原发性高血压病的蒙医辨证分型与颈动脉粥样硬化的关系
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摘要
目的运用蒙医辨证分型,对原发性高血压病致早期动脉粥样硬化的形成进行探讨。方法 2013年7月至2014年12月期间从内蒙古国际蒙医医院、内蒙古医科大学附属医院、内蒙古医科大学附属蒙中医院住院部及门诊收集符合诊断标准的原发性高血压病患者200例,进行蒙医辨证分型,分为赫依血偏盛型、巴达干赫依偏盛型、血希拉偏盛型、聚合型等4型,每型各50例,对入选的患者进行一般情况比较,并抽取入选患者清晨空腹静脉血,用ELISA酶标法分别测定血清一氧化氮(nitric oxide,NO)、血管紧张素转换酶2(angiotensin converting enzyme 2,ACE2)、高敏C反应蛋白(high-sensitivity C-reactive protein,HsCRP)浓度,采用PHILIPS iU22彩色多普勒超声诊断仪,测量颈动脉内膜-中层(intima-media thickness,IMT)厚度及是否形成斑块,根据所测得结果进行统计学比较。结果赫依血偏盛型、巴达干赫依偏盛型、血希拉偏盛型、聚合型4型间年龄、BMI、舒张压无统计学差异(P>0.05),性别、收缩压、压差、病程分布有统计差异(P<0.05),NO、ACE2、HsCPR浓度,LIMT、RIMT及斑块形成等均无统计学差异(P>0.05)。结论原发性高血压病蒙医各型均已形成颈动脉粥样硬化,但在蒙医各症型间无明显差异。
Objective By using Mongolian medicine dialectical types to investigate the early atherosclerosis induced by essential hypertension. Methods July 2013-December 2014 period from the Inner Mongolian International Hospital, Affiliated Hospital of Inner Mongolia University, Inner Mongolia Medical University Affiliated Hospital of inpatientand outpatient collected 200 cases of patients with essential hypertension, Conduct the Mongolian medicine dialectical types, Divided into the type of Hei Qisu piansheng, type of Badgan Hei piansheng, type of Qisu Xira piansheng, type of polymeric, And from the 4 types were randomly selected 50 patients with essential hypertension,the selected patients to comparing the general situation,the levels of serum nitric oxide(NO), angiotensin converting enzyme 2(ACE2) and high sensitivity C-reactive protein(HsCRP) were measured by ELISA with the selected patients' morning fasting blood and the thickness of the carotid intima-media(IMT) and the formation of plaques were measured by the PHILIPS iU22 color Doppler ultrasonography, and the results were statistically compared according to the measured results. Results There was no significant difference I,diastolic blood pressure(P>0.05), There were statistical differences in gender, systolic blood pressure,Pressure difference(P<0.05), And there was no significant difference in NO, ACE2, HsCPR concentration, LIMT, RIMT and plaque formation for the type of Hei Qisu piansheng, type of Badgan Hei piansheng, type of Qisu Xira piansheng, type of polymeric 4 types(P>0.05). Conclusion Hypertensive disease in all types have developed carotid atherosclerosis, but no significant difference in the Mongolia medicine various types.
Objective By using Mongolian medicine dialectical types to investigate the early atherosclerosis induced by essential hypertension. Methods July 2013-December 2014 period from the Inner Mongolian International Hospital, Affiliated Hospital of Inner Mongolia University, Inner Mongolia Medical University Affiliated Hospital of inpatientand outpatient collected 200 cases of patients with essential hypertension, Conduct the Mongolian medicine dialectical types, Divided into the type of Hei Qisu piansheng, type of Badgan Hei piansheng, type of Qisu Xira piansheng, type of polymeric, And from the 4 types were randomly selected 50 patients with essential hypertension,the selected patients to comparing the general situation,the levels of serum nitric oxide(NO), angiotensin converting enzyme 2(ACE2) and high sensitivity C-reactive protein(HsCRP) were measured by ELISA with the selected patients' morning fasting blood and the thickness of the carotid intima-media(IMT) and the formation of plaques were measured by the PHILIPS iU22 color Doppler ultrasonography, and the results were statistically compared according to the measured results. Results There was no significant difference I,diastolic blood pressure(P>0.05), There were statistical differences in gender, systolic blood pressure,Pressure difference(P<0.05), And there was no significant difference in NO, ACE2, HsCPR concentration, LIMT, RIMT and plaque formation for the type of Hei Qisu piansheng, type of Badgan Hei piansheng, type of Qisu Xira piansheng, type of polymeric 4 types(P>0.05). Conclusion Hypertensive disease in all types have developed carotid atherosclerosis, but no significant difference in the Mongolia medicine various types.
引文
[1] 王惠萍,付桂玲,于小洪.高血压颈动脉粥样硬化斑块的相关危险因素分析[J].中西医结合心脑血管病杂志,2014,12(1):39-40.
[2] AMER M S,ELAWAMl A E,KHATER M,et al.Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults [J].Jash,2011,5(5):395-400.
[3] 李丹,李玉洁,杨庆,等.血管内皮功能障碍与动脉粥样硬化研究进展[J].中国实验方剂学杂志,2012,18(8):272-276.
