuality、leucorrhea disorder and vagina abnormality. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05).
4. Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (p<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia、dizziness、fatigue and palpitation.
5. The study also finds different kinds of symptoms in Climacteric Syndrome, including deprementia(50.7%)、anxiety(83.7%)、restlessness (85.2%)、hyposexuality(55.0%)、vagina abnormality(53.5%), which indicates that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.
6. There is statistical significance in scores of PF, RP、VT、RE、MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function、body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role、mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role、mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period.
引文
[1]周佩英.更年期综合征定义及相关概念[J].中国社区医师,2003,19(8)：7-8.
[2]曾敬光.中医妇科学[M].北京：人民卫生出版社,1986：182.
[3]陈佑邦.中医病症诊断疗效标准[M].南京：南京大学出版社,1994：66.
[4]高章武.浅淡更年期综合征的中医辨证施治[J].甘肃中医,1994,7(2)：39.
[5]邹秀峰.辨证治疗女性更年期综合征56例[J].江苏中医,1997,18(8)：19.
[6]胡文凤.辨证治疗女性更年期综合征70例临床研究[J].北京中医,1997,(3)：26.
[7]史爱国,杜补红.辨证治疗更年期综合征[J].光明中医,1996,13(2)：45.
[8]宋卓敏.更年期综合征的辨治[J].天津中医学院学报,1998,17(3)：12.
[9]任世章.更年期综合征辨治七法[J].中华实用中西医杂志,2004,17(6)：886-886.
[10]罗元恺.妇女更年期综合征的中医治疗[J].新中医,1992,24(1)：16.
[11]李义方,熊超.从肾虚挟瘀论治更年期综合征[J].吉林中医药,1998, (3)：29.
[12]张大英.更年期综合征55临床分析[J].天津中医,1994,11(3)：7.
[13]钱丽旗.姜坤从肝论治更年期综合征[J].江苏中医,1997,18(8)：8.
[14]王桂生.妇女绝经前后诸证从肝论治106例临床研究[J].光明中医,1994,11(5)：22.
[15]李庆生.治疗妇女更年期综合征应重视柔肝疏肝、气阴双调[J].云南中医中药杂志,1997,18(3)：4.
[16]叶燕萍.更年期综合征辨证分型的研究[J].新中医,2000,32(9)：26.
[17]程文.绝经前后诸证发病机理与阴虚学说陕西中医[J].1994,15(2)：67.
[18]李晓丽,宋振华.近十年来中医治疗妇女更年期综合征概述[J].山东中医学院学报,1993,17(6)：59.
[19]王俊青.妇女更年期综合征辨证施治[J].陕西中医,1993,14(1)：41.
[20]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18(4)：25.
[21]徐伟,徐秀芬.妇女更年期综合征的中医辨证分型及临床治疗[J].内蒙古医学志,2001,36(12)：1028-1029.
[22]汪明.妇女更年期综合征的辨证施治[J].黔南民族师范学院学报,2001,5(3)：82-83.
[23]王小云,沈碧琼.更年期综合征临床辨治思路[J].黑龙江中医药,2001,(2)：8-9.
[24]高景丽.妇女更年期综合征的辨证论治探析[J].辽宁中医杂志,2003,30(4)：294.
[25]申春悌,张华强.400例更年期综合征临床证候辨证标准现场调查分析[J].中国中西医结合杂志,2004,24(6)：517-520.
[26]蔡新,余清.更年期妇女证型与性激素关系的探讨[J].中华实用中西医杂志,2006,19(3)： 355-35.
[27]李力,任婕.更年期综合征中医证候及证候要素分布特点的文献分析[J].中华中医药杂志,2008,23(3)：194-197.
[28]楼营.足部按摩巧治更年期综合征[J].养生月刊,2009,3：4-7.
[29]张弛,周章玲.耳穴贴压治疗更年期综合征的疗效分析[J].中国中医药现代远程教育,2009,7(9)：179.
