动物肠道物理屏障功能及乳酸杆菌的调控作用
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摘要
肠道不仅是体内最大的消化吸收场所,也是体内最大的免疫器官,肠道屏障功能与动物的健康状态和抗病能力息息相关。肠道物理屏障形成了肠腔和内环境之间的第一道防线,主要由单层柱状上皮细胞和细胞间紧密连接组成。乳酸杆菌是动物肠道内存在的正常微生物,也是生产中常用的益生菌添加剂,对肠道具有保护作用。本文从肠道物理屏障组成与功能、物理屏障损伤与调节机制、乳酸杆菌对动物肠道物理屏障功能的调节等方面进行综述。
引文
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[2]Yang F J,Hou C L,Zeng X F,et al..The Use of Lactic Acid Bacteria as a Probiotic in Swine Diets[J].Pathogens,2015,4:34-45.
[3]Hamdan A M,Ei-Sayed A F,Mahmoud M M.Effects of a novel marine probiotic,Lactobacillus plantarum AH 78,on growth performance and immuneresponse of Nile tilapia(Oreochromis niloticus)[J].J Appl Microbiol,2016,120(4):1061-1073.
[4]Sanz Y,De-Palma G.Gut microbiota and probiotics in modulation of epithelium and gut-associated lymphoid tissue function[J].Int Rev Immunol,2009,28(6):397-413.
[5]呙于明,刘丹,张炳坤.家禽肠道屏障功能及其营养调控[J].动物营养学报,2014,26(10):3091-3100.
[6]Miyauchi E,Morita H.Tanabe S.Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo[J].Journal of Dairy Science,2009,92(6):2400-2408.
[7]Van-Itallie C M.Anderson J M.Architecture of tight junctions and principles of molecular composition[J].Seminars in Cell&Developmental Biology,2014,36:157-165.
[8]G(u|¨)Nzel D,Yu A S.Claudins and the Modulation of Tight Junction Permeability[J].Physiol Rev,2013,93(2):525-569.
[9]Blasig I E,Bellmann C,Cording J,et al..Occludin protein family:oxidative stress and reducing conditions[J],Antioxid Redox Signal,2011,15(5):1195-1219.
[10]Takasawa A,Kojima T,Ninomiya T,et al..Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions[J].Cell Tissue Res,2013,351(1):73-84.
[11]徐姝燕.紧密连接相关蛋白Oecludin的研究进展[J].国际儿科学杂志,2012,39(5):451-454.
[12]Mariano C,Sasaki H.Brites D,et al..A look at tricellulin and its role in tight junction formation and maintenance[J].Eur J Cell Biol,2011,90(10):787-96.
[13]Balda M S,Matter K.Tight junctions as regulators of tissue remodeling[J].Current Opinion in Cell Biology,2016,42:94-101.
[14]Tamura A,Tsukita S.Paracellular barrier and channel functions of TJ claudins in organizing biological systems;advances in the field of barriology revealed in knockout mice[J].Semin Cell Dev Biol,2014,36:177-185.
[15]Krause G,Winkler L,Piehl Cet al..Structure and function of extracellular claudin domains[J].Ann N Y Acad Sci,2009,1165:34-43.
[16]Suzuki T.Regulation of intestinal epithelial permeability by tight junctions[J].Cellular and Molecular Life Sciences,2013,70(4):631-659.
[17]房贺.连接黏附分子A在促进MSC修复C14肝损伤中的作用及其机制[D].博士学位论文.上海:第二军医大学,2015.
[18]Luissint A C,Nusrat A,Parkos C A.JAM-related proteins in mucosal homeostasis and inflammation[J].Semin Immunopathol,2014,36:211-226.
[19]Rodgers L S,Beam M T,Anderson J M,et al..Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1[J].J Cell Sci,2013,126:1565-1575.
[20]Koch S.Nusrat A.Dynamic regulation of epithelial cell fate and barrier function by intercellular junction[J].Ann N Y Acad Sci,2009,1165:220-227.
[21]Fanning A S,Van-Itallie C M,Anderson J M.Zonula occludens-1 and-2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia[J].Mol Biol Cell,2012,23(4):577-590.
[22]Tokuda S.Higashi T.Furuse M.ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells:involvement of ZO-1 in the regulation of cytoskeleton and cell shape[J].PLoS One,2014,9(8):el04994.
[23]Li CGao M,Zhang W,et al..Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary ArteryDisease[J].Sci Rep,2016,6:29142.
[24]Ulluwishewa D.Anderson R CMcnabb W C.et al..Regulation of tight junction permeability by intestinal bacteria and dietary components[J].The Journal of Nutrition,2011,141(5):769-776.
[25]Garrod D.Chidgey M.Desmosome structure,composition and function[J].Biochim Biophys Acta,2008,1778(3):572-587.
[26]Brzozowski B,Mazur-Bialy A.Pajdo R,et al..Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease(IBD)Role of Brain-Gut Axis[J].Curr Neuropharmacol,2016 Apr 4.
[27]Elgin T G,Ken S L,Mcelroy S J.Development of the Neonatal Intestinal Microbiome and Its Association With Necrotizing Enterocolitis[J].Clin Ther,2016,38(4):706-715.
[28]栾兆双.断奶应激对仔猪肠上皮细胞紧密连接和p38MAPK的影响[D].硕士学位论文.杭州:浙江大学,2013.
[29]李鹏成.嗜酸乳酸杆菌S-层蛋白拮抗肠道病原菌黏附或入侵宿主细胞机制的研究[D].博士学位论文.南京:南京农业大学,2011.
[30]Xu C,Wu X,Hauck B K,et al..TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanism[J].Physiol Rep,2015,3(12).pii:el2636.
[31]Citalan-Madrid A F,Garcia-Ponce A,Vargas-Robles H,et al..Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function viacommon and unique mechanisms[J].Tissue Barriers,2013,1(5):e26938.
[32]Salinas R P,Ortiz-Flores R M.Distel J S,et al..Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDial and ROCK[J].PLos One,2015,10(12):e0145211.
[33]Xie L,Chiang E T,Wu X,et al..Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta[J].PLos One,2016,11(7):e0158865.
[34]Xu J,Wu P,Jiang W D,et al..Optimal dietary protein level improved growth,disease resistance,intestinal immune and physical barrierfunction of young grass carp(Ctenopharyngodon idella)[J].Fish Shellfish Immunol,2016,55:64-87.
[35]Missotten J A,Michiels J,Dierick N,et al..Effect of fermented moist feed on performance,gut bacteria and gut histo-morphology in broilers[J].Br Poult Sci,2013,54(5):627-634.
[36]Suo C,Yin Y S,Wang X N,,et al..Effects of Lactobacillus plantarum ZJ316 on pig growth and pork quality[J].BMC Vet Res,2012,8:89.
[37]邓军,李云峰,杨倩.枯草芽孢杆菌和猪源乳酸杆菌混合饲喂对仔猪肠绒毛发育的影响[J].畜牧兽医学报,2013,44(2):295-301.
[38]Qiao J Y,Li H H.Wang Z X,et al..Effects of Lactobacillus acidophilus dietary supplementation on the performance,intestinal barrier function,rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide[J].Antonie van Leeuwenhoek,2015,107:883-891.
[39]Mao X,Gu C,Hu H,et al..Dietary Lactobacillus rhamnosus GG Supplementation Improves the Mucosal Barrier Function in the Intestine of Weaned Piglets Challenged by Porcine Rotavirus[J].PLoS One,2016,11(1):e0146312.
[40]Wang A N,Cai C J,Zeng X F,et al..Dietary supplementation with Lactobacillus fermentum 15007 improves the antioxidative activity of weanling piglets challenged with diquat[J].J Appl Microbiol,2013,114(6):1582-1591.
[41]Wu S P,Yuan L J,Zhang Y G,et al..Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine[J].Gut Pathog,2013,5(1);22.
[42]Kim S HJeung W,Choi I D,et al..Lactic Acid Bacteria Improves Peyer's Patch Cell-Mediated Immunoglobulin A and Tight-Junction Expression in a Destructed Gut Microbial Environment[J].J Microbiol Biotechnol,2016,26(6):1035-1045.
[43]曹力,杨小军,刘南南,等.L.fermentum 1.2029对坏死性肠炎肉鸡回肠上皮紧密连接蛋白表达影响[J].中国兽医学报,2014,34(1):127-130.
[44]Laval L,Martin R,Nativided J N,et al..Lactobacillus rhamnosus CNCM 1-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice[J].Gut Microbes,2015,6(1):1-9.
[45]Wang Z,Wang L,Chen Z,et al..In Vitro Evaluation of Swine-Derived Lactobacillus reuteri:Probiotic Properties and Effects on Intestinal Porcine Epithelial Cells Challenged with Enterotoxigenic Escherichia coli K88[J].J Microbiol Biotechnol,2016,26(6):1018-1025.
[2]Yang F J,Hou C L,Zeng X F,et al..The Use of Lactic Acid Bacteria as a Probiotic in Swine Diets[J].Pathogens,2015,4:34-45.
[3]Hamdan A M,Ei-Sayed A F,Mahmoud M M.Effects of a novel marine probiotic,Lactobacillus plantarum AH 78,on growth performance and immuneresponse of Nile tilapia(Oreochromis niloticus)[J].J Appl Microbiol,2016,120(4):1061-1073.
[4]Sanz Y,De-Palma G.Gut microbiota and probiotics in modulation of epithelium and gut-associated lymphoid tissue function[J].Int Rev Immunol,2009,28(6):397-413.
[5]呙于明,刘丹,张炳坤.家禽肠道屏障功能及其营养调控[J].动物营养学报,2014,26(10):3091-3100.
[6]Miyauchi E,Morita H.Tanabe S.Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo[J].Journal of Dairy Science,2009,92(6):2400-2408.
[7]Van-Itallie C M.Anderson J M.Architecture of tight junctions and principles of molecular composition[J].Seminars in Cell&Developmental Biology,2014,36:157-165.
[8]G(u|¨)Nzel D,Yu A S.Claudins and the Modulation of Tight Junction Permeability[J].Physiol Rev,2013,93(2):525-569.
[9]Blasig I E,Bellmann C,Cording J,et al..Occludin protein family:oxidative stress and reducing conditions[J],Antioxid Redox Signal,2011,15(5):1195-1219.
[10]Takasawa A,Kojima T,Ninomiya T,et al..Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions[J].Cell Tissue Res,2013,351(1):73-84.
[11]徐姝燕.紧密连接相关蛋白Oecludin的研究进展[J].国际儿科学杂志,2012,39(5):451-454.
[12]Mariano C,Sasaki H.Brites D,et al..A look at tricellulin and its role in tight junction formation and maintenance[J].Eur J Cell Biol,2011,90(10):787-96.
[13]Balda M S,Matter K.Tight junctions as regulators of tissue remodeling[J].Current Opinion in Cell Biology,2016,42:94-101.
[14]Tamura A,Tsukita S.Paracellular barrier and channel functions of TJ claudins in organizing biological systems;advances in the field of barriology revealed in knockout mice[J].Semin Cell Dev Biol,2014,36:177-185.
[15]Krause G,Winkler L,Piehl Cet al..Structure and function of extracellular claudin domains[J].Ann N Y Acad Sci,2009,1165:34-43.
[16]Suzuki T.Regulation of intestinal epithelial permeability by tight junctions[J].Cellular and Molecular Life Sciences,2013,70(4):631-659.
[17]房贺.连接黏附分子A在促进MSC修复C14肝损伤中的作用及其机制[D].博士学位论文.上海:第二军医大学,2015.
[18]Luissint A C,Nusrat A,Parkos C A.JAM-related proteins in mucosal homeostasis and inflammation[J].Semin Immunopathol,2014,36:211-226.
[19]Rodgers L S,Beam M T,Anderson J M,et al..Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1[J].J Cell Sci,2013,126:1565-1575.
[20]Koch S.Nusrat A.Dynamic regulation of epithelial cell fate and barrier function by intercellular junction[J].Ann N Y Acad Sci,2009,1165:220-227.
[21]Fanning A S,Van-Itallie C M,Anderson J M.Zonula occludens-1 and-2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia[J].Mol Biol Cell,2012,23(4):577-590.
[22]Tokuda S.Higashi T.Furuse M.ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells:involvement of ZO-1 in the regulation of cytoskeleton and cell shape[J].PLoS One,2014,9(8):el04994.
[23]Li CGao M,Zhang W,et al..Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary ArteryDisease[J].Sci Rep,2016,6:29142.
[24]Ulluwishewa D.Anderson R CMcnabb W C.et al..Regulation of tight junction permeability by intestinal bacteria and dietary components[J].The Journal of Nutrition,2011,141(5):769-776.
