猪HOXA10基因的表达调控研究及激素诱导型启动子转基因小鼠与猪的制备与鉴定
|
摘要
产仔数性状的改良可以为养猪业带来巨大的经济效益。研究影响产仔数性状的重要候选基因的功能并应用于育种实践的工作已引起育种工作者们越来越多的重视。利用转基因动物技术进行母猪产仔数性状的改良具有广阔的发展前景。同源异形框基因HOXA10是近年来受到广泛关注的产仔数性状重要候选基因之一。转录因子HOXA10对子宫内膜的分化发育和胚胎附植的建立以及正常妊娠的维持的调控都起到必不可少的关键作用,并且受到雌激素(E2)和孕激素(P4)的调节而对产仔数产生影响。然而,关于猪HOXA10基因的转录调控研究很少。鉴于HOXA10基因在胚胎附植过程中的重要功效,我们对猪HOXA10基因的表达和调控机理进行了初步研究,并制备了转HOXA10基因动物模型。
本研究主要结果如下：
1.克隆获得了猪HOXA10基因包含完整CDS区域的cDNA序列(1363bp)并分析了其基因组的结构。HOXA10基因含有两个外显子和一个内含子；cDNA全长2628bp; CDS长1236bp编码411个氨基酸,其氨基酸序列与人类和小鼠同源性分别达90%和95%,发现氨基酸序列中存在一个同源结构域；
2.发现了2个猪HOXA10基因的SNP位点,其中一个位于第一外显子上。该外显子MslI多态位点的等位基因频率在国内外不同品种猪中的存在显著差异；性状关联分析结果显示,HOXA10基因SNP位点与母猪总产仔数显著相关,与产活仔数和初生重呈极显著相关；
3. RT-PCR结果显示猪HOXA10基因在子宫内膜组织中高表达,同时在膀胱和肾脏组织中表达量也很高,这一结果与小鼠HOXA10基因组织表达模式一致；定量PCR结果表明,HOXA10基因在不同妊娠时期的梅山猪和大白猪子宫内膜中呈差异表达,其中,在两个品种的各个时期中,妊娠15天的梅山猪子宫内膜中HOXA10基因的表达量最高,并且极显著的高于大白猪妊娠15天的子宫内膜(P<0.01)；而在妊娠50天时,大白猪子宫内膜HOXA10基因的表达量极显著高于梅山猪(P<0.01)；另外大白猪品种内比较,妊娠50天时子宫内膜中HOXA10基因的表达最高；
4. QPCR检测结果显示,腹腔注射2mg孕激素／天,可以显著增加妊娠第5天小鼠子宫内膜中HOXA10基因的表达水平,同时平均胚胎着床数增加1只；
5.利用系列删除载体构建和荧光素酶报告基因活性检测的方法首次鉴定了位于猪HOXA10基因5'上游的一个激素诱导型启动子区域,该启动子区域受到E2的刺激后活性增强；构建HOXA10基因激素诱导型重组载体pc3.1-Pro3-DNA,并且在Ishikawa细胞中验证该重组载体受到E2和P4的诱导后可以上调HOXA10基因的表达；
6.将pc3.1-Pro3-DNA重组载体线性化,利用显微注射法制备了转基因小鼠和转基因猪,并进行了PCR和Southern blot检测,结果共获得5只阳性首建鼠(F0),Southern blot检测出其中2只为阳性。这2只F0代转基因小鼠与野生型小鼠交配用于建系。经PCR和Southern blot检测,获得9只F1代阳性小鼠,阳性率达40.9%。PCR检测获得21只F2代阳性小鼠,阳性率达61.8%。其中对F2代阳性个体RT-PCR检测发现子宫内膜、肾脏和膀胱中均有外源HOXA10基因的表达。经PCR检测F1代和F2代的PCR鉴定结果表明,F0代鼠的转基因可稳定遗传给后代。另外,QPCR检测发现,妊娠第5天的阳性转基因小鼠子宫内膜中外源HOXA10基因的表达量显著高于正常发情第5天的阳性转基因小鼠,同时胚胎附植平均数比非妊娠的转基因小鼠多1只左右。显微注射法第一批共获得33头仔猪,通过PCR与Southern blot检测,得到4头阳性HOXA10转基因猪,阳性率为12.1%。
Improvement of litter size can bring huge economic benefits to pig industry, identification of crucial candidate genes and new approached affecting litter size are very important in pig research..Transgenic technology have a very good prospect in porcine reproductive traits improvement. In a previous study, Homeobox A10(HOXA10) was shown to be one of the most promising candidate genes which play major roles in endometrial differentiation and development, establishing the conditions required for implantation and normal pregnancy maintenance. HOXA10is a well-known transcriptional factor that can be regulated by estrogen (E2) and progesterone (P4). However, little work has focused on the regulation of the porcine HOXA10gene. Considering the important effects of HOXA10on embryo implantation, we investigated its expression and regulation mechanism, also provide theoretical basis and animal model for the improvement of porcine litter size.
The results are as follows:
1. The full-length of coding region of porcine HOXA10was cloned (1363bp), and its genomic structure were defined. HOXA10contains1exons and1intron. The cDNA of porcine HOXA10was2628bp in length, with a CDS of1236bp encoding a peptide of411amino acid residues, which showed90%and95%sequence similarity to that of human and mouse homologues, respectively.
2. Analysis of the DNA sequences of HOXA10revealed2SNPs, one of them is in exon1. Allele frequency of this HOXA10MslI polymorphism revealed great variation between6porcine breeds. Association analyses showed that the MslI polymorphism had significant (P<0.05) association with total number born (TNB), and extremely significant (P<0.01) association with number born alive (NBA) and birth weight (WB);
3. RT-PCR confirmed that the porcine HOXA10gene is highly expressed in the endometrium, bladder and kidney. QPCR showed that the expression of HOXA10was significantly higher on day15of gestation (gd15) in comparison to gd26(P<0.01), gd50(P<0.01) and day15of the estrous cycle (ed15) in the endometrium of Meishan pigs. In contrast, the highest expression in the endometrium of Yorkshire pigs was on gd50. Moreover, the abundance of HOXA10mRNA was the highest on gd15in Meishan pigs than in any other stage tested in the two breeds;
4. QPCR results showed that the endometrial expression of HOXA10is increased when the pregnant mice were injected progesterone (2mg/each per day), and the number of embryo is also increased, but the difference is not significant;
5. Deletion analysis and reporter expression assays identified a promoter region (-1044bp to+18bp) that is responsible for E2and P4-induced HOXA10transcription. Moreover, this promoter region enhanced the E2/P4-induced HOXA10expression in Ishikawa cells.
6. Lineralized pc3.1-Pro3-DNA plasmid was used to microinjection to establish transgenic mice and transgenic pigs. PCR and Southern blot analysis were used to identify the positive transgenic ones. Offspring carrying the foreign HOXA10were identified by PCR, and5of them were confirmed by Southern blot analysis. The two positive transgenic mice (F0) were mated to wild-type mice to establish transgenic lineages. PCR and Southern blot results showed there are9positive transgenic mice in F1, and21positive transgenic mice in F2. The positive transgenic rate was about40.9%and61.8%, respectively. RT-PCR analysis of F2showed that the foreign HOXA10were expressed in endometrium, kidney and bladder of all the ten female lineages. PCR analysis of F1and F2showed that the foreign HOXA10in the2positive Fo mice could be transmitted stably.In addition, QPCR results showed that the endometrial expression of HOXA10is increased significantly in pregnant transgenic mice on d5of gestation compared to the non-pregnant transgenic mice on d5of estrous cycle. Mean while the number of embryo is also increased.
PCR and Southern blotting analysis identified4positive transgenic pigs which carried the foreign HOXA10gene, the positive rate is12.1%.
In conclusion, we identified an E2/P4response element of the porcine HOXA10gene for the first time. Moreover, we assume that the porcine HOXA10gene may affect litter size by regulating implantation. The data from the present study contribute to the mechanism by which the porcine HOXA10gene regulates embryo implantation and prolificacy traits. We also established the hormone-inducible transgenic mice and transgenic pig which provide the animal model for the improvement of little size traits.
本研究主要结果如下：
1.克隆获得了猪HOXA10基因包含完整CDS区域的cDNA序列(1363bp)并分析了其基因组的结构。HOXA10基因含有两个外显子和一个内含子；cDNA全长2628bp; CDS长1236bp编码411个氨基酸,其氨基酸序列与人类和小鼠同源性分别达90%和95%,发现氨基酸序列中存在一个同源结构域；
2.发现了2个猪HOXA10基因的SNP位点,其中一个位于第一外显子上。该外显子MslI多态位点的等位基因频率在国内外不同品种猪中的存在显著差异；性状关联分析结果显示,HOXA10基因SNP位点与母猪总产仔数显著相关,与产活仔数和初生重呈极显著相关；
3. RT-PCR结果显示猪HOXA10基因在子宫内膜组织中高表达,同时在膀胱和肾脏组织中表达量也很高,这一结果与小鼠HOXA10基因组织表达模式一致；定量PCR结果表明,HOXA10基因在不同妊娠时期的梅山猪和大白猪子宫内膜中呈差异表达,其中,在两个品种的各个时期中,妊娠15天的梅山猪子宫内膜中HOXA10基因的表达量最高,并且极显著的高于大白猪妊娠15天的子宫内膜(P<0.01)；而在妊娠50天时,大白猪子宫内膜HOXA10基因的表达量极显著高于梅山猪(P<0.01)；另外大白猪品种内比较,妊娠50天时子宫内膜中HOXA10基因的表达最高；
4. QPCR检测结果显示,腹腔注射2mg孕激素／天,可以显著增加妊娠第5天小鼠子宫内膜中HOXA10基因的表达水平,同时平均胚胎着床数增加1只；
5.利用系列删除载体构建和荧光素酶报告基因活性检测的方法首次鉴定了位于猪HOXA10基因5'上游的一个激素诱导型启动子区域,该启动子区域受到E2的刺激后活性增强；构建HOXA10基因激素诱导型重组载体pc3.1-Pro3-DNA,并且在Ishikawa细胞中验证该重组载体受到E2和P4的诱导后可以上调HOXA10基因的表达；
6.将pc3.1-Pro3-DNA重组载体线性化,利用显微注射法制备了转基因小鼠和转基因猪,并进行了PCR和Southern blot检测,结果共获得5只阳性首建鼠(F0),Southern blot检测出其中2只为阳性。这2只F0代转基因小鼠与野生型小鼠交配用于建系。经PCR和Southern blot检测,获得9只F1代阳性小鼠,阳性率达40.9%。PCR检测获得21只F2代阳性小鼠,阳性率达61.8%。其中对F2代阳性个体RT-PCR检测发现子宫内膜、肾脏和膀胱中均有外源HOXA10基因的表达。经PCR检测F1代和F2代的PCR鉴定结果表明,F0代鼠的转基因可稳定遗传给后代。另外,QPCR检测发现,妊娠第5天的阳性转基因小鼠子宫内膜中外源HOXA10基因的表达量显著高于正常发情第5天的阳性转基因小鼠,同时胚胎附植平均数比非妊娠的转基因小鼠多1只左右。显微注射法第一批共获得33头仔猪,通过PCR与Southern blot检测,得到4头阳性HOXA10转基因猪,阳性率为12.1%。
Improvement of litter size can bring huge economic benefits to pig industry, identification of crucial candidate genes and new approached affecting litter size are very important in pig research..Transgenic technology have a very good prospect in porcine reproductive traits improvement. In a previous study, Homeobox A10(HOXA10) was shown to be one of the most promising candidate genes which play major roles in endometrial differentiation and development, establishing the conditions required for implantation and normal pregnancy maintenance. HOXA10is a well-known transcriptional factor that can be regulated by estrogen (E2) and progesterone (P4). However, little work has focused on the regulation of the porcine HOXA10gene. Considering the important effects of HOXA10on embryo implantation, we investigated its expression and regulation mechanism, also provide theoretical basis and animal model for the improvement of porcine litter size.