[30]王轶岩,赵长凤,李岩.针刺加耳穴贴压治疗妇女更年期综合征48例[J].光明中医,2009,24(9)：1731.
[31]慕化民.以“流注八穴”为主治疗更年期综合征87例[J].实用中医药杂志,1994,(5)： 21.
[32]李国安,俞吟.针刺治疗女性更年期综合征的临床研究[J].上海针灸杂志,2002,21(3)： 6.
[33]陈园秀,赵晓峰.针刺治疗更年期综合征300例临床研究[J].天津中医学院学报,2002,21(2)：20.
[34]张永刚,李瓦里,李庆云,等.针刺治疗女性更年期综合征肝肾阴虚证65例临床观察[J]。针灸临床杂志,2002,18(11)：24.
[35]刘方土。针刺治疗女性更年期综合征36例[J].江西中医药,2002,21(2)：20·
[36]孙良君.灸法治疗更年期功能性子官出血25例[J].中国针灸,1996,16(10)：49·
[37]叶运英.壮医药线灸治疗更年期功能性子宫出血66例[J].中国针灸,2000,20(4)：244.
[38]李芳莉.灸脐治疗女性更年期综合征的临床观察[J].中国针灸,2004,24(10)：689·
[39]唐碧漪.耳穴贴压治疗更年期综合征30例[J].上海针灸杂志,2002,21(2)：21·
[40]孙冬梅,单秋华,吴富东.耳穴贴压与针刺治疗女性更年期综合征疗效对比观察[J]·上海针灸杂志,2003,22(9)：38-40.
[41]段峻英.穴位埋线治疗更年期综合征68例[J].上海针灸杂志,2005,24(8)：3·
[42]丁习艺.穴位注射治疗更年期综合征31例[J].上海针灸杂志,2000,19(3)：15·
[43]曾振秀,罗惠萍.穴位注射治疗妇女更年期综合征38例观察[J].中医药学刊,2001,19：524.
[44]秦婵娟,秦耀娟.自拟宁坤汤治疗更年期综合征80例[J].光明中医,2009,24(9)：1717.
[45]周碧霞,陈岚.自拟妇更汤治疗更年期综合征疗效观察[J].中国乡村医药杂志,2009,16(10)：52-53.
[46]何小明,安洪泽.滋肾疏肝饮治疗更年期综合征76例小结[J].中医药导报,2010,16(2)：33-34.
[47]吴风霞.知母别甲六味汤治疗更年期综合征的体会[J].陕西中医学学报,2001,24(2)： 25.
[48]李向爽,向连敬,胡家才,等.更年康汤治疗更年期综合征200例[J].中医杂志,2001,42(1)：57.
[49]周云翔,殷养国,韩祖成.补肾安更汤治疗女性更年期综合征37例[J].陕西中医,2001,22(6)：325.
[50]吕雪平,王晓丽,从惠芳.更年灵治疗更年期综合征70例[J].中国中医药信息,1999(2)：57.
[51]朱文仙.滋水清肝饮治疗更年期综合征96例[J].中医杂志,2000,41(8)：459.
[52]毛秋芝.“更年健”对更年期综合征生殖内分泌的影响[J].上海中医药杂志,1993,21(1)： 14.
[53]李艳菊.女性更年期综合征从瘀辨证的体会[J].中国中医药信息杂志,2000,(9)：74.
[54]王萍.综合治疗女性更年期综合征[J].中华现代中西医杂志,2003,6(1)：13.
[55]寇东升,寇学良,吴建华.加味知柏地黄汤治疗更年期综合征80例[J].现代中医药,2009,29(6)：41.
[56]林梅,蔡俊.加味甘麦大枣汤治疗更年期综合征60例临床疗效观察[J].临床研究,2009,18(22)：103.
[57]胡然,胡思荣.桃花清心胶囊治疗更年期综合征的临床研究[J].湖北中医杂志,2009,31(11)：47-48.
[58]孙艳明.更年期综合征54例临床辨治体会[J].天津中医,1999,16(5)：19.
