包覆化学防晒剂的聚甲基丙烯酸甲酯粒子的制备及性能研究
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- 英文论文题名：Preparation and properties of poly(methyl methacrylate)particles incorporating a chemical sunscreen agent
- 论文作者：章苏宁 ; 王文扬 ; 王晓会
- 英文论文作者：Suning Zhang ; Wenyang Wang ; Xiaohui Wang ; School of Perfume and Aroma Technology ; Shanghai Institute of Technology
- 年：2016
- 作者机构：上海应用技术大学香料香精技术与工程学院;
- 论文关键词：聚甲基丙烯酸甲酯 ; 乳液聚合 ; 防晒 ; 包埋 ; 应用
- 英文论文关键词：PMMA ; emulsion polymerization ; sunscreen ; encapsulation ; application
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国化妆品学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Cosmetic China
- 语种：中文
- 分类号：TQ658.24
- 学会代码：ZGXE
- 会议名称：第十一届中国化妆品学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：8
- 文件大小：986k
- 原文格式：O
- 会议级别：全国
摘要
采用乳液聚合的方法来制备聚甲基丙烯酸甲酯/水杨酸乙基己酯(PMMA-EHS)化学防晒剂包覆粒子。并采用透射电子显微镜、扫描电子显微镜镜、傅里叶红外光谱、热重、激光粒度仪、SPF-防晒指数测试仪等方法表征所制备粒子的性能。其结果表明:化学防晒剂被包裹后,减少了与皮肤直接接触的面积,从而大大减少了对皮肤的刺激性。而且,与未被包裹的水杨酸乙基己酯相比,聚甲基丙烯酸甲酯/水杨酸乙基己酯防晒粒子防晒指数SPF值上升了41%,由此表明将水杨酸乙基己酯包裹在聚甲基丙烯酸甲酯里,能大大提高其防晒性能。另外,聚甲基丙烯酸甲酯/水杨酸乙基己酯粒子被证明在应用过程中不渗漏,且在配方中保持良好的稳定性。
In this work,poly(methyl methacrylate)-ethylhexyl salicylate(PMMA-EHS) particles were prepared via emulsion polymerization.Transmission electron microscopy(TEM),Scanning electron microscopy(SEM),Fourier transformation infrared spectroscopy(FT-IR),thermal gravimetric analysis(TGA),SPF-290 S computer operated analyzer system were used to investigate properties of the particles.The results show that encapsulating the chemical sunscreen agent EHS in PMMA particles greatly reduced the skin irritation induced by direct contacting with skin.Furthermore,compared with free EHS containing sunscreen cream,the sun protection factor(SPF) value of PMMA-EHS particle contained sunscreen cream increased by about 41.0%,which indicated a significant enhancement of UV protection ability by encapsulating EHS in PMMA.In addition,PMMA-EHS particles were proved to be no leakage and exhibited good stability in application.
In this work,poly(methyl methacrylate)-ethylhexyl salicylate(PMMA-EHS) particles were prepared via emulsion polymerization.Transmission electron microscopy(TEM),Scanning electron microscopy(SEM),Fourier transformation infrared spectroscopy(FT-IR),thermal gravimetric analysis(TGA),SPF-290 S computer operated analyzer system were used to investigate properties of the particles.The results show that encapsulating the chemical sunscreen agent EHS in PMMA particles greatly reduced the skin irritation induced by direct contacting with skin.Furthermore,compared with free EHS containing sunscreen cream,the sun protection factor(SPF) value of PMMA-EHS particle contained sunscreen cream increased by about 41.0%,which indicated a significant enhancement of UV protection ability by encapsulating EHS in PMMA.In addition,PMMA-EHS particles were proved to be no leakage and exhibited good stability in application.
引文
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2.Lautenschlager S,Wulf H,Pittelkow M.Photoprotection.Lancet.2007;370:528-537.
3.Perugini P,Simeoni S,Scalia S,et al.Effect of nanoparticle encapsulation on the photo stability of the sunscreen agent,2-ethylhexyl-pmethoxycinnamate.J.Pharm.2002;246:37-45.
4.Jimenez MM,Pelletier J,Bobin MF,et al.Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate:preparation and characterization.Dev.Technol.2004;9:329-339.