[25]Garrod D.Chidgey M.Desmosome structure,composition and function[J].Biochim Biophys Acta,2008,1778(3):572-587.
[26]Brzozowski B,Mazur-Bialy A.Pajdo R,et al..Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease(IBD)Role of Brain-Gut Axis[J].Curr Neuropharmacol,2016 Apr 4.
[27]Elgin T G,Ken S L,Mcelroy S J.Development of the Neonatal Intestinal Microbiome and Its Association With Necrotizing Enterocolitis[J].Clin Ther,2016,38(4):706-715.
[28]栾兆双.断奶应激对仔猪肠上皮细胞紧密连接和p38MAPK的影响[D].硕士学位论文.杭州:浙江大学,2013.
[29]李鹏成.嗜酸乳酸杆菌S-层蛋白拮抗肠道病原菌黏附或入侵宿主细胞机制的研究[D].博士学位论文.南京:南京农业大学,2011.
[30]Xu C,Wu X,Hauck B K,et al..TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanism[J].Physiol Rep,2015,3(12).pii:el2636.
[31]Citalan-Madrid A F,Garcia-Ponce A,Vargas-Robles H,et al..Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function viacommon and unique mechanisms[J].Tissue Barriers,2013,1(5):e26938.
[32]Salinas R P,Ortiz-Flores R M.Distel J S,et al..Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDial and ROCK[J].PLos One,2015,10(12):e0145211.
[33]Xie L,Chiang E T,Wu X,et al..Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta[J].PLos One,2016,11(7):e0158865.
[34]Xu J,Wu P,Jiang W D,et al..Optimal dietary protein level improved growth,disease resistance,intestinal immune and physical barrierfunction of young grass carp(Ctenopharyngodon idella)[J].Fish Shellfish Immunol,2016,55:64-87.
[35]Missotten J A,Michiels J,Dierick N,et al..Effect of fermented moist feed on performance,gut bacteria and gut histo-morphology in broilers[J].Br Poult Sci,2013,54(5):627-634.
[36]Suo C,Yin Y S,Wang X N,,et al..Effects of Lactobacillus plantarum ZJ316 on pig growth and pork quality[J].BMC Vet Res,2012,8:89.
[37]邓军,李云峰,杨倩.枯草芽孢杆菌和猪源乳酸杆菌混合饲喂对仔猪肠绒毛发育的影响[J].畜牧兽医学报,2013,44(2):295-301.
[38]Qiao J Y,Li H H.Wang Z X,et al..Effects of Lactobacillus acidophilus dietary supplementation on the performance,intestinal barrier function,rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide[J].Antonie van Leeuwenhoek,2015,107:883-891.
[39]Mao X,Gu C,Hu H,et al..Dietary Lactobacillus rhamnosus GG Supplementation Improves the Mucosal Barrier Function in the Intestine of Weaned Piglets Challenged by Porcine Rotavirus[J].PLoS One,2016,11(1):e0146312.
[40]Wang A N,Cai C J,Zeng X F,et al..Dietary supplementation with Lactobacillus fermentum 15007 improves the antioxidative activity of weanling piglets challenged with diquat[J].J Appl Microbiol,2013,114(6):1582-1591.
[41]Wu S P,Yuan L J,Zhang Y G,et al..Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine[J].Gut Pathog,2013,5(1);22.
[42]Kim S HJeung W,Choi I D,et al..Lactic Acid Bacteria Improves Peyer's Patch Cell-Mediated Immunoglobulin A and Tight-Junction Expression in a Destructed Gut Microbial Environment[J].J Microbiol Biotechnol,2016,26(6):1035-1045.
[43]曹力,杨小军,刘南南,等.L.fermentum 1.2029对坏死性肠炎肉鸡回肠上皮紧密连接蛋白表达影响[J].中国兽医学报,2014,34(1):127-130.
[44]Laval L,Martin R,Nativided J N,et al..Lactobacillus rhamnosus CNCM 1-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice[J].Gut Microbes,2015,6(1):1-9.
[45]Wang Z,Wang L,Chen Z,et al..In Vitro Evaluation of Swine-Derived Lactobacillus reuteri:Probiotic Properties and Effects on Intestinal Porcine Epithelial Cells Challenged with Enterotoxigenic Escherichia coli K88[J].J Microbiol Biotechnol,2016,26(6):1018-1025.
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