[59]陈晓明.分型辨治更年期综合征126例[J].甘肃中医学院学报,1998,15(3)：30.
[60]周琼.辨证治疗更年期综合征96例疗效观察[J].云南中医中药杂志,2004,25(3)：9-10.
[61]徐惠群,胡争艳.滋阴补肾、安神活血法治疗更年期综合征85例疗效观察[J].上海中医药杂志,2005,39(7)：31-32.
[62]夏兴云.辨证治疗更年期综合征200例[J].中华实用中西医杂志,2004,4(17)：1872-1873.
[63]周瑞华.辨证分型治疗更年期综合征105例临床分析[J].山西职工医学院学报,2003,13(1)：37-38.
[64]冯如兰,肖枚生.中医中药治疗更年期综合征60例[J].现代中西医结合杂志,2010,19(11)：1369.
[65]赫伟彦,姜坤.女性更年期综合征的辨证治疗[J].长春中医学院学报,2003,19(4)：36.
[66]郭毓芳.更年期综合征临床论治[J].青海医学杂志(中医药专辑),1992,29(11)：30.
[67]王小云.路志正教授从湿论治更年期综合征经验介绍[J].新中医,2003,35(7)：
12-13.
[68]张桂玲,申宏.从肾论治更年期综合征[J].甘肃中医学院学报,2000,17(2)：32.
[69]罗元恺.以补肾为主治疗更年期综合征的临床及实践研究[J].中国中西医综合杂志,1994,14(7)：396.
[70]崔明.中医辨证治疗更年期综合征患者的诊治体会[J].中国现代药物应用,2009,3(20)：57-58.
[71]翟永莉.中医辨证治疗女性更年期综合征81例[J].中医与中西医结合,2010,17(3)： 37.
[72]徐苓.妇产科学进展[M].长春出版社,2001：133.
[73]日润虎,刘志诚.女性更年期综合征的中西医认识[J].现代中西医结合杂志,2003,12(13)：1443.
[74]娄友群,江虹.激素替代疗法与药物选择[J].首都医药,1999,8：21-22·
[75]乐杰.妇产科学[M].第五版.人民卫生版社,2001：382-384.
[76]朗景和.更年期综合征中国农村医学[J].1983,C(1)：37-38.
[77]闫琳丽.围绝经期卵巢功能及老化机制的研究[J].国外医学妇产科学分册,1996,23(5)：262-265.
[78]王淑贞.妇产科理论与实践[M].上海科学技术出版社,1995：79.
[79]林守清,林萍,姜玉新,等.绝经后卵巢和子宫萎缩及血雌二醇降低的观察[J].中华妇产科杂志,1997,32(9)：524-527.
[80]吕述军,吕述彦,吕天河,等.血清FSH, LH, E2检测对女性围绝经期的诊断[J].标记免疫与临床,2001,8(1)：58.
[81]张雅萍,王秀霞.坤宁安丸对更年期综合征患者生殖内分泌-免疫功能的影响[J]·中医药信息,2001,18(3)：52-55.
[82]刘宏艳,王滨.电针对更年期大鼠神经内分泌免疫网络的影响[J].江苏中医药,2003,24(1)：49-51.
[83]李大金.更年期综合征生殖内分泌-免疫功能[M].上海医学,1996,19(1)：42·
[84]王跃清.p-内啡肽对更年期妇女潮热的影响[J].实用妇产科杂志,1999,15(6)：321.
[85]江仙远,夏振信.更年平调液对女性更年期综合征患者血浆儿茶酚胺的影响[J].新中医,2003,27(1)：63.
[86]步世忠,孙梅,张沅,等.更年健上调老年雌性大鼠下丘脑雌激素受体mRNA表达对P物质和β-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28-30.
[87]陈亚琼,叶雪清.血浆吲哚类神经递质与更年期综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41-42.
