基于限域效应机制的微波热疗增敏材料设计、制备与应用研究
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- 英文论文题名：The design, synthesis and application of microwave susceptible agents for tumor microwave thermotherapy based on confinement mechanism
- 论文作者：孟宪伟 ; 唐顺松 ; 付长慧 ; 刘天龙
- 英文论文作者：Xianwei Meng ; Shunsong Tang ; Changhui Fu ; Tianlong Liu ; Technical Institute of Physics and Chemistry ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院理化技术研究所;
- 论文关键词：热疗 ; 微波 ; 增敏 ; 限域效应 ; 肿瘤
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R730.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：148k
- 原文格式：D
- 会议级别：全国
摘要
肿瘤热疗技术作为一种绿色疗法受到越来越广泛的关注。其中,微波热疗技术具有可操作性强、升温速度快、热转换效率高以及组织穿透深度深等优点,成为最常用的临床癌症热疗手段之一。但是微波热疗对肿瘤的特异性与靶向性较差,而且无法对热疗剂量进行精确调控,导致正常组织热损伤与肿瘤细胞杀灭不彻底同时并存,极大制约了肿瘤微波热疗技术的临床应用。我们通过计算机模型模拟重建微波升温过程,发现微纳结构的限域作用引起的微波热疗增敏效应。并以此为理论基础,将具有微波增敏特性的治疗单元限制在微米或纳米中空球内部,增大微波热转化效率,提高肿瘤部位与正常组织之间的温差,改善微波热疗过程的特异性与靶向性。进一步将医学影像功能单元与微波增敏治疗单元复合,实现CT成像引导下进行肿瘤微波热疗,实时监测肿瘤组织的变化,有效调控热疗过程中微波热剂量,改善了热量传递安全性及有效性。这是利用微波热疗增敏材料实现体内肿瘤有效治疗的首次报道。
As the development of technology, thermal therapy of tumors has been widely applied in clinical field. Especially that the microwave thermal therapy of tumors has attracted much interest recently due to the maneuverability, faster heat generation from microwave radiation, depth of penetration in tissues, less susceptibility to local heat tissues and perfect ability of killing tumor cells. While it is difficult to limit the microwave into tumor region without damaging normal tissues. The microwave heating dose cannot be controlled accurately during the microwave thermal therapy procedure. These greatly restrict the development of microwave thermal therapy technology. Based on the confinement efficiency, we package microwave susceptible unit into hollow micron or nano-sized structure, to enhance the microwave thermal conversion efficiency and resolve the difficult of targeted heating tumor region. Simultaneously, we combine CT imaging unit to realize CT imaging guided microwave thermal therapy, which can control the microwave heating dose accurately.
As the development of technology, thermal therapy of tumors has been widely applied in clinical field. Especially that the microwave thermal therapy of tumors has attracted much interest recently due to the maneuverability, faster heat generation from microwave radiation, depth of penetration in tissues, less susceptibility to local heat tissues and perfect ability of killing tumor cells. While it is difficult to limit the microwave into tumor region without damaging normal tissues. The microwave heating dose cannot be controlled accurately during the microwave thermal therapy procedure. These greatly restrict the development of microwave thermal therapy technology. Based on the confinement efficiency, we package microwave susceptible unit into hollow micron or nano-sized structure, to enhance the microwave thermal conversion efficiency and resolve the difficult of targeted heating tumor region. Simultaneously, we combine CT imaging unit to realize CT imaging guided microwave thermal therapy, which can control the microwave heating dose accurately.
引文
[1]Meng X.Nanomedicine 2015,10:3311.
[2]Tan,L.;Wang,S.;Xu,K.;Liu,T.;Liang,P.;Niu,M.;Fu,C.;Shao,H.;Yu,J.;Ma,T.;Ren,X.;Li,H.;Dou,J.;Ren,J.;Meng X.Small 2016,DOI:10.1002/smll.201600191
[3]Shi,H;Niu,M.;Tan,L.;Liu,T.;Shao,H.;Fu,C.;Ren,X.;Ma,T.;Ren,J.;Li,L.;Liu,H.;Xu,K.;Wang,J.;Tang,F.;Meng X.Chemical Science 2015,6:5016.
[4]Shi,H;Liu,T.;Fu,C.;Tan,L.;Wang,J.;Ren,X.;Ren,J.;Wang,J.;Meng X.Biomaterials 2015,44:91.
[2]Tan,L.;Wang,S.;Xu,K.;Liu,T.;Liang,P.;Niu,M.;Fu,C.;Shao,H.;Yu,J.;Ma,T.;Ren,X.;Li,H.;Dou,J.;Ren,J.;Meng X.Small 2016,DOI:10.1002/smll.201600191
[3]Shi,H;Niu,M.;Tan,L.;Liu,T.;Shao,H.;Fu,C.;Ren,X.;Ma,T.;Ren,J.;Li,L.;Liu,H.;Xu,K.;Wang,J.;Tang,F.;Meng X.Chemical Science 2015,6:5016.
[4]Shi,H;Liu,T.;Fu,C.;Tan,L.;Wang,J.;Ren,X.;Ren,J.;Wang,J.;Meng X.Biomaterials 2015,44:91.
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