The results are as follows:
1. The full-length of coding region of porcine HOXA10was cloned (1363bp), and its genomic structure were defined. HOXA10contains1exons and1intron. The cDNA of porcine HOXA10was2628bp in length, with a CDS of1236bp encoding a peptide of411amino acid residues, which showed90%and95%sequence similarity to that of human and mouse homologues, respectively.
2. Analysis of the DNA sequences of HOXA10revealed2SNPs, one of them is in exon1. Allele frequency of this HOXA10MslI polymorphism revealed great variation between6porcine breeds. Association analyses showed that the MslI polymorphism had significant (P<0.05) association with total number born (TNB), and extremely significant (P<0.01) association with number born alive (NBA) and birth weight (WB);
3. RT-PCR confirmed that the porcine HOXA10gene is highly expressed in the endometrium, bladder and kidney. QPCR showed that the expression of HOXA10was significantly higher on day15of gestation (gd15) in comparison to gd26(P<0.01), gd50(P<0.01) and day15of the estrous cycle (ed15) in the endometrium of Meishan pigs. In contrast, the highest expression in the endometrium of Yorkshire pigs was on gd50. Moreover, the abundance of HOXA10mRNA was the highest on gd15in Meishan pigs than in any other stage tested in the two breeds;
4. QPCR results showed that the endometrial expression of HOXA10is increased when the pregnant mice were injected progesterone (2mg/each per day), and the number of embryo is also increased, but the difference is not significant;
5. Deletion analysis and reporter expression assays identified a promoter region (-1044bp to+18bp) that is responsible for E2and P4-induced HOXA10transcription. Moreover, this promoter region enhanced the E2/P4-induced HOXA10expression in Ishikawa cells.
6. Lineralized pc3.1-Pro3-DNA plasmid was used to microinjection to establish transgenic mice and transgenic pigs. PCR and Southern blot analysis were used to identify the positive transgenic ones. Offspring carrying the foreign HOXA10were identified by PCR, and5of them were confirmed by Southern blot analysis. The two positive transgenic mice (F0) were mated to wild-type mice to establish transgenic lineages. PCR and Southern blot results showed there are9positive transgenic mice in F1, and21positive transgenic mice in F2. The positive transgenic rate was about40.9%and61.8%, respectively. RT-PCR analysis of F2showed that the foreign HOXA10were expressed in endometrium, kidney and bladder of all the ten female lineages. PCR analysis of F1and F2showed that the foreign HOXA10in the2positive Fo mice could be transmitted stably.In addition, QPCR results showed that the endometrial expression of HOXA10is increased significantly in pregnant transgenic mice on d5of gestation compared to the non-pregnant transgenic mice on d5of estrous cycle. Mean while the number of embryo is also increased.
PCR and Southern blotting analysis identified4positive transgenic pigs which carried the foreign HOXA10gene, the positive rate is12.1%.
In conclusion, we identified an E2/P4response element of the porcine HOXA10gene for the first time. Moreover, we assume that the porcine HOXA10gene may affect litter size by regulating implantation. The data from the present study contribute to the mechanism by which the porcine HOXA10gene regulates embryo implantation and prolificacy traits. We also established the hormone-inducible transgenic mice and transgenic pig which provide the animal model for the improvement of little size traits.
引文
1.鲍时华,彭弋峰,林其德(2008).来曲唑对大鼠子宫内膜αvβ3和HOXA10表达的影响.生殖与避孕,28(4),193-197.
2.董方莉,谭丽,郑英(2005).影响子宫内膜接受性的相关因素研究进展.国外医学(计划生育分册).
3.郭瑞霞,王建六,赵丹,王志启,魏丽惠(2005).子宫内膜癌细胞系Ishikawa和HEC-1A细胞雌激素受体表达.中国妇产科临床杂志,272-274,304-323.
4.姜勋平,刘红林,丁家桐,钱云,朱猛进(2008).母猪FSH β基因多态与乳头数的关系研究.中国畜牧兽医,2(3),12-14.
5.赖巧红,章汉旺(2005).Wnt信号传导途径与胚胎着床.国外医学计划生育分册,24(3),116-119.
6.李光全,王立贤,张祥林(2001).猪胎盘效率与繁殖性能的关系.国外畜牧科技,28(6),38-41.
7.刘顺德(1999).基因标记定位在猪数量性状改良中的应用.养猪,(2),28-30.
8.彭中镇,樊斌,朱猛进,赵书红,刘榜(2010).母猪年生产力及其遗传改良.养猪,(6),37-40.
9.彭中镇(2011).猪产仔数的遗传改良.彭中镇文集,174-181.
10.秦鹏春,李云龙,谭景和(2001).哺乳动物胚胎学.北京：科学出版社,389-396.
11.施启顺(2005).猪经济性状主效基因研究进展.动物科学与动物医学,22(9),A-B.
12.宋晓明,杨增明(2004).家畜胚胎着床的分子调控.31(4),20-22.
13.王爱国(2006).现代实用养猪技术(第二版).北京：中国农业出版社,37-40.
14.王建辰,章孝荣(1998).动物生殖调控.合肥：安徽科学技术出版社.60.124,157-168.
15.阳艳,章汉旺(2006). EMX2、HOXA10与子宫内膜容受性.生殖与避孕,26(2),95-98.
16.张忠诚,朱士恩(2004).家畜繁殖学.北京：中国农业出版社,121-132.
17.周晓宁,方梅霞,何小梅,聂庆华,and张细权(2011).猪繁殖候选基因HoxA10的克隆及表达分析.湖南农业大学学报,37(1),60-64.
18.周生建,贾咏存,杨戎,陈晓玲,魏莎莉(2008). HOXa-10基因在小鼠胚胎着床过程中的作用.Acta. Anatomica. Sinica.39(2),248-251.
19.朱丽红,朱瑾(2010). HOXA10在胚胎着床过程中的调控机制Reproduction & Contraception,30(11),769-774.
20.朱作言,克圣,岳峰(1989).转基因鱼模型的建立.中国科学,B(2),147-155.
21. Achache, H., and Revel, A. (2006). Endometrial receptivity markers, the journey to successful embryo implantation. Human Reproduction Update 12,731-746.
22. Akbasa, G., Songa, J., and Taylor, H. (2004). A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES). J. Mol. Biol.340,1013-1023.
23. Albelda, S.M. and Buck, C.A. (1990). Integrins and other cell adhesion molecules. FASEB J.4 (11),2868-2880.
24. Anderson, L.L. (1978). Growth protein Content and distribution of early pig embryos. Anat. Rec.190,143-153.
25. Apiou, F., Flagiello, D., and Cillo, C. (1996). Fine mapping of human Hoxa gene cluster. Cytogenet Cell Genet 73,114-115.
26. Bagot, C.N., Troy, P.J., and Taylor, H.S. (2000). Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Ther.7,1378-1384.
27. Bazer, F.W., Burghardt, R.C., Johnson, G.A., Spencer, T.E., and Wu, G.Y. (2008). Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways. Reproductive Biology 8,179-211.
28. Bazer, F.W., Spencer, T.E., Johnson, G.A., Burghardt, R.C., and Wu, G.Y. (2009). Comparative aspects of implantation. Reproduction 138,195-209.
29. Bazer, F.W., Thatcher, W.W., and Martinat-Botte, F. (1988). Conceptus development in large white and prolific Chinese Meishan pigs. J. Reprod. Fertil.84(1),37-42.
30. Benson, G.V., Lim, H., and Paria, B.C. (1996). Mechanisms of reduced fertility in Hoxa-10 mutant mice:uterine homeosis and loss of maternal Hoxa10 expression. Development 122,2687-2696.
31. Benson, G.V., Nguyen, T.H., and Maas, R.L. (1995). The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol.15(3),1591-1601.
32. Bidanel, Legault J.P., and C. (1986). Experimental and prospective aspects of the utilization of prolific Chinese pig breeds in Europe. Proc 37th Meeting European Assoc Anim. Prod, Budapest.1,104-105.
33. Bidanel, J.P., Caritez, J.C., and Lagant, H. (1990). Ovulation rate and embryonic survival in gilts and sows with variable proportions of Meishan (MS) and Large White (LW) genes. Mean performance and crossbreeding parameters between MS and LW breeds. M. Molenat and C. Legault (Ed.) Chinese Pig Symposium. Institut National de la Recherche Agronomique, Jouy-en-Josas, France,109-110.
34. Biery, K.A., Bondioli, K.R., and Demayo, F.J. (1988). Gene transfer by pronuclear injection in the bovine. Theriogenology 29,224-229.
35. Blair, R.M., Geisert, R.D., Zavy, M.T., Yellin, T., Fulton, R.W., and Short, E.C. (1991). Endometrial surface and secretory alterations associated with embryonic mortality in gilts administered estradiol valerate on days 9 and 10 of gestation. Biol Reprod 44, 1063-1079.
36. Blitek, A.E., Czmarek, M.M., Kiewisz, J., and Ziecik, A.J. (2010a). Endometrial and conceptus expression of HOXA10, transforming growth factor (TGF)-1, leukaemia inhibitory factor (LIF) and prostaglandin H synthase-2 (PGHS-2) in early pregnant pigs with gonadotropin-induced estrus. Domest Anim Endocrinol 38,222-234.
37. Blitek, A., Kiewisz, J., and Waclawik, A. (2010b). Effect of steroids on HOXA10 mRNA and protein expression and prostaglandin production in the porcine endometrium. J. Reprod Dev,56(6),643-648.
38. Blitek, A.E. Morawska, J. Kiewisz, A.J., and Ziecik. (2011). Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation. Theriogenology 76,954-966.
39. Bolet Abstr, G, Martinat-Botte, F., Locatelli, P., Gruand, J., Terqui, M., and Berthelot, F. (1986). Components of prolificacy of hyperprolific Large White sows. Comparison with Meishan and control Large White sows. Genet Sel Evol.18,333-342.
40. Bowen, J.A. and Burghardt, R.C. (2000). Cellular mechanisms of implantation in domestic farm animals. Seminars in Cell and Developmental Biology 2,93-104.
41. Bromleigh, V.C., and Freedman, L.P. (2000). p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev 14,2581-2586
42. Carlos, S., Carlos, M., and Jose, R. (1998). Cytokines and embryo implantation. Reprod. Immunol.39,117-131.
43. Carson, D.D., Bagchi, L. Dey, S.K., Enders. A.C., Fazleabas, A.T., Lessey, B.A., and Yoshinaga K. (2000). Embryo implantation. Dev Biol.223(2),217-237.
44. Cermik, D., Selam, B., and Taylor, H.S. (2003). Regulation of HOXA10 expression by testosterone in vitro and in the endometrium of patientswith polycystic ovary syndrome. J. Clin Endocrinol Metab 88,238-243.
45. Chen, J.C., Wiley, A.A., Ho, T.Y., Frankshun, A.L., Hord, K.M., Bartol, F.F., and Bagnell, C.A. (2010). Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults. Reproduction 139,623-630.
46. Chen, Q., Zhang, Y., Lu, J., Wang, Q, Wang, S.J., Cao Y., Wang, H.B., and Duan, E. (2009). Embryo-uterine cross-talk during implantation:the role of Wnt signaling. Mol Hum Reprod 15,215-221.
