妊娠期妇女感染HPV及其对产妇和胎儿的影响分析
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- 论文作者：赖繁 ; 王晓东 ; 赵虎 ; 杨军
- 年：2016
- 作者机构：四川大学华西第二医院;
- 论文关键词：妊娠期 ; 人乳头瘤病毒(HPV) ; 产妇 ; 胎儿 ; 影响分析
- 英文论文关键词：gestation period ; human papilloma virus ; pregnant women ; fetus ; influence analysis
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R737.33;R714.2
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1898k
- 原文格式：D
- 会议级别：全国
摘要
目的分析妊娠期妇女感染人乳头瘤病毒(HPV)及其对产妇和胎儿的影响。方法选取2013年7月至2015年7月在我院产科门诊建卡产检且分娩的116例感染人乳头瘤病毒的产妇作为实验组研究对象,另选取同时期在我院产科门诊建卡产检且分娩的健康孕妇116例为对照组研究对象,分别对产妇分娩时羊水、胎盘组织及胎儿脐静脉血、口咽部分泌物与外阴分泌物中的HPV进行检测,分析产妇HPV的感染分型,并随访一年,观察HPV感染对产妇和胎儿的影响。结果实验组中单型HPV感染及高危型HPV感染的患者所占比例较大,分别为66.38%和76.72%;患者宫颈肉眼形态异常炎症、细胞学检验呈鳞状上皮病变是感染HPV的危险因素;两组患者在分娩方式、产后出血及胎儿生长受限等方面比较,差异无统计学意义(P>0.05);正常阴道分娩与剖宫产分娩的胎儿在羊水、胎盘组织及脐静脉血、口咽部分泌物、外阴分泌物或包皮分泌物中的HPV阳性检出率比较无明显差异(P>0.05);胎儿HPV感染率为24.14%,其中17例胎儿HPV感染分型与产妇一致,11例胎儿HPV感染分型与产妇不一致。结论单型HPV感染及高危型HPV感染是妊娠期妇女HPV感染的主要分型,妊娠期妇女感染HPV可通过垂直传播导致胎儿感染HPV,但胎儿的HPV感染分型与产妇不完全一致,且与产妇分娩方式无关,妊娠期妇女感染HPV对妊娠结局和胎儿的影响较小。
Objective To analyze the influence of human papilloma virus(HPV) and its effect on maternal and fetus during pregnancy.Methods Selected July 2014 to July 2016 ingynecology clinic cards production inspection and delivery of 116 cases of infection of human papilloma virus maternal as research object in the experimental group, select the same period inthe gynecology clinic cards production inspection and delivery of healthy pregnant women 116 cases as the subjects of the control group, respectively of parturient in amniotic fluid, placenta andfetal umbilical venous blood, oropharyngeal secretion and vulva secretion of HPV detection, analysis of maternal HPV infection type, and followed up for one year, and observe the effect of HPVinfection on maternal and fetal.Results In the experimental group of single HPV infection and high-risk HPV infection in patients with larger proportion, respectively 66.38% and 76.72%; thepatients with cervical eye form is inflammation, cytology was squamous epithelial lesions are the risk factors of HPV infection were compared between the two groups; in the mode of delivery, postpartum hemorrhage, fetal growth restriction, difference no statistical significance(P>0.05); two patients in the amniotic fluid, placenta and umbilical venous blood, oropharynx, vulva secretionor wrapping secretion in the HPV positive rate was not significantly different(P>0.05); the infection rate of fetal HPV was 24.14%, which is consistent with the classification of 17 cases of maternalfetal HPV infection, 11 cases of fetal HPV infection type and maternal inconsistent.Conclusions Single type HPV infection and high risk type HPV infection is pregnancy period of women withHPV infection, the main type, HPV infection in pregnant women can through vertical transmission cause fetal infection of HPV, but fetal HPV infections were divided into type and maternal notcompletely consistent and maternal mode of delivery and has nothing to do pregnancy period of women are infected with HPV on the outcome of pregnancy and the fetus has little effect.