[88]陈亚琼,吕小峰,黄艳红.绝经后潮热妇女血浆5-经色胺前体及代谢产物水平的
变化[J].中华妇产科杂志,2002,37(2)：726-728.
[89]鲁遂荣,方学韫.更年平调液对更年期大鼠自由基影响的实验研究[J].中国中医基础医学杂志,1998,4(8)：35-37.
[90]方玉荣,王立金,周昕.围绝经期妇女血清性激素水平与自由基、血脂含量的变化[J].实用妇产科杂志,2004,20(3)：151152.
[91]方玉荣,王立金,周听.围绝经期妇女血清性激素水平与自由基、血脂含量的变化[J].实用妇产科杂志,2004,20(3)：151-152.
[92]王莉,梅祖敏,田禾,等.循环一氧化氮在月经周期的变化[J].现代妇产科进展,1999,8(2)：152.
[93]曹泽毅.中华妇产科学[M].北京：人民卫生出版社,1999：2271-2311.
[94]糜若然.妇产科疾病的诊断治疗学[M].北京中国医药科技出版社,2000：839.
[95]林守清.女性围绝经期激素治疗国内外近期临床应用进展[J].中国实用妇科与产科杂志,2006,22(1)：23-25.
[96]林守清.激素补充治疗临床应用指南[J].实用妇产科杂志,2004,20(3)：136-137.
[97]林守清,宫伟雁,陈瑛.更年期性激素治疗的进展—介绍国际临床应用最新指南[M].国外医学妇幼保健分册,2005,16(5)：318-319.
[98]梁文郁.中西医结合防治更年期综合征[J].中国中医基础医学杂志,1999,5(3)：57.
[99]许丽绵,欧阳惠卿,卢如玲.更年期综合征病因病机及其证治述要[J].中医药学刊,2003,21(9)：1550-1553.
[100]赵可宁.初探夏桂成防治更年期综合征特色[J].南京中医药大学学报(自然科学版),2000,16(3)：178.
[101]崔国玲,杨慧萍.甘温除热法治疗更年期综合征30例[J].山东中医杂志,1996,15(12)：544.
[102]王晖,王健康.敛补肝气法治疗更年期综合征探讨[J].浙江中医学院学报,1997,21(1)： 18.
[103]孙静,胥受元.从肝论治更年期综合征的经验[J].江西中医药,2003,34(1)：9.
[104]傅淑平,张荣华,蔡字,等.从肾虚血瘀论治更年期综合征[J].陕西中医,2005,26(5)：435-436.
[105]杜莹.浅议更年期功血的辨证思路[J].新中医,2006,38(8)：3-4.
[106]潘善余.更年期综合征的中医认识与防治[J].浙江中医学院学报,2006,30(1)：53-55.
[107]吴秀艳,王天芳.中医证候诊断标准的研究思路[J].新中医,2007,39(3)：1-3.
[108]李燕.270例女性更年期综合征中医证候要素的临床研究[C].湖北中医学院09年硕士学位论文,2009：7.
[109]李力,任婕,杜彩凤,等.更年期综合征中医证候及证候要素分布特点的文献分析[J].中华中医药杂志,2008,23(3)：194-197.
[110]陈家旭,万霞,胡立胜.围绝经期综合征辨证分型的文献研究[J].中华中医药杂志,2006,21(11)：649-651.
[111]姬淑琴.从肝肾论治绝经前后诸证80例[J].山东中医杂志,2006,25(5)：323-324.
[112]王皋俊.从肝肾论治更年期综合征202例[J].中国中医急症,2006,15(5)：545-546.
[113]曲洪芳,陈书勘,李国海,等.更年期综合征妇女心理健康状况分析[J].中国健康心理学杂志,2007,15(8)：703-704.
[114]王伟炳,徐飚,栾荣生,等.中国三城市更年期综合征门诊妇女抑郁和焦虑症状现况调查[J].卫生研究,2008,37(2)：211-213.
[15]牛娜,陈长香.婚姻状况对妇女更年期综合征及抑郁症的影响[J].中华现代护理杂志,2008,14(23)：2462-2463.