47. Cheng, J.G., Rodriguez, C.I., and Stewart, C.L. (2002). Control of uterine receptivity and embryo implantation by steroid hormone regulation of LIF production and LIF receptor activity:towards a molecular understanding of "the window of implantation". Rev Endocr Metab Disord 3,119-126.
48. Cheng, Y.H., Imir, A., Fenkci, V., Yilmaz, M.B., and Bulun, S.E. (2007). Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Spl:a mechanism for defective estradiol metabolism. Am J Obstet Gynecol 196, 391-397.
49. Cordon, J.W. and Scangos, F.H. (1980). Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA (77),7380-7384.
50. Croy, B.A., Wessels, J.M., Linton, N.F., van den Heuvel, M., Edwards, A.K., and Tayade, C. (2009). Cellular and molecular events in early and mid gestation porcine implantation sites:a review. Soc Reprod Fertil Suppl 66,233-244.
51. Cyranoski, D. (2003). Koreans rustle up madness-resistant cows. Nature 426 (6968), 743.
52. Daftary, G., Kayisli, U., Seli, E., Bukulmez, O., Arici, A., and Taylor, H. (2007). Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertil. Steril.87,367-372.
53. Daftary, G.S. and Taylor, H.S. (2004). EMX2 Gene Expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. Clin Endocrinol Metab 89(5),2390-2396.
54. Daftary, G.S. and Taylor, H.S. (2006). Endocrine regulation of HOX genes. Endocrine Reviews 27(4),331-355.
55. Daftary, G.S., Troy, P.J., Bagot, C.N., Young, S.L., and Taylor, H.S. (2002). Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol 16,571-579.
56. Daikoku, T., Tranguch, S., Friedman, D.B., Das, S.K., Smith, D.F., and Dey, S.K., (2004). Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Mol. Endocrinol.19,683-697.
57. Dantzer, V. (1985). Electron microscopy of the initial stages of placentation in the pig. Anatomy and embryology.172(3),281-293.
58. Day, B.N., Anderson, L.L., Emmerson, M.A. (1959). Effect of estrogen and progesterone on early embryonic mortality in ovariectomized gilts. J. Anim. Sci.18, 607-613.
59. Dey, S.K., Lim, H., Das, S.K., Reese, J., Paria, B.C., Daikoku, T., and Wang, H., (2004). Molecular cues to implantation. Endocr. Rev.25,341-373.
60. Dhindsa, D.S. and Dziuk, P.J. (1968). Effect on pregnancy in the pig after killing embryos or fetuses in one uterine horn in early gestation. J. Anim. Sci.27(1), 122-126.
61. Du, H., Daftay, G.S., Lalwani, S.I., and Taylor, H.S. (2005). Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol 19(9),2222-2233.
62. Du, H., Sarno, J.L., and Taylor, H.S. (2006). Basic transcription element binding protein (BTEB1) is regulated by HOXA10 in endometrial cells. J Soc Gynecol Investig 13,71A-72A.
63. Dziuk, P. (1985). Effect of migration, distribution and spacing of pig embryos on pregnancy and fetal survival. Journal of reproduction and fertility.33,57-63.
64. Ferrell, C.M., Dorsam, S.T., and Ohta, H. (2004). Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+human cord blood cells. Stem Cells.23(5),644-655.
65. Ford, J.J. and Howard, H.J. (1997). Activin inhibition of estradiol and progesterone production in porcine granulosa cells. Journal of animal science.75(3),761-766.
66. Foucher, I., Volovitch, M., and Frain, M. (2002). HOXA5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism:evidence for an interaction between HOXA5 and Forkhead boxtranscription factors. Development 129, 4065-4074.
67. Fouladi, N.A.A., Jones, C.J., Nijjar, N. (2005). Characterization of the uterine phenotype during the peri-implantation period for LIF-nul. MF1 strain mice. Dev Biology 281(1),1-21.
68. Garlow, J.E. (2002). Analysis of osteopontin at the marginal-placental interface in pigs. Bi01. Reprod.66(3),718-725.
69. Geisert, R.D. and Yelich, J.V. (1997). Regulation of conceptus development and attachment in pigs. J. Reprod Fertil Suppl 52,133-149.
70. Geisert, R.D., Ross, J.W., Ashworth, M.D., White, F.J., Johnson, G.A., and DeSilva, U. (2006). Maternal recognition of pregnancy signal or endocrine disruptor:the two faces of oestrogen during establishment of pregnancy in the pig. Soc Reprod Fertil Suppl 62, 131-145.
71. Geisert, R.D., Thatcher, W.W., Roberts, R.M., and Bazer, F.W. (1982b). Establishment of pregnancy in the pig:Ⅲ. Endometrial secretory response to estradiol valerate administered on day 11 of the estrous cycle. Biol. Reprod 27,957-965.
72. Godbole, G.B., Modi, D.N., Puri, C.P., (2007). Regulation of Homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. Reproduction 134,513-523.
73. Gray, C.A., Taylor, K.M., Ramsey, W.S., Hill, J.R., Bazer, F.W., Bartol, F.F., and Spencer, T.E. (2001). Endometrial glands are required for pre-implantation conceptus elongation and survival. Biol. Reprod 64,1608-1613.
74. Gui, Y., Zhang, J., Yuan, L., and Lessey, B.A. (1999). Regulation of HOXA10 and its expression in normal and abnormal endometrium. Mol. Hum. Reprod.5,866-873.
75. Guo, B., Tian, Z., Han, B.C., Zhang, X.M., Yang, Z.M., and Yue, Z.P. (2008). Expression and hormonal regulation of HOXA10 in canine uterus during the peri-implantation period. Reprod. Domest. Anim. (October 30, Epub ahead of print).
76. Haley, C.S. and Lee, G.J. (1993). Genetic basis of prolificacy in Meishan pigs. J. Reprod Fertil Suppl 48,247-259.
77. Halhali, A., Acker, G.M. and Garabedian, M. (1991).1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. J. Reprod Fertil 91,59-64.
78. Hamann, H., Steinheuer, R. and Distl, O. (2004). Estimation of genetic parameters for litter size as a sow and boar trait in German herdbook Landrace and Pietrain swine. Livestock Production Science 85(2-3),201-207.
79. Hammer, R.E., Pursel, V.G., and Rexroad, C.E. (1985). Production of transgenic rabbits, sheep and pig by microinjction. Nature 15,680-683.
80. Hanenberg E.H.A.T., Knol E. F., and Merks, J.W.M. (2001). Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livestock Production Science 69(2),179-186.
81. Harvey, M.B., Leco, K.J., Arcellana-Panlilio, M.Y. (1995). Roles of growth factors during peri-implantation development. Mol. Human Repro 10,712-718.
82. Hayashi, K., Erikson, D.W., Tilford, S.A. (2009). Wnt genes in the mouse uterus: potential regu lation of implantation. Biol Reprod 80,989-1000.
83. Hewitt, S.C. and Korach, K.S. (2002). Estrogen receptors:structure, mechanisms and function. Rev Endocr Metab DisorcL 3(3),193-200.
84. Hirota, Y., Daikoku, T., Tranguch, S., Xie, H., Bradshaw, H.B., and Dey, S.K. (2010). Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest 120,803-815.
85. Hochi, S., Ninomiya, T., and Honma, M. (1990). Successful production of transgenic rats. Anim Biotech 1,175-184.
86. Horcajadas, J.A., Pellicer, A., and Simon, C., (2007). Wide genomic analysis of human endometrial receptivity:new times, new opportunities. Hum. Reprod. Update 13,77-86.
87. Hu, W., Feng, Z., Teresky, A.K., and Levine, A.J. (2007). p53 regulates maternal reproduction through LIF. Nature 450,721-724.
88. Huet-Hudson, Y.M., Andrews, G.K., and Dey, S.K. (1989). Cell type-specific localization of c-mycprotein in the mouse uterus:modulation by steroid hormones and analysis of the periimplantation period Endocrinology 125(3),1683-1690.
89. Hugh, S., Taylor, Aydin Arici, David Olive, and Peter Igarashi. (1998). HOXA10 is expressed in Response to Sex Steroids at the Time of Implantation in the Human Endometrium. J. Clin. Invest.7(101),1379-1384.
90. Illera, M.J., Cullinan, E., Gui, Y.T., Yuan, L.W., Beyler, S.A., and Lessey, B.A. (2000). Blockade of the α vβ3 integrin adversely affects implantation in the mouse. Biol. Reprod.62,1285-1290.
91. Jaenisch, R. and Mintz, B. (1974). Simian.virus SV40 DNA sequence in DNA of healthy adult mice derived from preimplantation blastocytes injicted with viral DNA. Proc Ncad Sci USA 74,1250-1254.
92. Jain, M., Tyagi, A.K., and Khurana, J.P. (2008). Genome-wide identification, classification, evolutionary expansion and expression analyses of homeobox genes in rice. FEBS J 275(11),2845-2861.
93. Johnson, G.A., Bazer, F.W., Burghardt, R.C., Spencer, T.E., Wu, G., and Bayless, K.J. (2009). Conceptus-uterus interactions in pigs:endometrial gene expression in response to estrogens and interferons from conceptuses. Soc Reprod Fertil SuppI 66, 321-332.
94. Johnson, R.K., Nielsen, M.K., and Casey, D.S. (1999). Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size. J. Anim. Sci.77,541-557.
95. Kelly, M., Daftary, G., and Taylor, H.S. (2006). An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal of Obstetrics and Gynecology 194,1100-1109.
96. Kennedy, T.G., Gillio-Meina, C., and Phang, S.H. (2007). Prostaglandins and the initiation of blastocyst implantation and decidualization. Reproduction 134,635-643.
97. Kim, J.J., Taylor, H.S., Akbas, G.E., Foucher, I., Trembleau, A., Jaffe, R.C., Fazleabas, A.T., Unterman, T.G. (2003). Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biol. Reprod.68,24-30.
98. Kim, J.J., Taylor, H.S., Lu, Z., Ladhani, O., Hastings, J.M., Jackson, K.S., Wu, Y., Guo, S.W., Fazleabas, A.T. (2007). Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol. Hum. Reprod.13,323-332.
99. Klein-Hittpass, L., Schorpp, M., Wagner, U., and Ryffel, G.U. (1986). An estrogen-responsive element derived from the 5'flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell 46,1053-1061.
100. Knight, J.W. and Kukoly, C.A. (1990). In vitro release of progesterone and estrone by the porcine placenta throughout gestation. Domest Anim Endocrinol 7, 497-508.
101.Knight, J.W. (1994). Aspects of placental estrogen synthesis in the pig. Exp Clin Endocrinol 102,175-184
102.Knorr, C., Uibeleisen, A.C., Kollers, S., Fries, R., and Brenig, B. (2001). Assignment of the homeobox gene (HOXA10) to porcine chromosome SSC18q23>q24 by Fish and confirmution by hybrid panel analyses. Cytogenet cell Genet 93,145-146
103.Kodaman, P.H. and Taylor, H.S. (2004). Hormonal regulation of implantation. Obstet Gynecol Clin North Am 31,745-766.
104.Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78,191-201.
105.Kuroiwa, Y., Kasinathan, P., Choi, Y.J., Naeem, R., and Tomizuka, K. (2002). Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol,20, 889-894.
106.Kuroiwa, Y., Kasinathan, P., Matsushita, H., Sathiyaselan, J., Sullivan, E.J., Kakitani, M., Tomizuka, K., Ishida, I., and Robl, J.M. (2004). Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle. Nat Genet 36,775-780.