5.Patel M,Jain SK,Yadav A,et al.Preparation and characterization of oxybenzone loaded gelatin microspheres for enhancement of sunscreening efficacy.Drug Deliv.2006;13:323-330.
6.Westerdahl J,Ingvar C,Masback A,et al.Risk of cutaneous malignant melanoma in relation to use of sunbeds:further evidence for UV-A carcinogenicity.Bri J Cancer.2000;82:1593-1599.
7.Wolf R,Wolf D.The opinions expressed herein are solely those of the authors and do not necessarily reflect the opinions of the institutions with which the authors are associated.Clin Dermatol.2000;18:661-666.
8.Chen-Yang YW,Chen YT,Li CC,et al.Preparation of UV-filter encapsulated mesoporous silica with high sunscreen ability.Mater Lett.2011;65:1060-1062
9.Sun W,He Q,Luo Y.Synthesis and properties of layered double hydroxides intercalated with cinnamic acid series organic UV ray absorbents.Materials Chemistry and Physics.2008;107:261-265.
10.Stiefel C and Schwack W.Photoprotection in changing times-UV filter efficacy and safety,sensitization processes and regulatory aspects.Int.J.Cosmet.Sci.2015;37:2-30
11.Stiefel C,Schwack W and Nguyen YTH.Photostability of Cosmetic UV Filters on Mammalian Skin Under UV Exposure.Photochemistry and Photobiology.2015;91:84-91
12.Stiefel C,Schwack W.Reactivity of cosmetic UV filters towards skin proteins:Model studies with Boc-lysine,Boc-Gly-Phe-Gly-Lys-OH,BSA and gelatin.Int.J.Cosmet Sci.2014;36:561-570
13.Tursilli R,Piel G,Delattre L,et al.Solid lipid microparticles containing the sunscreen agent,-dimethylaminobenzoate:Effect of the vehicle.Eur.J.Pharm.Biopharm.2007;66:483-487.
14.Yener G,Incegul T and Yener N.Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate.Int.J.Pharm.2003;258:203-207.
15.Patel M,Jain SK,Yadav A,et al.Preparation and characterization of oxybenzone loaded gelatin microspheres for enhancement of sunscreening efficacy.Drug Deliv.2006;13:323-330.
16.Rogers K.Multiparticulate carriers for sun-screening agents.Cosmet.Toil.1999;114:53-60.
17.Perugini P,Simeoni S,Scalia S,et al.Effect of nanoparticles encapsulation on the sunscreen agents,2-ethylhexyl-pmethoxycinnamate.Int.J.Pharm.2002;246:37-45.
18.Jimenez MM,Pelletier J,Bobin MF,et al.Poly-Epsilon-Caprolactone Nanocapsules Containing Octyl Methoxycinnamate:Preparation and Characterization.Dev.Technol.2004;9:329-339.
19.Chunjin S,Shuangxi L.A new healthy sunscreen system for human:Solid lipid nanoparticles as carrier for 3,4,5-trimethoxy-benzoylchitin and the improvement by adding Vitamin E.Int.J.Biol.Macromol.2005;36:116-119.
20.Lemperle G,Ott H,Charrier U,et al.PMMA microspheres for intradermal implantation:Part I.Animal research.Ann.Plast.Surg.1991;26:57-63.
21.Huang ZF,Qu XY,Chen Z.Nano-SiO2/PMMA-PU composite particles with core-shell structure via emulsion polymerization and their application in epoxy resin.J.Appl.Poly.Sci.2015;132:19
22.Lee CF,Liu YS.The preparation and characteristics of poly(methyl methacrylate-methylacrylate acid)/nano-ZnO omposite latex particlesPolym.Bull.2011;67:1245-1259
23.Liu YS,Chu CH,Tsai CA,et al.Synthesis and characteristics of poly(methyl methacrylate-methacrylic acid-3,3-(trimethoxysilyl)propyl methacrylate)hollow latex particles and their application to drug carriers.Polym.Bull.2012;69:699-714
2.Lautenschlager S,Wulf H,Pittelkow M.Photoprotection.Lancet.2007;370:528-537.
3.Perugini P,Simeoni S,Scalia S,et al.Effect of nanoparticle encapsulation on the photo stability of the sunscreen agent,2-ethylhexyl-pmethoxycinnamate.J.Pharm.2002;246:37-45.