[116]赵更力,王向群,王临虹,等.妇女个性特征与更年期综合征初探[J].中国心理卫生杂志,1998,12(3)：136-137.
[2]曾敬光.中医妇科学[M].北京：人民卫生出版社,1986：182.
[3]陈佑邦.中医病症诊断疗效标准[M].南京：南京大学出版社,1994：66.
[4]高章武.浅淡更年期综合征的中医辨证施治[J].甘肃中医,1994,7(2)：39.
[5]邹秀峰.辨证治疗女性更年期综合征56例[J].江苏中医,1997,18(8)：19.
[6]胡文凤.辨证治疗女性更年期综合征70例临床研究[J].北京中医,1997,(3)：26.
[7]史爱国,杜补红.辨证治疗更年期综合征[J].光明中医,1996,13(2)：45.
[8]宋卓敏.更年期综合征的辨治[J].天津中医学院学报,1998,17(3)：12.
[9]任世章.更年期综合征辨治七法[J].中华实用中西医杂志,2004,17(6)：886-886.
[10]罗元恺.妇女更年期综合征的中医治疗[J].新中医,1992,24(1)：16.
[11]李义方,熊超.从肾虚挟瘀论治更年期综合征[J].吉林中医药,1998, (3)：29.
[12]张大英.更年期综合征55临床分析[J].天津中医,1994,11(3)：7.
[13]钱丽旗.姜坤从肝论治更年期综合征[J].江苏中医,1997,18(8)：8.
[14]王桂生.妇女绝经前后诸证从肝论治106例临床研究[J].光明中医,1994,11(5)：22.
[15]李庆生.治疗妇女更年期综合征应重视柔肝疏肝、气阴双调[J].云南中医中药杂志,1997,18(3)：4.
[16]叶燕萍.更年期综合征辨证分型的研究[J].新中医,2000,32(9)：26.
[17]程文.绝经前后诸证发病机理与阴虚学说陕西中医[J].1994,15(2)：67.
[18]李晓丽,宋振华.近十年来中医治疗妇女更年期综合征概述[J].山东中医学院学报,1993,17(6)：59.
[19]王俊青.妇女更年期综合征辨证施治[J].陕西中医,1993,14(1)：41.
[20]毛凤仙.更年期综合征与冲任二脉[J].河南中医,1998,18(4)：25.
[21]徐伟,徐秀芬.妇女更年期综合征的中医辨证分型及临床治疗[J].内蒙古医学志,2001,36(12)：1028-1029.
[22]汪明.妇女更年期综合征的辨证施治[J].黔南民族师范学院学报,2001,5(3)：82-83.
[23]王小云,沈碧琼.更年期综合征临床辨治思路[J].黑龙江中医药,2001,(2)：8-9.
[24]高景丽.妇女更年期综合征的辨证论治探析[J].辽宁中医杂志,2003,30(4)：294.
[25]申春悌,张华强.400例更年期综合征临床证候辨证标准现场调查分析[J].中国中西医结合杂志,2004,24(6)：517-520.
[26]蔡新,余清.更年期妇女证型与性激素关系的探讨[J].中华实用中西医杂志,2006,19(3)： 355-35.
[27]李力,任婕.更年期综合征中医证候及证候要素分布特点的文献分析[J].中华中医药杂志,2008,23(3)：194-197.
[28]楼营.足部按摩巧治更年期综合征[J].养生月刊,2009,3：4-7.
[29]张弛,周章玲.耳穴贴压治疗更年期综合征的疗效分析[J].中国中医药现代远程教育,2009,7(9)：179.
[30]王轶岩,赵长凤,李岩.针刺加耳穴贴压治疗妇女更年期综合征48例[J].光明中医,2009,24(9)：1731.
[31]慕化民.以“流注八穴”为主治疗更年期综合征87例[J].实用中医药杂志,1994,(5)： 21.
[32]李国安,俞吟.针刺治疗女性更年期综合征的临床研究[J].上海针灸杂志,2002,21(3)： 6.
[33]陈园秀,赵晓峰.针刺治疗更年期综合征300例临床研究[J].天津中医学院学报,2002,21(2)：20.
[34]张永刚,李瓦里,李庆云,等.针刺治疗女性更年期综合征肝肾阴虚证65例临床观察[J]。针灸临床杂志,2002,18(11)：24.
[35]刘方土。针刺治疗女性更年期综合征36例[J].江西中医药,2002,21(2)：20·
[36]孙良君.灸法治疗更年期功能性子官出血25例[J].中国针灸,1996,16(10)：49·
[37]叶运英.壮医药线灸治疗更年期功能性子宫出血66例[J].中国针灸,2000,20(4)：244.
[38]李芳莉.灸脐治疗女性更年期综合征的临床观察[J].中国针灸,2004,24(10)：689·
[39]唐碧漪.耳穴贴压治疗更年期综合征30例[J].上海针灸杂志,2002,21(2)：21·
[40]孙冬梅,单秋华,吴富东.耳穴贴压与针刺治疗女性更年期综合征疗效对比观察[J]·上海针灸杂志,2003,22(9)：38-40.
[41]段峻英.穴位埋线治疗更年期综合征68例[J].上海针灸杂志,2005,24(8)：3·
[42]丁习艺.穴位注射治疗更年期综合征31例[J].上海针灸杂志,2000,19(3)：15·
[43]曾振秀,罗惠萍.穴位注射治疗妇女更年期综合征38例观察[J].中医药学刊,2001,19：524.
[44]秦婵娟,秦耀娟.自拟宁坤汤治疗更年期综合征80例[J].光明中医,2009,24(9)：1717.
[45]周碧霞,陈岚.自拟妇更汤治疗更年期综合征疗效观察[J].中国乡村医药杂志,2009,16(10)：52-53.
[46]何小明,安洪泽.滋肾疏肝饮治疗更年期综合征76例小结[J].中医药导报,2010,16(2)：33-34.
[47]吴风霞.知母别甲六味汤治疗更年期综合征的体会[J].陕西中医学学报,2001,24(2)： 25.
[48]李向爽,向连敬,胡家才,等.更年康汤治疗更年期综合征200例[J].中医杂志,2001,42(1)：57.
[49]周云翔,殷养国,韩祖成.补肾安更汤治疗女性更年期综合征37例[J].陕西中医,2001,22(6)：325.
[50]吕雪平,王晓丽,从惠芳.更年灵治疗更年期综合征70例[J].中国中医药信息,1999(2)：57.
[51]朱文仙.滋水清肝饮治疗更年期综合征96例[J].中医杂志,2000,41(8)：459.
[52]毛秋芝.“更年健”对更年期综合征生殖内分泌的影响[J].上海中医药杂志,1993,21(1)： 14.
[53]李艳菊.女性更年期综合征从瘀辨证的体会[J].中国中医药信息杂志,2000,(9)：74.
[54]王萍.综合治疗女性更年期综合征[J].中华现代中西医杂志,2003,6(1)：13.
[55]寇东升,寇学良,吴建华.加味知柏地黄汤治疗更年期综合征80例[J].现代中医药,2009,29(6)：41.
[56]林梅,蔡俊.加味甘麦大枣汤治疗更年期综合征60例临床疗效观察[J].临床研究,2009,18(22)：103.
[57]胡然,胡思荣.桃花清心胶囊治疗更年期综合征的临床研究[J].湖北中医杂志,2009,31(11)：47-48.
[58]孙艳明.更年期综合征54例临床辨治体会[J].天津中医,1999,16(5)：19.
[59]陈晓明.分型辨治更年期综合征126例[J].甘肃中医学院学报,1998,15(3)：30.
[60]周琼.辨证治疗更年期综合征96例疗效观察[J].云南中医中药杂志,2004,25(3)：9-10.