107.Lai, L.K-SD., Park, K.W., Cheong, H.T., Greenstein, J.L., Im, G.S., Samuel, M., Bonk, A., Rieke, A., Day, B.N., Murphy, C.N., Carter, D.B., Hawley, R.J., and Prather, R.S. (2002). Production of alpha-1,3-galactosyl transferase knockout pigs by nuclear transfer cloning. Science 295(5557),1089-1092
108.Lai, L., Kang, J.X., and Li, R. (2006). Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat. Biotechnol 24,435-436.
109.Leach, R.E., Khalifa, R., and Ramirez, N.D. (1999). Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. J Clin Endocrinol Metab 84(9),3355-3363.
110.Lee, B., Du, H., and Taylor, H.S. (2009). Experimenta 1 murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod 80,79-85.
111.Lee, J.G., Ritchie, M., Thompson, M., McDonald, A.A., Blasco A., Santacrew, M.A. Argente, M.J., and Haley, C.S. (1995). Uterine capacity and prenatal survival in Meishan and Large White pigs. Anim Sci.60,471-479.
112.Lessey, B.A. (2002). Adhesion molecules and implantation. J. Reprod. Immunol. 55(1-2),101-112.
113.Lessey, B.A., Damjanovich, L., Coutifaris, C., A Castelbaum, Albelda, S.M., and Buck, C.A. (1992). Integrin adhesion molecules in the human endometrium. J. CIin. Invest 90(1),188-195.
114.Lim, H., Ma, L., Ma,W.G, Maas, R.L., and Dey, S.K., (1999). Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Mol. Endocrinol.13,1005-1017.
115.Lim, H.J. and Dey, S.K. (2009). HB-EGF:a unique mediator of embryo uterine interactions during implantation. Exp Cell Res 315,619-626.
116.Linville, R.C., Pomp, D., Johnson, R., and Rothschild, M.F. (2001). Candidate gene analysis for loci affecting litter size and ovulation rate in swine. J. Anlm, Sci.79, 604-607.
117.Liu, X., Zhu, G, and Zhong, G (2007). Regulatory Effect of Estrogen, Progestin and HB-EGF on the Expression of HOXA10 Gene in Ishikawa Cells. Journal of Huazhong University of Science and Technology 27(4),464-467.
118.Lo, D., Pursel, V., and Linton, P.J. (1991). Expression of mouse IgA by transgenic mice, pigs and sheep. Eur. J. Immunol.21(4),1001-1006.
119.Lowney, P., Corral, J., Detmer, K., LeBeau, M.M., Deaven, L., Lawrence, H.J. and Largman, C. (1991). A human Hoxl homeobox gene exhibits myeloidspecific expression of alternative transcripts in human hematopoietic cells. Nucleic Acids Res. 19,3443-3449.
120.Lu, Z., Hardt, J., and Kim, J.J. (2008). Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation. Mol. Hum. Reprod. 14,357-366.
121.Mahmoud, T.H., McCuen, B.W., and Hao, Y. (2003). Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. Graefes Arch. Clin. Exp. Ophtalmol.241(4),298-308.
122.Martin, R., Taylor, M.B., Krikun, G., Lockwood, C., Akbas, G.E. and Taylor, H.S. (2007). Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein-1 Response Elements. J Clin Endocrinol Metab 92(5),1920-1926.
123.McCormack, S.A. and Glasser, S.R. (1980). Differential response of individual uterine cell types from immature rats treated with estradiol. Endocrinology 106, 1634-1649.
124.McGmnis, W., Garber, R.L., and Wirz, J. (1984). A homologous protein-coding sequence in Drosophia homeotic genes and its conservation in other metazoans. Cell 37,403-412.
125.McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68,283-302.
126.Meyer, W.R., Castelbaum, A.J., Somkuti, S., Sagoskin, A.W., Doyle, M., Harrisand, J.E., and Lessey, B.A. (1997). Hydrosalpinges adversely affect markers of endometrial receptivity. Hum. Reprod.12(7),1393-1398.
127.Modi, D. and Godbole, G (2009). HOXA10 signals on the highway through pregnancy. Journal of Reproductive Immunology 83,72-78.
128.Mohamed, O.A., Jonnaert, R.J., Labelle-Dumals, C., Kuroda, K., Clarke, H.J., and Dufort, D. (2005). Uterine Wnt/beta-catenin signaling is required for implantation. Proc Natl Acad Sci. USA.102(24),8579-8584.
129.Mohammad, Q. Hassan, Rahul Tare, Suk Hee Lee, Matthew Mandeville, Brian Weiner, Martin Montecino, Andre, J. van Wijnen, Janet, L. Stein, Gary, S. Stein, and Jane, B. (2007). Lian.HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes. Molecular and Cellular Biology 5, 3337-3352.
130.Muller, M., Brenig, B., and Winnacker, E.L. (1992). Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene 121(2),263-270.
131.Neal, S.M., Johnson, R.K. and Kittok R.J. (1989). Index selection for components of litter size in swine:response to five generations of selection. J. Anim. Sci.67, 1933-1945.
132.Nie, G.Y., Li, Y., and Minoura, H. (2003). A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod 9(5),279-290.
133.Niemann H. (2004). Transgenic pigs expressing plant genes. Proc. natl Acad. Sci. USA 101(19),7211-7212.
134.Nottle M.B., Nagashima H., and Verma P.J. (1999). Production and analysis of transgenic pigs containing a metallothionein porcine growth hormone gene construct. In Transgenic animals in agriculture (Murray, J.D., Anderson, G.B., Oberbauer, A.M., & McGloughlin, M.M., eds). CABI Publishing, New York 145-156.
135.Palmiter, R.D., Brinster, R.E., and Hammer, M.E. (1982). Dramatic growth of mice that develop from eggs microinjected with a metallothionein-growth hormone fusion gene. Nature 300,611-615.
136.Pantos, K., Nikas, G., and Makrakis, E. (2004). Clinical value of endometrial pinopodes detection in artificial donation cycles. Reprod Biomed Online 9(1),86-90.
137.Paria, B.C., Song, H. and Dey, S.K. (2001). Implantation:Molecular basis of embryo-uterine dialogue. International Journal of Developmental Biology 45(3), 597-605.
138.Paria, B.C., Das, S.K., and Dey, S.K. (1998). Embryo implantation requires estrogen-directed uterine preparation and eatecholestrogen-mediated embyronie activation. Adv. PharmacOl 42,840-843.
139.Patrick, J., Troy, Gaurang, S. Daftary, Catherine, N. Bagot, Hugh, S., and Taylor. (2003). Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10. Molecular and cellular biology 1,1-1.
140.Penna, I., Du, H., and Amanda, N. (2010). Endothelin type A receptor (ETA) expression is regulated by HOXA10 in human endometrial stromal cell. Reproductive Sciences 17(5),471-476.
141.Penna, I., Du, H., and Ferriani, R. (2008). Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Hum Reprod 14(10),613-618.
142.Piper, L.E., Bindon, B.M., and Davis, G.H. (1985). The single inheritance of the high litter size of the Boorola Merino. In:Land, R.B., Robinson, and D.W. Genetics of Reproduction in Sheep. Butterworths, London 115-125.
143.Polette, M., Nawroeki, B., Pintiaux, A. (1994). Expression of gelatinases A and B and their tissue inhibitors by cells of early and term human placenta and gestational endometrium. Lab Invest. (71),838-846.
144.Polge, C, Rowson, L.E. and Chang, M.C. (1966). The effect of reducing the number of embryos during early stages of gestation on the maintenance of pregnancy in the pig. Journal of reproduction and fertility 12(2),395-397.
145.Pope, W.F. and First, N.L. (1985). Factors affecting the survival of pig embryos. Theriogenology 23(1),91-105.
146.Pope, W.F. (1994). Embryonic mortality in swine. In:Geisert R.D. and Zavy M.T. Embryonic Mortality in Domestic Species. CRC Press, Boca Raton, FL.53-78.
147.Pursel, V.G., Pinkert, C.A. and Miller, K.F. (1989). Genetic engineering of livestock. Science 244 (4910),1281-1288.
148.Pusateri, A.E., Rothschild, M.F., Warner, C.M., and Ford, S.P. (1990). Changes in morphology, cell number, cell size and cellular estrogen content of individual littermate pig conceptuses on days 9 to 13 of gestation. J Anim Sci 68,3727-3735.
149.Quinn, C.E. and Casper, R.F. (2009). Pinopodes:a questionable role in endometrial receptivity. Hum Reprod Update 15 (2),229-236.
150.Quinn, C.E., Detmar, J., and Casper, R.F. (2007). Pinopodes are present in Lif null and Hoxa10 null mice. Fertil Steril 88 (Suppl 4),1021-1028.
151.Quinn, C., Ryan, E. and Claessens, E.A. (2007). The presence of pinopodes in the human endometrium does not delineate the implantation window. Fertil Steril 87(5), 1015-1021.
152.Rackow, B.W. and Taylor, H.S. (2008). Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil. Steril. (June 12, Epub ahead of print).
153.Radder, H. (2004). Exploiting abstract possibilities:a critique of the concept and practice of product patenting. J. Agric. Environ. Ethics 17(3),275-291.
154.Rao, R.P., Fischer, B., and Seshagiri, P.B. (2008). Embryo-endometrial expression of leukemia inhibitory factor in the golden hamster (Mesocricetus auratus):increased expression during proestrous and window of implantation stages. Reprod Fertil Develop 20(3),440-449.
155.Robl, J.M., Wang, Z., and Kasinathan, P. (2007). Transgenic animal production and animal biotechnology. Theriogenology 67,127-133.
156.Rosario, G.X., Modi, D.N., Sachdeva, G, Manjramkar, D.D., and Puri, C.P. (2005a). Morphological events in the primate endometrium the presence of a preimplantation embryo, detected by the serum preimplantation factor bioassay. Hum. Reprod.20, 61-71.
157.Rosario, G.X., Sachdeva, G, Manjramkar, D.D., Modi, D.N., Meherji, P.K., and Puri, C.P., (2005b). Endometrial expression of immunomodulatory cytokines and their regulators during early pregnancy in bonnet monkeys (Macaca radiata). Hum. Reprod. 20,3039-3046.
158.Rothschild, M.F. and Bidanel, J.P. (1998). Biology and geneties of reproduction. In: The Geneties of the Pig (Ed. by M.F. Rothschild & A. Ruvinsky), CAB International, and Oxon, UK.313-343.
159.Rothschild, M.F., Jacobson, C. and Vaske, D.A. (1994). A major gene for litter size in pigs. Proceeding of the fifth world congress on genetics to livestock production 21, 225-228.
160.Rubin, G.L., Harrold, A.J., Mills, J.A., Falany, C.N., and Coughtrie, M.W. (1999). Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 5, 995-1002.
161.Saito, S. (2000). Cytokine network at the feto-maternal interface. J. Reprod. Immunol. 47,87-103.
162.Sakkas, D., Lu, C., Zulfikaroglu, E., Neuber, E., and Taylor, H.S., (2003). A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line. Fertil. Steril.80,1169-1174.
163.Sanjoy K.D. (2006). Regional development of uterine decidualization:molecular signaling by Hoxa-10. Molecular Reproduction and Development 77,387-396.
164.Sarno, J.L., Kliman, H.J., and Taylor, H.S. (2005). HOXA10, Pbx2, and Meisl protein expression in the human endometrium:formation of multimeric complexes on HOXA10 target genes. J Clin Endocrinol Metab 90,522-528.
165.Sarno, J.L., Schatz, E, Lockwood, C.J., Huang, S.T.J., and Taylor, H.S. (2006). Thrombin and interleukin-1 r regulate HOXA10 expression in human term decidual cells:implications for preterm labor. J Clin Endocrinol Metab 91,2366-2372.
