重庆地区原发性高血压患者血浆心肌营养素-1水平与左室肥厚的关系
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- 英文论文题名：The relationship between CT-1 and left ventricular hypertrophy in essential hypertension patients in Chongqing
- 论文作者：陈云 ; 王曦 ; 陈明
- 英文论文作者：Chen Yun ; Wang Xi ; Chen Ming ; Department of Cardiology ; The First Affiliated Hospital of Chongqing Medical University
- 年：2017
- 作者机构：重庆医科大学附属第一医院心内科;
- 论文关键词：原发性高血压 ; 左室肥厚 ; 心肌营养素-1
- 英文论文关键词：essential hypertension ; left ventricular hypertrophy ; cardiotrophin-1
- 会议召开时间：2017-05-26
- 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
- 语种：中文
- 分类号：R544.11
- 学会代码：ZHXB
- 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
- 会议地点：中国湖北武汉
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：3
- 文件大小：364k
- 原文格式：O
- 会议级别：全国
摘要
目的:探讨重庆地区原发性高血压患者血浆心肌营养素-1(cardiotrophin-1,CT-1)水平与左室肥厚的关系。方法:纳入原发性高血压患者116例,其中单纯高血压(isolated hypertension group,IH)58例,高血压合并左室肥厚(Hypertension with left ventricular hypertrophy group,LVH)58例,并设立健康对照组(healthy control group,HC)50例。检测上述人群血浆CT-1浓度,并行超声心动图检查,比较各组人群CT-1水平,分析CT-1与超声心动图各项指标的相关性。结果:1)LVH组和IH组CT-1浓度显著高于HC组(626.17±211.14 vs.191.57±70.65,P=0.000;390.25±243.30vs.191.57±70.65 P=0.000)。2)Spearman秩相关分析显示,血浆CT-1水平与左室质量指数(Left ventricular mass index,LVMI)值有显著相关性(r=0.66,P=0.000)。结论:重庆地区原发性高血压患者血浆CT-1可能参与高血压左室肥厚的发生和进展。
Objective:To investigate the potential relation between plasma CT-1 and left ventricular hypertrophy in essential hypertensive patients.Methods:116 patients with essential hypertension were enrolled into the current study,including 58 cases of isolated hypertension group(IH),58 cases of Hypertension with left ventricular hypertrophy group,(LVH),and 50 cases of healthy control participants,(HC).All participants were subjected to test the concentration of plasma CT-1 and echocardiography of these patients.Compared the CT-1 level of each group,and analyzed the correlation between CT-1 and echocardiography.Results:1) Patients in the LVH group have the highest level of CT-1(626.17 ±211.14,P=0.000),followed by that of in the IH group(390.25 ± 243.30,P=0.000) and that of(191.57 ± 70.65,P=0.000) in the HC group.The concentration of CT-1 in these two groups was higher than that in HC group.2) The spearman test showed that plasma level of CT-1 was significantly with LVMI(Left ventricular mass index)(r-0.66,P=0.000).Conclusion:CT-1 was involved in the development of left ventricular hypertrophy in essential hypertension in Chongqing.Detection of plasma CT-1 concentrations may help the diagnosis of hypertensive heart disease.
Objective:To investigate the potential relation between plasma CT-1 and left ventricular hypertrophy in essential hypertensive patients.Methods:116 patients with essential hypertension were enrolled into the current study,including 58 cases of isolated hypertension group(IH),58 cases of Hypertension with left ventricular hypertrophy group,(LVH),and 50 cases of healthy control participants,(HC).All participants were subjected to test the concentration of plasma CT-1 and echocardiography of these patients.Compared the CT-1 level of each group,and analyzed the correlation between CT-1 and echocardiography.Results:1) Patients in the LVH group have the highest level of CT-1(626.17 ±211.14,P=0.000),followed by that of in the IH group(390.25 ± 243.30,P=0.000) and that of(191.57 ± 70.65,P=0.000) in the HC group.The concentration of CT-1 in these two groups was higher than that in HC group.2) The spearman test showed that plasma level of CT-1 was significantly with LVMI(Left ventricular mass index)(r-0.66,P=0.000).Conclusion:CT-1 was involved in the development of left ventricular hypertrophy in essential hypertension in Chongqing.Detection of plasma CT-1 concentrations may help the diagnosis of hypertensive heart disease.
引文
[1]GONZ LEZ A,L PEZ B,RAVASSA S,et al.Cardiotrophin-1 in hypertensive heart disease[J].Endocrine,2012,15;230-235.
[2]CELIK A,SAHIN S,KOC F,et al.Cardiotrophin-1 plasma levels are increased in patients with diastolicheart failure[J].Med Sci Monit,2012,18:CR25-31.
[3]吕丹,张连峰.心肌营养素-1在心脏发育和心脏病发生中的作用[J].中国分子心脏病学杂志,2008,8(1):55-59.
[4]Ravassa S,Beloqui O,Varo N;Association of cardiotrophin-1 with left ventricular systolic properties in asymptomatic hypertensive patients[J].JHypertens.2013 Mar;31(3):587-94.doi:0.1097/HJH.0b013e32835 ca903.
[5]叶炳华;高血压左室肥厚与血浆心肌营养素-1的关系[J];实用医学杂志2010年第26卷第13期。
[6]JOUGASAKI M.Cardiotrophin-1 in cardiovascular regulation[J],Adv Clin Chem,2010,52:41-76.
[7]TAKIMOTO Y,AOYANM T,IWANAGA Y,el al.Increased expression of cardiotrophin-1 during ventricular remodeling in hypertensive rats[J].Am J Physiol Heart Circ Physiol,2002,282(3):H896-H901.
[8]Lopez-Andres N,Fortuno MA,Diez J,Zannad F,Lacolley P,Rossignol P.Vascular effects of cardiotrophin-1:a role in hypertension?[J]J Hypertens 2010;28:1261-1272.
[9]Lopez-Andres N,Rousseau A,Akhtar R.Cardiotrophin 1 is involved in cardiac,vascular,and renal fibrosis and dysfunction[J].Hypertension 2012;60:563-573.
[10]Lopez B,Castellano JM,Gonzalez A.Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J].Hypertension 2007;50:977-983.
[11]atalia Lopez a,Javier Diez a,b,Maria Antonia Fortuno a,Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats[J].J Mol Cell Cardiol.2006 Nov;41(5):902-13.Epub 2006 Oct 2.
[12]Lopez-Andres N,Martin-Fernandez B,Rossignol Pel al.A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone[J].Am J Physiol Heart Circ Physiol,2011,301(6):H2372-H2382.
[13]PEZ B,GONZALEZ A,LASARTE J J,et al.Is plasma cardiotrophin-1 a maker of hypertensive heart disease?[J].J Hypertens,2005,23(3):625-632.
[14]Pemberton CJ,Raudsepp SD,Yandle TG,Cameron VA,Richards AM.Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch.Cardiovasc Res.2005;68:109-117.
[15]Warnes CA,Roberts WC.The heart in massive(more than 300 pounds or 136 kilograms)obesity.Analysis of 12 patients studied at necropsy[J].Am J Cardiol 1994;54:1087-91.
[16]Merlino G,Scaglione R,Corrao S,et al.Association between reduced lymphocyte beta-adrenergic receptors and left ventricular dysfunction in young obese subjects[J].Int J Obes Relat Metab Disord 1994;18:699-703.
[17]Messerli FH,Sungaard-Riise ED,Dreslinski GR,et al.Dimorphic cardiac adaptation to obesity and arterial hypertension[J].Ann Intern Med 1983;94:757-61.
[18]Nakajima T,Fuhoka S,Tokunaga K,et al.Noninvasive study of left ventricular performance in obese patients:Influences of duration of obesity[J].Circulation 1985;71:481-6.
[19]Ku C,Lin S,Wang D,et al.Left ventricular filling in normotensive obese adults[J].Am J Cardiol 1994;73:613-5.
[20]Alpert MA,Terry BE,Kelly DK.Effect of weight loss on cardiac chamber size,wall thickness and left ventricular function in morbid obesity[J].Am J Cardiol 1995;55:783-86.
[21]Zema MS,Caccavano M.Feasibility of detailed M-mode echocardiographic examination in markedly obese adults[J].Prospective study of50 patients.J Clin Ultrasound 1982;10:31-4.
[22]Garcia L,Laredo C,Arriaga J,et al.Echocardiographic findings in obesity[J].Rev Invest Clin 1982;34:235-42.
[23]Lauer MS,Anderson KM,Levy D.Separate and joint influences of obesity and mild hypertension on left ventricular mass and geometry;the Framingham Heart Study[J].J Am Coll Cardiol 1992;19:130-4.
[24]Kangxing Song,MD;1,2,*Shuxia Wang,MD;J Clin Hypertens(Greenwich)[J].2014;16:686-692.a2014Wiley Periodicals,Inc
[2]CELIK A,SAHIN S,KOC F,et al.Cardiotrophin-1 plasma levels are increased in patients with diastolicheart failure[J].Med Sci Monit,2012,18:CR25-31.
[3]吕丹,张连峰.心肌营养素-1在心脏发育和心脏病发生中的作用[J].中国分子心脏病学杂志,2008,8(1):55-59.
[4]Ravassa S,Beloqui O,Varo N;Association of cardiotrophin-1 with left ventricular systolic properties in asymptomatic hypertensive patients[J].JHypertens.2013 Mar;31(3):587-94.doi:0.1097/HJH.0b013e32835 ca903.
[5]叶炳华;高血压左室肥厚与血浆心肌营养素-1的关系[J];实用医学杂志2010年第26卷第13期。
[6]JOUGASAKI M.Cardiotrophin-1 in cardiovascular regulation[J],Adv Clin Chem,2010,52:41-76.
[7]TAKIMOTO Y,AOYANM T,IWANAGA Y,el al.Increased expression of cardiotrophin-1 during ventricular remodeling in hypertensive rats[J].Am J Physiol Heart Circ Physiol,2002,282(3):H896-H901.
[8]Lopez-Andres N,Fortuno MA,Diez J,Zannad F,Lacolley P,Rossignol P.Vascular effects of cardiotrophin-1:a role in hypertension?[J]J Hypertens 2010;28:1261-1272.
[9]Lopez-Andres N,Rousseau A,Akhtar R.Cardiotrophin 1 is involved in cardiac,vascular,and renal fibrosis and dysfunction[J].Hypertension 2012;60:563-573.
[10]Lopez B,Castellano JM,Gonzalez A.Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J].Hypertension 2007;50:977-983.
[11]atalia Lopez a,Javier Diez a,b,Maria Antonia Fortuno a,Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats[J].J Mol Cell Cardiol.2006 Nov;41(5):902-13.Epub 2006 Oct 2.
[12]Lopez-Andres N,Martin-Fernandez B,Rossignol Pel al.A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone[J].Am J Physiol Heart Circ Physiol,2011,301(6):H2372-H2382.
[13]PEZ B,GONZALEZ A,LASARTE J J,et al.Is plasma cardiotrophin-1 a maker of hypertensive heart disease?[J].J Hypertens,2005,23(3):625-632.
[14]Pemberton CJ,Raudsepp SD,Yandle TG,Cameron VA,Richards AM.Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch.Cardiovasc Res.2005;68:109-117.
[15]Warnes CA,Roberts WC.The heart in massive(more than 300 pounds or 136 kilograms)obesity.Analysis of 12 patients studied at necropsy[J].Am J Cardiol 1994;54:1087-91.
[16]Merlino G,Scaglione R,Corrao S,et al.Association between reduced lymphocyte beta-adrenergic receptors and left ventricular dysfunction in young obese subjects[J].Int J Obes Relat Metab Disord 1994;18:699-703.
[17]Messerli FH,Sungaard-Riise ED,Dreslinski GR,et al.Dimorphic cardiac adaptation to obesity and arterial hypertension[J].Ann Intern Med 1983;94:757-61.
[18]Nakajima T,Fuhoka S,Tokunaga K,et al.Noninvasive study of left ventricular performance in obese patients:Influences of duration of obesity[J].Circulation 1985;71:481-6.
[19]Ku C,Lin S,Wang D,et al.Left ventricular filling in normotensive obese adults[J].Am J Cardiol 1994;73:613-5.
[20]Alpert MA,Terry BE,Kelly DK.Effect of weight loss on cardiac chamber size,wall thickness and left ventricular function in morbid obesity[J].Am J Cardiol 1995;55:783-86.
[21]Zema MS,Caccavano M.Feasibility of detailed M-mode echocardiographic examination in markedly obese adults[J].Prospective study of50 patients.J Clin Ultrasound 1982;10:31-4.
[22]Garcia L,Laredo C,Arriaga J,et al.Echocardiographic findings in obesity[J].Rev Invest Clin 1982;34:235-42.
[23]Lauer MS,Anderson KM,Levy D.Separate and joint influences of obesity and mild hypertension on left ventricular mass and geometry;the Framingham Heart Study[J].J Am Coll Cardiol 1992;19:130-4.
[24]Kangxing Song,MD;1,2,*Shuxia Wang,MD;J Clin Hypertens(Greenwich)[J].2014;16:686-692.a2014Wiley Periodicals,Inc
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