[61]徐惠群,胡争艳.滋阴补肾、安神活血法治疗更年期综合征85例疗效观察[J].上海中医药杂志,2005,39(7)：31-32.
[62]夏兴云.辨证治疗更年期综合征200例[J].中华实用中西医杂志,2004,4(17)：1872-1873.
[63]周瑞华.辨证分型治疗更年期综合征105例临床分析[J].山西职工医学院学报,2003,13(1)：37-38.
[64]冯如兰,肖枚生.中医中药治疗更年期综合征60例[J].现代中西医结合杂志,2010,19(11)：1369.
[65]赫伟彦,姜坤.女性更年期综合征的辨证治疗[J].长春中医学院学报,2003,19(4)：36.
[66]郭毓芳.更年期综合征临床论治[J].青海医学杂志(中医药专辑),1992,29(11)：30.
[67]王小云.路志正教授从湿论治更年期综合征经验介绍[J].新中医,2003,35(7)：
12-13.
[68]张桂玲,申宏.从肾论治更年期综合征[J].甘肃中医学院学报,2000,17(2)：32.
[69]罗元恺.以补肾为主治疗更年期综合征的临床及实践研究[J].中国中西医综合杂志,1994,14(7)：396.
[70]崔明.中医辨证治疗更年期综合征患者的诊治体会[J].中国现代药物应用,2009,3(20)：57-58.
[71]翟永莉.中医辨证治疗女性更年期综合征81例[J].中医与中西医结合,2010,17(3)： 37.
[72]徐苓.妇产科学进展[M].长春出版社,2001：133.
[73]日润虎,刘志诚.女性更年期综合征的中西医认识[J].现代中西医结合杂志,2003,12(13)：1443.
[74]娄友群,江虹.激素替代疗法与药物选择[J].首都医药,1999,8：21-22·
[75]乐杰.妇产科学[M].第五版.人民卫生版社,2001：382-384.
[76]朗景和.更年期综合征中国农村医学[J].1983,C(1)：37-38.
[77]闫琳丽.围绝经期卵巢功能及老化机制的研究[J].国外医学妇产科学分册,1996,23(5)：262-265.
[78]王淑贞.妇产科理论与实践[M].上海科学技术出版社,1995：79.
[79]林守清,林萍,姜玉新,等.绝经后卵巢和子宫萎缩及血雌二醇降低的观察[J].中华妇产科杂志,1997,32(9)：524-527.
[80]吕述军,吕述彦,吕天河,等.血清FSH, LH, E2检测对女性围绝经期的诊断[J].标记免疫与临床,2001,8(1)：58.
[81]张雅萍,王秀霞.坤宁安丸对更年期综合征患者生殖内分泌-免疫功能的影响[J]·中医药信息,2001,18(3)：52-55.
[82]刘宏艳,王滨.电针对更年期大鼠神经内分泌免疫网络的影响[J].江苏中医药,2003,24(1)：49-51.
[83]李大金.更年期综合征生殖内分泌-免疫功能[M].上海医学,1996,19(1)：42·
[84]王跃清.p-内啡肽对更年期妇女潮热的影响[J].实用妇产科杂志,1999,15(6)：321.
[85]江仙远,夏振信.更年平调液对女性更年期综合征患者血浆儿茶酚胺的影响[J].新中医,2003,27(1)：63.
[86]步世忠,孙梅,张沅,等.更年健上调老年雌性大鼠下丘脑雌激素受体mRNA表达对P物质和β-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28-30.
[87]陈亚琼,叶雪清.血浆吲哚类神经递质与更年期综合征症状的相关分析[J].中华妇产科杂志,1996,31(1)：41-42.
[88]陈亚琼,吕小峰,黄艳红.绝经后潮热妇女血浆5-经色胺前体及代谢产物水平的
变化[J].中华妇产科杂志,2002,37(2)：726-728.
[89]鲁遂荣,方学韫.更年平调液对更年期大鼠自由基影响的实验研究[J].中国中医基础医学杂志,1998,4(8)：35-37.