166.Satokata, I., Benson, G, and Maas, R., (1995). Sexually dimorphic sterility phenotypes in Hoxa-10 deficient mice. Nature 374,460-463.
167.Schofield, G, and Kimber, S.J. (2005). Leukocyte subpopulations in the uteri of leukemia inhibitory factor knockout mice during early pregnancy. Biol Reprod 72, 872-878.
168.Scott, MR and Weiner, AJ. (1984). Structural relationships among genes that control development sequence homology between the antenapedia,ultrabithorax and fushi tarazu loci of rosophila. ProcNatl Acad Sci USA 81,4115-4122.
169.Sherwin, J.R., Freeman, T.C., Stephens, R.J., Kimber, S., Smith, A.G., Chambers, I., Smith, S.K., and Sharkey, A.M. (2004). Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation. Mol Endocrinol 18,2185-2195.
170.Simeone, A., Acampora, D., and Nigro, V. (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mechanisms of development 33(3),215-27.
171.Somkuti, S.G., Yuan, L.W., Fritz, M.A. (1997). Epidermal growth factor and sex steroid dynamically regulate a marker of endometrial receptivity Ishikawa cells. J Clin Endoerinol Metab.82(7),2192-2197.
172.Song, H., Lim, H. and Paria, B.C. (2002). Cytosolic phospholipase a 2alpha is crucial [correction of A2alpha deficiency is crucial] foron time embryo implantation that directs subsequent development. Development 129(12),2879-2889.
173.Spotter, A. and Distl, O. (2006). Genetic approaches to the improvement of fertility traits in the pig. The Veterinary Journal.172,234-247.
174.Spotter, A., Drogemuller, C, Hamann, H., and Distl, O. (2005). Evidence of a new leukemia inhibitory factor-associated genetic marker for lifter size in a synthetic pig line. J. Anim. Sci.83,2264-2270.
175.Stavreus-Evers, A., Aghajanova, L. and Brismar, H (2002). Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation. Mo l hum Reprod 8,765-769.
176.Stewart, C.L., Kaspar, P., Brunet, L.J., Bhatt, H., Gadi, I., Kontgen, F., and Abbondanzo, S.J. (1992). Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359,76-79.
177.Stroband, H.W., and Van der Lende, T. (1990). Embryonic and uterine development during early pregnancy in pigs. J Reprod Fertil Suppl 40,261-277.
178.Sun, H., Chen, L. and Yan, G. (2009). HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells. Biochem Biophy Res Communi 379(1),16-21.
179.Svingen, T. and Koopman, P. (2007). Involvement of homeobox genes in mammalian sexual development. Sex Develop 1 (1),12-23.
180.Takiko Daikoku, Haengseok Song, Yong Guo, Anne Riesewijk, Sietse Mosselman, Sanjoyk. Das and Sudhansuk. Dey. (2004). Uterine Msx-1 and Wnt4 Signaling Becomes Aberrant in Mice with the Loss of Leukemia Inhibitory Factor or Hoxa-10: Evidence for a Novel Cytokine-Homeobox-Wnt Signaling in Implantation. Molecular Endocrinology 18(5),1238-1250.
181.Tayade, C., Fang, Y., Hilchie, D., and Croy, B.A. (2007a). Lymphocyte contributions to altered endometrial angiogenesis during early and midgestation fetal loss. J Leukoc Biol 82,877-886.
182.Taylor, H.S., Bagot, C. and Kardana, A. (1999). HOX gene expression is altered in the endometrium of women with endometriosis. Human reproduction 14(5), 1328-1331.
183.Taylor, H.S., Arici, A., Olive, D., and Igarashi, P. (1998). HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest 101,1379-1384.
184.Taylor, H.S. and Fei, X.L. (2005). Emx2 regulates mammalian reproduction by altering endometrial cell proliferation. Mol Endocrinol 19(11),2839-2846.
185.Taylor, H.S., Vanden Heuvel, G.B., and Igarashi P. (1997). A conserved Hox axis in the mouse and human female reproductive system:late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57,1338-1345.
186.Tarraf, C.G. and Knight, J.W. (1995). Effect of uterine space and fetal sex on conceptus development and in vitro release of progesterone and estrone from regions of the porcine placenta throughout gestation. Domest Anim Endocrinol 12,63-71.
187.Tergui, M. (1992). Chinese Pig Symposium. France,19-32.
188.Troy, P.J., Daftary, G.S., and Bagot, C.N. (2003). Transcriptional repression of peri-Implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol 23(1),1-13.
189.Ulberg, L.C. and Rampacek, G.B. (1974). Ebryonic and fetal development:uterine components and influences. J. Anim. Soi 38(5),1013-1017.
190.Valle'e, M., Beaudry, D., Roberge, C., Matte, J.J., Blouin, R. and Palin, M.F.(2003). Isolation of Differentially Expressed Genes in Conceptuses and Endometrial Tissue of Sows in Early Gestation. Biol Reprod 69,1697-1706.
191.Vallet, J.L., Miles, J.R., and Freking, B.A. (2009). Development of the pig placenta. Soc Reprod Fertil Suppl 66,265-279.
192.Vitiello, D., Pinard, R., and Taylor, H.S. (2008). Gene expression profiling reveals putative HOXA10 downstream targets in the periimplantation mouse uterus. Reprod. Sci.15,529-535.
193.Vize, P.D., Michalska, A.E. and Ashman, R. (1988). Introduction of a porcine growth hormone fusion gene into transgenic pigs promotes growth. J. Cell Sci.90:295-300.
194. Wall, R.J. (2002). New gene transfer methods. Theriogenology 57,189-201.
195.Wessels, J.M., Linton, N.F., Croy, B.A., and Tayade, C. (2007). A review of molecular contrasts between arresting and viable porcine attachment sites. American Journal of Reproductive Immunology 58,470-480.
196.Wheeler, M.B. (2007). Agricultural applications for transgenic livestock. Trends Biotechnol 25(5),204-210.
197.White, D.J. (1992). Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transpl Int 5 Suppl 1,S648-650.
198.Wilmut, I., Ritchie, W.A., Haley, C.S., Ashworth, C.J., and Aitken, R.P. (1992). A comparison of rate and uniformity of embryo development in Meishan and European white pigs. J Reprod Fertil 95,45-56.
199.Wilson, M.E. and Ford, S.P. (2001). Comparative aspects of placental efficiency. Reprod. Suppl.58,223-232.
200. Wright, G. (1991). High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Biotechnology (NY) 9,830-834.
201.Wu, Y, Halverson, G. and Basir, Z. (2005). Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol 193,371-380.
202.Yao, M.W.M., Lim, H.J. and Schust, D.J. (2003). Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Molecular Endocrinology 17(4),610-627.
203.Yao, M.V., Lim, H., Schust, D.J., Choe, S.E., Farago, A., Ding, Y.Y., Michaud, S., Churchand, G.M., and Maas R.L. (2002). Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endoerinol 17(4),610-627.
204.Youngs, C.R., Ford, S.P., McGinnis, L.K. and Anderson, L.H. (1993). Investigations into the control of litter size in swine:I. Comparative studies on in vitro development of Meishan and Yorkshire preimplantation conceptuses. J Anim Sci 71,1561-1565.
205.Yong wu and Pei Jung. (1997). On structure and function of homeodomain. Devel Reprod Biol 6(1),81-89.
206.Yoshizawa, T., Handa, Y., Uematsu, Y, Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T., Arioka, K., Sato, H., Uchiyama, Y, Masushige, S., Fukamizu, A., Matsumoto, T., and Kato, S. (1997). Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16,391-396.
207.Zhu, Y., Hoell, P. and Ahlemeyer, B. (2006). PTEN:a crucial mediator of mitochondria-dependent apoptosis. Apoptosis 11(2),197-207.
2.董方莉,谭丽,郑英(2005).影响子宫内膜接受性的相关因素研究进展.国外医学(计划生育分册).
3.郭瑞霞,王建六,赵丹,王志启,魏丽惠(2005).子宫内膜癌细胞系Ishikawa和HEC-1A细胞雌激素受体表达.中国妇产科临床杂志,272-274,304-323.
4.姜勋平,刘红林,丁家桐,钱云,朱猛进(2008).母猪FSH β基因多态与乳头数的关系研究.中国畜牧兽医,2(3),12-14.
5.赖巧红,章汉旺(2005).Wnt信号传导途径与胚胎着床.国外医学计划生育分册,24(3),116-119.
6.李光全,王立贤,张祥林(2001).猪胎盘效率与繁殖性能的关系.国外畜牧科技,28(6),38-41.
7.刘顺德(1999).基因标记定位在猪数量性状改良中的应用.养猪,(2),28-30.
8.彭中镇,樊斌,朱猛进,赵书红,刘榜(2010).母猪年生产力及其遗传改良.养猪,(6),37-40.
9.彭中镇(2011).猪产仔数的遗传改良.彭中镇文集,174-181.
10.秦鹏春,李云龙,谭景和(2001).哺乳动物胚胎学.北京：科学出版社,389-396.
11.施启顺(2005).猪经济性状主效基因研究进展.动物科学与动物医学,22(9),A-B.
12.宋晓明,杨增明(2004).家畜胚胎着床的分子调控.31(4),20-22.
13.王爱国(2006).现代实用养猪技术(第二版).北京：中国农业出版社,37-40.
14.王建辰,章孝荣(1998).动物生殖调控.合肥：安徽科学技术出版社.60.124,157-168.
15.阳艳,章汉旺(2006). EMX2、HOXA10与子宫内膜容受性.生殖与避孕,26(2),95-98.
16.张忠诚,朱士恩(2004).家畜繁殖学.北京：中国农业出版社,121-132.
17.周晓宁,方梅霞,何小梅,聂庆华,and张细权(2011).猪繁殖候选基因HoxA10的克隆及表达分析.湖南农业大学学报,37(1),60-64.
18.周生建,贾咏存,杨戎,陈晓玲,魏莎莉(2008). HOXa-10基因在小鼠胚胎着床过程中的作用.Acta. Anatomica. Sinica.39(2),248-251.
19.朱丽红,朱瑾(2010). HOXA10在胚胎着床过程中的调控机制Reproduction & Contraception,30(11),769-774.
20.朱作言,克圣,岳峰(1989).转基因鱼模型的建立.中国科学,B(2),147-155.
21. Achache, H., and Revel, A. (2006). Endometrial receptivity markers, the journey to successful embryo implantation. Human Reproduction Update 12,731-746.
22. Akbasa, G., Songa, J., and Taylor, H. (2004). A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES). J. Mol. Biol.340,1013-1023.
23. Albelda, S.M. and Buck, C.A. (1990). Integrins and other cell adhesion molecules. FASEB J.4 (11),2868-2880.
24. Anderson, L.L. (1978). Growth protein Content and distribution of early pig embryos. Anat. Rec.190,143-153.
25. Apiou, F., Flagiello, D., and Cillo, C. (1996). Fine mapping of human Hoxa gene cluster. Cytogenet Cell Genet 73,114-115.
26. Bagot, C.N., Troy, P.J., and Taylor, H.S. (2000). Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Ther.7,1378-1384.
27. Bazer, F.W., Burghardt, R.C., Johnson, G.A., Spencer, T.E., and Wu, G.Y. (2008). Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways. Reproductive Biology 8,179-211.
28. Bazer, F.W., Spencer, T.E., Johnson, G.A., Burghardt, R.C., and Wu, G.Y. (2009). Comparative aspects of implantation. Reproduction 138,195-209.
29. Bazer, F.W., Thatcher, W.W., and Martinat-Botte, F. (1988). Conceptus development in large white and prolific Chinese Meishan pigs. J. Reprod. Fertil.84(1),37-42.