[4] 任志亮.血管紧张素转换酶2与疾病进展的相关性研究进展[J].心血管病学进展,2013,34(2):283-286.
[5] 赵晗章,唐力,朱芳.原发性高血压患者超敏 C 反应蛋白与颈动脉粥样硬化斑块的相关性[J].中国医科大学学报,2012,41(9):838-841.
[6] 德格吉日呼,娜仁高娃,德胜.高血压病的蒙医分型治疗[J].中国民族医药杂志,2008,3(4):20-21.
[7] 孟根杜希,哈申图雅.蒙药乌兰温都苏十一味丸治疗原发性高血压的观察[J].中医中药,2013,10(6):93-94.
[8] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[9] 包常山,额日敦其其格,张特日贡,等.原发性高血压的临床及病因研究[J].中国蒙医药,2013,27(9):37-40.
[10] 敖德德,孟根杜希,哈申图雅,等.高血压病蒙医诊治研究进展[J].中医药导报,2015,21(6):83-85.
[11] 陈伟伟,高润林,刘力生,等.《中国心血管病2015》概要[J].中国循环杂志,2016,31(6):521-528.
[12] 陈齐军,刘彬,杨潘杰,等.高血压与颈动脉粥样硬化相关性的研究进展[J].中华临床医师杂志,2014,8(13):2502-2505.
[13] 黄湘壹.信号分子一氧化氮与心血管疾病研究进展[J].社区医学杂志,2014,3(12):5-7.
[14] ZHANG LF.Region-specific vascular remodeling and its pre vention by artificial gravity in weightless environment[J].Eur J Appl Physiol,2013,11(3):2873-2878.
[15] 杨俊平,方五旺.血管紧张素转换酶2与心血管疾病[J].安徽医药,2013,17(5):861-863.
[16] 付锴.血管紧张素转换酶2与动脉粥样硬化的关系[J].西部医学,2012,24(3):614-617.
[17] 姜彩霞,郭建军,黎友隆.原发性高血压患者超敏C反应蛋白与颈动脉粥样硬化斑块的相关性[J].中国医药科学,2013,3(16):198-199.
[18] 金彩凤,包伟光.传统蒙医治疗高血压病的机理探讨[J].中国民族医药杂志,2009,3(3):20.
[19] 吕鹏飞,梁玉龙.血管内皮细胞功能损伤及保护措施中西医研究概况[J].河北中医,2014,36(1):139-141.
[2] AMER M S,ELAWAMl A E,KHATER M,et al.Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults [J].Jash,2011,5(5):395-400.
[3] 李丹,李玉洁,杨庆,等.血管内皮功能障碍与动脉粥样硬化研究进展[J].中国实验方剂学杂志,2012,18(8):272-276.
[4] 任志亮.血管紧张素转换酶2与疾病进展的相关性研究进展[J].心血管病学进展,2013,34(2):283-286.
[5] 赵晗章,唐力,朱芳.原发性高血压患者超敏 C 反应蛋白与颈动脉粥样硬化斑块的相关性[J].中国医科大学学报,2012,41(9):838-841.
[6] 德格吉日呼,娜仁高娃,德胜.高血压病的蒙医分型治疗[J].中国民族医药杂志,2008,3(4):20-21.
[7] 孟根杜希,哈申图雅.蒙药乌兰温都苏十一味丸治疗原发性高血压的观察[J].中医中药,2013,10(6):93-94.
[8] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[9] 包常山,额日敦其其格,张特日贡,等.原发性高血压的临床及病因研究[J].中国蒙医药,2013,27(9):37-40.
[10] 敖德德,孟根杜希,哈申图雅,等.高血压病蒙医诊治研究进展[J].中医药导报,2015,21(6):83-85.
[11] 陈伟伟,高润林,刘力生,等.《中国心血管病2015》概要[J].中国循环杂志,2016,31(6):521-528.
[12] 陈齐军,刘彬,杨潘杰,等.高血压与颈动脉粥样硬化相关性的研究进展[J].中华临床医师杂志,2014,8(13):2502-2505.
[13] 黄湘壹.信号分子一氧化氮与心血管疾病研究进展[J].社区医学杂志,2014,3(12):5-7.
[14] ZHANG LF.Region-specific vascular remodeling and its pre vention by artificial gravity in weightless environment[J].Eur J Appl Physiol,2013,11(3):2873-2878.
[15] 杨俊平,方五旺.血管紧张素转换酶2与心血管疾病[J].安徽医药,2013,17(5):861-863.
[16] 付锴.血管紧张素转换酶2与动脉粥样硬化的关系[J].西部医学,2012,24(3):614-617.
[17] 姜彩霞,郭建军,黎友隆.原发性高血压患者超敏C反应蛋白与颈动脉粥样硬化斑块的相关性[J].中国医药科学,2013,3(16):198-199.
[18] 金彩凤,包伟光.传统蒙医治疗高血压病的机理探讨[J].中国民族医药杂志,2009,3(3):20.
[19] 吕鹏飞,梁玉龙.血管内皮细胞功能损伤及保护措施中西医研究概况[J].河北中医,2014,36(1):139-141.
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