[90]方玉荣,王立金,周昕.围绝经期妇女血清性激素水平与自由基、血脂含量的变化[J].实用妇产科杂志,2004,20(3)：151152.
[91]方玉荣,王立金,周听.围绝经期妇女血清性激素水平与自由基、血脂含量的变化[J].实用妇产科杂志,2004,20(3)：151-152.
[92]王莉,梅祖敏,田禾,等.循环一氧化氮在月经周期的变化[J].现代妇产科进展,1999,8(2)：152.
[93]曹泽毅.中华妇产科学[M].北京：人民卫生出版社,1999：2271-2311.
[94]糜若然.妇产科疾病的诊断治疗学[M].北京中国医药科技出版社,2000：839.
[95]林守清.女性围绝经期激素治疗国内外近期临床应用进展[J].中国实用妇科与产科杂志,2006,22(1)：23-25.
[96]林守清.激素补充治疗临床应用指南[J].实用妇产科杂志,2004,20(3)：136-137.
[97]林守清,宫伟雁,陈瑛.更年期性激素治疗的进展—介绍国际临床应用最新指南[M].国外医学妇幼保健分册,2005,16(5)：318-319.
[98]梁文郁.中西医结合防治更年期综合征[J].中国中医基础医学杂志,1999,5(3)：57.
[99]许丽绵,欧阳惠卿,卢如玲.更年期综合征病因病机及其证治述要[J].中医药学刊,2003,21(9)：1550-1553.
[100]赵可宁.初探夏桂成防治更年期综合征特色[J].南京中医药大学学报(自然科学版),2000,16(3)：178.
[101]崔国玲,杨慧萍.甘温除热法治疗更年期综合征30例[J].山东中医杂志,1996,15(12)：544.
[102]王晖,王健康.敛补肝气法治疗更年期综合征探讨[J].浙江中医学院学报,1997,21(1)： 18.
[103]孙静,胥受元.从肝论治更年期综合征的经验[J].江西中医药,2003,34(1)：9.
[104]傅淑平,张荣华,蔡字,等.从肾虚血瘀论治更年期综合征[J].陕西中医,2005,26(5)：435-436.
[105]杜莹.浅议更年期功血的辨证思路[J].新中医,2006,38(8)：3-4.
[106]潘善余.更年期综合征的中医认识与防治[J].浙江中医学院学报,2006,30(1)：53-55.
[107]吴秀艳,王天芳.中医证候诊断标准的研究思路[J].新中医,2007,39(3)：1-3.
[108]李燕.270例女性更年期综合征中医证候要素的临床研究[C].湖北中医学院09年硕士学位论文,2009：7.
[109]李力,任婕,杜彩凤,等.更年期综合征中医证候及证候要素分布特点的文献分析[J].中华中医药杂志,2008,23(3)：194-197.
[110]陈家旭,万霞,胡立胜.围绝经期综合征辨证分型的文献研究[J].中华中医药杂志,2006,21(11)：649-651.
[111]姬淑琴.从肝肾论治绝经前后诸证80例[J].山东中医杂志,2006,25(5)：323-324.
[112]王皋俊.从肝肾论治更年期综合征202例[J].中国中医急症,2006,15(5)：545-546.
[113]曲洪芳,陈书勘,李国海,等.更年期综合征妇女心理健康状况分析[J].中国健康心理学杂志,2007,15(8)：703-704.
[114]王伟炳,徐飚,栾荣生,等.中国三城市更年期综合征门诊妇女抑郁和焦虑症状现况调查[J].卫生研究,2008,37(2)：211-213.
[15]牛娜,陈长香.婚姻状况对妇女更年期综合征及抑郁症的影响[J].中华现代护理杂志,2008,14(23)：2462-2463.
[116]赵更力,王向群,王临虹,等.妇女个性特征与更年期综合征初探[J].中国心理卫生杂志,1998,12(3)：136-137.
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