30. Benson, G.V., Lim, H., and Paria, B.C. (1996). Mechanisms of reduced fertility in Hoxa-10 mutant mice:uterine homeosis and loss of maternal Hoxa10 expression. Development 122,2687-2696.
31. Benson, G.V., Nguyen, T.H., and Maas, R.L. (1995). The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol.15(3),1591-1601.
32. Bidanel, Legault J.P., and C. (1986). Experimental and prospective aspects of the utilization of prolific Chinese pig breeds in Europe. Proc 37th Meeting European Assoc Anim. Prod, Budapest.1,104-105.
33. Bidanel, J.P., Caritez, J.C., and Lagant, H. (1990). Ovulation rate and embryonic survival in gilts and sows with variable proportions of Meishan (MS) and Large White (LW) genes. Mean performance and crossbreeding parameters between MS and LW breeds. M. Molenat and C. Legault (Ed.) Chinese Pig Symposium. Institut National de la Recherche Agronomique, Jouy-en-Josas, France,109-110.
34. Biery, K.A., Bondioli, K.R., and Demayo, F.J. (1988). Gene transfer by pronuclear injection in the bovine. Theriogenology 29,224-229.
35. Blair, R.M., Geisert, R.D., Zavy, M.T., Yellin, T., Fulton, R.W., and Short, E.C. (1991). Endometrial surface and secretory alterations associated with embryonic mortality in gilts administered estradiol valerate on days 9 and 10 of gestation. Biol Reprod 44, 1063-1079.
36. Blitek, A.E., Czmarek, M.M., Kiewisz, J., and Ziecik, A.J. (2010a). Endometrial and conceptus expression of HOXA10, transforming growth factor (TGF)-1, leukaemia inhibitory factor (LIF) and prostaglandin H synthase-2 (PGHS-2) in early pregnant pigs with gonadotropin-induced estrus. Domest Anim Endocrinol 38,222-234.
37. Blitek, A., Kiewisz, J., and Waclawik, A. (2010b). Effect of steroids on HOXA10 mRNA and protein expression and prostaglandin production in the porcine endometrium. J. Reprod Dev,56(6),643-648.
38. Blitek, A.E. Morawska, J. Kiewisz, A.J., and Ziecik. (2011). Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation. Theriogenology 76,954-966.
39. Bolet Abstr, G, Martinat-Botte, F., Locatelli, P., Gruand, J., Terqui, M., and Berthelot, F. (1986). Components of prolificacy of hyperprolific Large White sows. Comparison with Meishan and control Large White sows. Genet Sel Evol.18,333-342.
40. Bowen, J.A. and Burghardt, R.C. (2000). Cellular mechanisms of implantation in domestic farm animals. Seminars in Cell and Developmental Biology 2,93-104.
41. Bromleigh, V.C., and Freedman, L.P. (2000). p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev 14,2581-2586
42. Carlos, S., Carlos, M., and Jose, R. (1998). Cytokines and embryo implantation. Reprod. Immunol.39,117-131.
43. Carson, D.D., Bagchi, L. Dey, S.K., Enders. A.C., Fazleabas, A.T., Lessey, B.A., and Yoshinaga K. (2000). Embryo implantation. Dev Biol.223(2),217-237.
44. Cermik, D., Selam, B., and Taylor, H.S. (2003). Regulation of HOXA10 expression by testosterone in vitro and in the endometrium of patientswith polycystic ovary syndrome. J. Clin Endocrinol Metab 88,238-243.
45. Chen, J.C., Wiley, A.A., Ho, T.Y., Frankshun, A.L., Hord, K.M., Bartol, F.F., and Bagnell, C.A. (2010). Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults. Reproduction 139,623-630.
46. Chen, Q., Zhang, Y., Lu, J., Wang, Q, Wang, S.J., Cao Y., Wang, H.B., and Duan, E. (2009). Embryo-uterine cross-talk during implantation:the role of Wnt signaling. Mol Hum Reprod 15,215-221.
47. Cheng, J.G., Rodriguez, C.I., and Stewart, C.L. (2002). Control of uterine receptivity and embryo implantation by steroid hormone regulation of LIF production and LIF receptor activity:towards a molecular understanding of "the window of implantation". Rev Endocr Metab Disord 3,119-126.
48. Cheng, Y.H., Imir, A., Fenkci, V., Yilmaz, M.B., and Bulun, S.E. (2007). Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Spl:a mechanism for defective estradiol metabolism. Am J Obstet Gynecol 196, 391-397.
49. Cordon, J.W. and Scangos, F.H. (1980). Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA (77),7380-7384.
50. Croy, B.A., Wessels, J.M., Linton, N.F., van den Heuvel, M., Edwards, A.K., and Tayade, C. (2009). Cellular and molecular events in early and mid gestation porcine implantation sites:a review. Soc Reprod Fertil Suppl 66,233-244.
51. Cyranoski, D. (2003). Koreans rustle up madness-resistant cows. Nature 426 (6968), 743.
52. Daftary, G., Kayisli, U., Seli, E., Bukulmez, O., Arici, A., and Taylor, H. (2007). Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertil. Steril.87,367-372.
53. Daftary, G.S. and Taylor, H.S. (2004). EMX2 Gene Expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. Clin Endocrinol Metab 89(5),2390-2396.
54. Daftary, G.S. and Taylor, H.S. (2006). Endocrine regulation of HOX genes. Endocrine Reviews 27(4),331-355.
55. Daftary, G.S., Troy, P.J., Bagot, C.N., Young, S.L., and Taylor, H.S. (2002). Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol 16,571-579.
56. Daikoku, T., Tranguch, S., Friedman, D.B., Das, S.K., Smith, D.F., and Dey, S.K., (2004). Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Mol. Endocrinol.19,683-697.
57. Dantzer, V. (1985). Electron microscopy of the initial stages of placentation in the pig. Anatomy and embryology.172(3),281-293.
58. Day, B.N., Anderson, L.L., Emmerson, M.A. (1959). Effect of estrogen and progesterone on early embryonic mortality in ovariectomized gilts. J. Anim. Sci.18, 607-613.
59. Dey, S.K., Lim, H., Das, S.K., Reese, J., Paria, B.C., Daikoku, T., and Wang, H., (2004). Molecular cues to implantation. Endocr. Rev.25,341-373.
60. Dhindsa, D.S. and Dziuk, P.J. (1968). Effect on pregnancy in the pig after killing embryos or fetuses in one uterine horn in early gestation. J. Anim. Sci.27(1), 122-126.
61. Du, H., Daftay, G.S., Lalwani, S.I., and Taylor, H.S. (2005). Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol 19(9),2222-2233.
62. Du, H., Sarno, J.L., and Taylor, H.S. (2006). Basic transcription element binding protein (BTEB1) is regulated by HOXA10 in endometrial cells. J Soc Gynecol Investig 13,71A-72A.
63. Dziuk, P. (1985). Effect of migration, distribution and spacing of pig embryos on pregnancy and fetal survival. Journal of reproduction and fertility.33,57-63.
64. Ferrell, C.M., Dorsam, S.T., and Ohta, H. (2004). Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+human cord blood cells. Stem Cells.23(5),644-655.
65. Ford, J.J. and Howard, H.J. (1997). Activin inhibition of estradiol and progesterone production in porcine granulosa cells. Journal of animal science.75(3),761-766.
66. Foucher, I., Volovitch, M., and Frain, M. (2002). HOXA5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism:evidence for an interaction between HOXA5 and Forkhead boxtranscription factors. Development 129, 4065-4074.
67. Fouladi, N.A.A., Jones, C.J., Nijjar, N. (2005). Characterization of the uterine phenotype during the peri-implantation period for LIF-nul. MF1 strain mice. Dev Biology 281(1),1-21.
68. Garlow, J.E. (2002). Analysis of osteopontin at the marginal-placental interface in pigs. Bi01. Reprod.66(3),718-725.
69. Geisert, R.D. and Yelich, J.V. (1997). Regulation of conceptus development and attachment in pigs. J. Reprod Fertil Suppl 52,133-149.
70. Geisert, R.D., Ross, J.W., Ashworth, M.D., White, F.J., Johnson, G.A., and DeSilva, U. (2006). Maternal recognition of pregnancy signal or endocrine disruptor:the two faces of oestrogen during establishment of pregnancy in the pig. Soc Reprod Fertil Suppl 62, 131-145.
71. Geisert, R.D., Thatcher, W.W., Roberts, R.M., and Bazer, F.W. (1982b). Establishment of pregnancy in the pig:Ⅲ. Endometrial secretory response to estradiol valerate administered on day 11 of the estrous cycle. Biol. Reprod 27,957-965.
72. Godbole, G.B., Modi, D.N., Puri, C.P., (2007). Regulation of Homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. Reproduction 134,513-523.
73. Gray, C.A., Taylor, K.M., Ramsey, W.S., Hill, J.R., Bazer, F.W., Bartol, F.F., and Spencer, T.E. (2001). Endometrial glands are required for pre-implantation conceptus elongation and survival. Biol. Reprod 64,1608-1613.
74. Gui, Y., Zhang, J., Yuan, L., and Lessey, B.A. (1999). Regulation of HOXA10 and its expression in normal and abnormal endometrium. Mol. Hum. Reprod.5,866-873.
75. Guo, B., Tian, Z., Han, B.C., Zhang, X.M., Yang, Z.M., and Yue, Z.P. (2008). Expression and hormonal regulation of HOXA10 in canine uterus during the peri-implantation period. Reprod. Domest. Anim. (October 30, Epub ahead of print).
76. Haley, C.S. and Lee, G.J. (1993). Genetic basis of prolificacy in Meishan pigs. J. Reprod Fertil Suppl 48,247-259.
77. Halhali, A., Acker, G.M. and Garabedian, M. (1991).1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. J. Reprod Fertil 91,59-64.
78. Hamann, H., Steinheuer, R. and Distl, O. (2004). Estimation of genetic parameters for litter size as a sow and boar trait in German herdbook Landrace and Pietrain swine. Livestock Production Science 85(2-3),201-207.
79. Hammer, R.E., Pursel, V.G., and Rexroad, C.E. (1985). Production of transgenic rabbits, sheep and pig by microinjction. Nature 15,680-683.
80. Hanenberg E.H.A.T., Knol E. F., and Merks, J.W.M. (2001). Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livestock Production Science 69(2),179-186.
81. Harvey, M.B., Leco, K.J., Arcellana-Panlilio, M.Y. (1995). Roles of growth factors during peri-implantation development. Mol. Human Repro 10,712-718.
82. Hayashi, K., Erikson, D.W., Tilford, S.A. (2009). Wnt genes in the mouse uterus: potential regu lation of implantation. Biol Reprod 80,989-1000.
83. Hewitt, S.C. and Korach, K.S. (2002). Estrogen receptors:structure, mechanisms and function. Rev Endocr Metab DisorcL 3(3),193-200.
84. Hirota, Y., Daikoku, T., Tranguch, S., Xie, H., Bradshaw, H.B., and Dey, S.K. (2010). Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest 120,803-815.
85. Hochi, S., Ninomiya, T., and Honma, M. (1990). Successful production of transgenic rats. Anim Biotech 1,175-184.
86. Horcajadas, J.A., Pellicer, A., and Simon, C., (2007). Wide genomic analysis of human endometrial receptivity:new times, new opportunities. Hum. Reprod. Update 13,77-86.
87. Hu, W., Feng, Z., Teresky, A.K., and Levine, A.J. (2007). p53 regulates maternal reproduction through LIF. Nature 450,721-724.