Objective To analyze the influence of human papilloma virus(HPV) and its effect on maternal and fetus during pregnancy.Methods Selected July 2014 to July 2016 ingynecology clinic cards production inspection and delivery of 116 cases of infection of human papilloma virus maternal as research object in the experimental group, select the same period inthe gynecology clinic cards production inspection and delivery of healthy pregnant women 116 cases as the subjects of the control group, respectively of parturient in amniotic fluid, placenta andfetal umbilical venous blood, oropharyngeal secretion and vulva secretion of HPV detection, analysis of maternal HPV infection type, and followed up for one year, and observe the effect of HPVinfection on maternal and fetal.Results In the experimental group of single HPV infection and high-risk HPV infection in patients with larger proportion, respectively 66.38% and 76.72%; thepatients with cervical eye form is inflammation, cytology was squamous epithelial lesions are the risk factors of HPV infection were compared between the two groups; in the mode of delivery, postpartum hemorrhage, fetal growth restriction, difference no statistical significance(P>0.05); two patients in the amniotic fluid, placenta and umbilical venous blood, oropharynx, vulva secretionor wrapping secretion in the HPV positive rate was not significantly different(P>0.05); the infection rate of fetal HPV was 24.14%, which is consistent with the classification of 17 cases of maternalfetal HPV infection, 11 cases of fetal HPV infection type and maternal inconsistent.Conclusions Single type HPV infection and high risk type HPV infection is pregnancy period of women withHPV infection, the main type, HPV infection in pregnant women can through vertical transmission cause fetal infection of HPV, but fetal HPV infections were divided into type and maternal notcompletely consistent and maternal mode of delivery and has nothing to do pregnancy period of women are infected with HPV on the outcome of pregnancy and the fetus has little effect.
引文
[1]王丹丹,杨慧琳,杨伶俐.妊娠晚期宫颈高危型人乳头状瘤病毒感染及自然转归状况分析[J].上海交通大学学报(医学版),2013,33(11):1488.
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[9]朱佳佳,杨君,余友霞,等.重庆地区278例产褥期妇女高危型H PV感染状况及对H PV认知情况调查分析[J].检验医学与临床,2012,9(22):2785-2786.
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[15]郑晓霞,王谢桐,于珊.妊娠期人乳头瘤病毒感染对母儿影响的探讨[J].实用妇产科杂志,2011,27(03):223-226.
[2]周小玲,黄瑾.妊娠与高危型人乳头瘤病毒感染易感性的相关分析[J].中国优生与遗传杂志,2011,12(03):60-61.
[3]任睿,刘燕,周美英,等.妊娠期高危型人乳头瘤病毒感染的临床分析[J].中国妇幼保健,2014,29(15):2342-2343.
[4]姚恒,李静文.妊娠期及产后妇女高危型人乳头状瘤病毒感染分析[J].中国医药导报,2013,10(04):28-29.
[5]王新忠,赵俊红.妊娠及非妊娠妇女宫颈感染人乳头瘤病毒的基因亚型检测及分析[J].中国临床医学,2014,24(03):288-290.
[6]郑晓霞,张宏,杨秋红.妊娠合并人乳头瘤病毒感染203例临床分析[J].中国妇幼保健,2011,26(09):1312-1314.
[7]丁海燕,陈寒波,孙超.产妇高危型人乳头状瘤病毒感染分析[J].中华医院感染学杂志,2014,24(13):3330-3332.
[8]邓雅静,杜琳.妊娠晚期HPV潜伏感染对妊娠的影响分析[J].中国性科学,2013,22(05):62-64.
[9]朱佳佳,杨君,余友霞,等.重庆地区278例产褥期妇女高危型H PV感染状况及对H PV认知情况调查分析[J].检验医学与临床,2012,9(22):2785-2786.
[10]刘建华.妊娠期生殖道HPV感染及其对妊娠的影响[J].国际生殖健康/计划生育杂志,2015,34(06):467-470.
[11]魏振玲,黄华.妊娠期孕妇人乳头状瘤病毒感染的分型与母婴垂直传播的相关性研究[J].中华医院感染学杂志,2014,24(01):12-14.
[12]金燕,陈彩蓉,郭晓燕,等.孕期及产后妇女高危型人乳头状瘤病毒感染状况分析[J].南方医科大学学报,2011,31(04):709-710.
[13]邓瑛,陈志梅,陈彬,等.人乳头瘤病毒经产道母婴垂直传播的分析[J].中国肿瘤,2014,23(11):913-916.
[14]周蓓蓓,张丽娜,范燕燕,等.孕期人乳头瘤病毒感染类型与母婴垂直传播的前瞻性研究[J].现代妇产科进展,2012,21(03):208-196.
[15]郑晓霞,王谢桐,于珊.妊娠期人乳头瘤病毒感染对母儿影响的探讨[J].实用妇产科杂志,2011,27(03):223-226.
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