肽类表面活性剂二(月桂酰胺谷氨酰胺)赖氨酸钠制备神经酰胺纳米乳液
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- 英文论文题名：Nanoemulsification of Ceramide-2 by Sodium Dilauramidoglutamide Lysine,a Novel Peptide-based Gemini Surfactant
- 论文作者：田永红 ; 郭奕光 ; 杨雪芳 ; 张婉萍
- 英文论文作者：TIAN Yong-hong ; Yi Guang-guo ; Xue Fang-yang ; ZHANG Wan-ping ; School of Perfume and Aroma Technology ; Shanghai Institute of Technology ; Shanghai Jahwa Corporations
- 年：2016
- 作者机构：上海应用技术学院·香料香精技术与工程学院;上海家化有限公司;
- 论文关键词：二(月桂酰胺谷氨酰胺)赖氨酸钠 ; 神经酰胺 ; 结晶度 ; 纳米乳液
- 英文论文关键词：sodium dilauramidoglutamide lysine ; ceramide-2 ; crystallinity ; nanoemulsions
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国化妆品学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Cosmetic China
- 语种：中文
- 分类号：TQ658
- 学会代码：ZGXE
- 会议名称：第十一届中国化妆品学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：9
- 文件大小：1650k
- 原文格式：O
- 会议级别：全国
摘要
新型的肽类表面活性剂二(月桂酰胺谷氨酰胺)赖氨酸钠(DLGL)被用来制备含活性成分神经酰胺的纳米乳液。本文通过X-射线衍射法,差示扫描量热法,红外光谱法研究了DLGL分子与神经酰胺分子之间的相互作用,通过扫描电镜和透射电镜表征了纳米乳液的相貌形态,通过神经酰胺纳米乳液50℃下粒径随时间的变化表征了其稳定性。实验结果表明:DLGL可以显著降低神经酰胺的结晶度;扫描电镜和透射电镜表明纳米乳液外貌呈球形,粒径在300nm左右;50℃下储存一个月,纳米乳液粒径没有显著变化。
A novel peptide-based gemini surfactant,namely,sodium dilauramidoglutamide lysine(DLGL) was employed to fabricate a stable nanoemulsion system for the delivery of hydrophobic bioactive ceramide-2molecules.The phase properties and morphology and stability of the nanoemulsion were investigated by focusing on the interaction between DLGL and ceramide-2 molecules.The investigation of the phase properties of the mixture of DLGL and ceramide-2 by X-ray diffraction,differential scanning calorimetry,and Fourier transform infrared spectroscopy revealed remarkable reduction in the crystallinity of ceramide-2 due to the presence of DLGL.The spherical shape and nanometer size of nanoemulsions emulsified by DLGL were characterized by scanning electron microscopy and transmission electron microscopy.The nanoemulsions prepared using DLGL exhibited significant improvement in the dispersion stability without any significant changes in the particle sizes even after storing them for a month at 50 ℃.
A novel peptide-based gemini surfactant,namely,sodium dilauramidoglutamide lysine(DLGL) was employed to fabricate a stable nanoemulsion system for the delivery of hydrophobic bioactive ceramide-2molecules.The phase properties and morphology and stability of the nanoemulsion were investigated by focusing on the interaction between DLGL and ceramide-2 molecules.The investigation of the phase properties of the mixture of DLGL and ceramide-2 by X-ray diffraction,differential scanning calorimetry,and Fourier transform infrared spectroscopy revealed remarkable reduction in the crystallinity of ceramide-2 due to the presence of DLGL.The spherical shape and nanometer size of nanoemulsions emulsified by DLGL were characterized by scanning electron microscopy and transmission electron microscopy.The nanoemulsions prepared using DLGL exhibited significant improvement in the dispersion stability without any significant changes in the particle sizes even after storing them for a month at 50 ℃.
引文
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[8]A.K.Tiwari,M.Sowmiya,S.K.Saha.Study on premicellar and micellar aggregates of gemini surfactants with hydroxyl substituted spacers in aqueous solution using a probe showing TICT fluorescence properties.Journal of Photochemistry and Photobiology A:Chemistry 223(2011):6-13.
[9]B.Sohrabi,A.Bazyari,M.Hashemianzadeh.Effect of ethylene glycol on micellization and surdace properties of Gemini surfactant solutions.Colloids and surfaces A:Physicochemical and Engineering Aspects 364(2010):87-93.
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[11]T.Hikima,Y.Tamura,Y.Yamawaki,M.Yamamoto.Skin accumulation and penetration of a hydrophilic compound by a novel gemini surfactant,sodium dilauramidoglutamide lysine.International Journal of Pharmaceutics 443(2013):288-292.
[12]S.kiguchi.Study on novel peptide-based gemini amphiphilic compound,Pellicer L-30 and application to the cosmetic.Fragrance J.36(2008):67-74.
[13]L.Lin,Y.Ye,K.Chen.New surfactant for shampoos and conditioners from Presperse.Chemical Engineering World 10(2010):9.
[14]K.B.ita.Transdermal drug delivery:progress and challenges.Journal of Drug Delivery Science and Technology 3(2014):245-250.
[15]M.Valsecchi,L.Mauri,R.Casellato,M.G.Ciampa.Ceramides as Possible Nutraceutical Compounds:Characterization of the Ceramides of the Moro Blood Orange(Citrus sinensis).Agricultural and food chemistry 60(2012):10103-10110.
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[19]Y.Tokudome,Y.Saito,F.Sato.Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity.Colloids and surfaces B:Biointerfaces 73(2009):92-96.
[20]D.Kim,E.J.An,J.Kim,S.Han.Fabrication and characterization of pseudo-ceramide-based liposomal membranes.Colloids and surfaces B:Biointerfaces 73(2009):207-211.
[21]D.Kim,W.R.Park,J.Hwan Kim,E.C.Cho.Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function.Colloids and surfaces B:Biointerfaces 94(2012):236-241.
[22]M.K.Kim,E.S.Jeong,K.W.N.Kim,Seung Han Park.Nanoemulsification of pseudo-ceramide by molecular association with mannosylerythritol lipid.Colloids and surfaces B:Biointerfaces116(2014):597-602.
[23]Y.Li,J.Zheng,H.Xiao,D.J.McClements.Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds:Influence of formulation parameters on polymethoxyflavone crystallization.Food Hydrocolloids 27(2012):517-528.
[24]N.Ohta,I.Hatta.Interaction among molecules in mixtures of ceramide/stearic acid,ceramide/cholesterol and ceramide/stearic acid/cholesterol.Chemistry and Physics of Lipids115(2002):93-105.
[25]O.M.Al Zoubi M.N.Normah.Critical moisture content for successful cryopreservation of embryonic axes of Fortunella polyandra determined by differential scanning calorimetry(DSC).Acta Physiol Plant 37(2015):1727.
[26]S.Kumar,J.K.Randhawa.Paliperidone-loaded spherical solid lipid nanoparticles.The royal Society of Chemistry 4(2014):30186-30192.
[27]H.Kim,J.K.Lim,D.Kim,S.T.Lim.Formation of crystalline complexes between amylomaize dextrin and ceramide.Carbohydrate Polymers101(2014):407-414.
[28]S.Kim,M.J.Stebe,J.L.Blin,A.Pasc.pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix.Journal of Material Chemistry B 2(2014):7910-7917.
[29]D.J.McClements.Edible nanoemulsions:fabrication,properties,and functional performance.The royal Society of Chemistry 7(2011):2297-2316.
[30]V.Klang,N.B.Matsko,C.Valenta,F.Hofer.Electron microscopy of nanoemusions:An essential tool for characterisation and stability assessment.Micron 43(2012):85-103.
[2]R.Li,F.Yan,J.Zhang,C.Xu.The self-assembly properties of a series of polymerizable cationic gemini surfactants:Effect of the acryoxyl group.Colloids and surfaces A:Physicochemical and Engineering Aspects 444(2014):276-282.
[3]L.Perez,A.Pinazo,R.Pons,M.Infante.Gemini surfactants from natural amino acids.Advances in Colloid and Interface Science 205(2014):134-155.
[4]H.Li,C.Yu,R.Chen,J.Li,J.Li.Novel ionic liquid-type Gemini surfactants:Synthesis,surface property and antimicrobial activity.Colloids and surfaces A:Physicochemical and Engineering Aspects 395(2012):116-124.
[5]P.Parekh,D.Varade,J.Parikh,P.Bahadur.Anionic-cationic mixed surfactant systems:Micellar interaction of sodium dodecyl trioxyethylene sulfate with cationic gemini durfactants.Colloids and surfaces A:Physicochemical and Engineering Aspects385(2011):111-120.
[6]D.Zhu,F.Cheng,Y.Chen,S.Jiang.Preparation,characterization and properties of anionic gemini surfactants with long rigid or semi-rigid spacers.Colloids and surfaces A:Physicochemical and Engineering Aspects 397(2012):l-7.
[7]D.Tikariha,N.Singh,M.L.Satnami,K.K.Ghosh.Physicochemical characterization of cationic gemini surfactants and their effect on reaction kinetics in ethylene glycol-water medium.Colloids and surfaces A:Physicochemical and Engineering Aspects 411(2012):1-11.
[8]A.K.Tiwari,M.Sowmiya,S.K.Saha.Study on premicellar and micellar aggregates of gemini surfactants with hydroxyl substituted spacers in aqueous solution using a probe showing TICT fluorescence properties.Journal of Photochemistry and Photobiology A:Chemistry 223(2011):6-13.
[9]B.Sohrabi,A.Bazyari,M.Hashemianzadeh.Effect of ethylene glycol on micellization and surdace properties of Gemini surfactant solutions.Colloids and surfaces A:Physicochemical and Engineering Aspects 364(2010):87-93.
[10]M.Wang,Y.Han,F.Qiao,Y.Wang.Aggregation behavior of a gemini surfactant with a tripeptide spacer.Royal society of chemistry11(2015):1517-1524.
[11]T.Hikima,Y.Tamura,Y.Yamawaki,M.Yamamoto.Skin accumulation and penetration of a hydrophilic compound by a novel gemini surfactant,sodium dilauramidoglutamide lysine.International Journal of Pharmaceutics 443(2013):288-292.
[12]S.kiguchi.Study on novel peptide-based gemini amphiphilic compound,Pellicer L-30 and application to the cosmetic.Fragrance J.36(2008):67-74.
[13]L.Lin,Y.Ye,K.Chen.New surfactant for shampoos and conditioners from Presperse.Chemical Engineering World 10(2010):9.
[14]K.B.ita.Transdermal drug delivery:progress and challenges.Journal of Drug Delivery Science and Technology 3(2014):245-250.
[15]M.Valsecchi,L.Mauri,R.Casellato,M.G.Ciampa.Ceramides as Possible Nutraceutical Compounds:Characterization of the Ceramides of the Moro Blood Orange(Citrus sinensis).Agricultural and food chemistry 60(2012):10103-10110.
[16]S.Hatziantoniou,G.Deli,Y.Nikas,C.Demetzos,G.Th.Papaioannou.Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides.Micron 38(2007):819-823.
[17]H.Watanabe,Y.Obata,K.Ishida,K.Takayama.Effect of 1-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum.Colloids and surfaces B:Biointerfaces 73(2009):116-121.
[18]T.Imura,H.Sakai,H.Yamauchi.Preparation of liposomes containing Ceramide 3 and their membrane characteristics.Colloids and surfaces B:Biointerfaces 20(2001):1-8.
[19]Y.Tokudome,Y.Saito,F.Sato.Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity.Colloids and surfaces B:Biointerfaces 73(2009):92-96.
[20]D.Kim,E.J.An,J.Kim,S.Han.Fabrication and characterization of pseudo-ceramide-based liposomal membranes.Colloids and surfaces B:Biointerfaces 73(2009):207-211.
[21]D.Kim,W.R.Park,J.Hwan Kim,E.C.Cho.Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function.Colloids and surfaces B:Biointerfaces 94(2012):236-241.
[22]M.K.Kim,E.S.Jeong,K.W.N.Kim,Seung Han Park.Nanoemulsification of pseudo-ceramide by molecular association with mannosylerythritol lipid.Colloids and surfaces B:Biointerfaces116(2014):597-602.
[23]Y.Li,J.Zheng,H.Xiao,D.J.McClements.Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds:Influence of formulation parameters on polymethoxyflavone crystallization.Food Hydrocolloids 27(2012):517-528.
[24]N.Ohta,I.Hatta.Interaction among molecules in mixtures of ceramide/stearic acid,ceramide/cholesterol and ceramide/stearic acid/cholesterol.Chemistry and Physics of Lipids115(2002):93-105.
[25]O.M.Al Zoubi M.N.Normah.Critical moisture content for successful cryopreservation of embryonic axes of Fortunella polyandra determined by differential scanning calorimetry(DSC).Acta Physiol Plant 37(2015):1727.
[26]S.Kumar,J.K.Randhawa.Paliperidone-loaded spherical solid lipid nanoparticles.The royal Society of Chemistry 4(2014):30186-30192.
[27]H.Kim,J.K.Lim,D.Kim,S.T.Lim.Formation of crystalline complexes between amylomaize dextrin and ceramide.Carbohydrate Polymers101(2014):407-414.
[28]S.Kim,M.J.Stebe,J.L.Blin,A.Pasc.pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix.Journal of Material Chemistry B 2(2014):7910-7917.
[29]D.J.McClements.Edible nanoemulsions:fabrication,properties,and functional performance.The royal Society of Chemistry 7(2011):2297-2316.
[30]V.Klang,N.B.Matsko,C.Valenta,F.Hofer.Electron microscopy of nanoemusions:An essential tool for characterisation and stability assessment.Micron 43(2012):85-103.
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