88. Huet-Hudson, Y.M., Andrews, G.K., and Dey, S.K. (1989). Cell type-specific localization of c-mycprotein in the mouse uterus:modulation by steroid hormones and analysis of the periimplantation period Endocrinology 125(3),1683-1690.
89. Hugh, S., Taylor, Aydin Arici, David Olive, and Peter Igarashi. (1998). HOXA10 is expressed in Response to Sex Steroids at the Time of Implantation in the Human Endometrium. J. Clin. Invest.7(101),1379-1384.
90. Illera, M.J., Cullinan, E., Gui, Y.T., Yuan, L.W., Beyler, S.A., and Lessey, B.A. (2000). Blockade of the α vβ3 integrin adversely affects implantation in the mouse. Biol. Reprod.62,1285-1290.
91. Jaenisch, R. and Mintz, B. (1974). Simian.virus SV40 DNA sequence in DNA of healthy adult mice derived from preimplantation blastocytes injicted with viral DNA. Proc Ncad Sci USA 74,1250-1254.
92. Jain, M., Tyagi, A.K., and Khurana, J.P. (2008). Genome-wide identification, classification, evolutionary expansion and expression analyses of homeobox genes in rice. FEBS J 275(11),2845-2861.
93. Johnson, G.A., Bazer, F.W., Burghardt, R.C., Spencer, T.E., Wu, G., and Bayless, K.J. (2009). Conceptus-uterus interactions in pigs:endometrial gene expression in response to estrogens and interferons from conceptuses. Soc Reprod Fertil SuppI 66, 321-332.
94. Johnson, R.K., Nielsen, M.K., and Casey, D.S. (1999). Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size. J. Anim. Sci.77,541-557.
95. Kelly, M., Daftary, G., and Taylor, H.S. (2006). An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal of Obstetrics and Gynecology 194,1100-1109.
96. Kennedy, T.G., Gillio-Meina, C., and Phang, S.H. (2007). Prostaglandins and the initiation of blastocyst implantation and decidualization. Reproduction 134,635-643.
97. Kim, J.J., Taylor, H.S., Akbas, G.E., Foucher, I., Trembleau, A., Jaffe, R.C., Fazleabas, A.T., Unterman, T.G. (2003). Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biol. Reprod.68,24-30.
98. Kim, J.J., Taylor, H.S., Lu, Z., Ladhani, O., Hastings, J.M., Jackson, K.S., Wu, Y., Guo, S.W., Fazleabas, A.T. (2007). Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol. Hum. Reprod.13,323-332.
99. Klein-Hittpass, L., Schorpp, M., Wagner, U., and Ryffel, G.U. (1986). An estrogen-responsive element derived from the 5'flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell 46,1053-1061.
100. Knight, J.W. and Kukoly, C.A. (1990). In vitro release of progesterone and estrone by the porcine placenta throughout gestation. Domest Anim Endocrinol 7, 497-508.
101.Knight, J.W. (1994). Aspects of placental estrogen synthesis in the pig. Exp Clin Endocrinol 102,175-184
102.Knorr, C., Uibeleisen, A.C., Kollers, S., Fries, R., and Brenig, B. (2001). Assignment of the homeobox gene (HOXA10) to porcine chromosome SSC18q23>q24 by Fish and confirmution by hybrid panel analyses. Cytogenet cell Genet 93,145-146
103.Kodaman, P.H. and Taylor, H.S. (2004). Hormonal regulation of implantation. Obstet Gynecol Clin North Am 31,745-766.
104.Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78,191-201.
105.Kuroiwa, Y., Kasinathan, P., Choi, Y.J., Naeem, R., and Tomizuka, K. (2002). Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol,20, 889-894.
106.Kuroiwa, Y., Kasinathan, P., Matsushita, H., Sathiyaselan, J., Sullivan, E.J., Kakitani, M., Tomizuka, K., Ishida, I., and Robl, J.M. (2004). Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle. Nat Genet 36,775-780.
107.Lai, L.K-SD., Park, K.W., Cheong, H.T., Greenstein, J.L., Im, G.S., Samuel, M., Bonk, A., Rieke, A., Day, B.N., Murphy, C.N., Carter, D.B., Hawley, R.J., and Prather, R.S. (2002). Production of alpha-1,3-galactosyl transferase knockout pigs by nuclear transfer cloning. Science 295(5557),1089-1092
108.Lai, L., Kang, J.X., and Li, R. (2006). Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat. Biotechnol 24,435-436.
109.Leach, R.E., Khalifa, R., and Ramirez, N.D. (1999). Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. J Clin Endocrinol Metab 84(9),3355-3363.
110.Lee, B., Du, H., and Taylor, H.S. (2009). Experimenta 1 murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod 80,79-85.
111.Lee, J.G., Ritchie, M., Thompson, M., McDonald, A.A., Blasco A., Santacrew, M.A. Argente, M.J., and Haley, C.S. (1995). Uterine capacity and prenatal survival in Meishan and Large White pigs. Anim Sci.60,471-479.
112.Lessey, B.A. (2002). Adhesion molecules and implantation. J. Reprod. Immunol. 55(1-2),101-112.
113.Lessey, B.A., Damjanovich, L., Coutifaris, C., A Castelbaum, Albelda, S.M., and Buck, C.A. (1992). Integrin adhesion molecules in the human endometrium. J. CIin. Invest 90(1),188-195.
114.Lim, H., Ma, L., Ma,W.G, Maas, R.L., and Dey, S.K., (1999). Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Mol. Endocrinol.13,1005-1017.
115.Lim, H.J. and Dey, S.K. (2009). HB-EGF:a unique mediator of embryo uterine interactions during implantation. Exp Cell Res 315,619-626.
116.Linville, R.C., Pomp, D., Johnson, R., and Rothschild, M.F. (2001). Candidate gene analysis for loci affecting litter size and ovulation rate in swine. J. Anlm, Sci.79, 604-607.
117.Liu, X., Zhu, G, and Zhong, G (2007). Regulatory Effect of Estrogen, Progestin and HB-EGF on the Expression of HOXA10 Gene in Ishikawa Cells. Journal of Huazhong University of Science and Technology 27(4),464-467.
118.Lo, D., Pursel, V., and Linton, P.J. (1991). Expression of mouse IgA by transgenic mice, pigs and sheep. Eur. J. Immunol.21(4),1001-1006.
119.Lowney, P., Corral, J., Detmer, K., LeBeau, M.M., Deaven, L., Lawrence, H.J. and Largman, C. (1991). A human Hoxl homeobox gene exhibits myeloidspecific expression of alternative transcripts in human hematopoietic cells. Nucleic Acids Res. 19,3443-3449.
120.Lu, Z., Hardt, J., and Kim, J.J. (2008). Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation. Mol. Hum. Reprod. 14,357-366.
121.Mahmoud, T.H., McCuen, B.W., and Hao, Y. (2003). Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. Graefes Arch. Clin. Exp. Ophtalmol.241(4),298-308.
122.Martin, R., Taylor, M.B., Krikun, G., Lockwood, C., Akbas, G.E. and Taylor, H.S. (2007). Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein-1 Response Elements. J Clin Endocrinol Metab 92(5),1920-1926.
123.McCormack, S.A. and Glasser, S.R. (1980). Differential response of individual uterine cell types from immature rats treated with estradiol. Endocrinology 106, 1634-1649.
124.McGmnis, W., Garber, R.L., and Wirz, J. (1984). A homologous protein-coding sequence in Drosophia homeotic genes and its conservation in other metazoans. Cell 37,403-412.
125.McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68,283-302.
126.Meyer, W.R., Castelbaum, A.J., Somkuti, S., Sagoskin, A.W., Doyle, M., Harrisand, J.E., and Lessey, B.A. (1997). Hydrosalpinges adversely affect markers of endometrial receptivity. Hum. Reprod.12(7),1393-1398.
127.Modi, D. and Godbole, G (2009). HOXA10 signals on the highway through pregnancy. Journal of Reproductive Immunology 83,72-78.
128.Mohamed, O.A., Jonnaert, R.J., Labelle-Dumals, C., Kuroda, K., Clarke, H.J., and Dufort, D. (2005). Uterine Wnt/beta-catenin signaling is required for implantation. Proc Natl Acad Sci. USA.102(24),8579-8584.
129.Mohammad, Q. Hassan, Rahul Tare, Suk Hee Lee, Matthew Mandeville, Brian Weiner, Martin Montecino, Andre, J. van Wijnen, Janet, L. Stein, Gary, S. Stein, and Jane, B. (2007). Lian.HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes. Molecular and Cellular Biology 5, 3337-3352.
130.Muller, M., Brenig, B., and Winnacker, E.L. (1992). Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene 121(2),263-270.
131.Neal, S.M., Johnson, R.K. and Kittok R.J. (1989). Index selection for components of litter size in swine:response to five generations of selection. J. Anim. Sci.67, 1933-1945.
132.Nie, G.Y., Li, Y., and Minoura, H. (2003). A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod 9(5),279-290.
133.Niemann H. (2004). Transgenic pigs expressing plant genes. Proc. natl Acad. Sci. USA 101(19),7211-7212.
134.Nottle M.B., Nagashima H., and Verma P.J. (1999). Production and analysis of transgenic pigs containing a metallothionein porcine growth hormone gene construct. In Transgenic animals in agriculture (Murray, J.D., Anderson, G.B., Oberbauer, A.M., & McGloughlin, M.M., eds). CABI Publishing, New York 145-156.
135.Palmiter, R.D., Brinster, R.E., and Hammer, M.E. (1982). Dramatic growth of mice that develop from eggs microinjected with a metallothionein-growth hormone fusion gene. Nature 300,611-615.
136.Pantos, K., Nikas, G., and Makrakis, E. (2004). Clinical value of endometrial pinopodes detection in artificial donation cycles. Reprod Biomed Online 9(1),86-90.
137.Paria, B.C., Song, H. and Dey, S.K. (2001). Implantation:Molecular basis of embryo-uterine dialogue. International Journal of Developmental Biology 45(3), 597-605.
138.Paria, B.C., Das, S.K., and Dey, S.K. (1998). Embryo implantation requires estrogen-directed uterine preparation and eatecholestrogen-mediated embyronie activation. Adv. PharmacOl 42,840-843.
139.Patrick, J., Troy, Gaurang, S. Daftary, Catherine, N. Bagot, Hugh, S., and Taylor. (2003). Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10. Molecular and cellular biology 1,1-1.
140.Penna, I., Du, H., and Amanda, N. (2010). Endothelin type A receptor (ETA) expression is regulated by HOXA10 in human endometrial stromal cell. Reproductive Sciences 17(5),471-476.
141.Penna, I., Du, H., and Ferriani, R. (2008). Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Hum Reprod 14(10),613-618.
142.Piper, L.E., Bindon, B.M., and Davis, G.H. (1985). The single inheritance of the high litter size of the Boorola Merino. In:Land, R.B., Robinson, and D.W. Genetics of Reproduction in Sheep. Butterworths, London 115-125.
143.Polette, M., Nawroeki, B., Pintiaux, A. (1994). Expression of gelatinases A and B and their tissue inhibitors by cells of early and term human placenta and gestational endometrium. Lab Invest. (71),838-846.
144.Polge, C, Rowson, L.E. and Chang, M.C. (1966). The effect of reducing the number of embryos during early stages of gestation on the maintenance of pregnancy in the pig. Journal of reproduction and fertility 12(2),395-397.
145.Pope, W.F. and First, N.L. (1985). Factors affecting the survival of pig embryos. Theriogenology 23(1),91-105.
146.Pope, W.F. (1994). Embryonic mortality in swine. In:Geisert R.D. and Zavy M.T. Embryonic Mortality in Domestic Species. CRC Press, Boca Raton, FL.53-78.