4.Jimenez MM,Pelletier J,Bobin MF,et al.Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate:preparation and characterization.Dev.Technol.2004;9:329-339.
5.Patel M,Jain SK,Yadav A,et al.Preparation and characterization of oxybenzone loaded gelatin microspheres for enhancement of sunscreening efficacy.Drug Deliv.2006;13:323-330.
6.Westerdahl J,Ingvar C,Masback A,et al.Risk of cutaneous malignant melanoma in relation to use of sunbeds:further evidence for UV-A carcinogenicity.Bri J Cancer.2000;82:1593-1599.
7.Wolf R,Wolf D.The opinions expressed herein are solely those of the authors and do not necessarily reflect the opinions of the institutions with which the authors are associated.Clin Dermatol.2000;18:661-666.
8.Chen-Yang YW,Chen YT,Li CC,et al.Preparation of UV-filter encapsulated mesoporous silica with high sunscreen ability.Mater Lett.2011;65:1060-1062
9.Sun W,He Q,Luo Y.Synthesis and properties of layered double hydroxides intercalated with cinnamic acid series organic UV ray absorbents.Materials Chemistry and Physics.2008;107:261-265.
10.Stiefel C and Schwack W.Photoprotection in changing times-UV filter efficacy and safety,sensitization processes and regulatory aspects.Int.J.Cosmet.Sci.2015;37:2-30
11.Stiefel C,Schwack W and Nguyen YTH.Photostability of Cosmetic UV Filters on Mammalian Skin Under UV Exposure.Photochemistry and Photobiology.2015;91:84-91
12.Stiefel C,Schwack W.Reactivity of cosmetic UV filters towards skin proteins:Model studies with Boc-lysine,Boc-Gly-Phe-Gly-Lys-OH,BSA and gelatin.Int.J.Cosmet Sci.2014;36:561-570
13.Tursilli R,Piel G,Delattre L,et al.Solid lipid microparticles containing the sunscreen agent,-dimethylaminobenzoate:Effect of the vehicle.Eur.J.Pharm.Biopharm.2007;66:483-487.
14.Yener G,Incegul T and Yener N.Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate.Int.J.Pharm.2003;258:203-207.
15.Patel M,Jain SK,Yadav A,et al.Preparation and characterization of oxybenzone loaded gelatin microspheres for enhancement of sunscreening efficacy.Drug Deliv.2006;13:323-330.
16.Rogers K.Multiparticulate carriers for sun-screening agents.Cosmet.Toil.1999;114:53-60.
17.Perugini P,Simeoni S,Scalia S,et al.Effect of nanoparticles encapsulation on the sunscreen agents,2-ethylhexyl-pmethoxycinnamate.Int.J.Pharm.2002;246:37-45.
18.Jimenez MM,Pelletier J,Bobin MF,et al.Poly-Epsilon-Caprolactone Nanocapsules Containing Octyl Methoxycinnamate:Preparation and Characterization.Dev.Technol.2004;9:329-339.
19.Chunjin S,Shuangxi L.A new healthy sunscreen system for human:Solid lipid nanoparticles as carrier for 3,4,5-trimethoxy-benzoylchitin and the improvement by adding Vitamin E.Int.J.Biol.Macromol.2005;36:116-119.
20.Lemperle G,Ott H,Charrier U,et al.PMMA microspheres for intradermal implantation:Part I.Animal research.Ann.Plast.Surg.1991;26:57-63.
21.Huang ZF,Qu XY,Chen Z.Nano-SiO2/PMMA-PU composite particles with core-shell structure via emulsion polymerization and their application in epoxy resin.J.Appl.Poly.Sci.2015;132:19
22.Lee CF,Liu YS.The preparation and characteristics of poly(methyl methacrylate-methylacrylate acid)/nano-ZnO omposite latex particlesPolym.Bull.2011;67:1245-1259
23.Liu YS,Chu CH,Tsai CA,et al.Synthesis and characteristics of poly(methyl methacrylate-methacrylic acid-3,3-(trimethoxysilyl)propyl methacrylate)hollow latex particles and their application to drug carriers.Polym.Bull.2012;69:699-714
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