147.Pursel, V.G., Pinkert, C.A. and Miller, K.F. (1989). Genetic engineering of livestock. Science 244 (4910),1281-1288.
148.Pusateri, A.E., Rothschild, M.F., Warner, C.M., and Ford, S.P. (1990). Changes in morphology, cell number, cell size and cellular estrogen content of individual littermate pig conceptuses on days 9 to 13 of gestation. J Anim Sci 68,3727-3735.
149.Quinn, C.E. and Casper, R.F. (2009). Pinopodes:a questionable role in endometrial receptivity. Hum Reprod Update 15 (2),229-236.
150.Quinn, C.E., Detmar, J., and Casper, R.F. (2007). Pinopodes are present in Lif null and Hoxa10 null mice. Fertil Steril 88 (Suppl 4),1021-1028.
151.Quinn, C., Ryan, E. and Claessens, E.A. (2007). The presence of pinopodes in the human endometrium does not delineate the implantation window. Fertil Steril 87(5), 1015-1021.
152.Rackow, B.W. and Taylor, H.S. (2008). Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil. Steril. (June 12, Epub ahead of print).
153.Radder, H. (2004). Exploiting abstract possibilities:a critique of the concept and practice of product patenting. J. Agric. Environ. Ethics 17(3),275-291.
154.Rao, R.P., Fischer, B., and Seshagiri, P.B. (2008). Embryo-endometrial expression of leukemia inhibitory factor in the golden hamster (Mesocricetus auratus):increased expression during proestrous and window of implantation stages. Reprod Fertil Develop 20(3),440-449.
155.Robl, J.M., Wang, Z., and Kasinathan, P. (2007). Transgenic animal production and animal biotechnology. Theriogenology 67,127-133.
156.Rosario, G.X., Modi, D.N., Sachdeva, G, Manjramkar, D.D., and Puri, C.P. (2005a). Morphological events in the primate endometrium the presence of a preimplantation embryo, detected by the serum preimplantation factor bioassay. Hum. Reprod.20, 61-71.
157.Rosario, G.X., Sachdeva, G, Manjramkar, D.D., Modi, D.N., Meherji, P.K., and Puri, C.P., (2005b). Endometrial expression of immunomodulatory cytokines and their regulators during early pregnancy in bonnet monkeys (Macaca radiata). Hum. Reprod. 20,3039-3046.
158.Rothschild, M.F. and Bidanel, J.P. (1998). Biology and geneties of reproduction. In: The Geneties of the Pig (Ed. by M.F. Rothschild & A. Ruvinsky), CAB International, and Oxon, UK.313-343.
159.Rothschild, M.F., Jacobson, C. and Vaske, D.A. (1994). A major gene for litter size in pigs. Proceeding of the fifth world congress on genetics to livestock production 21, 225-228.
160.Rubin, G.L., Harrold, A.J., Mills, J.A., Falany, C.N., and Coughtrie, M.W. (1999). Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 5, 995-1002.
161.Saito, S. (2000). Cytokine network at the feto-maternal interface. J. Reprod. Immunol. 47,87-103.
162.Sakkas, D., Lu, C., Zulfikaroglu, E., Neuber, E., and Taylor, H.S., (2003). A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line. Fertil. Steril.80,1169-1174.
163.Sanjoy K.D. (2006). Regional development of uterine decidualization:molecular signaling by Hoxa-10. Molecular Reproduction and Development 77,387-396.
164.Sarno, J.L., Kliman, H.J., and Taylor, H.S. (2005). HOXA10, Pbx2, and Meisl protein expression in the human endometrium:formation of multimeric complexes on HOXA10 target genes. J Clin Endocrinol Metab 90,522-528.
165.Sarno, J.L., Schatz, E, Lockwood, C.J., Huang, S.T.J., and Taylor, H.S. (2006). Thrombin and interleukin-1 r regulate HOXA10 expression in human term decidual cells:implications for preterm labor. J Clin Endocrinol Metab 91,2366-2372.
166.Satokata, I., Benson, G, and Maas, R., (1995). Sexually dimorphic sterility phenotypes in Hoxa-10 deficient mice. Nature 374,460-463.
167.Schofield, G, and Kimber, S.J. (2005). Leukocyte subpopulations in the uteri of leukemia inhibitory factor knockout mice during early pregnancy. Biol Reprod 72, 872-878.
168.Scott, MR and Weiner, AJ. (1984). Structural relationships among genes that control development sequence homology between the antenapedia,ultrabithorax and fushi tarazu loci of rosophila. ProcNatl Acad Sci USA 81,4115-4122.
169.Sherwin, J.R., Freeman, T.C., Stephens, R.J., Kimber, S., Smith, A.G., Chambers, I., Smith, S.K., and Sharkey, A.M. (2004). Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation. Mol Endocrinol 18,2185-2195.
170.Simeone, A., Acampora, D., and Nigro, V. (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mechanisms of development 33(3),215-27.
171.Somkuti, S.G., Yuan, L.W., Fritz, M.A. (1997). Epidermal growth factor and sex steroid dynamically regulate a marker of endometrial receptivity Ishikawa cells. J Clin Endoerinol Metab.82(7),2192-2197.
172.Song, H., Lim, H. and Paria, B.C. (2002). Cytosolic phospholipase a 2alpha is crucial [correction of A2alpha deficiency is crucial] foron time embryo implantation that directs subsequent development. Development 129(12),2879-2889.
173.Spotter, A. and Distl, O. (2006). Genetic approaches to the improvement of fertility traits in the pig. The Veterinary Journal.172,234-247.
174.Spotter, A., Drogemuller, C, Hamann, H., and Distl, O. (2005). Evidence of a new leukemia inhibitory factor-associated genetic marker for lifter size in a synthetic pig line. J. Anim. Sci.83,2264-2270.
175.Stavreus-Evers, A., Aghajanova, L. and Brismar, H (2002). Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation. Mo l hum Reprod 8,765-769.
176.Stewart, C.L., Kaspar, P., Brunet, L.J., Bhatt, H., Gadi, I., Kontgen, F., and Abbondanzo, S.J. (1992). Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359,76-79.
177.Stroband, H.W., and Van der Lende, T. (1990). Embryonic and uterine development during early pregnancy in pigs. J Reprod Fertil Suppl 40,261-277.
178.Sun, H., Chen, L. and Yan, G. (2009). HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells. Biochem Biophy Res Communi 379(1),16-21.
179.Svingen, T. and Koopman, P. (2007). Involvement of homeobox genes in mammalian sexual development. Sex Develop 1 (1),12-23.
180.Takiko Daikoku, Haengseok Song, Yong Guo, Anne Riesewijk, Sietse Mosselman, Sanjoyk. Das and Sudhansuk. Dey. (2004). Uterine Msx-1 and Wnt4 Signaling Becomes Aberrant in Mice with the Loss of Leukemia Inhibitory Factor or Hoxa-10: Evidence for a Novel Cytokine-Homeobox-Wnt Signaling in Implantation. Molecular Endocrinology 18(5),1238-1250.
181.Tayade, C., Fang, Y., Hilchie, D., and Croy, B.A. (2007a). Lymphocyte contributions to altered endometrial angiogenesis during early and midgestation fetal loss. J Leukoc Biol 82,877-886.
182.Taylor, H.S., Bagot, C. and Kardana, A. (1999). HOX gene expression is altered in the endometrium of women with endometriosis. Human reproduction 14(5), 1328-1331.
183.Taylor, H.S., Arici, A., Olive, D., and Igarashi, P. (1998). HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest 101,1379-1384.
184.Taylor, H.S. and Fei, X.L. (2005). Emx2 regulates mammalian reproduction by altering endometrial cell proliferation. Mol Endocrinol 19(11),2839-2846.
185.Taylor, H.S., Vanden Heuvel, G.B., and Igarashi P. (1997). A conserved Hox axis in the mouse and human female reproductive system:late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57,1338-1345.
186.Tarraf, C.G. and Knight, J.W. (1995). Effect of uterine space and fetal sex on conceptus development and in vitro release of progesterone and estrone from regions of the porcine placenta throughout gestation. Domest Anim Endocrinol 12,63-71.
187.Tergui, M. (1992). Chinese Pig Symposium. France,19-32.
188.Troy, P.J., Daftary, G.S., and Bagot, C.N. (2003). Transcriptional repression of peri-Implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol 23(1),1-13.
189.Ulberg, L.C. and Rampacek, G.B. (1974). Ebryonic and fetal development:uterine components and influences. J. Anim. Soi 38(5),1013-1017.
190.Valle'e, M., Beaudry, D., Roberge, C., Matte, J.J., Blouin, R. and Palin, M.F.(2003). Isolation of Differentially Expressed Genes in Conceptuses and Endometrial Tissue of Sows in Early Gestation. Biol Reprod 69,1697-1706.
191.Vallet, J.L., Miles, J.R., and Freking, B.A. (2009). Development of the pig placenta. Soc Reprod Fertil Suppl 66,265-279.
192.Vitiello, D., Pinard, R., and Taylor, H.S. (2008). Gene expression profiling reveals putative HOXA10 downstream targets in the periimplantation mouse uterus. Reprod. Sci.15,529-535.
193.Vize, P.D., Michalska, A.E. and Ashman, R. (1988). Introduction of a porcine growth hormone fusion gene into transgenic pigs promotes growth. J. Cell Sci.90:295-300.
194. Wall, R.J. (2002). New gene transfer methods. Theriogenology 57,189-201.
195.Wessels, J.M., Linton, N.F., Croy, B.A., and Tayade, C. (2007). A review of molecular contrasts between arresting and viable porcine attachment sites. American Journal of Reproductive Immunology 58,470-480.
196.Wheeler, M.B. (2007). Agricultural applications for transgenic livestock. Trends Biotechnol 25(5),204-210.
197.White, D.J. (1992). Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transpl Int 5 Suppl 1,S648-650.
198.Wilmut, I., Ritchie, W.A., Haley, C.S., Ashworth, C.J., and Aitken, R.P. (1992). A comparison of rate and uniformity of embryo development in Meishan and European white pigs. J Reprod Fertil 95,45-56.
199.Wilson, M.E. and Ford, S.P. (2001). Comparative aspects of placental efficiency. Reprod. Suppl.58,223-232.
200. Wright, G. (1991). High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Biotechnology (NY) 9,830-834.
201.Wu, Y, Halverson, G. and Basir, Z. (2005). Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol 193,371-380.
202.Yao, M.W.M., Lim, H.J. and Schust, D.J. (2003). Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Molecular Endocrinology 17(4),610-627.
203.Yao, M.V., Lim, H., Schust, D.J., Choe, S.E., Farago, A., Ding, Y.Y., Michaud, S., Churchand, G.M., and Maas R.L. (2002). Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endoerinol 17(4),610-627.
204.Youngs, C.R., Ford, S.P., McGinnis, L.K. and Anderson, L.H. (1993). Investigations into the control of litter size in swine:I. Comparative studies on in vitro development of Meishan and Yorkshire preimplantation conceptuses. J Anim Sci 71,1561-1565.
205.Yong wu and Pei Jung. (1997). On structure and function of homeodomain. Devel Reprod Biol 6(1),81-89.
206.Yoshizawa, T., Handa, Y., Uematsu, Y, Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T., Arioka, K., Sato, H., Uchiyama, Y, Masushige, S., Fukamizu, A., Matsumoto, T., and Kato, S. (1997). Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16,391-396.
207.Zhu, Y., Hoell, P. and Ahlemeyer, B. (2006). PTEN:a crucial mediator of mitochondria-dependent apoptosis. Apoptosis 11(2),197-207.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |